Clinical trials: Surgical Oncology
Stage IIB Breast Cancer, Stage IIIA Breast Cancer
A Study of Gemcitabine, Epirubicin, and Paclitaxel Combination Chemotherapy Given Before Surgery to Patients With Locally Advanced Breast Cancer
The primary purpose of this study is to determine whether locally advanced breast cancer responds (by shrinking, by not progressing or by being destroyed) to combined chemotherapy (gemcitabine, epirubicin and paclitaxel) given…
- Conditions
- Stage IIB Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IV Breast Cancer
- Trial name
- NCT00378313
- Testing
- gemcitabine, epirubicin, paclitaxel
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- NSABP Foundation Inc
Esophageal Cancer, Weight Gain
Resection of the Esophagus and Subsequent Weight Loss
The investigators aim to ascertain how food reward signals and eating behaviour relates to the gut-brain pathway in weight-losing patients after curative surgery for oesophageal cancer, and how this pathway responds to clinical…
- Conditions
- Esophageal Cancer, Weight Gain, Eating Behavior, Food Reward
- Trial name
- REWARD (NCT03377660)
- Testing
- Clinical treatment
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Advanced or Metastatic Solid Tumors, FGFR Mutations
Efficacy and Safety of Pemigatinib in Participants With Solid Tumors With FGFR Mutations or Translocations (FIGHT-208)
The purpose of this study is to evaluate the efficacy and safety of pemigatinib in participants with previously treated locally advanced/metastatic or surgically unresectable solid tumors harboring activating FGFR mutations or…
- Conditions
- Advanced or Metastatic Solid Tumors, FGFR Mutations, FGFR Translocations
- Trial name
- NCT04003623
- Testing
- Pemigatinib
- Where
- 11 sites in United States
- Volunteers
- 1 people
- Sponsor
- Incyte Corporation
Estrogen Receptor-negative Breast Cancer, Estrogen Receptor-positive Breast Cancer
Combination Chemotherapy and Filgrastim Before Surgery in Treating Patients With HER2-Positive Breast Cancer That Can Be Removed By Surgery
This phase II trial studies how well giving combination chemotherapy and filgrastim together before surgery works in treating patients with human epidermal growth receptor 2 (HER2)-positive breast cancer that can be removed by…
- Conditions
- Estrogen Receptor-negative Breast Cancer, Estrogen Receptor-positive Breast Cancer, HER2-positive Breast Cancer, Progesterone Receptor-negative Breast Cancer
- Trial name
- NCT00194779
- Testing
- doxorubicin hydrochloride, cyclophosphamide, paclitaxel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
Lung Cancer
Combination Chemotherapy and Radiation Therapy Followed By Surgery in Treating Patients With Stage IIB or Stage IIIA Non-Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00006469
- Testing
- carboplatin, paclitaxel, conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Medstar Health Research Institute
Laparoscopic Hepatectomy, Hepatocellular Carcinoma
Surgical Specification and Efficacy Evaluation of Total Laparoscopic Left Liver Resection
Recent clinical experience showed that laparoscopic hepatectomy has advantages of minimally invasive compared to open liver resection, however, laparoscopic liver resection is still difficult and risky.
- Trial name
- NCT02131441
- Testing
- laparoscopic hepatectomy, open liver resection
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Pregnancy, Breast Cancer
Breast Cancer During Pregnancy
Patients are managed clinically according to ad hoc standards and scientific knowledge by a multidisciplinary team. Clinical decisions are made after a patient physician discussion. Blood and tissue samples are collected.
- Trial name
- BRCAPRE (NCT02102282)
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
C-Reactive Protein, Anastomotic Leak
C-protein Reactive for the Detection of Anastomotic Leakage After Surgery for Digestive Cancer
The aim of this study is to investigate the diagnostic accuracy of the C Protein Reactive (CRP) for the detection of Anastomotic leakage after surgery for digestive cancer.
- Conditions
- C-Reactive Protein, Anastomotic Leak, Digestive System Neoplasm
- Trial name
- NCT04133324
- Testing
- C-reactive protein
- Where
- Morocco
- Volunteers
- 500 people
- Sponsor
- Moroccan Society of Surgery
Surgery--Complications, Brain Tumor
Why Still in Neurosurgical Ward After Tumor Craniotomy?
The aim of this prospective observational study is to identify the specific reasons that prolong a hospital stay after elective tumor craniotomy.
- Trial name
- NCT05288088
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Stent Occlusion, Long-term Oncologic Results
Long-term Outcomes of Colonic Stent as a "Bridge to Surgery" for Malignant Large-bowel Obstruction
Study of long-term outcomes of colonic stent as a "bridge to surgery" for malignant large-bowel obstruction.
- Trial name
- NCT04111042
- Testing
- stenting
- Where
- Spain
- Volunteers
- 117 people
- Sponsor
- Corporacion Parc Tauli
Recurrent Ovarian Carcinoma
Secondary Interval Cytoreductive Surgery in Platinum-sensitive Recurrent Epithelial Ovarian Cancer
About 80% of advanced ovarian cancer patients recurred in 2-3 years. Secondary cytoreduction benefits selected patients who have high chance of complete resection.
- Trial name
- SCENIC (NCT06292286)
- Testing
- Carboplatin or cisplatin, Paclitaxel, gemcitabine or liposomal doxorubicin with or without bevacizumab or biosimilar, Bevacizumab or biosimilar
- Where
- Hong Kong
- Volunteers
- 18 people
- Sponsor
- The University of Hong Kong
Thymoma, Thymic Carcinoma
Chemotherapy Plus Cetuximab Followed by Surgical Resection in Patients With Locally Advanced or Recurrent Thymoma or Thymic Carcinoma
The main purpose of this study is to find out the good and the bad effects that the combination of cetuximab with the traditional chemotherapy regimen of cisplatin, doxorubicin, and cyclophosphamide has when given to patients…
- Conditions
- Thymoma, Thymic Carcinoma, Clinical Masaoka Stage II to IVA
- Trial name
- NCT01025089
- Testing
- Cetuximab, Cisplatin, Doxorubicin & Cyclophosphamide
- Where
- 8 sites in United States
- Volunteers
- 18 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer Surgery
Effect of Intravenous S-ketamine on Opioid Consumption
Female patients with an American Society of Anesthesia (ASA) physical status I-II, scheduled for elective breast cancer surgery will be included in the study.
- Trial name
- NCT05060068
- Testing
- S-ketamine (low dose), S-ketamine (high dose)
- Where
- China
- Volunteers
- 345 people
- Sponsor
- The Second Hospital of Anhui Medical University
Small Pulmonary Nodules, Pulmonary Nodule Localization
Monarch Robotic Bronchoscopy for Lung Nodule ICG Dye Marking Before VATS
This is a single-center, prospective, single-arm clinical study conducted at Beijing Cancer Hospital to evaluate the effectiveness, safety, and learning curve of preoperative indocyanine green (ICG) dye marking mixed with…
- Conditions
- Small Pulmonary Nodules, Pulmonary Nodule Localization, Lung Cancer (Suspected or Confirmed), Video-assisted Thoracoscopic Surgery (VATS)
- Trial name
- REALM (NCT07177924)
- Testing
- Monarch RAB with CBCT-guided ICG Dye Marking
- Volunteers
- 50 people
- Sponsor
- Peking University Cancer Hospital & Institute
Breast Cancer Female
Prone Breast Radiotherapy Treatment Planning Observational Study
The study purpose is to evaluate whether or not clinical characteristics of women with breast cancer can predict which position for radiation treatment, prone or supine, will be associated with a dosimetry gain.
- Trial name
- HUGProne (NCT02237469)
- Testing
- Prone and supine simulation
- Where
- Switzerland
- Volunteers
- 280 people
- Sponsor
- Vincent Vinh-Hung
Glioblastoma (GBM)
Limited Target Volume Radiotherapy After Glioblastoma Surgery
Research on radiotherapy target volumes for glioblastoma is increasingly focused on exploring more limited yet effective irradiation fields, aiming to achieve local control while minimizing acute and long-term neurotoxicity.
- Trial name
- NCT07368283
- Testing
- limited-field radiotherapy
- Volunteers
- 79 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Pancreatic Cancer With Liver Metastases
Surgical Management of Pancreatic Cancer With Liver Metastasis (Oligometastasis)
Pancreatic cancer is one of the most serious forms of cancer. When it has already spread to the liver, treatment usually consists of chemotherapy rather than surgery.
- Trial name
- POlig (NCT07446946)
- Volunteers
- 68,303 people
- Sponsor
- Richard Hunger
Breast Cancer, Malignant Neoplasm of Breast
Breast Reconstruction Following Breast Cancer in Very High Risk Patients
The purpose of this study is to: 1. Evaluate whether immediate or delayed reconstruction should be offered for breast reconstruction candidates with higher risk for surgical complications by comparing complications, quality of…
- Trial name
- NCT03261323
- Testing
- Immediate Breast Reconstruction, Delayed Breast Reconstruction, Breast-Q questionnaire
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Lung Cancer (NSCLC), Neoadjuvant Immunotherapy
Safety, Efficacy, and Survival Outcomes of Neoadjuvant/Induction Immunotherapy in Surgical and Radiotherapeutic Management of Non-Small Cell Lung Cancer
This multicenter retrospective real-world study aims to evaluate the safety, efficacy and survival outcomes of neoadjuvant/induction immunotherapy in patients with non-small cell lung cancer (NSCLC).
- Conditions
- Lung Cancer (NSCLC), Neoadjuvant Immunotherapy, Radiotherapy, Lung Surgery
- Trial name
- NCT06926179
- Testing
- neoadjuvant immunotherapy
- Where
- 4 sites in China
- Volunteers
- 500 people
- Sponsor
- Peking University Cancer Hospital & Institute
Uterine Myoma, Persistent Post-menpausal Bleeding
Intravenous or Intra-abdominal Local Anesthetics for Postoperative Pain Management.
Local anesthetics (LA) are increasingly used for postoperative pain management. Speicifically, several studies have found benefit of LA injected intra-abdominally following abdominal hysterectomy.
- Conditions
- Uterine Myoma, Persistent Post-menpausal Bleeding, Uterine Cancer
- Trial name
- PoPuLAR (NCT01492179)
- Testing
- Normal saline, Intravenous Lidocaine, Intra-abdominal Lidocaine
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Örebro University, Sweden
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