Clinical trials: Surgical Procedures
Breast Cancer
PEAK PlasmaBlade™ 4.0 Versus Traditional Electrosurgery in Lumpectomy
The purpose of this clinical study is to quantify the difference in thermal injury depth at the surgical margin in breast lumpectomy specimens excised with the PlasmaBlade; to subjectively assess histopathologic sample quality…
- Trial name
- PRECISE (NCT00960154)
- Testing
- PEAK PlasmaBlade, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Medtronic Surgical Technologies
Surgery
Device to Reduce Surgery Site Contamination
The objective of this study is to determine whether the Air Barrier System device reduces airborne particulate and airborne colony forming units present at a surgery site.
- Trial name
- NCT00972153
- Testing
- Air Barrier System Device
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Nimbic Systems, LLC
Digital Block
Comparison of Three Methods of Hemoglobin Monitoring
This study will further investigate the Masimo SpHb [FDA Approved] continuous non-invasive hemoglobin monitor in spine surgery patients.
- Trial name
- NCT01284296
- Testing
- Lidocaine digital block, Masimo SpHb continuous hemoglobin monitor
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Breast Cancer
Radiofrequency of Breast Cancers in Non Surgical Patients
To determine the efficacy and tolerance of ultrasonography (US)-guided percutaneous radiofrequency (RF) ablation with endocrine therapy in elderly patients with breast cancer who decline or are not candidates for surgery.
- Trial name
- RF-SEIN (NCT00210223)
- Testing
- ultrasonography (US)-guided percutaneous radiofrequency (RF) ablation with endocrine therapy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Institut Bergonié
Surgical Skin Preparation
In-vivo Efficacy of Patient Preoperative Prep, ZuraPrep (ZP)
The objective of the study is to demonstrate the antimicrobial efficacy of the Zurex Preoperative Prep (ZuraPrep - clear) on skin flora of the abdomen and inguinal regions of human subjects.
- Trial name
- ZP (NCT03782103)
- Testing
- ZuraPrep Clear Solution, ChloraPrep, ZuraPrep Vehicle
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Zurex Pharma, Inc.
Trauma-related Wound, Surgical Incision
3M™ Topical Tissue Adhesive Versus Commercially Available Tissue Adhesive for the Closure of Lacerations and Incisions
The purpose of this study is to generate safety and performance data for 3M™ Topical Tissue Adhesive. Enrolled subjects with qualifying trauma lacerations or surgical incisions will be randomized to receive 3M™ Topical Tissue…
- Conditions
- Trauma-related Wound, Surgical Incision, Surgical Wound, Laceration
- Trial name
- Lublin (NCT06217081)
- Testing
- 3M Topical Tissue Adhesive, Histoacryl® Blue Topical Skin Adhesive
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Fluid Overload, Anesthesia; Adverse Effect, Spinal and Epidural
Can Vena Cava Ultrasound Guided Volume Repletion Prevent Spinal Induced Significant Hypotension in Elective Patients?
Aim of this study is to determine whether Inferior Vena Cava analyzed by trans-thoracic echocardiography is an effective method to guide titrated fluid repletion in non critical patients, in order both to decrease post procedural…
- Conditions
- Fluid Overload, Anesthesia; Adverse Effect, Spinal and Epidural, Regional Anesthesia Morbidity
- Trial name
- NCT02271477
- Testing
- Ultrasound-guided volemic repletion
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Myopia
The Accuracy of Flap Thickness Versus the Pre-determined Surgical Planning Using WaveLight® FS200
The objective is to evaluate the resultant thickness of the FS200 created LASIK flap compared to plan at the surgical visit.
- Trial name
- NCT05501795
- Testing
- WaveLight® FS200 femtosecond laser
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Stephen Wexler
Urinary Incontinence, Sarcopenia
The Urinary Incontinence Treatment Study
Investigators plan a prospective cohort study with an adaptive design based on physical function status. The design will involve tracking the number of women recruited with physical function impairment and those without any…
- Trial name
- UNITS (NCT03057834)
- Testing
- Pelvic floor muscle exercise
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Diabetic Foot Ulcer, Surgical Wound
The Effect of Natrox® Oxygen Wound Therapy on the Healing Rate of Chronic Diabetic Foot Ulcers
A Multicentre Randomized Controlled Trial to Investigate the Effect of Natrox Topical Oxygen Wound Therapy on the Healing rates of Diabetic Foot Ulcers.
- Trial name
- NCT03905863
- Testing
- Natrox® Oxygen Wound Therapy
- Where
- 20 sites in United States, Puerto Rico
- Volunteers
- 145 people
- Sponsor
- Inotec AMD Limited
Polyneuropathies, Obesity
Effect of Exercise and Surgical Weight Loss on Polyneuropathy
The purpose of this research study is to evaluate how exercise and surgical weight loss affect how likely an individual is to develop peripheral neuropathy and other neurologic complications.
- Conditions
- Polyneuropathies, Obesity, Bariatric Surgery Candidate
- Trial name
- NCT03617185
- Testing
- High Intensity Interval Training (HIIT), Routine Exercise, Bariatric surgery
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Michigan
Macromastia
Study of Prineo (Dermabond Protape) Versus Sutures in Breast Procedures
This is a prospective, controlled, randomized, multi-center clinical study of up to 80 patients with full thickness surgical incisions associated with bi-lateral breast procedures.
- Trial name
- NCT00558246
- Testing
- Dermabond Protape (Prineo), Suture
- Where
- 5 sites in Belgium, Germany and 2 more
- Volunteers
- 79 people
- Sponsor
- Ethicon, Inc.
Neuromuscular Blockade, Postoperative Complications
Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery
The investigators will conduct a prospective, randomized trial to assess the impact of neuromuscular blockade on early (<72 hours post-ICU admission) postoperative respiratory complications in cardiac surgical patients.
- Trial name
- NCT02635542
- Testing
- Succinylcholine, Cisatracurium
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Fatigue, Self Efficacy
Understanding the Post-Surgical Non-Small Cell Lung Cancer Patient's Symptom Experience
Among 13 core symptoms across 3,106 breast, colorectal, prostate, and lung cancer patients, persons with lung cancer were the most symptomatic, with moderate to severe fatigue being reported with the greatest prevalence.
- Conditions
- Fatigue, Self Efficacy, Quality of Life, Physical Activity
- Trial name
- NCT03724331
- Testing
- Light Physical Activity 1, Light Physical Activity 2, Support Education Activity
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- University of Nebraska
Glioblastoma, Recurrent Glioblastoma
VB-111 in Surgically Accessible Recurrent/Progressive GBM
This research study is studying a new viral cancer therapy, ofranergene obadenovec (VB-111), for recurrent or progressive glioblastoma (GBM), a brain tumor that is growing or progressing despite earlier treatment.
- Trial name
- NCT04406272
- Testing
- VB11, Surgery, Bevacizumab
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Dana-Farber Cancer Institute
Glaucoma
Use of Ranibizumab With Mitomycin C During Trabeculectomy
The purpose of the study is to study the safety of the combination of ranibizumab and MMC vs monotherapy MMC vs intravitreal ranibizumab injection in patients with glaucoma.
- Trial name
- OCTOPUS (NCT00661583)
- Testing
- Ranibizumab, Ranibizumab and MMC, MMC
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Invasive Candidiasis
β-D-Glucan (BDG) Surveillance With Preemptive Anidulafungin vs. Standard Care for Invasive Candidiasis in Surgical Intensive Care Unit (SICU) Patients
This is a single center, prospective, open label assessment of β-D-glucan surveillance with preemptive anidulafungin therapy versus standard care for the prevention of invasive candidiasis in at-risk surgical intensive care unit…
- Trial name
- NCT00672841
- Testing
- Preemptive Therapy with Anidulafungin, Empiric antifungal therapy based on physician discretion.
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Duke University
Tonsillitis
PEAK PlasmaBlade TnA Versus Traditional Electrosurgery in Subcapsular Tonsillectomy
The objective of this clinical study is to evaluate the operative performance of the PEAK PlasmaBlade® TnA during subcapsular tonsillectomy; to monitor and record post-operative clinical outcome variables; and to compare these…
- Trial name
- PRECISE (NCT01193556)
- Testing
- PEAK PlasmaBlade TnA, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Medtronic Surgical Technologies
Wound of Skin, Wound Heal
Efficacy and Safety of 0.25% Timolol Gel in Healing Surgical Open Wounds
The use of topical beta-blockers, such as 0.25% timolol, in promoting wound healing is currently emerging in the academic literature.
- Conditions
- Wound of Skin, Wound Heal, Wound Open, Surgical Wound
- Trial name
- NCT03452072
- Testing
- 0.25% Timolol gel with paraffin gauze dressings, Vaseline dressing
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pelvic Organ Prolapse
FINPOP 2015: Incidence, Methods, Complications and Quality of Life of Pelvic Organ Prolapse Operations in Finland 2015
The aim of this study is to investigate the safety and effectivity of pelvic organ prolapse (POP) surgery. In this multi center study the population consists of POP operations done in Finland year 2015.The study is prospective…
- Trial name
- NCT02716506
- Testing
- POP surgery
- Where
- Finland
- Volunteers
- 3,515 people, healthy volunteers welcome
- Sponsor
- Society for Gynecological Surgery in Finland
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