Clinical trials: Surgical Oncology
Breast Cancer
Paclitaxel and Radiation Therapy in Treating Patients Undergoing Surgery for Stage II or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00647218
- Testing
- Post-operative adjuvant therapy, neoadjuvant therapy, therapeutic surgical procedure
- Where
- 6 sites in United States
- Volunteers
- 38 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Pancreas Cancer
Pemigatinib in Subjects With Adenosquamous Carcinoma of the Pancreas
The purpose of this research is to determine the benefit of pemigatinib in patients with advanced metastatic or surgically unresectable adenosquamous carcinoma of the pancreas who have progressed on previous therapy.
- Trial name
- NCT05216120
- Testing
- Pemigatinib 4.5 MG
- Where
- United States
- Sponsor
- HonorHealth Research Institute
Clear Cell Renal Cell Carcinoma, Renal Cell Carcinoma (RCC)
Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer
This phase III trial compares the effect of adding tivozanib to standard therapy pembrolizumab versus pembrolizumab alone for the treatment of patients with high-risk renal cell carcinoma (RCC).
- Conditions
- Clear Cell Renal Cell Carcinoma, Renal Cell Carcinoma (RCC), Stage II Renal Pelvis Cancer AJCC v8, Stage III Renal Pelvis Cancer AJCC v8
- Trial name
- STRIKE (NCT06661720)
- Testing
- Pembrolizumab, Tivozanib, Biospecimen Collection
- Where
- 425 sites in United States
- Volunteers
- 1,040 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8
Daratumumab or FMS Inhibitor JNJ-40346527 Before Surgery in Treating Patients With High-Risk, Resectable Localized or Locally Advanced Prostate Cancer
This phase I trial studies the side effects of daratumumab or FMS inhibitor JNJ-40346527 before surgery in treating patients with high-risk prostate cancer that can be removed by surgery and has not spread to other parts of the…
- Conditions
- Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8, Stage IIIA Prostate Cancer AJCC v8, Stage IIIB Prostate Cancer AJCC v8
- Trial name
- NCT03177460
- Testing
- Daratumumab, FMS Inhibitor JNJ-40346527, Radical Prostatectomy
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Improving Surgical Decision-making in Young Women With Breast Cancer
The overall goal of this study is to qualitatively assess the surgical decision-making process from both the patient and physician perspective 1. Conduct short in-person interviews with young women prior to surgery 2.
- Trial name
- NCT02644382
- Testing
- qualitative data collection, survey, decision aid
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Pancreatic Ductal Adenocarcinoma (PDAC), Borderline Resectable Pancreatic Cancer
PDAC Regression and Intraoperative Surgical Margin With Neoadjuvant TAMP (PRISM-TAMP)
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival outcomes, even when treated with modern chemotherapy and radiation.
- Conditions
- Pancreatic Ductal Adenocarcinoma (PDAC), Borderline Resectable Pancreatic Cancer, Pancreatic Neoplasms
- Trial name
- PRISM-TAMP (NCT07477418)
- Testing
- Gemcitabine Delivered by Transarterial Microperfusion
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Vermont
Colorectal Cancer
Effect of Stent Placement on Short Term Survival of Left Sided Obstructive Colorectal Cancers
The aim of this observational study is to determine effect of stent placement on survival results in first three years in a patient who applied to the emergency department with obstruction due to colorectal cancer.
- Trial name
- NCT06437691
- Testing
- Self-Expandable Metallic Stent Placement
- Volunteers
- 65 people
- Sponsor
- Yasir Musa Kesgin, MD
Pancreatic Cancer, Surgery
Immunologic Signatures Following Surgery for Pancreatic Cancer
The goal of this pilot study is to evaluate and describe the immunologic and overall outcomes of subjects who undergo routine pancreatectomy with or without irreversible electroporation (IRE) for pancreatic cancer.
- Trial name
- NCT03001518
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Whey Protein, Postoperative Outcomes
Effect of Whey Protein Supplementation on Postoperative Outcomes After Gynecological Cancer Surgery
Major surgeries including gynecological cancer surgery can make surgical stress that leads to increased burden of postoperative complications, delayed length of hospital stay and increased mortality rate.
- Conditions
- Whey Protein, Postoperative Outcomes, Gynecological Cancer Surgery
- Trial name
- NCT06035510
- Testing
- whey protein supplement
- Where
- Thailand
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Anastomosis; Complications, Anastomosis, Surgical
Role of Indexed Oxygen Delivery in Anastomotic Insufficiencies in Elective Laparoscopic Colorectal Resections for Cancer
Colorectal cancer is a very commonly diagnosed malignancy worldwide, and surgical resection remains the mainstay of treatment. Outcomes depend on preoperative staging, surgical quality, complication rates, and multidisciplinary…
- Conditions
- Anastomosis; Complications, Anastomosis, Surgical, Anastomosis, Leaking, Anastomotic Leaks
- Trial name
- NCT07099820
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Saint Camillus International University of Health Sciences
Breast Cancer
Metformin Hydrochloride in Treating Women With Stage I or Stage II Breast Cancer That Can Be Removed By Surgery
RATIONALE: Metformin hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I trial is studying how well metformin hydrochloride works in treating women with…
- Trial name
- NCT00984490
- Testing
- metformin hydrochloride, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Glioblastoma, Surgery
Neoadjuvant Chemoradiation for Resectable Glioblastoma
Preoperative therapy has not been well studied in resectable glioblastoma. This study attempts to prospectively assess the feasibility and efficacy of preoperative chemo radiation in improving local control, as this is the…
- Conditions
- Glioblastoma, Surgery, High Grade Glioma
- Trial name
- NeoGlio (NCT04209790)
- Testing
- Neoadjuvant chemoradiation, Drug Therapy with Temozolomide (benzolamide) (Standard of Care), Surgery post Radiation and Temozolomide (benzolamide)
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Geisinger Clinic
Locally Advanced Rectal Cancer
Brachytherapy Followed by Nivolumab Prior to Surgery in Rectal Cancer
This is a small Phase II study testing whether targeted internal radiation treatment (HDREBT) followed by two doses of the immunotherapy drug Nivolumab is safe, practical, and potentially effective before patients undergo surgery…
- Trial name
- IMPERIA (NCT07645118)
- Testing
- Nivolumab, HDRBET, Total Mesorectal Excision (TME)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Dr. Te Vuong
Colorectal Neoplasms Malignant
Socioeconomic Position in Acute Colorectal Cancer Surgery
Acute colon cancer surgery has a poor 90-day mortality of 21.0% compared with only 3% after elective colorectal cancer surgery in Denmark.
- Trial name
- NCT03581890
- Testing
- Socioeconomic position
- Volunteers
- 35,000 people
- Sponsor
- Zealand University Hospital
Esophageal Cancer
S-1, Cisplatin, and Radiation Therapy in Treating Patients With Stage IIA, Stage III, or Stage IVA Esophageal Cancer That Can Be Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as S-1 and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00659113
- Testing
- cisplatin, tegafur-gimeracil-oteracil potassium, cytology specimen collection procedure
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Yonsei University
Breast Cancer, Breast Cancer Female
Microbiome and Association With Implant Infections
The most common tissue expander-related infections are from Staphylococcus and Pseudomonas species. In addition, from breast tissue microbiome studies, Staphylococcus and Pseudomonas show variable abundance across samples.
- Conditions
- Breast Cancer, Breast Cancer Female, Genetic Predisposition to Disease
- Trial name
- NCT05020574
- Testing
- Cephalexin
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Francisco
Analgesia
Erector Spinae Block Versus Caudal Block for Perioperative Analgesia in Pediatric Cancer Patients
The study aim to compare ultrasound guided erector spinae plane block versus ultrasound guided caudal block in perioperative analgesia for pediatric cancer patients
- Trial name
- NCT05153720
- Testing
- Erector spinae plane block, Caudal block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute, Egypt
Adrenal Incidentalomas
Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas
The general objective is to evaluate the consequences of surgical removal of SCSI on hypertension and cardiovascular risk factors in order to determine on an evidence-based basis if surgical excision of SCSI is preferable to an…
- Trial name
- CHIRACIC (NCT02364089)
- Testing
- Laparoscopic surgical removal of the adrenal tumor, Standardized medical treatment of hypertension by SAHR
- Where
- 17 sites in France, Germany and 1 more
- Volunteers
- 78 people
- Sponsor
- University Hospital, Bordeaux
Degenerative Disc Disease (DDD), Spinal Stenosis
PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials
This is a prospective, multi-center, observational Post-Market Clinical Follow-Up (PMCF) study designed to collect additional safety and clinical performance data on CE-marked Titania® spinal instrumentation and fusion systems…
- Conditions
- Degenerative Disc Disease (DDD), Spinal Stenosis, Spondylolisthesis, Spinal Deformities
- Trial name
- INFO SPINE (NCT07615491)
- Testing
- Titania® Cervical Interbody Fusion Cage (Titanium), Titania® Cervical Interbody Fusion Cage (PEEK), Titania® Posterior Cervical Stabilization System
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 561 people
- Sponsor
- Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co.
Oncology, Fertility Issues
Percutaneous Laparoscopy for Ovarian Tissue Cryopreservation.
To compare surgical outcomes of oncologic patients that underwent conventional laparoscopy and percutaneous laparoscopy for cryopreservation of ovarian tissue.
- Conditions
- Oncology, Fertility Issues, Surgery
- Trial name
- NCT05134090
- Testing
- Ovaian tissue explant
- Where
- Italy
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
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