Clinical trials: Surgical Site Infection After Major Surgery
Peritonitis, Postoperative Complications
Intravenous Immunoglobulin in Combination Therapy With Antibacterial Agents for SSI of the Lower Digestive Tract
The purpose of this study is to assess the clinical usefulness of IVIG in combination therapy with antibacterial agents for severe peritonitis after lower digestive tract surgery.
- Trial name
- NCT00511212
- Testing
- intravenous immunoglobulin
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Multicenter Clinical Study Group of Osaka, Colorectal Cancer Treatment Group
Surgical Site Infection After Major Surgery, Anaesthesia
PeRiOperative Medicine Platform Trial
Our specific aims are to investigate whether conservative (≤30%), intermediate (50%), or liberal (80%) inspired oxygen during and immediately after surgery: Aim 1: Reduces surgical site infections (SSIs or "wound infections") and…
- Conditions
- Surgical Site Infection After Major Surgery, Anaesthesia, Major Complications, Quality of Recovery (QoR-15)
- Trial name
- PROMPT (NCT07186634)
- Testing
- Liberal inspired oxygen, Conservative inspired oxygen, Intermediate inspired oxygen
- Where
- 2 sites in Australia, New Zealand
- Volunteers
- 7,800 people
- Sponsor
- Monash University
Surgical Site Infection After Major Surgery, Surgical Site Infections
Assessing the Effect of the Silver Dressing on Surgical Site Infections in Adult Patients Post Cardiac Surgery: a Single Center Randomized Control Trial
RCT on post-cardiac surgery patients using silver dressings vs. standard care. Conducted in ICU, CCU, telemetry units. Outcomes assessed via checklist \& modified Parsonnet Score.
- Trial name
- NCT07008040
- Testing
- Silver dressing
- Where
- Saudi Arabia
- Volunteers
- 145 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Peritoneal Surface Malignancy, Postoperative Adhesion
SurgiPerito Trial: High-Purity Type-I Collagen for Peritoneal Reconstruction After Cytoreductive Surgery
This dual-centre, randomized controlled trial evaluates the safety and efficacy of high-purity Type-I collagen-based biomaterial, as a peritoneal substitute following peritonectomy in patients undergoing cytoreductive surgery…
- Conditions
- Peritoneal Surface Malignancy, Postoperative Adhesion, Bowel Obstruction, Wound Complications
- Trial name
- NCT07241091
- Testing
- High-Purity Type-I Collagen Scaffold, Standard Peritonectomy Closure
- Where
- 2 sites in India
- Volunteers
- 60 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Combat Related Symptoms, Combat Trauma
DRONE-WOUND Study: Severe Infection After Drone-Related Combat Trauma
Drone-related combat injuries have become one of the most devastating mechanisms of injury in modern warfare. These injuries often cause extensive tissue devitalization, contamination, open fractures, vascular injuries, and…
- Conditions
- Combat Related Symptoms, Combat Trauma, Infection, Infection Complication
- Trial name
- DRONE-WOUND (NCT07706608)
- Where
- Ukraine
- Volunteers
- 500 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Surgical Wound Infection, Postoperative Wound Infection
Study Evaluating Severe Surgical Site Infections (SSIs) Following Contaminated Or Dirty-infected Abdominal Surgery
This is an observational study to evaluate the relative importance of the known risk factors for severe surgical site infections (SSIs) on the development of the more severe SSI cases, and to describe the demographic, clinical…
- Trial name
- EURIDICE (NCT00906074)
- Testing
- Elective or emergency abdominal surgery
- Volunteers
- 180 people
- Sponsor
- Pfizer
Surgical Site Infection After Major Surgery
Effect of High Dose Insulin on Infectious Complications Following Major Surgery
Despite improvements in surgical techniques and perioperative care, the high incidence of postoperative surgical site infections remains a major problem in patients undergoing major abdominal surgery (liver, pancreatic and…
- Trial name
- NCT01528189
- Testing
- Hyperinsulinemic normoglycemic clamp, Standard glucose management
- Where
- 3 sites in Canada, Chile
- Volunteers
- 480 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Surgical Site Infection, Surgical Procedures, Operative
Polihexanide SSIs Measures Bundle (PSMB) During Enhanced Recovery After Major Digestive Surgery
This is a randomized controlled, prospective, multicenter superiority trial with two parallel treatment groups and single blinding (local investigators performing postoperative follow up will be blinded for group allocation)…
- Trial name
- POSSIBLE (NCT06338163)
- Testing
- Polihexanide-based bundle, Standard bundle
- Where
- 3 sites in Italy
- Volunteers
- 2,000 people
- Sponsor
- Marco Catarci
Surgical Site Infection After Major Surgery
Impact of Prontosan Wound Gel X on Surgical Site Infections in Cardiac Surgery
This study aims to evaluate the effects of Prontosan® Wound Gel X on the incidence of superficial surgical site infections (SSI) in adult patients undergoing elective cardiac surgery with median sternotomy.
- Trial name
- PRONTOSAN (NCT07275307)
- Testing
- Application of Prontosan Wound Gel X
- Where
- Italy
- Volunteers
- 456 people
- Sponsor
- IRCCS Policlinico S. Donato
Heart Attack, Cardiac Arrest
Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes Surveys
Based on limited published epidemiological data, up to an alarming 1 in 50 surgical inpatients die within 30 postoperative days.
- Conditions
- Heart Attack, Cardiac Arrest, Congestive Heart Failure, Atrial Fibrillation
- Trial name
- SATISFY-SOS (NCT02032030)
- Where
- United States
- Volunteers
- 73,952 people
- Sponsor
- Washington University School of Medicine
Post Operative Surgical Site Infection
Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT 2
The PRCT evaluates infection outcomes as well as fracture and antibiotic-related complications to include the emergence of resistant bacteria associated with two different antibiotic strategies in the treatment of Gustilo type…
- Trial name
- SEXTANT 2 (NCT04678154)
- Testing
- Standard of care, Vancomycin and Tobramycin
- Where
- 31 sites in United States
- Volunteers
- 600 people
- Sponsor
- Major Extremity Trauma Research Consortium
Amputation Wound, Amputation Stump Complication
RCT on NPWT for Incisions Following Major Lower-limb Amputation to Reduce Surgical Site Infection
Surgical site infections following lower extremity amputations have been reported in up to 40% of patients. Surgical site infections have significant morbidity and even mortality in terms of emergency room visits, length of…
- Conditions
- Amputation Wound, Amputation Stump Complication, Amputation Stump; Infection, Infection
- Trial name
- NCT03144726
- Testing
- Negative pressure wound therapy, Standard dressing
- Volunteers
- 290 people
- Sponsor
- London Health Sciences Centre
Pancreatectomy, Pancreatic Surgery
PAN-ICIS Study: ICIS for Early Detection of Infectious Complications in Pancreatic Surgery
This study examines a new blood test called ICIS, which may help detect infections earlier after pancreatic surgery. Patients will have routine blood samples taken during their hospital stay, with no extra procedures required.
- Conditions
- Pancreatectomy, Pancreatic Surgery, Intensive Care (ICU), Inflamatory Markers
- Trial name
- PAN-ICIS (NCT07248527)
- Where
- Czechia
- Volunteers
- 400 people
- Sponsor
- Charles University, Czech Republic
Wound Surgical, Wound Infection
PINTA - Prophylactic Incisional Negative Pressure Therapy for Major Amputations
Post-operative wound issues in abdominal surgery have a significant impact on patient outcomes. This study is taking place to investigate if Negative Pressure Wound Therapy (NPWT) dressings reduces Surgical Site Infections, post…
- Conditions
- Wound Surgical, Wound Infection, Cosmesis
- Trial name
- PINTA (NCT06025253)
- Testing
- Negative Pressure Wound Therapy, Standard Wound Dressing
- Where
- 7 sites in Ireland
- Volunteers
- 728 people
- Sponsor
- Royal College of Surgeons, Ireland