Clinical trials: Surgical Wound Haemorrhage
Intracranial Hemorrhages, Surgery
Evaluation of Surgery in Elderly With Traumatic Acute SubDural Hematoma
Rationale: The rapidly increasing number of elderly (≥ 65 years old) with traumatic brain injury (TBI) is accompanied by substantial medical and economic consequences.
- Trial name
- RESET-ASDH (NCT04648436)
- Testing
- Early neurosurgical hematoma evacuation, Conservative treatment (best medical management)
- Where
- Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Hip Fracture
Tranexamic Acid in HIp Fracture Surgery (THIF Study)
The purpose of this study is to assess the efficacy of tranexamic acid in hip fracture surgery on the reduction of allogeneic red blood cell transfusion.
- Trial name
- THIF (NCT00327106)
- Testing
- Tranexamic acid (Exacyl)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Tranexamic Acid, Burn
TXA Study in Major Burn Surgery
Major surgery can result in blood loss that can require a blood transfusion during and/or after surgery. Tranexamic acid (TXA) is a medication that was first introduced in the 1960's as a treatment for heavy menstrual bleeding.
- Conditions
- Tranexamic Acid, Burn, Major Surgery
- Trial name
- NCT02753816
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Corewell Health West
Bleeding, Surgical Wound
Traumacel FAM Trium in the Post-market Surveillance Phase
The investigational medical device Traumacel FAM Trium is a sterile plant polysaccharide haemostatic agent based on the oxidized cellulose in the form of multilayer nonwoven fabric.
- Trial name
- NCT05177874
- Testing
- Traumacel FAM Trium, Surgicel Fibrillar
- Where
- Czechia
- Volunteers
- 98 people
- Sponsor
- Bioster, a.s.
Surgical Site Infection (SSI), Wound Healing Complication
Prophylactic Use of ciNPWT in Gynecologic Laparotomy
This is a prospective, open-label, non-randomized interventional feasibility study with a nested qualitative analysis. The study exploratively verifies the feasibility of targeted prophylactic closed incision negative pressure…
- Conditions
- Surgical Site Infection (SSI), Wound Healing Complication, Seroma, Hematoma
- Trial name
- NCT07645547
- Testing
- closed incision negative pressure wound therapy (ciNPWT)
- Volunteers
- 30 people
- Sponsor
- University Hospital Hradec Kralove
Chronic Subdural Hematoma, Anesthesia
Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH
A prospective, multicenter, randomized controlled trial is designed to evaluate the safety of nerve block anesthesia combined with sedative anesthesia versus general anesthesia during burr hole craniostomy with drainage for…
- Trial name
- NCT05888389
- Testing
- Cranial Nerve Block Anesthesia Combined With Sedative Anesthesia, General Anesthesia
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Beijing Tiantan Hospital
Bleeding, Pain
Colibricare Efficacy on Oral Surgical Procedures/Extraction Wound and Gingiva Retraction
In this randomized, three-arm trial, 120 patients undergoing wisdoms' extractions were assigned to control (gauze pressure application), commercial sponge, or Coli-sorb® groups.
- Trial name
- NCT07638930
- Testing
- wisdoms' surgical extractions
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Cairo University
Postoperative Pain, Soft Tissue Bleeding
Comparison of Er,Cr:YSGG and Diode Lasers In Second Stage Implant Surgery
The study evaluates postoperative pain, intraoperative bleeding and wound healing after second stage implant surgery. Submerged implants were exposed with diode laser in Group 1 (n=20) and by using Er,Cr:YSGG laser in Group 2…
- Conditions
- Postoperative Pain, Soft Tissue Bleeding, Wound Heal
- Trial name
- NCT03819244
- Testing
- 940 nm Gallium Aluminum Arsenide Diode Laser, 2780 nm Er,Cr:YSGG Laser
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Chronic SDH and the Efficacy of Embolization
Endovascular Embolization for Chronic Subdural Hematomas Following Surgical Evacuation
This study is designed to evaluate the effectiveness of endovascular embolization of middle meningeal artery following evacuation of subdural hematomas (SDHs) to assess rate of recurrence.
- Trial name
- endovascular (NCT04272996)
- Testing
- Craniotomy only, Craniotomy + Endovascular embolization of the middle meningeal vessels
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Augusta University
Bleeding, Complications
Comparing Different Routes and Doses of Phytonadione (Vitamin K) for Reversing Warfarin Treated Patients With Hip Fracture Before Surgery
It is well known that femoral neck fractures carry a significant increase in patients' mortality and that surgical intervention is the preferred treatment.
- Trial name
- NCT00905229
- Testing
- Phytonadione
- Where
- Israel
- Sponsor
- HaEmek Medical Center, Israel
Blood Transfusion, Hip Fracture Surgeries
Hip Fracture Surgery Timing and Blood Transfusion Risk in Patients on DOACs
This study looks at patients with hip fractures who are taking direct oral anticoagulants (DOACs), a type of blood thinner. In many hospitals, surgery for these patients is delayed because of concerns about bleeding, but waiting…
- Conditions
- Blood Transfusion, Hip Fracture Surgeries, Geriatric, Bleeding Complications
- Trial name
- OPTIMIZEDOAC (NCT07309848)
- Where
- 7 sites in Netherlands
- Volunteers
- 374 people
- Sponsor
- St. Antonius Hospital
Hemoglobin Level Measurement, Blood Loss During Surgery
Efficacy of Tranexamic Acid Reducing Blood Loss During Maxillofacial Trauma Surgery
Tranexamic acid (TXA) is an inexpensive, easily used and relatively safe drug. It inhibits plasminogen activation and plasmin thus retards clot disintegration.Therapeutic application of tranexamic acid in trauma for preventing…
- Conditions
- Hemoglobin Level Measurement, Blood Loss During Surgery, Duration of Surgery
- Trial name
- NCT07392034
- Testing
- Tranexamic Acid (TXA), Normal saline
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nishtar Medical University
Surgical Site Infection, Surgical Wound
Optimizing Closed Incision Negative Pressure Wound Therapy in Emergency Laparotomy
The purpose of this study is to find differences in rates of surgical site infections following emergency laparotomy with the use of two different incisional negative pressure wound therapy (iNPWT)devices.
- Conditions
- Surgical Site Infection, Surgical Wound, Surgical Wound Infection, Surgical Complication
- Trial name
- OPTIWOUND (NCT05716490)
- Testing
- Incisional negative pressure wound therapy, Control group - standard wound dressing
- Where
- Portugal
- Volunteers
- 114 people
- Sponsor
- Centro Hospitalar do Tâmega e Sousa
Abdominal Injuries, Wounds and Injuries
Predictors of In-Hospital Mortality in Severe Abdominal Trauma
Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and…
- Conditions
- Abdominal Injuries, Wounds and Injuries, Wounds, Nonpenetrating, Wounds, Penetrating
- Trial name
- NCT07843628
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Osteoarthritis, Hip, Joint Deformities, Acquired
Efficacy of Aquamantys for Reducing Transfusions With Anterior Supine Intermuscular Approach Total Hip Arthroplasty
The purpose of this study is to establish whether or not there is a clinical advantage to the use of Aquamantys® System from Medtronic Advanced Energy (formerly Salient Surgical Technologies) in patients undergoing primary total…
- Conditions
- Osteoarthritis, Hip, Joint Deformities, Acquired, Hip Dislocation, Congenital, Osteonecrosis
- Trial name
- Aquamantys (NCT01583465)
- Testing
- Aquamantys, standard electrocautery (Bovie)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Joint Implant Surgeons, Inc.
Hyperthermic Intraperitoneal Chemotherapy, Hepatocellular Carcinoma
Surgical Resection Combined With Intraperitoneal Hyperthermic Chemotherapy
Patients with ruptured liver cancer and bleeding after surgical resection were included according to the criteria of admission, and the patients were divided into experimental and control groups.
- Conditions
- Hyperthermic Intraperitoneal Chemotherapy, Hepatocellular Carcinoma, Ruptured Liver
- Trial name
- NCT06247293
- Testing
- intraperitoneal hyperthermic perfusion chemotherapy
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Chronic Subdural Hematoma
Targeting Spreading Depolarization After Chronic Subdural Hematoma Surgery (TASD)
Chronic Subdural Hematoma (cSDH) is an extremely common problem, particularly in the aging population, where fluid like collections compress the brain, frequently requiring surgical drainage.
- Trial name
- TASD (NCT04966546)
- Testing
- Memantine Hydrochloride
- Where
- United States
- Sponsor
- University of New Mexico
Chronic Subdural Hematomas
Middle Meningeal Artery Coagulation During Burr-Hole Drainage for Chronic Subdural Haematoma (BURR-MMA)
Chronic subdural haematoma (cSDH) is a common condition in older adults, usually treated by burr-hole surgery to drain the collection.
- Trial name
- BURR-MMA (NCT07549893)
- Testing
- CT-Guided Intra-Operative Middle Meningeal Artery Interruption
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Surgery
The Effects of Zn-containing Granulate on Patient Morbidity and Wound Healing After Free Gingival Graft Surgery
There is no study in the literature showing the effects of Zn on wound healing after free gingival graft (FGG) operation. The aim of this randomized clinical study was to compare the early healing results of the palatal wound…
- Trial name
- NCT05684913
- Testing
- Zn granulate stent after FGG surgery, Hemostatic agent suturing
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Surgical Wound, Bleeding
Serum Concentration of Tranexamic Acid After Topical Administration in Massive Weight Loss Skin Reducing Surgery
Tranexamic acid is a drug that prevents clotted blood from dissolving and hence reduces bleeding. It is routinely given intravenously in many surgical situations where there is a risk of major bleeding.
- Trial name
- NCT03101124
- Testing
- Tranexamic Acid 25 mg/ml for wound surface moistening, Tranexamic Acid 5 mg/ml as bolus in wound cavity, Tranexamic Acid Injectable Solution
- Where
- Norway
- Volunteers
- 36 people
- Sponsor
- St. Olavs Hospital