Clinical trials: Surgical Resection
Trismus
Effectiveness of Serratiopeptidase After Mandibular Third Molar Surgery
This randomized controlled trial was conducted to compare the effect of serratiopeptidase versus no intervention on postoperative mouth opening, swelling, and trismus following surgical removal of mesioangular mandibular third…
- Trial name
- NCT07543146
- Testing
- Serratiopeptidase, Standard Postoperative Care
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Sharif Medical Research Center
Cancer, Solid Malignant Tumors
High-Resolution PET-CT Imaging for Surgical Margin Visualization
Imaging will be exploratory and be used intraoperatively. There have been no discovered risks associated with the device to be used in this study, and none are anticipated given the diagnostic and non-invasive, 'ex vivo' nature…
- Conditions
- Cancer, Solid Malignant Tumors, SCC - Squamous Cell Carcinoma, HNSCC
- Trial name
- NCT06915454
- Testing
- Intra-op PET/CT Specimen Scanner
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Parenchymous Tissue Surgical Bleeding
Safety and Efficacy of Fibrin Sealant Grifols (FS Grifols) During Parenchymous Tissue Open Surgeries
This study is designed to assess the safety and efficacy of Fibrin Sealant Grifols in patients undergoing open surgical procedures where bleeding may be present on parenchymous tissue (e.g., solid abdominal organs such as the…
- Trial name
- NCT01754480
- Testing
- Fibrin Sealant Grifols, Surgicel®
- Where
- 33 sites in United States, Hungary and 2 more
- Volunteers
- 325 people
- Sponsor
- Instituto Grifols, S.A.
Crohn Disease
Post-operative CRP Trend After Ileocolic Resection in Crohn's Disease Patients.
Our aim is to analyze C-Reactive Protein trends during the post-operative course in Crohn's Disease patients having undergone ileocolic resection and primary anastomosis, for the purpose of anastomotic leak early diagnosis.
- Trial name
- NCT04739579
- Testing
- C-Reactive Protein
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Central Hospital, Nancy, France
Pain, Postoperative
The Effect of Parecoxib Sodium Intravenous Patient-controlled Analgesia in Laparotomic Liver Resection
The investigators hypothesized that using new intravenous infusion pump of patient-controlled analgesia (parecoxib sodium 1 mg/mL + normal saline) would significantly improve postoperative pain control compare to conventional…
- Trial name
- NCT02408146
- Testing
- conventional intravenous infusion pump, parecoxib, intravenous infusion pump of patient-controlled analgesia
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
HCC
Triple vs. Dual Adjuvant Therapy Following Liver Resection for HCC.
Vessels that encapsulate tumor clusters (VETC) is an invasive metastatic factor in HCC independent of the epithelial mesenchyme transition (EMT), and VETC-positive patients have a higher rate of postoperative recurrence.
- Trial name
- NCT06311942
- Testing
- HAIC plus PD-1 inhibitors plus lenvatinib, PD-1 inhibitors plus lenvatinib
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chen Xiaoping
Neoplasm of Lateral Wall of Urinary Bladder
Safety Study of Bipolar Versus Monopolar Transurethral Resection of Bladder Tumors
This is a single-center, prospective, randomized, controlled trial comparing two established transurethral electrical resection methods of urinary bladder tumors regarding their risk of stimulating the obturator nerve.
- Trial name
- NCT01446822
- Testing
- Bipolar transurethral resection of the urinary bladder (PlasmaKinetic, Gyrus, Fresenius), Monopolar transurethral resection of the urinary bladder (Storz GmbH &Co., Erbotom, Purisole)
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- Daniel Stephan Engeler
Rectal Cancer, Left Colic Artery Stenosis (Diagnosis)
Robotic-Assisted or Laparoscopic Radical Resection for Rectal Cancer With or Without Left Colic Artery Preservation
Brief Summary Background The preservation of the left colic artery (LCA) during rectal cancer resection remains a topic of controversy, and there is a notable absence of robust evidence regarding the outcomes associated with LCA…
- Conditions
- Rectal Cancer, Left Colic Artery Stenosis (Diagnosis), Robotic Assisted Laparoscopic Surgery
- Trial name
- NCT06376227
- Testing
- with or without Left Colic Artery Preservation
- Where
- China
- Volunteers
- 1,164 people
- Sponsor
- Northern Jiangsu People's Hospital
Liver Cancer, Adult
NIR-II Fluorescence-Guided Hepatectomy Using ICG-Cisplatin Nanoprobes for HCC
This prospective, single-arm exploratory study evaluates the feasibility and safety of a novel ICG-Cisplatin self-assembled nanoprobe (NIR-II NanoM) for fluorescence-guided surgery in patients with Hepatocellular Carcinoma (HCC).
- Trial name
- NCT07295262
- Testing
- ICG-Cisplatin Nanoprobe (NIR-II NanoM), Fluorescence-guided Hepatectomy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- West China Hospital
Low Anterior Resection Syndrome (LARS>20), Refractory Medical Treatment After Rectal Resection
A Prospective Pilot Study to Assess the Efficacy of BOTOX-A in Patients With Low Anterior Resection Syndrome (LARS>20) and Refractory Medical Treatment After Rectal Resection
After rectal resection for cancer (with or without stoma), patients may have digestive sequelae. LARS (Low Anterior Resection Syndrome) includes bowel frequency, stool fragmentation, urgency, and faecal incontinence.
- Trial name
- BOTOX-TME (NCT04991688)
- Testing
- BOTOX-A
- Where
- France
- Volunteers
- 11 people
- Sponsor
- University Hospital, Bordeaux
Hepatocellular Carcinoma, Radiotherapy
Randomized Study of Adjuvant Radiotherapy After Curative Resection of HCC With Narrow Margin (RAISE)
RAISE is a multicenter randomized controlled trial to assess the efficacy of adjuvant radiotherapy for controlling postsurgical recurrence in HCC patients with narrow margin (≤ 1 cm) after curative resection.
- Conditions
- Hepatocellular Carcinoma, Radiotherapy, Hepatectomy
- Trial name
- RAISE (NCT03732105)
- Testing
- Surgery-radiotherapy
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Sun Yat-sen University
Gastric Cancer
A Randomized Phase III Study of Adjuvant Chemotherapy With or Without Chemo-radiotherapy in Patients With Local Advanced Gastric Cancer After D2 Resection.
The purpose of this study is to explore the role of adjuvant chemo-radiotherapy in patients with local advanced gastric cancer.
- Trial name
- NCT02648841
- Testing
- Adjuvant Concurrent Chemo-radiotherapy, Adjuvant chemotherapy for active comparator group, Adjuvant chemotherapy for experimental group
- Where
- China
- Volunteers
- 588 people
- Sponsor
- Chinese Academy of Medical Sciences
Colon Polyp
NBI-NearFocus Assisted Cold Snare Polypectomy Improves the Complete Resection Rate of Small Colorectal Polyps: a Prospective Single-arm Observational Study
NBI-NearFocus can assist cold snare polypectomy (CSP) to remove small colorectal polyps, but its specific efficacy is not clear.The aim of this study was to assess the efficacy of CSP with NBI-NearFocus evaluation of polypectomy…
- Trial name
- NCT06601426
- Testing
- CSP
- Where
- China
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Liver Surgery, Liver Cancer
3D Liver Volumetry
The study aims to improve preoperative evaluation of liver resection volume in patients undergoing major hepatectomies. Accurate prediction of the planned resection and the future liver remnant (FLR) is critical to minimize the…
- Conditions
- Liver Surgery, Liver Cancer, Surgical Planning, Liver
- Trial name
- NCT07297615
- Testing
- 3d reconstruction
- Where
- Austria
- Volunteers
- 25 people
- Sponsor
- Medical University of Graz
Cancer, Liver Diseases
Perioperative Energy Expenditure in Major Liver Resection
Rationale: Complication rates after major liver resections remain as high as 43%. Many initiatives have been taken to reduce postoperative morbidity.
- Conditions
- Cancer, Liver Diseases, Liver Neoplasms
- Trial name
- PRO-NRG (NCT05931068)
- Testing
- Pre- and postoperative assessment
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Brow Ptosis, Surgical Wound
An Analysis of Dermabond vs. Non-Absorbable Sutures in Skin Closure for Brow Ptosis Procedures
The goal of this clinical trial is to compare Dermabond with non-absorbable sutures in skin closure after brow ptosis surgery. The main questions it aims to answer are: if Dermabond provides equivalent wound healing compared to…
- Trial name
- NCT05981443
- Testing
- Dermabond, Non-Absorbable Sutures
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Cody Blanchard
Rectal Cancer
Preservation Vs. Dissection of No. 253 Lymph Nodes of Robotic Resection for Mid/Low Rectal Cancer
In this study, patients with middle or low rectal cancer will receive robotic radical resection, and will be randomly assigned to receive inferior mesenteric artery lymph nodes dissection or preservation.
- Trial name
- REAL2 (NCT06956976)
- Testing
- Dissection of Inferior Mesenteric Artery Root Lymph Node, Preservation of Inferior Mesenteric Artery Root Lymph Node
- Where
- China
- Volunteers
- 1,596 people
- Sponsor
- Fudan University
Third Molars Extraction
Avatar-assisted Pre- and Post-operative Information Following Surgical Removal of a Mandibular Third Molar.
This study assess the efficacy of digital avatar-assisted pre- and post-operative information against nurse-led oral and written information following SRM3 including an analysis of potential risk factors associated with impaired…
- Trial name
- NCT07805304
- Testing
- Avatar-assisted pre- and post-operative information following surgical removal of an mandibular third molar
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Urinary Bladder Neoplasms, Transurethral Resection
Ultrasound-Guided ONB for Transurethral Procedures - Interadductor Approach
Obturator nerve block is an effective method to prevent adductor muscles contraction during transurethral resection of bladder tumour localized on the lateral wall.
- Conditions
- Urinary Bladder Neoplasms, Transurethral Resection, Nerve Block
- Trial name
- NCT02696733
- Testing
- Ultrasound, lidocaine 2%, 0.9% Natrium Chloratum with a 2nd generation cephalosporin
- Where
- 2 sites in Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Thyroid Neoplasms
Safety and Efficacy of Dexmedetomidine in Controlling Hemodynamics During Resection of Active Thyroid Secreting Tumors
Experienced anesthesiologists often attempt to anticipate and blunt the hypertensive responses seen in varying degrees at critical moments of surgical stimulation.
- Trial name
- NCT07434206
- Testing
- Dexmedetomidine Injection [Precedex]
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- South Egypt Cancer Institute
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