Clinical trials: Survival , Tumor
Metastatic Prostate Cancer
The Present Study Aims to Compare Patients Who Receive the Investigational Product (177Lu-DOTA-rosopatamab) Plus Standard of Care, in Comparison to Standard of Care Only
This multinational, multicenter, prospective, randomized, controlled, open label Phase 3 study is designed to investigate and confirm the benefits and risks associated with the PSMA-targeted antibody, 177Lu DOTA rosopatamab…
- Trial name
- NCT04876651
- Testing
- 177Lu-DOTA-rosopatamb, Standard of Care
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 16 people
- Sponsor
- Telix Pharmaceuticals (Innovations) Pty Ltd
Colorectal Cancer, Chemotherapeutic Toxicity
Aerobic Fitness or Muscle Mass Training to Improve Colorectal Cancer Outcome
Evidence from randomized controlled trials shows that exercise during cancer treatment benefits physical fitness, fatigue and quality of life.
- Conditions
- Colorectal Cancer, Chemotherapeutic Toxicity, Survivorship, Lifestyle
- Trial name
- AMICO (NCT04754672)
- Testing
- Continuous aerobic and resistance exercise intervention, Continuous aerobic and aerobic interval exercise intervention
- Where
- 13 sites in Netherlands
- Volunteers
- 228 people
- Sponsor
- Radboud University Medical Center
Breast Cancer
Combination Chemotherapy in Treating Older Women With Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one chemotherapy drug may kill more tumor cells.
- Trial name
- NCT00010075
- Testing
- fluorouracil, leucovorin calcium, mitoxantrone hydrochloride
- Where
- 6 sites in France
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Gastric Adenocarcinoma
Gender Differences in Gastric Cancer Care and Its Adherence to Guidelines in Germany
Background: Gastric cancer is the fifth most common cancer globally and the fourth leading cause of cancer-related mortality. While gender differences in gastric cancer care are underexplored in Germany, international studies…
- Trial name
- MaGen (NCT06902337)
- Where
- Germany
- Volunteers
- 75,000 people
- Sponsor
- Medizinische Hochschule Brandenburg Theodor Fontane
Medulloblastoma, Childhood, Survivorship
Cognitive Rehabilitation for Survivors of Childhood Medulloblastoma Using Real Time Hemodynamic Neurofeedback
This study will evaluate a new way to help childhood medulloblastoma survivors improve their thinking and memory skills. Many survivors experience long term challenges with attention and working memory because of the tumor and…
- Trial name
- NCT07830134
- Testing
- rt fMRI Neurofeedback (DLPFC), rt fMRI Neurofeedback (PAC)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- St. Jude Children's Research Hospital
Leukemia, Myeloid, Acute
Survival in Patients Older Than 60 Years With Newly Diagnosed AML in Spain
Prospective, multicenter, observational, national study (EPA-SP) that aims to describe the survival and the quality of life, the clinical management strategies and the prognostic factors for survival related to the patient, in a…
- Trial name
- NCT03435341
- Where
- 40 sites in Spain
- Volunteers
- 151 people
- Sponsor
- Celgene
Cervical Cancer Stage IB2, Cervical Cancer Stage IIa
Minimally Invasive Radical Hysterectomy Using Endoscopic Stapler in Stage IB2 or IIA1 Cervical Cancer
This study is a multicenter, open-label, non-inferiority, randomized controlled, investigator-initiated clinical trial comparing the efficacy and safety of open radical hysterectomy versus minimally invasive radical hysterectomy…
- Trial name
- SOLUTION2 (NCT07256977)
- Testing
- Open radical hysterectomy, Minimally invasive radical hysterectomy
- Where
- South Korea
- Volunteers
- 494 people
- Sponsor
- Seoul National University Hospital
NSCLC (Advanced Non-small Cell Lung Cancer), Metastatic NSCLC
Phase 3 Study of Nogapendekin Alfa Inbakicept Plus Standard of Care vs Standard of Care in First-Line Advanced or Metastatic NSCLC
This is a randomized, open-label, phase 3 study evaluating nogapendekin alfa inbakicept (NAI) plus chemoimmunotherapy containing pembrolizumab and platinum-based chemotherapy versus chemoimmunotherapy alone as first-line…
- Trial name
- NCT07524257
- Testing
- Drug: Nogapendekin alfa inbakicept (NAI), Pembrolizumab, Cisplatin or Carboplatin
- Sponsor
- ImmunityBio, Inc.
Oesophageal Cancer
Predictive Value of Pet Scan With Fdg Performed During Irradiation in Patients Treated for Oesaphagus Carcinoma
The poor prognosis in the early-stage of oesophageal carcinoma cancer is due to potential worsening of the disease (local relapse, metastasis), to insufficient efficacy and toxicity of actual treatments.
- Trial name
- RTEP3 (NCT00934505)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Henri Becquerel
Epithelial Ovarian Cancer, Fallopian Tube Cancer
Stratified Evaluation of PDS and NACT-IDS in Ovarian Cancer (FOCUS)
The purpose of this study is to answer the fundamental question 'The Optimal Timing of Surgery' in advanced ovarian cancer patients with different tumor burden, and to perform translational study.
- Conditions
- Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- NCT04515602
- Testing
- Primary debulking surgery, Neoadjuvant chemotherapy, PARPi
- Where
- 4 sites in China
- Volunteers
- 410 people
- Sponsor
- Shanghai Gynecologic Oncology Group
Lung Cancer, Cancer
Bintrafusp Alfa Program Rollover Study
This study is designed to provide continuous access to treatment with bintrafusp alfa for eligible participants from ongoing bintrafusp alfa parent studies (NCT02517398, NCT02699515, NCT04246489, NCT03840915, NCT03631706…
- Trial name
- NCT05061823
- Testing
- Bintrafusp alfa
- Where
- 21 sites in United States, Belgium and 10 more
- Volunteers
- 22 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Salivary Gland Cancer, Salivary Gland Neoplasms
Survival With Patients Treated With Salivary Gland Cancer
Salivary gland malignancies is very heterogenous group of tumors regarding tumor histology and localization. The aim of this study is to assess main clinical and pathological parameters related to patients survival
- Trial name
- NCT05390294
- Testing
- Surgical intervention with or without postoperative adjuvant therapy
- Where
- Serbia
- Volunteers
- 250 people
- Sponsor
- Clinical Center of Vojvodina
Esophageal Cancer
Prognostic Analysis of Esophageal Cancer with Complete Pathological Response After Neoadjuvant Therapy
Esophageal cancer is one of the most common malignant tumors worldwide, with high invasiveness and lethality. Currently, the treatment for resectable locally advanced esophageal cancer mainly consists of a treatment model…
- Trial name
- NCT06889402
- Testing
- Neoadjuvant therapy with PD-L1 inhibitor
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Hepatocellular Carcinoma (HCC)
Regional Lymph Node Metastasis and Survival Outcomes in Advanced HCC
Tumor-draining lymph nodes play an important role in anti-tumor immune responses. In patients with hepatocellular carcinoma (HCC), however, the relationship between regional lymph node metastasis (LNM) and immunotherapy-based…
- Trial name
- CHANCE2421 (NCT06876753)
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- Zhongda Hospital
Brain Tumor
Influences of Propofol and Sevoflurane Anesthesia in Brain Tumor
In the preoperative waiting area, the patients are randomly assigned and divided into two groups according to the allocation sequence table (corresponding to 1:1 randomization) generated by the computer.
- Trial name
- anesthetics (NCT05141877)
- Testing
- Propofol, Sevoflurane
- Where
- Taiwan
- Volunteers
- 706 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Anal Cancer
Beyond Survival: Addressing Gynecological and Sexual Health in Women After Radiotherapy for Anal Cancer
The goal of this observational study is to learn how radiotherapy for anal cancer affects the vaginal and sexual health of women after treatment.
- Trial name
- DACG VI (NCT07296237)
- Where
- 3 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Aarhus University Hospital
Neoplasms
Beta-carotene and Alpha-tocopherol Chemoprevention of Second Primary Malignancies in Head and Neck Cancer Patients
Epidemiologic studies suggest that low dietary intakes and low plasma concentrations of antioxidant vitamins and minerals are associated with increased risks of cancer, especially for epidermoid tumors.
- Trial name
- NCT00169845
- Testing
- Alpha-Tocopherol and Beta-Carotene
- Where
- Canada
- Volunteers
- 540 people
- Sponsor
- Laval University
Rectal Cancer
Conventional Versus Individual Extralvator Abdominoperineal Excision for Advanced Lower Rectal Cancer
An alternative treatment for low rectal cancer is the extralevator abdominoperineal excision (ELAPE) technique. We aim to compare the outcomes of patients undergoing conventional ELAPE versus Individual ELAPE.
- Trial name
- ELAPE (NCT02036112)
- Testing
- conventional ELAPE, Individual ELAPE
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Chao Yang Hospital
Metastatic Breast Cancer
Survival Endpoints in Women Treated for Metastatic Breast Cancer: Contribution of Real-life Databases
Overall survival (OS) is considered the most reliable cancer endpoint and used by the Health Rregulatory authorities (HRA). OS presents multiple advantages in cancer randomized controlled trials (RCT): it is universally accepted…
- Trial name
- NCT03676257
- Testing
- Chemotherapy (exclusive), Endocrine therapy (exclusive), Combination of endocrine therapy and chemotherapy
- Where
- France
- Volunteers
- 20,033 people
- Sponsor
- Institut Bergonié
Hepatocellular Carcinoma
Immunosuppression in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma
The purpose of this study is to determine the safety and efficacy of sirolimus-based immunosuppressive therapy in patients following orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC), with regard to HCC…
- Trial name
- NCT00355862
- Testing
- CNI, MMF, Steroids, Aza etc. (mTOR inhibitor free), Sirolimus
- Where
- Germany
- Volunteers
- 525 people
- Sponsor
- University of Regensburg
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