Clinical trials: Surgical Resection
Liver Neoplasms, Hepatectomy
Hypovolemic Phlebotomy to Reduce Blood Transfusions in Major Hepatic Resections
Major liver resection is associated with substantial intraoperative blood loss and subsequently blood transfusions. Blood transfusion in elective liver surgery is a significant factor of perioperative morbidity and mortality, as…
- Conditions
- Liver Neoplasms, Hepatectomy, Blood Transfusion, Blood Loss, Surgical
- Trial name
- PRICE2 (NCT03651154)
- Testing
- Hypovolemic Phlebotomy
- Where
- 4 sites in Canada
- Volunteers
- 440 people
- Sponsor
- Ottawa Hospital Research Institute
Colorectal Liver Metastasis (CRLM)
Ablation With Systemic Therapy vs Liver Resection With Systemic Therapy for Colorectal Liver Metastasis
For patients with colorectal liver metastases (CRLM) ≤5 cm, Clinical guidelines recommend surgery, but a growing number of studies have shown that thermal ablation is as effective as surgery.
- Trial name
- ASRS-CRLM (NCT07559851)
- Testing
- ablation combined with systemic therapy, liver resection combined with systemic therapy
- Where
- China
- Volunteers
- 151 people
- Sponsor
- The First Hospital of Jilin University
Prolonged Air Leak, Phrenic Nerve
Postoperative Effects of Intraoperative Temporary Phrenic Nerve Paralysis in Lung Resection Surgery
This prospective clinical study aimed to evaluate the postoperative effects of temporary phrenic nerve paralysis induced by intraoperative phrenic nerve crush during lung resection surgery.
- Conditions
- Prolonged Air Leak, Phrenic Nerve, EMG
- Trial name
- PNCrush (NCT07259031)
- Testing
- İntraoperative phrenic nerve compression
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Ferdane Melike Duran
Low Anterior Resection Syndrome
The Effects of Colorectal Prehabilitation Via Reinfusion or Retention Enema of Ileal Contents Filtrate on the Defecation Functions for the LAR Patients With Ileostomy Before Stoma Closure
This study was a single-center RCT study to compare the effect of preoperative prehabilitation treatment of ileostomy contents filtrate reinfusion through distal ileocolon or retention of enema colon with that of traditional…
- Trial name
- NCT06569966
- Testing
- preoperative prehabilitation treatment of ileostomy contents filtrate reinfusion through distal ileocolon or retention of enema colon
- Where
- China
- Volunteers
- 154 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Peritoneal Dessication Damage and Inflammation, Peri-operative Hypothermia
Warm Humid Gas Insufflation for Appendix Removal by Minimally Invasive Surgery Warm Humid Insufflation for Appendix Removal by Minimally Invasive Surgery Trial (WARMIST)
In laparoscopic (key-hole) surgery, the use of cold dry carbon dioxide gas to inflate the abdominal cavity for the creation a clear operating field, results in damage to the cavity lining, known as the peritoneum.
- Trial name
- WARMIST (NCT01027455)
- Testing
- Fisher and Paykel Insuflow (MR 860) Surgical Humidification Device, Laparoscopic Appendicectomy
- Where
- New Zealand
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Hepatocellular Carcinoma (HCC)
PD-1/IL-2 Bispecific Antibody as Neoadjuvant Therapy for Early Recurrent Hepatocellular Carcinoma After Curative Hepatectomy
This is a single-arm, phase II clinical study designed to evaluate the efficacy and safety of a recombinant PD-1/IL-2 bispecific antibody, as neoadjuvant therapy in hepatocellular carcinoma (HCC) patients who experienced early…
- Trial name
- NCT07644208
- Testing
- PD-1/IL-2 Bispecific Antibody Fusion Protein
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Bone Cancer
Osteosarcoma Maintenance Therapy With OST31-164
Up to 45 Patients aged 12 to 39 with osteosarcoma (bone cancer) that had recurred in the lungs and has recently been surgically removed will be enrolled.
- Trial name
- OST-164-01 (NCT04974008)
- Testing
- OST31-164
- Where
- 21 sites in United States
- Volunteers
- 39 people
- Sponsor
- Emerald Clinical Inc.
Grade III Obesity, Type 2 Diabetes Mellitus
Metabolic Changes After Bariatric Surgery
Literature data clearly demonstrate that treatment of obese patients is very expensive, long and achieve weight loss may not be permanent, and regardless of whether the treatment dominated diet therapy, physical activity, or…
- Trial name
- NCT02893891
- Testing
- Laparoscopic sleeve gastrectomy, Laparoscopic gastric plication, Intragastric balloon
- Where
- 2 sites in Czechia
- Volunteers
- 150 people
- Sponsor
- University Hospital Ostrava
Bladder Cancer
Performance, Feasibility, and Safety Study for a Novel Endoluminal Robotic System for En-Bloc Resection of Bladder Tumours: First-In-Human Trial
This is a prospective, single-arm study to evaluate the feasibility and safety of performing transurethral en-bloc resection of bladder tumours using the Zenith robotic system.
- Trial name
- NCT06281080
- Testing
- En-Bloc Resection of Bladder Tumours
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
Flexor Tendon Injury, Lesions Of The Fingers Flexor Tendons
Treatment for Partial Lesions of the Fingers Flexor Tendons : Tangential Resection or Direct Suture
Flexors tendon injuries are frequent and serious with a potential of definitive functional aftereffects. In the case of partial injury, the treatment is debated.
- Trial name
- FLEXOR (NCT02461680)
- Testing
- tangential resection, suture
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Strasbourg, France
Recurrent Glioblastoma (WHO-Grade IV Glioma)
Microsurgical Resection Combined With Photodynamic Therapy for Recurrent Glioblastoma
This single-center, prospective, single-arm, open-label clinical study evaluates the effectiveness and safety of microsurgical resection combined with photodynamic therapy (PDT) in patients with recurrent glioblastoma (GBM).
- Trial name
- PDT-rGBM (NCT07832448)
- Testing
- Hematoporphyrin Injection (Hiporfin), Microsurgical Tumor Resection, 630-nm Semiconductor Laser
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Yonggao Mou
Colorectal Polyps
Application of Changyanning Granule in Endoscopic Resection of Colorectal Polyps
This study aims to evaluate the efficacy of Chanyanning granules in patients undergoing endoscopic resection of colorectal polyps with a basal diameter of 5-30 mm.
- Trial name
- NCT06927258
- Testing
- changyanning granules
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Colorectal Polyp, Colon Adenoma
Cold Snare Endoscopic Mucosal Resection (EMR) vs Cold EMR With Margin Snare Tip Soft Coagulation (STSC)
Randomised controlled trial comparing cold snare endoscopic mucosal resection (EMR) with cold snare EMR and adjuvant margin STSC in the complete resection of 15-40mm lateral-spreading adenomas
- Conditions
- Colorectal Polyp, Colon Adenoma, Colon Cancer
- Trial name
- NCT05041478
- Testing
- Cold Snare Endoscopic mucosal resection with adjuvant snare tip soft coagulation, Cold Snare Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Western Sydney Local Health District
Subdural Pressure During Supratentorial Brain Tumour Resection
Neurosurgery Recruitment Maneuver Study
Background. Patients undergoing neurosurgical procedures experience higher rates of postoperative respiratory failure compared to the broader surgical population.
- Trial name
- NCT02093117
- Testing
- Recruitment maneuver
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of British Columbia
Effects of the Elements
Healing Assessment of Osseous Defects After Surgical Removal of Periapical Lesions
recruited patients with periapical lesions will be divided into three groups and surgically treated with three types of bone graft (hydroxyappatite, nanohydroxyappatite and PRF WITH NANOHYDROXTAPPATITE) and then evaluated for…
- Trial name
- NCT05100615
- Testing
- surgery
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Minia University
Bone Tumor
Radiological Evaluation of 3D Printed Porous Collars in Hip and Knee Resection Prostheses: Pilot Study.
This study aims to evaluate the osseointegration of 3D printed porous collars in hip and knee resection prostheses, in order to eliminate one of the causes of diaphyseal osteolysis, which often lead to loosening of the implants…
- Trial name
- COLLARS (NCT06180525)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Regina Elena Cancer Institute
Clear Cell Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma
Adding a Live Biotherapeutic Product (CBM588) to Pembrolizumab for the Treatment of Renal Cell Cancer After Surgery
This phase II trial compares the effect of adding a Live Biotherapeutic Product called CBM588 to pembrolizumab versus pembrolizumab alone in preventing return of disease (recurrence) after surgery for patients with renal cell…
- Conditions
- Clear Cell Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Stage II Renal Cell Cancer AJCC v8, Stage III Renal Cell Cancer AJCC v8
- Trial name
- NCT07037004
- Testing
- Biospecimen Collection, Clostridium butyricum CBM588 Strain, Computed Tomography
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- City of Hope Medical Center
Osteosarcoma
Upfront Surgical Resection for Osteosarcoma
The goal of this pilot study is to learn about patients with newly diagnosed osteosarcoma of an extremity, and whether surgically removing the tumor prior to the administration of any chemotherapy will improve functional…
- Trial name
- UFSR for OS (NCT06384404)
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Montefiore Medical Center
Brain and Central Nervous System Tumors, Neuroblastoma
Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors
RATIONALE: Monoclonal antibodies can locate tumor cells and deliver tumor-killing substances, such as radioactive iodine, to them without harming normal cells.
- Trial name
- NCT00003484
- Testing
- carmustine, irinotecan hydrochloride, surgical procedure
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Darell D. Bigner, MD, PhD
Liver Tumor
Intraoperative Blood Loss Under Standard Versus Low Pneumoperitoneum Pressure During Laparoscopic Liver Resection.
Commonly the pressure of about 14 mmHg is applied during laparoscopic liver resection (LLR) with moderate neuromuscular blockade.
- Trial name
- NCT06060899
- Testing
- Pneumoperitoneum 14mmHg, Pneumoperitoneum 10mmHg
- Where
- Poland
- Volunteers
- 36 people
- Sponsor
- Medical University of Warsaw
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