Clinical trials: Survival , Tumor
Rectal Cancer, Anastomotic Leak
Does the Management of Anastomotic Leakage After Low Rectal Resection Affect Survival
The aim of this retrospective cohort-study is to assess the effects of AL and its severity divided according the ISREC-classification on the long-term oncological outcome.
- Trial name
- ISRECLeak (NCT06059924)
- Testing
- Anastomotic leakage
- Where
- Switzerland
- Volunteers
- 941 people
- Sponsor
- Cantonal Hospital of St. Gallen
Acute Myeloid Leukemia
Extramedullary Acute Myeloid Leukemia (eAML): Retrospective Single Center Cohort Study, Clinicopathological, Molecular Analysis and Survival Outcomes
Patients with extramedullary leukemia were identified over 10 years (January 2003 to September 2019). Clinicopathological,genetic-molecular features were identified and survival outcomes were studied and analyzed.
- Trial name
- NCT05057299
- Testing
- retrospective data analysis
- Where
- Jordan
- Volunteers
- 32 people
- Sponsor
- King Hussein Cancer Center
Oral Squamous Cell Carcinoma
Survival Benefit of Elective Neck Dissection in T1,2N0M0 Oral Squamous Cell Carcinoma
Controversy over surgical treatment of clinically negative neck in early stage oral squamous cell carcinoma revolves around the uncertainty of its impact on patient prognosis.
- Trial name
- NCT01334320
- Testing
- elective neck dissection
- Where
- 4 sites in China
- Volunteers
- 448 people
- Sponsor
- Sun Yat-sen University
Prostate Cancer
Survival Outcomes and Tumor Molecular Profile Following Bicalutamide Neoadjuvant Therapy
As clinical primary endpoints we assessed whether existed differences in: 1. PSA recurrence rate stratified according to treatment modalities 2.
- Trial name
- NCT00418080
- Testing
- bicalutamide
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- University of L'Aquila
Chondrosarcoma
A Phase II Study of EVEROLIMUS in Patients With Primary or Relapsed Chondrosarcomas
The mainstay of chondrosarcoma treatment is a wide surgical resection. Unfortunately, this is a rare occurrence, and patients with incomplete resection have very poor therapeutic options.
- Trial name
- CHONRAD (NCT02008019)
- Testing
- Everolimus 2.5 mg/day, Everolimus 10 mg/day
- Where
- 12 sites in France
- Volunteers
- 57 people
- Sponsor
- Centre Leon Berard
Lymphoma, Autonomic Imbalance
Ivabradine in the Management of Cardiac Autonomic Dysfunction Associated With Thoracic Radiation Therapy.
This study will explore whether ivabradine lowers heart rate, and thus improves exercise capacity, in survivors of lymphoma who have an elevated resting heart rate as a side effect of prior radiation treatment.
- Conditions
- Lymphoma, Autonomic Imbalance, Cancer Survivorship
- Trial name
- NCT03137537
- Testing
- Ivabradine
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Dana-Farber Cancer Institute
Metastatic Melanoma, Unresectable Melanoma
IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Advanced Melanoma (IOB-013 / KN-D18)
Phase 3, multicenter, international, open-label, randomized, 2-arm trial investigating the safety and efficacy of IO102-IO103 in combination with pembrolizumab as first-line treatment for patients with previously untreated…
- Trial name
- NCT05155254
- Testing
- IO102-IO103, Pembrolizumab
- Where
- 112 sites in United States, Australia and 14 more
- Volunteers
- 407 people
- Sponsor
- IO Biotech
Lymphoma, Follicular
Study of Prognosis of Follicular Lymphoma Through a Prospective Collection of Data (F2-study)
The F2-study is a complement of the previous studies of the Follicular Lymphoma Prognostic Factors Project which permitted the development of the Follicular Lymphoma International Prognostic Index (FLIPI).
- Trial name
- NCT01250223
- Where
- 51 sites in United States, Argentina and 6 more
- Volunteers
- 1,093 people
- Sponsor
- Associazione Angela Serra per la ricerca sul cancro
Glioblastoma Multiforme
Determination of Immune Phenotype in Glioblastoma Patients
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Despite intensive research efforts and a multimodal management that actually consists of surgery, radiotherapy and chemotherapy with temozolomide…
- Trial name
- NCT02751138
- Testing
- Surgery
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Ulm
Early-stage Breast Cancer, Breast Cancer Female
The ConnectedCancerCare Pilot Study (CCC)
This study is an NCI-funded, randomized control pilot trial to evaluate: (1) the feasibility and acceptability of a web-based, personalized navigation tool (ConnectedCancerCare) and (2) explore whether the tool improves delivery…
- Conditions
- Early-stage Breast Cancer, Breast Cancer Female, Survivorship, Cancer Survivors
- Trial name
- CCC (NCT03618017)
- Testing
- CCC website, Static care plan
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Michigan Rogel Cancer Center
Neoplasms, Colorectal, Neoplasm Metastasis
A Longitudinal Study of Colorectal Cancer Patients With Metastatic Disease in Middle-Norway
The main objective is to provide original research results that may change clinical practice related to metastatic colorectal cancer.
- Trial name
- NCT02395224
- Testing
- cancer treatment and follow-up according to current regional and national guidelines
- Where
- 7 sites in Norway
- Volunteers
- 354 people
- Sponsor
- Norwegian University of Science and Technology
Colorectal Cancer
An Observational Study on The Correlation Between Time of Initiation of Avastin (Bevacizumab) Treatment And Progression-Free Survival in Patients With Colorectal Cancer (CRONOS 1)
This single arm, prospective, observational study will assess the correlation between the time from start of chemotherapy to the start of Avastin (bevacizumab) treatment with progression-free survival in patients with previously…
- Trial name
- NCT01277120
- Where
- Romania
- Volunteers
- 174 people
- Sponsor
- Hoffmann-La Roche
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
A Vaccine (STEMVAC) for Improving Survival in Patients With Triple-Negative Breast Cancer and Moderate or Extensive Residual Cancer Burden
This phase II trial evaluates whether a multi-antigen vaccine called STEMVAC improves disease-free survival after surgery in patients with triple-negative breast cancer (TNBC) and moderate or extensive residual cancer burden.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Triple-Negative Breast Carcinoma
- Trial name
- NCT07721259
- Testing
- CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine, Recombinant Granulocyte-Macrophage Colony-Stimulating Factor, Biospecimen Collection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
Gynecologic Cancer
Lifestyle and Empowerment Techniques in Survivorship of Gynecologic Oncology
This pilot study is evaluating a new smartphone application named the LETSGO app. The LETSGO app is designed to promote empowerment in patients after treatment for gynecological cancer.
- Trial name
- LETSGO (NCT03453788)
- Testing
- LETSGO app
- Where
- Norway
- Volunteers
- 24 people
- Sponsor
- Sorlandet Hospital HF
Lymphoma,, Non-Hodgkin Lymphoma,
Mild-dose IMRT for Early-staged Extranodal Nasal-type NK/T-cell Lymphoma With CR Tumor After GELOX Chemotherapy
This study is to make sure whether reduced-dose radiation treatment is sufficient to control the disease in patients with early-staged extranodal nasal-type NK/T-cell lymphoma, who have got complete remission tumor after…
- Conditions
- Lymphoma,, Non-Hodgkin Lymphoma,, Extranodal NK/T-cell Lymphoma,Nasal-type,
- Trial name
- NCT02229682
- Testing
- Mild-dose IMRT
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-sen University
Astrocytoma, Astrocytic Tumors
Impact of IDH Mutation and Adjuvant Chemo(radio)therapy on Survival Outcome in Grade II/III Astrocytoma
This study looked at a type of brain tumor called astrocytoma and how specific genetic changes like IDH mutations affect patients outcomes.
- Conditions
- Astrocytoma, Astrocytic Tumors, Astrocytoma of Brain
- Trial name
- NCT06620926
- Testing
- IDH mutant-type, IDH wild-type
- Where
- Egypt
- Volunteers
- 811 people
- Sponsor
- asmaa salama ibrahim
Cholangiocarcinoma
the Impact of Early Palliative Care on the Survival of Locally Advanced and / or Metastatic Cholangiocarcinoma Patients
The prognosis for cholangiocarcinoma is bad. Potentially, early management by a palliative care team could increase overall survival.
- Trial name
- NCT04415190
- Testing
- early palliative care
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Central Hospital, Nancy, France
NSCLC
Chemotherapy of Elderly Patients With Non-Small-Cell Lung Cancer (NSCLC)
The last ASCO recommendations in 2003 for the treatment of a CBNPC of stage IIIB/IV of elderly people, are to manage a monochemotherapy.
- Trial name
- NCT00298415
- Testing
- Paclitaxel + Carboplatin, Monotherapy (gemcitabine or vinorelbine)
- Where
- 5 sites in France
- Volunteers
- 451 people
- Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
Prostate Cancer Metastatic
The Prognosis of Lipid Reprogramming With Rosuvastatin, in Castrated Egyptian Prostate Cancer Patients
Aim: The role of surgical castration and rosuvastatin treatment on lipid profile and lipid metabolism related markers was evaluated for their prognostic significance in metastatic prostate cancer (mPC) patients.
- Trial name
- NCT04776889
- Testing
- Rosuvastatin 20mg, surgical castration
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute, Egypt
Acute Promyelocytic Leukemia (APL)
Oral Arsenic With ATRA for Newly Diagnosed Patients With Acute Promyelocytic Leukemia
It is a non-randomized, multicenter, prospective study, aiming to treat patients with newly diagnosed acute promyelocytic leukemia with a combination of oral arsenic and atra, with low dose chemotherapy for those with high-risk…
- Trial name
- IC-APL2020 (NCT06982274)
- Testing
- Realgar-Indigo Naturalis Formulation
- Where
- Brazil
- Volunteers
- 115 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
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