Clinical trials: Surgical Wound Healing
Parastomal Hernia
Improving Decisions and Outcomes in Parastomal Hernia Surgery
The goal of this observational study is to help improve decisions about planned surgery for parastomal hernia and understand the results of treatment.
- Trial name
- IDOPS (NCT07866339)
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Erling Oma
Knee Cartilage Defects
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
This study will test whether CARTISTEM is safe and works better than debridement (a surgery that cleans out damaged tissue) for people with knee cartilage damage and osteoarthritis.
- Trial name
- CARTISTEM23-01 (NCT07339111)
- Testing
- CARTISTEM® + Debridement, Debridement
- Where
- 35 sites in United States
- Volunteers
- 300 people
- Sponsor
- Medipost, Inc.
Corneal Diseases
Using in Vivo Confocal Microscope to Evaluate the Corneal Wound Healing After Various Ocular Surgeries
Although epi-keratome laser-assisted in situ keratomileusis (Epi-LASIK), penetrating keratoplasty and pars plana vitrectomy with corneal epithelial debridement for diabetic retinopathy are surgeries commonly performed, the…
- Trial name
- NCT00491439
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Carbuncle
Comparison of Wound Healing for Diabetic Carbuncle Treated With Incision and Drainage Technique Using Cruciate Incision vs Saucerization Technique Both Followed by Vacuum Assisted Closure.
The goal of this clinical trial is to compare the effectiveness of two surgical techniques for wound healing in diabetic patients aged 25-70 years with a carbuncle requiring surgical drainage.
- Trial name
- NCT07428265
- Testing
- Incision & Drainage Technique Using Cruciate Incision Followed by VAC, Saucerization Technique Followed by VAC
- Where
- Pakistan
- Volunteers
- 124 people
- Sponsor
- King Edward Medical University
Delayed Healing
PICO Breast Reduction Clinical Study Looking at Incision Healing Complications
The purpose of this study is to see if the use of a single-use negative pressure wound therapy system (NPWT) will have an effect on the reduction of post-surgical incision healing complications following breast reduction surgery…
- Trial name
- NCT01640366
- Testing
- PICO
- Where
- 6 sites in United States, France and 2 more
- Volunteers
- 200 people
- Sponsor
- Smith & Nephew, Inc.
Surgical Site Infections
Continuous v Bolus Infusion of Cefazolin During Ventral Hernia Repair
Patients undergoing an elective ventral hernia repair will be randomly assigned to receive either bolus infusion or continuous infusion of the cefazolin as the prophylactic antibiotic.
- Trial name
- NCT02666365
- Testing
- Bolus infusion of Cefazolin, Continuous infusion of Cefazolin
- Sponsor
- Milton S. Hershey Medical Center
Nonunion Fracture, Delayed Bone Healing
Using the Boneflo System During Orthopedic and Trauma Surgery: A Prospective Multicenter Study
Critical bone defects, non-unions, and delayed bone healing remain major challenges in orthopedic and trauma surgery and often require bone grafting.
- Conditions
- Nonunion Fracture, Delayed Bone Healing, Critical Bone Defects
- Trial name
- BoneFlo (NCT07562165)
- Testing
- Intraoperative bioactivation of bone substitute materials using the Boneflo® Tissue Collector System.
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universität Duisburg-Essen
Esophageal Atresia
Endoscopic Ultrasound Findings in Esophageal Atresia Following Surgical Repair
Children with esophageal atresia who undergo surgical repair are at risk for anastomotic stricture following surgery. Esophageal stricture can be treated with serial endoscopic dilation but may ultimately need surgical resection…
- Trial name
- NCT04259528
- Testing
- Pediatric endoscopic ultrasound
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Hernia, Ventral
Complex Ventral Hernia Repair Using Biologic or Synthetic Mesh
Hernias are often treated using a prosthetic mesh to add support to the healing wound. Prosthetic meshes have been used for decades to repair ventral hernias, level 1 data regarding which type of mesh to use is limited.
- Trial name
- CVHR (NCT02041494)
- Testing
- Ventralight, Strattice
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Hobart Harris
Cryo Analgesia, Pectus Surgery
Long Term Safety of Preoperative Percutaneous Intercostal Cryoneurolysis
Follow up of patients who underwent percutaneous cryoneurolysis for pectus excavatum repair (the Nuss procedure) pain management
- Trial name
- CRYOFUP (NCT07657845)
- Testing
- Self-report Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) Questionnaire - Pediatric Quality of Life Inventory (PedsQL™) Questionnaire - Patient Self-Assessment Sensory Scale
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Papa Giovanni XXIII Hospital
PRF
Topical Application of PRF Before Radiation Therapy
The primary goal of this study is to observe whether PRP promotes the wound healing before a radiation therapy or not, compared to the natural healing of a tooth extraction socket.
- Trial name
- PRF (NCT06406530)
- Testing
- PRF, Natural Healing
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- University of Giessen
Heart Septal Defects, Ventricular, Aortic Valve Insufficiency
Aortic Regurgitation After Surgical Repair of Outlet-Type Ventricular Septal Defect
The major risk factors of aortic valve replacement in three outlet types VSD after surgical repair were the severity of preoperative AR and older operation age.
- Trial name
- NCT00173186
- Where
- Taiwan
- Volunteers
- 411 people
- Sponsor
- National Taiwan University Hospital
Ewing Sarcoma, Bone Neoplasms
Neoadjuvant Radiotherapy and Surgery for High-Risk Localized Ewing Sarcoma
This is a single-center, single-arm, prospective observational study to evaluate the long-term local control rate, safety, and efficacy of preoperative neoadjuvant radiotherapy (36-45 Gy) followed by sequential radical surgery…
- Trial name
- NCT07620431
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Peking University People's Hospital
Rotator Cuff Tear
Surgical Safety and Effectiveness in Orthopedics: Swiss-wide Multicenter Evaluation and Prediction of Core Outcomes in Arthroscopic Rotator Cuff Reconstruction
Surgical safety and effectiveness in orthopedics: Swiss-wide multicenter evaluation and prediction of core outcomes in arthroscopic rotator cuff reconstruction.
- Trial name
- ARCR_Pred (NCT04321005)
- Testing
- arthroscopic rotator cuff reconstruction
- Where
- 20 sites in Germany, Switzerland
- Volunteers
- 973 people
- Sponsor
- University Hospital, Basel, Switzerland
Osteoarthritis of Knee, Edema
Microcurrent Stimulation Reduces Post-Operative Swelling and Healing Time Following Knee Replacement Surgery
The purpose of this study is to determine if patients undergoing a total knee arthroplasty (TKA) experience a clinically significant reduction in healing time when treated post operatively with a specific form of micro and…
- Conditions
- Osteoarthritis of Knee, Edema, Wounds and Injuries
- Trial name
- NCT02623660
- Testing
- ODIN1, Standard Care, Diagnostic Device Testing
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bioelectric Research Corporation
Wound of Skin, Abdominal Wound
Safety and Efficacy of MRG-001 in Wound Healing in Abdominoplasty Patients
Surgical excisions are one of the most frequent cutaneous wounds. This study will compare the safety and preliminary efficacy of a novel fixed-dose combination drug MRG-001 in pre-abdominoplasty surgical excisions and scar…
- Trial name
- NCT05844527
- Testing
- MRG-001, Saline
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- MedRegen LLC
Endometrial Cancer, Immunotherapy
Immunotherapy for Surgery Avoidance in Vulnerable dMMR Endometrial Cancer
Efficacy evaluate of iparomlimab and tuvonralimab (a PD-1/CTLA-4 bispecific antibody) in patients with surgically resectable dMMR endometrial cancer.
- Conditions
- Endometrial Cancer, Immunotherapy, Mismatch Repair Deficiency
- Trial name
- IMMUNE-SAVE (NCT07369986)
- Testing
- Iparomlimab and Tuvonralimab (QL1706)
- Volunteers
- 30 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Wound
Doubleblinded RCT of the Omnilux on Lower Extremity Surgical Wounds Left to Heal by Second Intention
The goal of the study is to evaluate the effectiveness of the light-emitting diode (LED) in promoting healing of the wound on lower leg as a result of surgery.
- Trial name
- NCT02383056
- Testing
- Omnilux
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Miami
Chronic Rhinosinusitis With Nasal Polyps
Effect of Oral Vitamin D3 on Chronic Rhinosinusitis Treatment in Adults With Lower Vitamin D Levels
The purpose of the study is to test the clinical efficacy of oral Vitamin D3 on Wound Healing in patients with Chronic Rhinosinusitis With Nasal Polyposis and Lower Vitamin D Levels After Endonasal Endoscopic Sinus Surgery
- Trial name
- NCT02668861
- Testing
- Vitamin D, Budesonide Nasal Spray
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital of Shanxi Medical University
Skin Structures and Soft Tissue Infections, Wound Infection
The PLUS Study: Comparison of VicrylPlus® Versus Vicryl® for Repair of Perineal Tears
INTRODUCTION It is estimated that over 80% of women who give vaginal birth will sustain some form of perineal tear and of these 60-70% will require suturing.
- Trial name
- NCT02863874
- Testing
- VicrylPlus®, Vicryl®
- Where
- Sweden
- Volunteers
- 1,890 people
- Sponsor
- Region Skane
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