Clinical trials: Survival , Tumor
Neoplams, Prostate Cancer (Adenocarcinoma)
Pilot Feasibility Study of a Dyadic Culinary Nutrition Intervention
This study will determine the feasibility and acceptability of a 12-week dyadic culinary nutrition program among Hispanic prostate cancer survivor/caregiver dyads using a randomized controlled trial design.
- Conditions
- Neoplams, Prostate Cancer (Adenocarcinoma), Cancer Survivors, Caregiver Burden
- Trial name
- CHEF (NCT07702864)
- Testing
- Cooking Healthy - Engaging Families (CHEF), Control
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Non-small Cell Lung Cancer
Study of Pembrolizumab (MK-3475) Versus Platinum-Based Chemotherapy for Participants With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Advanced or Metastatic Non-Small Cell Lung Cancer (MK-3475-042/KEYNOTE-042)-China Extension Study
In the China extension study, Chinese participants with programmed cell death ligand 1 (PD-L1)-positive non-small cell lung cancer (NSCLC) will be randomized to receive single agent pembrolizumab for up to 35 treatments or…
- Trial name
- NCT03850444
- Testing
- pembrolizumab, carboplatin, paclitaxel
- Volunteers
- 262 people
- Sponsor
- Merck Sharp & Dohme LLC
Lung Cancer, Thoracic Surgery
Epidural Anesthesia-analgesia and Long-term Survival After Lung Cancer Surgery
Available studies suggest that regional anesthesia-analgesia may decrease the occurrence of recurrence/metastasis in patients after cancer surgery. However, evidences from prospective studies are still lacking.
- Conditions
- Lung Cancer, Thoracic Surgery, Anesthesia, Epidural, Neoplasm Recurrence, Local
- Trial name
- NCT02801409
- Testing
- General anesthesia alone, Combined epidural-general anesthesia
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University First Hospital
Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8, Metastatic Breast Carcinoma
Testing Whether Treating Breast Cancer Metastases With Surgery or High-Dose Radiation Improves Survival
This randomized phase II/III trial studies how well standard of care therapy with stereotactic radiosurgery and/or surgery works and compares it to standard of care therapy alone in treating patients with breast cancer that has…
- Conditions
- Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8, Metastatic Breast Carcinoma, Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Liver
- Trial name
- NCT02364557
- Testing
- Stereotactic Body Radiotherapy, Surgery
- Where
- 162 sites in United States, Canada and 2 more
- Volunteers
- 129 people
- Sponsor
- NRG Oncology
Malignant Neoplasm, Malignant Neoplasm of Rectum
Dietary Fiber During Radiotherapy - a Placebo-controlled Randomized Trial
The investigators hypothesize that an increase in dietary fiber intake during radiation therapy may provide better long-term intestinal health for the cancer survivor.
- Conditions
- Malignant Neoplasm, Malignant Neoplasm of Rectum, Malignant Neoplasm of Anus, Malignant Neoplasm of Urinary Bladder
- Trial name
- FIDURA (NCT04534075)
- Where
- Sweden
- Volunteers
- 354 people
- Sponsor
- Sahlgrenska University Hospital
Liver Cancer, Pancreatic Cancer
Phase II Trial Evaluating OS With Therasphere® + 2nd-Line FOLFOX in Pancreatic Liver Mets
The purpose of this study is to evaluate the safety and impact on survival with treatment with 90-Y glass microspheres in conjunction with leucovorin, 5-fluorouracil (5-FU) and oxaliplatin (FOLFOX) as second-line treatment with…
- Trial name
- NCT01581307
- Testing
- FOLFOX7 (Folinic acid, 5-Fluorouracil, and Oxaliplatin), TheraSpheres
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Chronic Pain, Neuropathic Pain
Transcranial Direct Current Stimulation for Chemotherapy-Related Chronic Pain in Cancer Survivors
The goal of this clinical trial is to learn if transcranial direct current stimulation (tDCS) combined with a working-memory task can treat chronic pain and related emotional and cognitive problems after chemotherapy in adult…
- Conditions
- Chronic Pain, Neuropathic Pain, Cancer Survivors, Anxiety
- Trial name
- ONCOSTIM (NCT07912775)
- Testing
- Active tDCS with Sternberg task
- Where
- 2 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Instituto de investigación e innovación biomédica de Cádiz
Acute Myeloid Leukemia (AML), Acute Lymphoid Leukemia (ALL)
A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant
The purpose of this study is to see if conditioning regimens that include personalized rabbit ATG (P-rATG) help the immune system recover sooner and decrease the chances of transplant-related side effects.
- Conditions
- Acute Myeloid Leukemia (AML), Acute Lymphoid Leukemia (ALL), Myelodysplastic Syndromes (MDS)
- Trial name
- NCT04872595
- Testing
- Personalized rATG (P-rATG), Hyper fractionated total body irradiation, Thiotepa
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Advanced Non Small Cell Lung Cancer
Almonertinib Plus Microwave Ablation in Advanced Non-small Cell Lung Cancer
Almonertinib, as a third-generation EGFR-TKI, has been used for the treatment of advanced non small cell lung cancer. How to improve the progression free survival in advance was a challenge.
- Trial name
- MWA (NCT04755738)
- Testing
- Almonertinib plus microwave ablation
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Qianfoshan Hospital
Blood Loss, Intensive Care
D2 Versus D3 Dissection in Laparoscopic Right Hemicolectomy
Evaluating the differences between D2 and D3 lymphadenectomy in laparoscopic right hemicolectomy in patients with right cancer colon post-operative outcome, intra-operative blood transfusion, post-operative ICU admission…
- Conditions
- Blood Loss, Intensive Care, Anastomotic Leakage, Lymph Node Disease
- Trial name
- NCT06049758
- Testing
- LAPAROSCOPIC RIGHT HEMICOLECTOMY procedure (intervention), Enoxaparin 40 Mg/0.4 mL Injectable Solution, Levofloxacin 500mg
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Oral Cancer, Head and Neck Cancer
Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery
Following surgery to remove tumours of the head and neck, patients undergo reconstruction with free flaps - tissue that is taken from elsewhere in the body and given a new blood supply by attaching it to vessels in the neck.
- Conditions
- Oral Cancer, Head and Neck Cancer, Free Flap, Hypotension
- Trial name
- Free4Flow (NCT01418118)
- Testing
- Epinephrine, Norepinephrine, Dobutamine
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Oxford University Hospitals NHS Trust
Lung Cancer
Monoclonal Antibody Therapy Plus BCG in Treating Patients With Limited-Stage Small Cell Lung Cancer
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. BCG may activate the immune system to kill tumor cells.
- Trial name
- NCT00006352
- Testing
- BCG vaccine, monoclonal antibody BEC2
- Where
- Netherlands
- Volunteers
- 453 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Sarcopenia, Lung Cancer
Lung Cancer Surgery in Sarcopenia Patients With Old Age
The presence of sarcopenia before lung resection surgery might be an important factor of short-term and long-term prognosis in lung cancer patients.
- Trial name
- LUCAS-PEN (NCT05346185)
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Seoul National University Hospital
Locally Advanced Gastric Cancer, Tumor Immune Microenvironment
Machine Learning Model Guided by TLS Predicts Survival and Immune Features in Gastric Cancer
This study aims to develop and validate a machine learning model that uses information from tertiary lymphoid structures (TLSs)-specialized immune-related cell clusters found near tumors-to predict survival outcomes and immune…
- Conditions
- Locally Advanced Gastric Cancer, Tumor Immune Microenvironment, Tertiary Lymphoid Structures (TLS)
- Trial name
- NCT06979817
- Testing
- TLS-Informed Machine Learning Prognostic Model
- Volunteers
- 1,200 people
- Sponsor
- Qun Zhao
Colorectal Neoplasms, Neoplasm Metastasis
New Adjuvant Chemotherapy of Asymptomatic Resectable Primary Lesion With Unresectable Liver-limited Metastases
To evaluate the survival benefit of pre-operation chemotherapy of primary tumor tesection (PTR) compared upfront PTR for colorectal cancer (CRC) patients with an asymptomatic resectable primary tumor and synchronous unresectable…
- Conditions
- Colorectal Neoplasms, Neoplasm Metastasis, Liver Neoplasms, Chemotherapy; Maternal, Affecting Fetus
- Trial name
- NCT01307878
- Testing
- chemotherapy ± targeted therapy
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Fudan University
Malignant Pleural Mesotheliomas
Vascularity Impact on the Treatment Outcome in Malignant Pleural Mesothelioma(VITMPM)
The purpose of this study is to To assess the correlation between the predictive factor of vascularity (CD74) in malignant pleural mesothelioma and treatment results (response rate, and overall survival) .
- Trial name
- VITMPM (NCT02603315)
- Testing
- marker CD74 and vascular endothelial growth factor VEGF
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Prostate Cancer, Erectile Dysfunction
A Bio-psychosocial Sexual Health Intervention for Prostate Cancer Survivors and Partners: a Feasibility Study
The burden of sexual dysfunction after prostate cancer surgery is responsible for the single greatest impact on patient/partner health-related quality of life; substantially more so than concern for cancer recurrence, or any…
- Conditions
- Prostate Cancer, Erectile Dysfunction, Sexual Dysfunction
- Trial name
- BSHR (NCT02640131)
- Testing
- Biomedical Component, Psychosocial Component, Attention Control
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- University Health Network, Toronto
Colorectal Cancer
The Continuing Care Needs in Colorectal Cancer Patients in Different Stages
The aims of this study are to: 1. explore supportive care needs in colorectal cancer patients with treatment and survivors; 2. compare the supportive care needs in different stage of colorectal cancer; 3.
- Trial name
- NCT00961129
- Where
- Taiwan
- Volunteers
- 269 people
- Sponsor
- National Taiwan University Hospital
Neoplasia Prostate
PALLiON - PALLiative Care In ONcology
A major concern in today's oncology is the complexity of treatment that increases costs. A main contributor is the increasing use of chemo- and radiotherapy during end of life (EoL: the last 12 months of life).
- Trial name
- PALLiON (NCT03088202)
- Testing
- Educational program, Standardized care pathways, Early palliative care
- Where
- 12 sites in Norway
- Volunteers
- 659 people
- Sponsor
- Oslo University Hospital
Department of Anorectal Surgery, Changhai Hospital Affiliated to Naval Medical University
A Randomized, Controlled, Multicenter, Noninferiority Clinical Study of Perioperative and Oncological Safety in Patients With Rectal Cancer
Laparoscopic natural orifice specimen extraction surgery (NOSES) for low rectal cancer has a good minimally invasive effect. However, the NOSES prognosis studies are all small sample retrospective studies.
- Trial name
- NCT05503381
- Testing
- Laparoscopic radical resection of low rectal cancer with transanal specimens
- Volunteers
- 500 people
- Sponsor
- Changhai Hospital
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