Clinical trials: Surgical Wound Infection
Surgical Site Infection
Decolonization to Reduce After-Surgery Events of Surgical Site Infection
The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce…
- Trial name
- DECREASE SSI (NCT05586776)
- Testing
- 4% Chlorhexidine Gluconate, 2% Mupirocin
- Where
- 4 sites in United States
- Volunteers
- 2,700 people
- Sponsor
- University of California, Irvine
Wound Surgical, Wound Infection
PROPEL-2: Prophylactic Negative Pressure Wound Therapy in Laparotomy Wounds
Post-operative wound issues in abdominal surgery have a significant impact on patient outcomes. This study is taking place to investigate if Negative Pressure Wound Therapy (NPWT) dressings reduces Surgical Site Infections, post…
- Conditions
- Wound Surgical, Wound Infection, Cosmesis
- Trial name
- PROPEL-2 (NCT05977816)
- Testing
- Negative Pressure Wound Therapy, Standard wound dressing
- Where
- 10 sites in Ireland
- Volunteers
- 2,000 people
- Sponsor
- Royal College of Surgeons, Ireland
Wound Surgical, Wound Infection
PINTA - Prophylactic Incisional Negative Pressure Therapy for Major Amputations
Post-operative wound issues in abdominal surgery have a significant impact on patient outcomes. This study is taking place to investigate if Negative Pressure Wound Therapy (NPWT) dressings reduces Surgical Site Infections, post…
- Conditions
- Wound Surgical, Wound Infection, Cosmesis
- Trial name
- PINTA (NCT06025253)
- Testing
- Negative Pressure Wound Therapy, Standard Wound Dressing
- Where
- 7 sites in Ireland
- Volunteers
- 728 people
- Sponsor
- Royal College of Surgeons, Ireland
Cesarean Section, Surgical Site Infection
Effect of Betadine Vaginal Cleansing Before Cesarean Section to Reduce Postoperative Infectious Morbidity
This randomized controlled trial aims to evaluate the efficacy of preoperative vaginal cleansing with 5% povidone-iodine in reducing postoperative infectious morbidity among women undergoing cesarean section.
- Conditions
- Cesarean Section, Surgical Site Infection, Endometritis
- Trial name
- NCT07715409
- Testing
- Povidone-iodine 5% solution
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mohamed Mousa Mohamed Mousa
Combat Related Symptoms, Combat Trauma
DRONE-WOUND Study: Severe Infection After Drone-Related Combat Trauma
Drone-related combat injuries have become one of the most devastating mechanisms of injury in modern warfare. These injuries often cause extensive tissue devitalization, contamination, open fractures, vascular injuries, and…
- Conditions
- Combat Related Symptoms, Combat Trauma, Infection, Infection Complication
- Trial name
- DRONE-WOUND (NCT07706608)
- Where
- Ukraine
- Volunteers
- 500 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
ExtraCorporeal Membrane Oxygenation (ECMO), Wound Complications
Closed Incision NPWT to Prevent Wound Complications Post-ECMO
Patients undergoing extracorporeal membrane oxygenation (ECMO) are at increased risk of wound complications at the vascular access site after decannulation. These complications may delay recovery and increase healthcare burden.
- Conditions
- ExtraCorporeal Membrane Oxygenation (ECMO), Wound Complications, Surgical Site Infection (SSI)
- Trial name
- PREVENT-ECMO (NCT07709546)
- Testing
- Prophylactic Closed-Incision Negative Pressure Wound Therapy, Standard Wound Dressing
- Volunteers
- 144 people
- Sponsor
- St. Antonius Hospital
Surgical Site Infection, Colon Surgery
D-PLEX 312 - Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection (SHIELD II)
Phase III, Prospective, Multinational, Multicenter, Randomized, Controlled, Two-arm, Double Blind Study to Assess Efficacy and Safety of D-PLEX Administered Concomitantly with the Standard of Care (SoC), Compared to a SoC Treated…
- Conditions
- Surgical Site Infection, Colon Surgery, Abdominal Surgery, Post-Op Infection
- Trial name
- D-PLEX312 (NCT04411199)
- Testing
- D-PLEX, Standard of Care (SoC)
- Where
- 58 sites in United States, Bosnia and Herzegovina and 11 more
- Volunteers
- 975 people
- Sponsor
- PolyPid Ltd.
Surgical Site Infection (SSI)
Rationale of Subcutaneous Levofloxacin Infiltration as an Adjunct for Surgical Site Infection Prevention in Emergency Laparotomy
Surgical site infection (SSI) remains a major cause of postoperative morbidity following emergency laparotomy, particularly in contaminated and dirty/infected abdominal conditions.
- Trial name
- NCT07696819
- Testing
- Levofloxacin
- Where
- Bangladesh
- Volunteers
- 90 people
- Sponsor
- Sylhet M.A.G.Osmani Medical College
Wound Healing Time, Total Hip Arthroplasty (THA)
Wound Healing, Dressing Type, and Dressing Change Frequency in THA
Surgical wound complications following primary total hip arthroplasty remain a significant clinical challenge despite advances in wound care technologies.
- Trial name
- CAP-HIP (NCT07655388)
- Testing
- VACUTEX™ wound dressing, Octenisept® wound care dressing
- Where
- Serbia
- Volunteers
- 90 people
- Sponsor
- Clinical Center of Vojvodina
Surgical Site Infection
De-Implementation of Unnecessary Surgical Antibiotic Prophylaxis in Children
The overall objective of this study is to identify the best strategy to eliminate unnecessary antibiotic use after surgery in pediatric surgical procedures considered low-risk for an SSI.
- Trial name
- OPerAtiC (NCT04366440)
- Testing
- Order set review and modification with facilitation, Order set review and modification
- Where
- 10 sites in United States
- Volunteers
- 18,267 people
- Sponsor
- Washington University School of Medicine
Surgical Incision, Wound Dehiscence
Treating Emergency Laparotomy Incisions With Negative Pressure Wound Therapy
The goal of this clinical trial is to investigate Negative Pressure Wound Therapy (NPWT) in adults undergoing emergency laparotomy.
- Conditions
- Surgical Incision, Wound Dehiscence, Surgical Site Infection, Incisional Hernia
- Trial name
- TELIN (NCT07003906)
- Testing
- Negative pressure wound therapy, Standard postoperative dressing
- Where
- 6 sites in Sweden
- Volunteers
- 720 people
- Sponsor
- Uppsala University
Surgical Site Infection After Major Surgery
Impact of Prontosan Wound Gel X on Surgical Site Infections in Cardiac Surgery
This study aims to evaluate the effects of Prontosan® Wound Gel X on the incidence of superficial surgical site infections (SSI) in adult patients undergoing elective cardiac surgery with median sternotomy.
- Trial name
- PRONTOSAN (NCT07275307)
- Testing
- Application of Prontosan Wound Gel X
- Where
- Italy
- Volunteers
- 456 people
- Sponsor
- IRCCS Policlinico S. Donato
Cesarean Section, Surgical Site Infection
Steri-Strip Application Versus Standard Wound Closure for Cesarean Section Incisions
This study is evaluating whether Steri-Strips® provide additional benefits when used after cesarean section (C-section) surgery.
- Conditions
- Cesarean Section, Surgical Site Infection, Wound Dehiscence, Seroma
- Trial name
- STRIP-CS (NCT07686913)
- Testing
- Steri-Strip™ Skin Closures, Standard Cesarean Wound Closure
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- Riverside University Health System Medical Center
Appendicitis, Surgical Wound Infection
Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial)
The goal of this clinical trial is to compare primary wound closure (PC) versus delayed primary closure (DPC) after standardized wound decontamination using the High-Efficiency Incision and Drainage with Irrigation (HIEDI)…
- Conditions
- Appendicitis, Surgical Wound Infection, Postoperative Complications, Wound Healing
- Trial name
- HIEDI-Yemen (NCT07688109)
- Testing
- Primary Closure with HIEDI, Delayed Primary Closure with HIEDI
- Where
- 3 sites in Yemen
- Volunteers
- 200 people
- Sponsor
- Sana'a University
Surgical Site Infection, Sternal Infection
D-PLEX 302: Efficacy and Safety of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery
Prospective, Multinational, Multicenter, Randomized, Parallel Controlled, Two arms, Single Blind, Study to Assess the Efficacy and Safety of D-PLEX Administered Concomitantly with the Standard of Care (SOC) IV Prophylactic…
- Conditions
- Surgical Site Infection, Sternal Infection, Cardiac Surgery
- Trial name
- NCT03558984
- Testing
- D-PLEX, Standard of Care
- Where
- 3 sites in United States, Israel
- Volunteers
- 2 people
- Sponsor
- PolyPid Ltd.
Surgical Site Infection
Intraoperative Oxygen Concentration on Incidence of Surgical Site Infection
Surgical site infections (SSI) are the most common healthcare-associated infections and sources of morbidity and over-mortality.
- Trial name
- NCT06108791
- Testing
- FIO2=0.8, FIO2=0.33
- Where
- Egypt
- Volunteers
- 146 people
- Sponsor
- Assiut University
Surgical Site Infection (SSI), Spine Surgery
Investigation of the PREVENTIA® Irrigation Solution for Reducing Bacteria in Spinal Surgery With Implants - A Comparative Study
Spinal surgery carries a risk of surgical wound infections (i.e., the entry of bacteria). Despite various preventive measures, such infections continue to occur, particularly in operations involving implants.
- Conditions
- Surgical Site Infection (SSI), Spine Surgery, Surgical Site Infection Prevention
- Trial name
- PROTECT-SPINE (NCT07667036)
- Testing
- Preventia Surgical Solution, 0.9 % NaCl
- Where
- Switzerland
- Volunteers
- 114 people
- Sponsor
- Universität Luzern
Surgical Site Infection
Local Subcutaneous Gentamicin for Prevention of Surgical Site Infection After Elective Cesarean Section
The goal of this clinical trial is to evaluate whether local subcutaneous administration of gentamicin reduces the incidence of surgical site infection (SSI) following elective cesarean section.
- Trial name
- NCT07311395
- Testing
- Gentamicin, Standard antibiotic prophylaxis
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Surgical Site Infection (SSI)
Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During Orthopedic Surgeries in Egyptian Patients.
A randomized controlled trial on adults who underwent orthopedic surgery. To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT) cefazolin administration in…
- Trial name
- NCT07655596
- Testing
- Cefazolin 2 g Infusion, Cefazolin 2 GM Injection
- Volunteers
- 100 people
- Sponsor
- Helwan University
Surgical Site Infection (SSI)
Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During CABG Surgeries in Egyptian Patients.
A randomized controlled trial on adults who underwent coronary artery bypass grafting (CABG) surgery. To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT)…
- Trial name
- NCT07658378
- Testing
- Cefazolin 2 g Infusion, Cefazolin 2 GM Injection
- Volunteers
- 100 people
- Sponsor
- Helwan University