Clinical trials: Surgical Site Infection Prevention
Vancomycin, Implantable Neural Stimulator
Intrawound Vancomycin Prophylaxis for Neural Stimulator
The implantable pulse generator (IPG) is a device that generates electrical current to stimulate the spine, heart, or brain for various chronic conditions.
- Conditions
- Vancomycin, Implantable Neural Stimulator, Deep Brain Stimulation, Surgical Site Infection
- Trial name
- IV-DIRT (NCT03221023)
- Testing
- Vancomycin Hydrochloride, Saline Solution
- Where
- Canada
- Volunteers
- 900 people
- Sponsor
- University of British Columbia
Surgical Site Infection, Thrombosis
Tumescent Anesthesia Antibiotic Delivery (TAAD)
This is a multicenter randomized clinical trial (RCT) comparing two modes of antibiotic delivery: Control: Intravenous Antibiotic Delivery (IVAD) Treatment: IVAD + TAAD The Food \& Drug Administration (FDA) has approved our…
- Conditions
- Surgical Site Infection, Thrombosis, Sepsis
- Trial name
- TAAD (NCT03226626)
- Testing
- Tumescent Anesthesia and antibiotic delivery (TAAD) plus IVAD, SubQKath
- Volunteers
- 330 people
- Sponsor
- HK Surgical, Inc.
Complicated Appendicitis, Acute Appendicitis
Antibiotic Instillation in Appendicitis
Appendicitis (inflammation of the wall of the appendix, causing pain and tenderness in the abdomen) has a range of severity that goes from simple to complicated.
- Trial name
- NCT05470517
- Testing
- Ceftriaxone, Intra-peritoneal Fluid Aspiration
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Johns Hopkins All Children's Hospital
Surgical Site Infection (SSI), Cesarean Section Wound
Subcutaneous Drain Versus Wound Irrigation by Normal Saline for Prevention of Surgical Site Infection Following Caesarean Section in Obese Patients.
This is a prospective randomized controlled trial conducted at Ain Shams University Maternity Hospital to compare subcutaneous drain versus wound irrigation with normal saline for the prevention of surgical site infection…
- Trial name
- NCT07517718
- Testing
- Subcutaneous Drain, Normal Saline
- Where
- Egypt
- Volunteers
- 189 people
- Sponsor
- Ain Shams University
Gastrointestinal Surgery, Mirabilite
External Application of Mirabilite to Promote Recovery in Patients After Gastrointestinal Surgery
This study evaluates the efficacy and safety of topical Mirabilite (sodium sulfate) application for managing postoperative outcomes in patients undergoing gastrointestinal cancer surgery.
- Conditions
- Gastrointestinal Surgery, Mirabilite, Surgical Site Infection, Postoperative Gastrointestinal Dysfunction
- Trial name
- NCT06696729
- Testing
- Topical Mirabilite Application for Postoperative Gastrointestinal Patients, Standard Postoperative Care for Gastrointestinal Patients
- Where
- China
- Volunteers
- 301 people
- Sponsor
- Nanchang University
Surgical Site Infection
WHO Checklist- Based Infection Prevention Guidelines in Mulago Hospital
This prospective cohort study will assess all mothers undergoing elective and emergency caesarean delivery in the labour ward theatre at Mulago National Referral Hospital based temporarily at Kawempe Hospital.
- Trial name
- NCT03822039
- Where
- Uganda
- Volunteers
- 768 people
- Sponsor
- Makerere University
Surgical Site Infection, Surgery--Complications
Prophylaxis of Surgical Wound Infection With Topical Antibiotics
Surgical site infection (SSI) is the main complication of surgery. The prevention of superficial SSI by topical prophylaxis is controversial.
- Conditions
- Surgical Site Infection, Surgery--Complications, Colorectal Surgery, Cesarean Section; Infection
- Trial name
- NCT04476212
- Testing
- Topical antibiotic prophylaxis
- Where
- Spain
- Volunteers
- 560 people
- Sponsor
- Hospital de Granollers
Surgical Wound Infection
Study of the Efficacy of Preoperative Cefuroxime Prophylaxis to Prevent Surgical Site Infection in Herniated Disk Surgery
The purpose of the study is to determine whether a single, pre-operative dose of cefuroxime is effective in preventing surgical site infection in patients undergoing surgery for herniated disk
- Trial name
- NCT00530400
- Testing
- cefuroxime
- Where
- 2 sites in Switzerland
- Volunteers
- 1,369 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Surgical Site Infection
Randomized Controlled Trial to Evaluate the Optimal Timing of Surgical Antimicrobial Prophylaxis
Surgical site infections (SSI) are the most frequent hospital acquired infections in patients who underwent surgery. With regards to the increasing financial restraint in patient care, the socio-economic burden of SSI in the…
- Trial name
- NCT01790529
- Testing
- Early administration of SAP (Cefuroxime (plus metronidazole in colorectal surgery)) in anesthetic room (75 to 30 minutes prior to skin incision), Late administration of SAP (Cefuroxime (plus metronidazole in colorectal surgery)) in the operating theatre (within 30 minutes prior to skin incision)
- Where
- Switzerland
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Appendicitis
A Randomized Controlled Trial on Wound Irrigation in Open Appendectomy.
A large retrospective study compared wound irrigation with antiseptic solution, with antimicrobial agent, and with normal saline in patients undergoing open appendectomy and concluded an evident superiority of antibiotic wound…
- Trial name
- NCT04332809
- Testing
- saline-gentamicin irrigation, saline irrigation
- Where
- Egypt
- Volunteers
- 208 people
- Sponsor
- Mansoura University
Seroma, Surgical Site Infection
Prevention of Seroma Following Inguinal Lymph Node Dissection With Prophylactic Incisional Negative Pressure Wound Therapy
Inguinal lymph node dissection (ILND) is indicated following metastatic malignant melanoma, and is associated with a high-complication rate, of which many begin with the formation of seroma and ends in complicated wound healing…
- Conditions
- Seroma, Surgical Site Infection, Lymphedema, Quality of Life
- Trial name
- NCT03433937
- Testing
- Negative pressure wound therapy, Micropore tape
- Where
- 4 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- Odense University Hospital
Suture Techniques, Wound Closure Techniques
Small Bites Vs Large Bites Abdominal Midline Incisional Closure
The goal of this trial is to compare the effectiveness of small bite versus large bite abdominal incision closure in emergency settings. It will also evaluate the safety and outcomes of each technique.
- Conditions
- Suture Techniques, Wound Closure Techniques, Laparotomy/Standerds, Surgical Wound Dehiscence
- Trial name
- NCT07154277
- Testing
- Small bite closure, Large bite closure
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Dow University of Health Sciences
Surgical Site Infection, Cesarean Section; Infection
Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound Infections
This will be a single-center randomized control trial comparing the efficacy of two different formulations of Chlorhexidine surgical skin preparation in preventing cesarean section wound infections.
- Trial name
- NCT05920122
- Testing
- 2% Chlorhexidine gluconate with 70% alcohol, 4% Chlorhexidine Gluconate aqueous solution
- Where
- United States
- Volunteers
- 1,398 people, healthy volunteers welcome
- Sponsor
- Hyagriv Simhan
Infection Prosthesis Hip and Knee, Infection, Prosthesis Related
Results of Extended Versus Single Dose Antibiotic Prophylaxis In Orthopedic Revision Arthroplasty in Nijmegen.
The goal of this randomized control trial is to investigate the superiority of 5 days (extended) versus a single dose of cefazolin prophylaxis in revision arthroplasty of the hip and knee.
- Conditions
- Infection Prosthesis Hip and Knee, Infection, Prosthesis Related, Joint Infection, Infection, Surgical Site
- Trial name
- REViSION (NCT06402591)
- Testing
- Cefazolin
- Where
- Netherlands
- Volunteers
- 751 people
- Sponsor
- Radboud University Medical Center
Radical Cystectomy, Surgical Site Infection
Optimized Perioperative Antibiotic Prophylaxis in Radical Cystectomy
Cystectomy with urinary diversion (ileal conduit, orthotopic ileal bladder substitute, continent catheterizable pouch) is the best treatment option for patients with muscle-invasive bladder cancer.
- Conditions
- Radical Cystectomy, Surgical Site Infection, Urologic Cancer, Perioperative/Postoperative Complications
- Trial name
- PAPRAC (NCT03305627)
- Testing
- Short PAP, Extended PAP
- Where
- 2 sites in Switzerland
- Volunteers
- 196 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Peritoneal Surface Malignancy, Postoperative Adhesion
SurgiPerito Trial: High-Purity Type-I Collagen for Peritoneal Reconstruction After Cytoreductive Surgery
This dual-centre, randomized controlled trial evaluates the safety and efficacy of high-purity Type-I collagen-based biomaterial, as a peritoneal substitute following peritonectomy in patients undergoing cytoreductive surgery…
- Conditions
- Peritoneal Surface Malignancy, Postoperative Adhesion, Bowel Obstruction, Wound Complications
- Trial name
- NCT07241091
- Testing
- High-Purity Type-I Collagen Scaffold, Standard Peritonectomy Closure
- Where
- 2 sites in India
- Volunteers
- 60 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Vascular Diseases, Peripheral Vascular Disease
Topical Gentamicin and Vancomycin for Vascular Surgical Site Infection Prophylaxis
Many patients who undergo vascular surgery to improve the blood flow to their legs are at risk of developing an infection in the surgical site and are then at risk of serious complications such as hospital readmission, failure of…
- Conditions
- Vascular Diseases, Peripheral Vascular Disease, Surgical Site Infection, Bypass Complication
- Trial name
- NCT04238923
- Testing
- Topical vancomycin paste (1g vancomycin powder + 4mL sterile saline) and Collatamp G gentamicin-eluting sponge (Azralez Pharmaceuticals; 2.0mg gentamicin sulphate/cm2 to cover wound)
- Volunteers
- 356 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Incarcerated Hernia, Appendicitis Acute
Prevention of Postoperative Hernias in Emergency Surgery
The aim of this observational study is to understand the risk factors and incidence of postoperative hernias among patients undergoing emergency surgery.
- Conditions
- Incarcerated Hernia, Appendicitis Acute, Cholecystitis, Acute, Ileus
- Trial name
- PROPHECY (NCT06815822)
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Jan Kochanowski University
Surgical Site Infection
Air Barrier System for the Prevention of Surgical Site Infection
Airborne particles are present in all indoor environments including the operating room. Most of these particles come from the surgical staff moving around in the room, positioning of the patient during surgery, and the movement…
- Trial name
- ABS (NCT01610271)
- Testing
- Air Barrier System
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Nimbic Systems, LLC
Rectal Cancer
Antibiotic Prophylaxis in Rectal Cancer Surgery: Oral With Intravenous Versus Intravenous Antibiotics.
This is a randomized, controlled, parallel study to determine the efficiency of oral antibiotics in reduction of surgical site infection (SSI) in rectal cancer surgery.
- Trial name
- NCT03436719
- Testing
- Oral antibiotic, Intravenous antibiotic, Mechanical Bowel Preparation
- Where
- Russia
- Volunteers
- 280 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation