Clinical trials: Surgical Procedures
Breast Cancer
Study to Assess Effectiveness of Giving Combination of Standard Chemotherapy Drugs Versus Combination of Standard Chemotherapy and New Drug Ixabepilone When Given Before Surgical Removal of Early Stage Breast Cancer
The study will evaluate the effectiveness of ixabepilone when given after doxorubicin plus cyclophosphamide (AC) compared to standard treatment of paclitaxel given after doxorubicin plus cyclophosphamide in patients with early…
- Trial name
- NCT00455533
- Testing
- Ixabepilone, Paclitaxel, Cyclophosphamide
- Where
- 49 sites in United States, Argentina and 13 more
- Volunteers
- 384 people
- Sponsor
- Bristol-Myers Squibb
Surgical Site Infection
DFA-02 in Patients Undergoing Colorectal Surgery
This is a randomized, double-blind, placebo controlled, safety, tolerability, and pharmacokinetic dose escalation Phase II study of DFA-02 in patients undergoing colorectal surgery to evaluate the safety, tolerability and…
- Trial name
- NCT01496352
- Testing
- DFA-02
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Gynecomastia
Renuvion APR System When Used as an Adjunct Procedure In Gynecomastia Surgery
This is a prospective, multi-center, single-blinded, randomized study of up to 10 study subjects undergoing bilateral gynecomastia surgery with Renuvion APR System used as an adjunct procedure on one side.
- Trial name
- NCT05093049
- Testing
- Renuvion APR System, Gynecomastia Correction Surgery
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Apyx Medical
Liver Cancer, Pancreatic Cancer
Postoperative Thoracic Epidural Analgesia Versus Intravenous Patient-Controlled Analgesia For Liver and/or Pancreas
The goal of this clinical research study is to learn if there is a difference in patients' quality of recovery if they receive 1 of 2 standard kinds of pain control treatments after surgery on the liver and/or pancreas.
- Trial name
- NCT01438476
- Testing
- Intravenous Patient-Controlled Analgesia (IVPCA), Thoracic Epidural Analgesia (TEA), Questionnaires
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- M.D. Anderson Cancer Center
Complications; Cesarean Section, Surgical Wound Infection
Subcuticular Suture for Cesarean Skin Incision Closure
A comparison of the type of suture used for cesarean skin incision approximation and the subsequent rate of wound complications has not been widely studied.
- Trial name
- NCT02459093
- Testing
- poliglecaprone 25 suture, polyglactin 910 suture
- Where
- 2 sites in United States
- Volunteers
- 550 people
- Sponsor
- Montefiore Medical Center
Fractures, Comminuted, Surgical Wound Dehiscence
Application of Indocyanine Green Angiography for Closed Operative Calcaneus Fractures
Researchers in the Orthopaedic surgery department at LSU Medical Center-Shreveport hope to learn if patterns of blood-flow around the incision site of patients undergoing surgery for heel-bone fractures can help predict whether…
- Conditions
- Fractures, Comminuted, Surgical Wound Dehiscence, Necrosis
- Trial name
- NCT01693484
- Testing
- ICG (Indocyanine Green)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Cardiovascular Diseases, Coronary Disease
Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease
This study will compare medical therapy with coronary bypass surgery and/or surgical ventricular reconstruction for patients with congestive heart failure and coronary artery disease (CAD).
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Failure, Congestive, Heart Diseases
- Trial name
- STICH (NCT00023595)
- Testing
- CABG surgery plus MED, Active Medication Alone, CABG plus MED and SVR
- Where
- United States
- Volunteers
- 2,136 people
- Sponsor
- Duke University
Surgery, Pneumonia
Multicenter Infection Surveillance Study Following Open Heart Surgery
The main goals of the study are as follows: (1) to determine the correlation between pain management using continuous infusion of local anesthetics and the incidence of pneumonia and surgical infection in cardiac surgery…
- Conditions
- Surgery, Pneumonia, Surgical Site Infection
- Trial name
- NCT00673712
- Testing
- Continuous Sternal Block, Opioid based analgesia
- Where
- 8 sites in United States
- Volunteers
- 647 people
- Sponsor
- Halyard Health
Urinary Incontinence, Cystic Fibrosis
Cystic Fibrosis and Urinary Incontinence
Evaluate the feasibility of a randomized controlled trial of non-surgical urinary incontinence (UI) management options for women with CF.
- Trial name
- NCT04922255
- Testing
- Reusable Underwear, Disposable urethral support, Pelvic floor physical therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Megan Bradley
Skin Closure of Surgical Incisions by Tissue Glue vs Suture
Tissue Glue (Cyanoacrylate) Versus Conventional Suture in Kidney Donors
By means of a prospective, randomised trial the investigators want to examine skin closure in living donors - subjected to laparoscopic, hand-assisted nephrectomy - by tissue glue (Cyanoacrylate (Liquiband)) versus conventional…
- Trial name
- TG-CYANO (NCT01521871)
- Testing
- Skin wound closure by tissue glue, Skin wound closure by conventional suture + dressing
- Where
- Norway
- Volunteers
- 64 people
- Sponsor
- Oslo University Hospital
Invasive Breast Cancer
Pre-Surgical Intervention for Targeted Therapies for Breast Cancer
The purpose of this study is to determine the feasibility of a short term administration of a targeted therapy (i.e., anastrozole) in women with newly diagnosed early invasive or non invasive breast cancer during the interval…
- Trial name
- NCT01004744
- Testing
- Anastrozole
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Partial Tear of Rotator Cuff, Tendinopathy of Rotator Cuff
Non-Surgical Treatment for Rotator-Cuff Tears Using Platelet-Rich-Plasma
The goal of this project is to identify an effective and conservative approach to treating partial thickness rotator cuff tears (PTRCT) that otherwise would end with a surgical correction needed.
- Trial name
- NCT02246530
- Testing
- PRP injection into PTRCT, Subacromial steroid bursal injection
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Alabama at Birmingham
Jugular Venous Blood Flow
Jugular Venous Flow Healthy Volunteers
Our hypothesis is that there will be a decrease in internal jugular venous flow in the park bench position when compared to the supine position.
- Trial name
- NCT02002494
- Testing
- Different positions
- Where
- Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Prolapse, Urinary Incontinence
Long-term Effectiveness of Abdominal Sacrocolpopexy for the Treatment of Pelvic Organ Prolapse
The Colpopexy and Urinary Reduction Effort (CARE) trial is a research study designed to evaluate whether the addition of a second surgical procedure in addition to a procedure for female pelvic organ prolapse (POP) affects the…
- Trial name
- E-CARE (NCT00099372)
- Where
- 8 sites in United States
- Volunteers
- 215 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Operative Procedures, Complications
Surgical Stress Markers for Postoperative Complications: a Prospective Study
The aim of this study is to evaluate the predictive value of albumine, C-reactive protein (CRP), procalcitonin, and lactates in terms of surgical stress and postoperative complications.
- Trial name
- NCT02356484
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Postoperative Complications, Obesity
Negative Pressure Wound Therapy in Obese Gynecologic Oncology Patients
The purpose of the study is to test whether the use of a new wound closure technique can decrease the rates of wound complications in obese cancer patients.
- Conditions
- Postoperative Complications, Obesity, Gynecologic Neoplasms
- Trial name
- NCT02309944
- Testing
- Standard Wound Closure, Prevena™ Incision Management System
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Arthroscopic Surgical Treatment of High-grade (>50%) Partialthickness
Treatment of Partial-Thickness Rotator Cuff Tears
The goal of this clinical trial is to demonstrate that REGENETEN is superior to standard repair techniques when surgically treating high-grade (>50%) partial-thickness tears.
- Trial name
- REGEN PUB 2018 (NCT03734536)
- Testing
- REGENETEN™ Bioinductive Implant, Arthroscopic repair of the high-grade (>50%) partial-thickness
- Where
- 10 sites in United States
- Volunteers
- 168 people
- Sponsor
- Smith & Nephew, Inc.
Surgical Site Infection
Effect of Standard Normothermia Protocol On Surgical Site Infections
Aim of this study is to investigate the efficiency of a standard normothermia protocol and effects on postoperative Surgical Site Infection (SSI) rate.
- Trial name
- NCT02961244
- Testing
- Prewarming and perioperative warming with Forced Air Warming device and its blankets., Forced Air Warming blanket
- Volunteers
- 118 people
- Sponsor
- Dokuz Eylul University
Surgical Site Reaction
The Use of the Prevena Incision Management System (PIMS) on Closed Incisions in Renal Transplant Subjects
This study is being conducted to see how safe and effective the Prevena Incision Management System "Prevena" is when placed over a renal transplantation incision. Prevena provides negative pressure (suction) wound therapy.
- Trial name
- PIMS (NCT01341444)
- Testing
- Prevena Incision Management System, Standard of Care for Surgical Incisions
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- KCI USA, Inc
Scoliosis Idiopathic, Pain, Postoperative
Virtual Reality After Pediatric Scoliosis Surgery
The purpose of this study is to evaluate the use of virtual reality after scoliosis surgery in pediatric patients.
- Trial name
- VRAS-PS (NCT04584970)
- Testing
- Applied VR, Apple iPad
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of North Carolina, Chapel Hill
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