Clinical trials: Surgical Wound Healing
Edentulous Alveolar Ridge, Dental Trauma
Dimensional Changes of the Labial Alveolar Ridge After Socket Shield Technique With Computer Guided Root Sectioning
In this study, the dimensional changes of the labial alveolar ridge are digitally assessed after immediate implant placement using the socket shield technique with computer guided sectioning of the root.
- Trial name
- NCT05366985
- Testing
- Socket shield technique with computer guided sectioning of the root
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Inguinal Hernia, Indirect, Children, Only
Inflammatory Stress Response in Pediatric Inguinal Hernia Repair
Today there are various surgical techniques for inguinal hernia. In this study, investigators want to compare the ''PIRS'' operating technique laparoscopy and modified "Marcy" operating technique with open inguinal access.
- Conditions
- Inguinal Hernia, Indirect, Children, Only, Inflammatory Response, Surgery
- Trial name
- NCT03203343
- Testing
- Operation - PIRS, Operation - MARCY
- Where
- Croatia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital of Split
Circulatory Arrest
Aprotinin Use and Renal Outcome in Hypothermic Bypass and Circulatory Arrest for Surgical Repair of Thoracic Aorta.
Primary Objective: The aim of this study is to assess the effects of Aprotinin (an antifibrinolytic drug used to reduce bleeding during cardiac surgery) on renal function in patients undergoing surgery with use of hypothermic…
- Trial name
- NCT00405093
- Where
- United States
- Volunteers
- 1,250 people
- Sponsor
- Weill Medical College of Cornell University
Scar
Botox in the Healing of Surgical Wounds of the Neck
The investigators hypothesize that Botox A will reduce scarring and improve healing of surgical neck wounds.
- Trial name
- NCT01177358
- Testing
- Botulinum Toxin Type A, Normal Saline
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Wound, Re-Epithelialization
Phenytoin in the Healing of Clean Surgical Wounds
The purpose of this study is to investigate the potential healing properties of phenytoin. The investigators will use the donor site of a split skin thickness graft (SSTG) to model a basic wound in a randomized controlled trial…
- Trial name
- NCT02413658
- Testing
- Phenytoin, Sugar solution
- Where
- Cambodia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Surgical Center, Cambodia
Degenerative Mitral Valve Disease, Mitral Regurgitation
Long Term Results of Surgical and Percutaneous Double Orefices Mitral Repair in Patient With p2 Prolapse Causing Degenerative Mitral Regurgitation
Mitral regurgitation is a pathology affecting the left atrioventricular valve that causes a volumetric and pressure overload in the left chambers due to the loss of unidirectionality normally guaranteed by the cardiac valve…
- Trial name
- NCT05836532
- Testing
- Central edge-to-edge
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Michele De Bonis
Congenital Heart Disease, Cardiopulmonary Bypass
Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair
The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing…
- Conditions
- Congenital Heart Disease, Cardiopulmonary Bypass, Mechanical Ventilation, Peep Titration in Lung Protective Ventilation
- Trial name
- ILOCO-CHD (NCT07486167)
- Testing
- End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Tendon Injuries, Tendinopathy
NuShield in Surgical Peroneal Tendon Repair
The purpose of this study is to evaluate the use of NuShield in subjects requiring surgical tendon repair.
- Trial name
- NCT03828916
- Testing
- NuShield
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- NuTech Medical, Inc
Scar, Incision
A Safety and Efficacy Study to Evaluate AIV001 in Wound Healing Following Surgical Incision
To evaluate the safety, efficacy and pharmacokinetic profile of ascending concentrations of the study medication compared with vehicle in subjects with incisional wounds
- Conditions
- Scar, Incision, Abdominal, Wound (Morphologic Abnormality)
- Trial name
- NCT03639883
- Testing
- AIV001
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AiViva BioPharma, Inc.
Pulmonary Hypertension
A Study to Evaluate the Efficacy, Safety and Tolerability of PDNO Infusion in Patients With Pulmonary Hypertension After Cardiopulmonary Bypass Surgery
This is an open-label, multicenter study evaluating the dose, effect, safety and tolerability of intravenous PDNO infusion given to patients undergoing cardiopulmonary bypass (CPB) surgery with post-operative acute pulmonary…
- Trial name
- NCT05699486
- Testing
- PDNO
- Where
- 2 sites in Sweden
- Volunteers
- 12 people
- Sponsor
- Attgeno AB
Inguinal Hernia, Groin Hernia
A Global Prospective Study on Inguinal Hernia Surgery
The primary aim of the HIPPO study is to identify compliance to audit standards (pre-operative and intraoperative) standards for the repair and management of inguinal hernia.
- Conditions
- Inguinal Hernia, Groin Hernia, Surgery
- Trial name
- HIPPO (NCT05748886)
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Pain
Photo-biomodulation Therapy for Pain Relief After Caesarean Section
C-sections may result in a lot of pain that is distressing to the mother, and can impact bonding with the baby. Although there are medications used to treat strong pain, they are not good to use after C-sections because they can…
- Trial name
- PBMT (NCT05738239)
- Testing
- Laser therapy
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- McMaster University
Gingival Pigmentation
Effect of Non-eugenol Periodontal Pack With and Without PRF on Post-operative Pain and Wound Healing After Gingival Depigmentation
In an era where less than ideal esthetics is not accepted, the request for esthetic procedures is widely sought after. Melanin, a brown pigment, is the most common natural pigment contributing to endogenous pigmentation of…
- Trial name
- NCT04495205
- Testing
- PRF under non-eugenol containing periodontal pack, Non-eugenol containing periodontal pack
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Paraesophageal Hernia
ACELL Mesh for Paraesophageal Hernia Repair
This is a prospective, case-matched, systematic follow up of up to 70 pre-existing patients whom underwent paraesophageal hernia repair between June 1, 2012 and September 30, 2016.
- Trial name
- NCT03058731
- Testing
- Matristem, Control
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of South Florida
Abdominal Aortic Aneurysm, Surgery
Aneurysm Diameter and Surgical Outcome
Aneurysm diameter is an important risk for rupture and related death in affected patients. This study will evaluate whether aneurysms size may even influence post procedural outcomes both in open surgical repair and in…
- Conditions
- Abdominal Aortic Aneurysm, Surgery, Outcome, Fatal
- Trial name
- ADASO (NCT04422054)
- Testing
- Open Surgery, Endovascular Surgery
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Catanzaro
Surgical Wound Infection
The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to Heal
The goal of this clinical trial is to learn if reducing bacterial load on the skin and nostrils with topical antibacterial soap and ointment, respectively, reduces rate of infection in surgical sites on lower leg wounds left open…
- Trial name
- NCT07142408
- Testing
- Chlorhexidine gluconate (4%), Mupirocin 2% Ointment
- Where
- United States
- Volunteers
- 848 people
- Sponsor
- Cooper Norcross Health
Pelvic Organ Prolapse
Dynamic Magnetic Resonance Imaging Before and After Vaginal Prolapse Repair
This study is to describe the impact of vaginal reconstruction, including an intraperitoneal vaginal vault suspension for pelvic organ prolapse (POP) on pelvic anatomy using dynamic magnetic resonance imaging (MRI) of the pelvis.
- Trial name
- NCT03315715
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- TriHealth Inc.
Mastectomy, Breast Reconstruction
CiNPWT Using in Mastectomy Wound Care After DIEP Flaps for Breast Reconstruction
Background: Closed-incision negative pressure wound therapy (ciNPWT) is effective in reducing postoperative complications, yet its use in free flap breast reconstruction mastectomy wound remains controversial due to concerns that…
- Conditions
- Mastectomy, Breast Reconstruction, Closed-Incision Negative Pressure Therapy
- Trial name
- NCT07546968
- Testing
- Closed-Incision Negative Pressure Wound Therapy (CiNPWT)
- Where
- Taiwan
- Volunteers
- 253 people
- Sponsor
- Chiayi Christian Hospital
Aortic Aneurysm, Abdominal, Arterial Occlusive Diseases
The Use of Cardiovascular Biomarkers in Abdominal Aortic Surgery
The aim of the present study is the evaluation of cardiovascular biomarkers in patients with abdominal aortic aneurysms (AAA) or abdominal aortic occlusive disease AOD) undergoing open (OR) or endovascular aortic repair (EVAR)…
- Trial name
- BIAS (NCT02122497)
- Testing
- abdominal aortic surgery
- Where
- Austria
- Volunteers
- 500 people
- Sponsor
- Prim PD Dr Afshin Assadian
Hip Fractures
Non Invasive Cardiac Output Monitoring to Guide Goal Directed Fluid Therapy in High Risk Patients Undergoing Urgent Surgical Repair of Proximal Femoral Fractures
Improving or maximising cardiac output in the perioperative setting through the use of goal directed fluid therapy has been shown to reduce complications and length of hospital stay in patients undergoing major abdominal surgery.
- Trial name
- ClearNOF (NCT02382185)
- Testing
- Fluid optimisation, Optimisation of blood pressure, Application of clearsight monitor
- Where
- 2 sites in United Kingdom
- Volunteers
- 240 people
- Sponsor
- York Teaching Hospitals NHS Foundation Trust
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