Clinical trials: Surgery of Upper Gastrointestinal Tract Cancer
Cancer Esophagus, Pancreatic Cancer
Effect of Chewing Gum on Postoperative Bowel Function Following Upper GI Tract Cancer Surgery
Every patient undergoing surgery in the abdomen will experience temporary paralysis of bowel function. This study evaluates whether chewing gum can reduce the bowel paralysis after surgery in patients undergoing either esophageal…
- Trial name
- NCT02260128
- Testing
- Chewing gum
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Michael Bau Mortensen
Esophageal Cancer
Trial of Enteral Nutrition Enriched With Eicosapentaenoic Acid (EPA) in Upper Gastrointestinal Cancer Surgery
This study aims to examine whether providing tube feeding with a formula enriched with omega-3 fats is better than traditional standard tube feeding in terms of preserving nutritional status, improving immune function and…
- Trial name
- NCT00790140
- Testing
- Prosure, Ensure Plus
- Where
- Ireland
- Volunteers
- 120 people
- Sponsor
- University of Dublin, Trinity College
Cancer, Digestive System, Cancer, Rectum
PREHAB - Improving Condition Before Surgery
The pilot research project is focused on the feasibility of a prehabilitation program for two groups of diagnoses (esophageal and stomach cancer, rectal cancer).
- Trial name
- NCT05646043
- Testing
- Physical training, Muscle strength training
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Ostrava
Immunonutrition, Gastric Cancer
Effect of Preoperative Immunonutrition in Upper Digestive Tract
Randomized, double-blind, multicenter clinical trial that will evaluate the effects of immuno-nutrition in the preoperative period in patients with cancer of the upper digestive tract (esophagus, stomach, and pancreas).
- Conditions
- Immunonutrition, Gastric Cancer, Esophageal Cancer, Pancreas Cancer
- Trial name
- NCT04027088
- Testing
- Immunonutrition, Standard
- Where
- 2 sites in Spain
- Volunteers
- 178 people
- Sponsor
- Complexo Hospitalario Universitario de A Coruña
Surgery of Upper Gastrointestinal Tract Cancer
Prehabilitation for Upper Gastrointestinal Tract Cancer Surgery
Patients receiving surgery of upper gastrointestinal tract are often elderly, frail, malnourished, with poor functional reserve. They are associated with poor post-operative outcomes.
- Trial name
- NCT07713888
- Testing
- Prehabilitation
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taichung Tzu Chi Hospital
Gastric Cancer, Pancreatic Cancer
The Impact of Immunostimulating Nutrition on the Outcome of Surgery
The aim of the study was to assess the clinical effect of immunostimulatory enteral and parenteral nutrition in patients undergoing resection for gastrointestinal cancer.
- Trial name
- NCT00558155
- Testing
- peptisorb, Stresson, Parenteral nutrition
- Where
- Poland
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Obesity, Obesity, Morbid
Luso-Cor Stent Compared to Other Endoscopic Techniques for Management of Fistulas and Anastomotic Dehiscences(ES-LCCE-UDFM)
The global prevalence of obesity has prompted an increase in bariatric surgery, which is the only management strategy that provides long-term weight loss and improvement of obesity-related diseases.
- Conditions
- Obesity, Obesity, Morbid, Esophageal Cancer, Esophageal Neoplasms
- Trial name
- ES-LCCE-UDFM (NCT06862479)
- Testing
- Endoscopic management of fistulas with stents or vacum therapy
- Where
- Portugal
- Volunteers
- 180 people
- Sponsor
- Unidade Local de Saúde Santa Maria
Gastrointestinal Neoplasms, Mesenteric Traction Syndrome
Mesenteric Traction Syndrome During Upper Gastrointestinal Surgery
It is the hypothesis of this project that the Mesenteric Traction Syndrome (MTS) is a common event during upper gastrointestinal cancer surgery (UGC surgery) and that the induction of the syndrome is an important factor in…
- Trial name
- NCT02507414
- Testing
- Blood samples, Measurement of microcirculation, Head down tilt
- Volunteers
- 75 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Head and Neck Cancer, Covid19
Impact of Covid-19 Pandemic on Management of Head and Neck Cancers
Since its emergence in late December 2019, the SARS-CoV-2 coronavirus has spread rapidly, causing a global health crisis. The disease caused by this highly contagious respiratory virus is called COVID-19.
- Conditions
- Head and Neck Cancer, Covid19, Patient Care
- Trial name
- VADS-Covid (NCT04704466)
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Upper Gastrointestinal Disorders, Lower Gastrointestinal Disorders
Sarcopenia and Physiology Assessments in Cancer Patients
Primary Aim: To establish a reliable relationship between oxygen uptake (VO2) at estimated lactate threshold (AT) and CT-derived body composition measurments (e.g.
- Conditions
- Upper Gastrointestinal Disorders, Lower Gastrointestinal Disorders, Hepatobiliary Cancer
- Trial name
- NCT03641118
- Testing
- Cardiopulmonary exercise test
- Where
- United Kingdom
- Volunteers
- 639 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Upper Urinary Tract Urothelial Carcinoma
The Danish Bladder Cancer Group 23 Study - A European Study on Cancer in the Upper Urinary Tract
This is a study looking at how patients with a rare type of cancer in the pelvis and ureter of the kidney - called upper urinary tract urothelial carcinoma (UTUC) - is currently treated.
- Trial name
- EuroCUT (NCT07077447)
- Testing
- Kidney sparing surgery for high-risk upper urinary tract urothelial carcinoma
- Where
- 5 sites in Denmark, Norway
- Volunteers
- 2,500 people
- Sponsor
- Zealand University Hospital
Esophageal Neoplasms, Stomach Neoplasms
Food Intake and Gut Hormones in Patients Who Have Undergone Upper Gastrointestinal Surgery for Cancer
Improvements to treatment strategies for patients upper gastrointestinal cancers have produced an increasing population of people who remain free from disease recurrence in the long term.
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02385617
- Testing
- Octreotide
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Upper Digestive Tract Cancer
Application of Medical Imaging Procedures in Surgery Implanting in Cancerology With the Aim to Reduce Invasive Acts
Aero digestive Cancer patients treated by external head and neck radiotherapy and/or by curie-therapy and/or mandible reconstruction by microanastomosed fibula flaps.
- Trial name
- ATIM (NCT00925509)
- Testing
- Therapeutic assessment -Radio-surgical guidance.
- Where
- 4 sites in France
- Volunteers
- 53 people
- Sponsor
- Centre Leon Berard
Effects of Chemotherapy, Cancer
The Effect of Chemotherapy on Lactate Threshold in Cancer Patients
It is important to assess patients' fitness for major cancer surgery which carries a high risk of mortality. Patients with poor heart and lung function have a higher risk of death after major cancer surgery.
- Trial name
- NCT01335555
- Where
- United Kingdom
- Volunteers
- 89 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Cancer
The Wessex Fit-4-Cancer Surgery Trial
Trial Phase: Phase III: A multi-centre efficacy pragmatic factorial design randomised controlled trial with patient informed development and process evaluation Indication: Patients undergoing major electively resectable intra …
- Trial name
- WesFit (NCT03509428)
- Testing
- SRETP, Psychological support
- Where
- United Kingdom
- Volunteers
- 1,560 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Upper GI Cancer
Immunonutrition for Surgical Prehabilitation of Patients With Upper GI Cancer
Perioperative immunonutrition has been proposed as a strategy to modulate the inflammatory response and improve outcomes after upper GI surgery.
- Trial name
- IMNUTPREH-UGIC (NCT07884214)
- Testing
- Oral nutritional supplements with immunonutrition (enriched with arginine, nucleotides, vitamin D and omega-3-fatty acid), Standart of care
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Cholecystitis, Perforated Duodenal Ulcer
Incentive Spirometry and Upper Abdominal Laparoscopic Surgery
To compare the effects of volume-oriented versus flow-oriented incentive spirometry on pulmonary function tests and functional capacity in patients of upper abdominal laparoscopic surgery.
- Conditions
- Cholecystitis, Perforated Duodenal Ulcer, Diaphragmatic Hernia, Benign Pancreas Tumor
- Trial name
- NCT04716166
- Testing
- Volume-oriented incentive spirometry, Flow-oriented incentive spirometry
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Esophageal Neoplasms, Stomach Neoplasms
Longitudinal Assessment of Gut Hormone Secretion Following Upper Gastrointestinal Surgery for Cancer
Surgery is the cornerstone of treatment for patients with oesophageal or gastric cancer, but while surgical removal of the tumour (oesophagectomy or gastrectomy) may offer the best chance of cure, these are major operations…
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02385630
- Testing
- Standardized 400kcal semi-liquid meal
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- St. James's Hospital, Ireland
Esophageal Cancer, Gastric Cancer
Sarcopenia and Visceral Obesity in Esophageal and Gastric Cancer
In line with improvements in oncologic outcome for patients with esophageal cancer, the attritional impact of curative treatment with respect to functional status and health-related quality of life (HR-QL) in survivorship is…
- Conditions
- Esophageal Cancer, Gastric Cancer, Sarcopenia, Sarcopenic Obesity
- Trial name
- NCT03061370
- Testing
- Esophagectomy or Gastrectomy
- Where
- 2 sites in Ireland
- Volunteers
- 317 people
- Sponsor
- St. James's Hospital, Ireland
Early-stage Upper Gastrointestinal Cancer, Stomach Cancer, Adenocarcinoma
Clinical Study on Using Laparoscopic Sentinel Lymph Node Navigation Combined With Dual Endoscopy Surgery for Early Gastric Cancer
Gastric cancer is a common malignant tumour worldwide, and in China, the incidence and mortality rates of gastric cancer remain high.
- Conditions
- Early-stage Upper Gastrointestinal Cancer, Stomach Cancer, Adenocarcinoma, Laparoscopy-assisted Surgery, Endoscope
- Trial name
- NCT07708012
- Testing
- Combined double-scope surgery
- Where
- 2 sites in China
- Volunteers
- 9 people
- Sponsor
- wangdongsheng