Clinical trials: Surgical Stress Response
Aortic Stenosis
The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery
This study is looking at the effects of high spinal anesthesia (also known as total spinal anesthesia) combined with general anesthesia versus general anesthesia alone on the following: Stress response: Patients undergoing aortic…
- Trial name
- NCT00348920
- Testing
- High Spinal and General Anesthesia
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
ERAS, Pancreas Cancer
Compliance With ERAS Protocol in Pancreatic Surgery, Stress Response and Outcomes
The purpose of this study is to evaluate the impact of compliance with enhanced recovery after surgery (ERAS) program on patient reported outcomes (PROs), surgery-specific outcomes and stress response after pancreatic surgery.
- Conditions
- ERAS, Pancreas Cancer, Pancreas; Fistula, Delayed Gastric Emptying
- Trial name
- NCT05518643
- Testing
- ERAS protocol
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- University of Thessaly
Complete Spinal Cord Injury, Surgery
Anesthetic Requirement and Stress Hormone Response During Surgery in Spinal Cord-injured Patients
Spinal cord injury (SCI) reduces anesthetic requirements and stress hormonal responses. Anesthetic requirements and stress hormone response are compared in SCI patients undergoing anesthesia with sevoflurane supplemented with…
- Trial name
- NCT01683916
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Chonnam National University Hospital
Tetralogy of Fallot (TOF), Ventricular Septal Defects (VSD)
Measures to Lower the Stress Response in Pediatric Cardiac Surgery
Cardiac surgery induces a measurable stress response in patients which leads to increased morbidity and mortality post-operatively.
- Conditions
- Tetralogy of Fallot (TOF), Ventricular Septal Defects (VSD), Atrioventricular Septal Defects (AVSD)
- Trial name
- NCT00848393
- Testing
- Fentanyl (High Dose), Fentanyl (Low Dose), Fentanyl (Low Dose) + Dexmedetomidine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Nationwide Children's Hospital
General Anesthetic Drug Adverse Reaction
Postoperative Effects of Propofol Versus Sevoflurane Anesthesia
Background: The choice of appropriate anesthetics is essential to protect brain function, decrease perioperative complications, and provide high-quality care, and better quality of life.
- Trial name
- NCT05935930
- Testing
- Propofol 10 MG/ML Injection, Sevoflurane Inhalation Liquid
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Damanhour Teaching Hospital
Stress Response of Endotracheal Intubation and Surgical Field Clarity in FESS
Melatonin vs Metoprolol or Dexmedetomidine to Improve Surgical Field in FESS
This randomized controlled study at Zagazig University Hospitals will include 112 patients undergoing elective functional endoscopic sinus surgery, allocated into four groups (Melatonin, Metoprolol, Dexmedetomidine, Control).
- Trial name
- NCT07568873
- Testing
- Melatonin, Metoprolol (MET), Dexmedetomidine
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Zagazig University
Surgical Stress and Immune Function
Surgical Stress and Colorectal Surgery
The purpose of this study is to evaluate surgical stress and immune function after robotic versus laparoscopic colectomy.
- Trial name
- ESSIMIC (NCT02871960)
- Testing
- Robotic and Laparoscopic Colectomy
- Volunteers
- 170 people
- Sponsor
- Federico II University
Knee Osteoarthritis
An Artificial Intelligence-based Approach in Total Knee Arthroplasty: From Inflammatory Responses to Personalized Medicine
Goal: The goal of this interventional study is to understand how multimodal preoperative data can predict outcomes after Total Knee Arthroplasty (TKA) and improve personalized medicine practices.
- Trial name
- AI-TKA (NCT06634654)
- Testing
- Total Knee Arthroplasty, Multifaceted diagnostic assessments, Follow-ups
- Where
- Italy
- Volunteers
- 197 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Gastro-Oesophageal Reflux
Laparoscopy in Children: Does it Decrease the Metabolic, Endocrine and Inflammatory Stress Response to Surgery
The aim of this trial was to characterise the intra and post operative metabolic, endocrine and inflammatory response to laparoscopic fundoplication in children.
- Trial name
- NCT00231543
- Testing
- Laparoscopic fundoplication, open Nissen fundoplication
- Where
- United Kingdom
- Sponsor
- Institute of Child Health
Kinesiophobia, Anterior Cruciate Ligament Injuries
Stress Response to Virtual Risky Movement Exposure and Kinesiophobia After Anterior Cruciate Ligament (ACL) Surgery
In this study, patients who have completed their rehabilitation after Anterior Cruciate Ligament (ACL) reconstruction surgery will be examined with physiological stress response test while being exposed to risky athletic…
- Trial name
- NCT05929261
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Ege University
Laryngoscopic Stress Response, Video Laryngoscopy
Effect of Video Laryngoscopy Versus Conventional Laryngoscopy Upon Hemodynamics
In general anestheisa airway is secured by passing a tube down the widpipe. This helps the patient to breath via ventilator during anesthesia.
- Conditions
- Laryngoscopic Stress Response, Video Laryngoscopy, Conventional Laryngoscopy
- Trial name
- NCT07300878
- Testing
- C MAC hyperangulated video laryngoscopy, Conventional macintosh laryngoscopy
- Where
- Pakistan
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Muscle Weakness, Anesthesia
The Effect of Anesthesia on Perioperative Muscle Weakness and Neuro-endocrine Stress Response
The effect of surgery, in contrary to critical illness, on muscle weakness hasn't been thoroughly investigated. Recent data suggest that elective surgery may also induce muscle weakness.
- Conditions
- Muscle Weakness, Anesthesia, Anesthesia, Local, Surgery
- Trial name
- MUSCLE (NCT03600454)
- Testing
- General anesthesia, Spinal anesthesia, General anesthesia and epidural analgesia
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Ziekenhuis Oost-Limburg
Cardiac Surgery
The Effect of Insulin on Protein Metabolism After Cardiac Surgery
Background: The hyperinsulinemic-normoglycaemic clamp technique is a precise method of providing insulin and glucose while maintaining normoglycemia. High-dose insulin has profound effects on glucose and protein metabolism.
- Trial name
- NCT01601561
- Testing
- Regular human insulin injection
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Surgery, Immune System and Related Disorders
Immune Modulation by Enhanced vs Standard Prehabilitation Program Before Major Surgery
Over 30 million surgeries are performed annually in the US. Up to 30% of surgical patients experience delayed surgical recovery, marked by prolonged post-surgical pain, opioid consumption, and functional impairment, which…
- Conditions
- Surgery, Immune System and Related Disorders, Preoperative Care, Gastrointestinal Disease
- Trial name
- NCT04498208
- Testing
- Physical Prehabilitation, Stress Reduction Prehabilitation, Cognitive Prehabilitation
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Stanford University
Colorectal Cancer, Anesthesia
Effects of Dexmedetomidine/Lidocaine/Intrathecal Morphine on Cancer Metastasis Biomarker After Colorectal Surgery
This is a prospective randomized controlled trial. Investigators aimed to compare the effect of three different anesthetic adjuvants (continuous infusion of lidocaine or dexmedetomidine, intrathecal morphine injection) on the…
- Conditions
- Colorectal Cancer, Anesthesia, Cancer Metastatic, Inflammation
- Trial name
- NCT05742438
- Testing
- Lidocaine IV, Dexmedetomidine IV, intrathecal morphine
- Where
- South Korea
- Volunteers
- 114 people
- Sponsor
- Samsung Medical Center
Adenotonsillectomy, Preoperative Anxiety
Timing Of Midazolam İn Children Undergoing Adenotonsillectomy: Effects On Stress, Cortisol, And Recovery
This study is a prospective, randomized, controlled clinical trial designed to evaluate the optimal timing of midazolam administration in children undergoing adenotonsillectomy.
- Conditions
- Adenotonsillectomy, Preoperative Anxiety, Surgical Stress Response, Postoperative Pain
- Trial name
- Timing-Midazol (NCT07622641)
- Testing
- Midazolam (Oral), Midazolam (Intravenous)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Erzurum City Hospital
Coronary Artery Disease, Postoperative Care
CABG-AI-Supported Discharge Education
This randomized controlled trial will evaluate the effectiveness of artificial intelligence-supported individualized discharge education for patients undergoing coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Artery Disease, Postoperative Care, Patient Discharge, Recovery of Function
- Trial name
- AI-D-E-CABG (NCT07503678)
- Testing
- AI-Supported Individualized Discharge Education, Standard Discharge Education
- Volunteers
- 128 people
- Sponsor
- Hasan Kalyoncu University
Inflammatory Bowel Diseases
Anti Tumor Necrosis Factor Alpha Agents and Surgical Stress Response
Background: The immunologic response to stress is regulated by the cytokines. Anti-Tumor Necrosis Factor-α agents are antibodies directed against a key cytokine in the process angiogenesis and collagen synthesis.
- Trial name
- NCT01974869
- Testing
- Anti-tumor necrosis factor alpha agents
- Where
- 4 sites in Denmark
- Volunteers
- 47 people
- Sponsor
- El-Hussuna, Alaa, M.D.
Hernia, Inguinal, Laparoscopy
Transabdominal Preperitoneal Inguinal Hernia Repair
The present study seeks to determine whether improved visual acuity and enhanced flexibility of the robotic platform results in a reduced surgical stress response and an improvement in indices of surgical outcome measures for…
- Trial name
- TAPP (NCT05839587)
- Testing
- Robotic TAPP, Laparoscopic TAPP
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University of Southern Denmark
Pain, Pain After Surgery
Tourniquet Exposure and Risk of Chronic Pain After Severe Limb Trauma
Severe limb trauma often requires the use of a tourniquet to stop life-threatening bleeding. While tourniquets are essential for saving lives, prolonged interruption of blood flow may lead to tissue ischemia, nerve injury, and…
- Conditions
- Pain, Pain After Surgery, Phantom Limb Pain After Amputation, Military Combat Stress Reaction
- Trial name
- TOURNI-PAIN (NCT07475871)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)