Clinical trials: Surgical Condition
Obesity, Morbid
Different Limb Lengths in Gastric Bypass Surgery (SLIM) - Part 3: Metabolism and Inflammation
Investigation of underlying metabolic mechanisms and impact on the two surgical procedures on inflammatory factors.
- Trial name
- SLIM - Part 3 (NCT05471037)
- Testing
- Long Biliopancreatic Limb LRYGB, Short Biliopancreatic Limb LRYGB
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Post Operative Pain, Spinal Surgery
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and…
- Trial name
- MEND (NCT07222072)
- Testing
- Methadone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Pain, Postoperative, Endodontically Treated Teeth
Postoperative Pain Intensity Associated With the Use of Different Nickel Titanium Instrumentation Systems
In this study the effect of different engine-driven nickel titanium (Ni-Ti) instrumentation systems (OneShape, Revo S and WaveOne) on postoperative dental pain in patients with asymptomatic teeth after a single-appointment root…
- Trial name
- NCT03478241
- Testing
- Group 1: single file rotary motion, Group 2: multiple file rotary motion, Group 3: single file reciprocal motion
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Lung Cancer
Research on Building and Application of Internet-based Home Pre-rehabilitation Model for Lung Surgery Patients.
This study, based on the Internet platform, involving family caregivers in preoperative management, not only promotes patient compliance with preoperative rehabilitation exercise, but also provides multi-way rehabilitation…
- Trial name
- NCT06458894
- Testing
- Prerehabilitation
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Obesity and Obesity-related Medical Conditions, Sarcopenic Obesity
Changes in Fat and Muscle Tissue Function and Their Impact on Metabolic Health After Bariatric Surgery
This prospective, single-center observational cohort study aims to explore the relationship between skeletal muscle quality, fat distribution, and metabolic health in Chinese patients with obesity, and to evaluate how bariatric…
- Conditions
- Obesity and Obesity-related Medical Conditions, Sarcopenic Obesity, Adipose Tissue, Abdominal
- Trial name
- NCT07035483
- Testing
- bariatric surgery
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shaihong Zhu
Stress Urinary Incontinence
Reducing Early Urinary Disorders After Stress Incontinence Surgery: The Role of Vaginal Wall Tension.
The progress in surgical procedures for treating female stress urinary incontinence has led to the development of tension-free techniques such as the trans-obturator tape (TOT).
- Trial name
- NCT06292702
- Testing
- Traditional Burch colposuspension, Modified Burch colposuspension
- Where
- Syria
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Damascus University
Surgical Site Infection
Prophylactic Effects for Preventing Surgical Site Infection in Third Molar Surgery
The purpose of this study is to determine the incidence of surgical site infection (SSIs) after third molar surgery for different duration of intravenous ampicillin administration.
- Trial name
- NCT06368102
- Testing
- Ampicillin
- Where
- Japan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Uji Takeda Hospital
Hernia, Inguinal
Comparing Bi-level and Single-level ESP Block for Open Inguinal Hernia Repair
The goal of this clinical trial is to compare the effects of single-level and bi-level erector spinae plane block in open inguinal hernia repair surgery.
- Trial name
- NCT06155253
- Testing
- Erector spinae plane block
- Where
- Hong Kong
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospital Authority, Hong Kong
Pancreas Neoplasm, Neuroendocrine Tumors
Portal Vein Resection in Pancreatic Neuroendocrine Tumours
The limited evidence on the value of portal vein resection in patients with borderline resectable and/or locally advanced PanNENs is an incentive to carry out a retrospective multicentre study amongst centres with specific…
- Trial name
- PVNET (NCT04336839)
- Testing
- Portal vein resection / reconstruction
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Molar, Third, Third Molar Surgery
3D Evaluation of Postoperative Edema After Third Molar Surgery
Surgical removal of third molars is recognized as one of the most frequent procedures performed in oral surgery. Literature is rich in studies attempting to demonstrate the benefit of corticosteroids in third molar surgery…
- Conditions
- Molar, Third, Third Molar Surgery, Soft Tissue Swelling, Pain, Postoperative
- Trial name
- NCT05941130
- Testing
- Combination of corticosteroid (methylprednisolone - Medrol, 16mg Pfizer Laboratories) therapy and non-steroidal anti-inflammatory (Ibuprofen 600mg Mylan) therapy, Non-steroidal anti-inflammatory therapy (Ibuprofen 600mg Mylan)
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Implantology Institute
Cognitive and Behavioral Impairment
Incidence of Postoperative Cognitive Decline in Patients With Preexisting Cognitive Impairment
This study aims to find out how often memory and thinking problems happen after surgery in people who already have memory issues before their operation. These memory problems are called postoperative cognitive decline (POCD).
- Trial name
- NCT07135336
- Testing
- surgery, norma
- Where
- China
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Peking University Shenzhen Hospital
Video-Assisted Thoracic Surgery
Quality of Postoperative Recovery (QoR-15T) in Patients Undergoing Video-Assisted Thoracoscopic Surgery (VATS)
Video-assisted thoracoscopic surgery (VATS) is a minimally invasive technique that provides faster recovery after thoracic surgery.
- Trial name
- NCT06558331
- Testing
- Bupivacaine 0,25%, Bupivacaine 0,375%
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Essential Tremor
Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy
Focused ultrasound for Essential Tremor is an FDA approved treatment performed by neurosurgeons at the Ohio State Center for Neuromodulation that utilizes ultrasound technology to create a lesion in the thalamus of Essential…
- Trial name
- NCT03560622
- Testing
- multi-modality neuroimaging
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vibhor Krishna
Normal Pressure Hydrocephalus
White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH)
Idiopathic Normal Pressure Hydrocephalus (iNPH) is a progressive condition of the elderly that results in severe disability. iNPH can dramatically respond to Cerebral spinal fluid(CSF)-shunting where excess ventricular fluid is…
- Trial name
- OWN-NPH (NCT07103681)
- Testing
- Ventriculoperitoneal Shunt (VP), Brain and Skin Biopsy, MRI Brain
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Ulcer, Skin Ulcer
Epidermal Grafting in Wound Healing
Split thickness skin grafting is the normal standard of care for wound closure. However, this is an invasive procedure and associated with pain also there can be additional donor site morbidity.
- Conditions
- Ulcer, Skin Ulcer, Wounds and Injuries
- Trial name
- EPIGRAAFT (NCT02535481)
- Testing
- Epidermal grafting, Split thickness skin grafting
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University College, London
Nursing Care, Patient Education
Comparison Of The Effects Of Different Body Mechanics Education
The study evaluated the comparison of the different patient education methods. The study involved two stages of data collection: one during the preoperative period, the other during the sixth postoperative week.
- Trial name
- NCT03792230
- Testing
- Video, Brochure
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Mild Cognitive Impairment
Preoperative Cognitive Screening of Surgical Patients 65 Years of Age or Older
The overall objectives of this study are to improve outcomes of surgical patients 65 years of age or older through risk stratification based on preoperative screening of cognition / mental function.
- Trial name
- NCT02570451
- Testing
- Patient Survey, Mini Cog, Independent Activities of Daily Living Score Sheet
- Where
- United States
- Volunteers
- 711 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Nerve Block, Neuromuscular Blockade
Dosage of Mepivacaine in Ultrasound Axillary Block
The use of ultrasonography as an adjunct to regional anesthesia has significantly increased in recent years. Brachial plexus blockade by an axillary approach is amenable to the use of ultrasound guidance.
- Conditions
- Nerve Block, Neuromuscular Blockade, Anesthesia
- Trial name
- NCT01485653
- Testing
- Mepivacaine
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Postoperative Nausea and Vomiting
Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery
The goal of this clinical trial is to see if pantoprazole (a proton pump inhibitor used for acid reflux/heart burn) can reduce nausea and vomiting after gynecologic surgery in women between the ages of 18 and 79.
- Trial name
- NCT06488001
- Testing
- pantoprazole
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, Portsmouth
Postoperative Nausea and Vomiting
Midazolam Versus Dexamethasone-ondansetron in Preventing Postoperative Nausea-vomiting for Laparoscopic Surgeries
Postoperative nausea and vomiting(PONV) affects 11 to 60 % of patients undergoing surgery and is a major cause of postoperative morbidity.
- Trial name
- NCT03603119
- Testing
- Normal saline, Midazolam, Dexamethasone, ondansetron
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
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