Clinical trials: Surgical Wound Healing
Aortic Aneurysm
Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA)
A multi-center, randomized clinical trial that will compare endovascular repair with standard open surgery in the repair of abdominal aortic aneurysms (AAA).
- Trial name
- OVER (NCT00094575)
- Testing
- Endovascular Repair, Standard Open Repair
- Where
- 42 sites in United States
- Volunteers
- 881 people
- Sponsor
- VA Office of Research and Development
Ventral Hernia Repair
Robotic Single Port Ventral Hernia Repair
Evaluation of the perioperative outcomes of robotic suprapubic ventral hernia repair with the Da Vinci Singe Port (SP) system
- Trial name
- ESPRESSOH (NCT07755657)
- Testing
- SP2 eTEP, da Vinci Single Port Surgical System
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Blood Loss, Surgical
Efficacy Study of Recombinant Protein (Ecallantide) to Reduce Blood Loss During Primary Coronary Bypass Grafting or Valve Repair/Replacement
The primary objective of this study was to assess the efficacy and safety of 2 dose levels of ecallantide versus placebo in reducing blood loss following cardiopulmonary bypass (CPB), as measured by chest tube drainage during the…
- Trial name
- NCT00448864
- Testing
- Ecallantide
- Where
- 15 sites in United States
- Volunteers
- 75 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Pilonidal Sinus, Wound Healing
ENVELOP: Wound Care Following Pilonidal Sinus Surgery
This is a single-blinded, multicentre, prospective randomised controlled trial (RCT) comparing post-operative and patient-reported outcomes for patients undergoing application of negative-pressure wound therapy (NPWT) after sinus…
- Trial name
- ENVELOP (NCT06647290)
- Testing
- Negative Pressure Wound Therapy, Standard wound care
- Where
- 10 sites in Ireland
- Volunteers
- 200 people
- Sponsor
- Royal College of Surgeons, Ireland
Palatal Donor Site Wound Healing, Platelet Rich Fibrin
Characterizing the Effects of Platelet-Rich Fibrin (PRF) as a Palatal Wound Dressing on Quality of Life and Sleep Following Mucogingival Surgery. Study Was Conducted at the Air Force Post Graduate Dental School. All HIPPA Consents and Research Informed Consents Are Located at JBSA-Lackland.
The goal of this clinical trial (2-arm) is to determine if the application of platelet rich fibrin (PRF) to palatal donor sites influence patients quality of life, sleep efficiency, and healing following mucogingival surgery.
- Conditions
- Palatal Donor Site Wound Healing, Platelet Rich Fibrin, Sleep Quality, Pain
- Trial name
- NCT07637838
- Testing
- Platelet rich fibrin, Control Group: collagen matrices or oxidized cellulose membrane
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- 59th Medical Wing
Meningomyelocele
Stress-associated Epigenetic Alterations in Newborns After Fetal Surgery
Open spina bifida or myelomeningocele (MMC) is a devastating congenital defect of the central nervous system for which there is no cure. The etiology of MMC remains poorly understood.
- Trial name
- NCT04027374
- Testing
- Fetal surgery for MMC repair
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Preterm Infant, Anesthesia
The Comparison of Laryngeal Mask Airway and Endotracheal Tube in General Anesthesia for Premature Neonates
Objectives: To compare the perioperative respiratory adverse events between using laryngeal mask airway and endotracheal tube in preterm neonates receiving general anesthesia for hernia surgery.
- Conditions
- Preterm Infant, Anesthesia, Respiratory Complication
- Trial name
- NCT03931902
- Testing
- intubation with Endotracheal tube, intubation with laryngeal mask airway
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Cleft Lip, Cleft Palate
Cleft Palate Surgery and Speech Development
Compare the outcome of two primary surgeries techniques (von Langenbeck and Furlow double z-plasty) performed on children with cleft lip/palate to determine if one results in significantly better velopharyngeal competency for…
- Trial name
- NCT00004639
- Testing
- Furlow double z-plasty palatoplasty palate repair, Von Langenbeck palatoplasty palate repair
- Where
- 2 sites in United States, Brazil
- Volunteers
- 475 people
- Sponsor
- University of Florida
Ventral Hernia Repair
Reducing INfection at the Surgical SitE With Antibiotic Irrigation During Ventral Hernia Repair (RINSE Trial)
This is a study to determine if the incidence of infection at the Surgical SitE is impacted if with Antibiotic Irrigation is used during Ventral Hernia Repair (RINSE Trial)
- Trial name
- RINSE (NCT03945357)
- Testing
- Gemcitabine/ clindamycin, Normal saline
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Prisma Health-Upstate
ACL Injury, ACL Tears
Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction
This is a prospective, multi-center, randomized, double-blind, placebo-controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in improving postoperative outcomes following anterior cruciate ligament reconstruction…
- Conditions
- ACL Injury, ACL Tears, ACL Surgery
- Trial name
- NCT07115056
- Testing
- Tranexamic Acid (TXA)
- Where
- 6 sites in United States
- Sponsor
- Campbell Clinic
Chronic Instability of Joint
Factors Associated With Full Recovery After Surgical Repair of Shoulder Instability
Case control study to evaluate different factors (e.g muscle strength, psychological factors) that are associated with full recovery and functional status 6 months after surgical repair of shoulder instability.
- Trial name
- NCT02978365
- Testing
- Questionnaires, Isokinetic Strength Measurement
- Where
- Israel
- Volunteers
- 44 people
- Sponsor
- Uri Gottlieb
Nasal Polyps, Chronic Sinusitis
Wound Healing After Endoscopic Sinus Surgery
This study aims to determine the effect of Thymoquinone (0.5%) and olive oil ointment on Wound healing after Endoscopic sinus surgery.
- Trial name
- NCT06070311
- Testing
- Thymoquinone (0.5%) and Olive oil ointment
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Aortic Coarctation, Cardiac Output, Low
Correlation of Cardiac Index Measured by the PRAM Method With NIRS and Lactate Levels in Pediatric Aortic Coarctation Surgery
This prospective observational study aims to evaluate the correlation between cardiac index measured by the MostCare™ system (Pressure Recording Analytical Method, PRAM) and cerebral/renal regional oxygen saturation measured by…
- Trial name
- MostCare-Ped (NCT07568431)
- Testing
- MostCare (PRAM), Near-Infrared Spectroscopy (NIRS), Arterial Blood Gas with Lactate
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Konya City Hospital
Pelvic Organ Prolapse
Native Tissue Repair With Surgical Pelvic Organ Pessary - an RCT
This is an RCT looking at the primary outcome of composite success following anterior repair with native tissue at 6, 12, 24 months in two arms.
- Trial name
- NTRSPOP (NCT02808377)
- Testing
- Surgical Pelvic Organ Pessary
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Distal Bicep Tendon Rupture
Trial Comparing Single Versus Double Incision to Repair Distal Bicep Tendon Ruptures
The purpose of this study to to determine whether a single incision technique or a double incision technique is more effective in the surgical treatment of distal bicep tendon ruptures.
- Trial name
- BRT (NCT01322828)
- Testing
- Distal bicep tendon reconstruction
- Where
- 2 sites in Canada
- Volunteers
- 92 people
- Sponsor
- Hand and Upper Limb Clinic, Canada
Acute Achilles Tendon Rupture
Popliteal Nerve Block for Acute Achilles Tendon Rupture Repair Surgery
Achilles tendon rupture is common, yet the value of popliteal nerve block for postoperative pain control during surgical repair remains uncertain.
- Trial name
- NCT06886815
- Testing
- Popliteal Nerve Block
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Women's College Hospital
Mitral Valve Disease
Assessment of Sustained Systolic-to-diastolic Flexibility of the Mitral Valve Annulus With the Sorin MEMO 3D Mitral Anuloplasty Ring
Mitral valve reconstruction commonly requires the use of an anuloplasty device to assure long-term durability of the repair. Among mitral anuloplasty devices, varying from rigid to complete flexible ring substitutes, the most…
- Trial name
- MEMO 3D (NCT01987635)
- Testing
- MEMO 3D ring, Standard use of rigid ring., 3D Echocardiography
- Where
- Belgium
- Volunteers
- 33 people
- Sponsor
- University Hospital, Ghent
Congenital Heart Disease, Congenital Heart Defect
Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters
Cardiac denervation is inherent to the arterial switch (ASO) technique for the repair of transposition of the great arteries (TGA) and the long term reinnervation process has not been studied.
- Conditions
- Congenital Heart Disease, Congenital Heart Defect, Transposition of the Great Arteries
- Trial name
- NCT03469843
- Testing
- Non intervention
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Mitral Regurgitation
TEER for Severe DMR of Low to Intermediate Surgery Risk
To investigate the efficacy and safety of transcatheter mitral valve edge-to-edge repair (TEER) for severe degenerative mitral regurgitation (DMR) patients of low to intermediate surgery risk.
- Trial name
- NCT06162780
- Testing
- ultrasonic cardiography (UCG), TEER
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Healing Wound, Iron-deficiency
Impact of Iron Stores on Wound Healing in Plastic Surgery
In breast reduction surgery, delayed wound healing may increase surgical site infections, cutaneous necrosis and may be related to psychological harm.Some risk factors have been identified : smoking, diabetes, overweight.
- Conditions
- Healing Wound, Iron-deficiency, Surgical Wound
- Trial name
- IRONPLAST (NCT04276168)
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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