Clinical trials: Surgical Stress Response
Pain, Pain After Surgery
Tourniquet Exposure and Risk of Chronic Pain After Severe Limb Trauma
Severe limb trauma often requires the use of a tourniquet to stop life-threatening bleeding. While tourniquets are essential for saving lives, prolonged interruption of blood flow may lead to tissue ischemia, nerve injury, and…
- Conditions
- Pain, Pain After Surgery, Phantom Limb Pain After Amputation, Military Combat Stress Reaction
- Trial name
- TOURNI-PAIN (NCT07475871)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Surgery
Animal-assisted Therapy in Pediatric Surgery: Post-operative Benefits
The relationship between human beings and animals, especially dogs, has existed for thousands of years. Historically, animals have held an important role in this relationship as they provide company, stimulus and motivation.
- Trial name
- NCT02284100
- Testing
- animal assisted therapy
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Response to Hyperoxia
Hyperoxic Oxidative Stress During Abdominal Surgery
Our aim is to compare the effects of 80% and 40% Fraction of inspired oxygen on oxidative stress, antioxidant response (in plasma and bronchoalveolar lavage), extubation quality, preanesthetic and postanesthetic expiration tidal…
- Trial name
- NCT01793454
- Testing
- Fraction of inspired oxygen 40%, Fraction of inspired oxygen 80%
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Ultrasound, External Oblique
Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery
This study aims to evaluate the efficacy of ultrasound-guided external oblique and rectus abdominis plane block on the neuroendocrine stress response and postoperative analgesia in adults undergoing umbilical hernia repair.
- Conditions
- Ultrasound, External Oblique, Rectus Abdominis Plane Block, Neuroendocrine Stress Response
- Trial name
- NCT07324863
- Testing
- General anesthesia, External oblique and rectus abdominis plane (EXORA) block
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome
Prediction of Inflammatory Response and Hypotensive Syndrome After Cardiac Surgery by Preoperative Copeptin Level
The purpose of this study is to find a preoperative biomarker before cardiac surgery with cardiopulmonary bypass related to severe postoperative inflammatory response and circulatory complications.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome, Stress Response, Cardiac Surgery Prognosis
- Trial name
- MicorSIRS (NCT03288610)
- Testing
- Preoperative copeptin level
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Postoperative Cognitive Dysfunction
Cognitive Dysfunction Following Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is the most common complication after cardiac surgery. This prospective study was conducted to investigate the mechanisms of development of POCD following cardiac surgery taking into…
- Trial name
- CDCS (NCT02767713)
- Testing
- Dexamethasone
- Volunteers
- 171 people
- Sponsor
- Clinical Hospital Center, Split
Preoperative Anxiety, Cesarean Section
Effect of Video-Based Versus Verbal Preoperative Information on Anxiety and Cortisol Levels in Elective Cesarean Section
Preoperative anxiety is a common problem in patients undergoing elective cesarean section and may negatively affect perioperative outcomes through activation of the stress response, including increased cortisol levels.
- Conditions
- Preoperative Anxiety, Cesarean Section, Surgical Stress Response, Cortisol
- Trial name
- NCT07521592
- Testing
- Verbal Preoperative Information, Video-Based Preoperative Information
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Laparoscopic Cholecystectomy Surgery
Attenuate the Stress Response in Laparoscopic Cholecystectomy
Aims of this study are to compare the effectiveness of dexmedetomidine versus fentanyl-midazolam in attenuating hemodynamic stress response during laparoscopic cholecystectomy (mainly HR).
- Trial name
- NCT07425444
- Testing
- Dexmedetomidine, Fentanyl- midazolam
- Volunteers
- 50 people
- Sponsor
- Assiut University
Anesthesia, Stress, Physiological
Adductor Canal Block Versus Patient Controlled Analgesia, in the Surgical Stress Response for Anterior Cruciate Ligament Repair
To evaluate the surgical stress response in anterior cruciate ligament repair with an adductor canal block versus patient controlled endovenous analgesia.
- Conditions
- Anesthesia, Stress, Physiological, Surgery
- Trial name
- NCT04797546
- Testing
- Adductor Canal Block, Morphine Patient Controlled Analgesia
- Where
- Chile
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Cardiac Surgery
The Effect of Insulin on Protein Metabolism After Cardiac Surgery
Background: The hyperinsulinemic-normoglycaemic clamp technique is a precise method of providing insulin and glucose while maintaining normoglycemia. High-dose insulin has profound effects on glucose and protein metabolism.
- Trial name
- NCT01601561
- Testing
- Regular human insulin injection
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Enhanced Recovery After Surgery, Spine Surgery
Enhanced Recovery After Spine Surgery
Enhanced recovery pathways (ERP) after surgery have been shown to decrease length of stay and perioperative complications in a range of surgical specialties.
- Trial name
- NCT02949518
- Testing
- Enhanced Recovery Pathway (ERP) for Spine
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York