Clinical trials: Survival , Tumor
Muscle-Invasive Bladder Carcinoma, Chemotherapy Effect
Role of NAC in cT0 Muscle-invasive Bladder Cancer After Maximal TURBt
This prospective randomized controlled trial (RCT) is designed to provide high level evidence describing the non-inferiority of radical cystectomy (RC) alone versus neoadjuvant chemotherapy (NAC) plus RC on survival outcomes of…
- Conditions
- Muscle-Invasive Bladder Carcinoma, Chemotherapy Effect, Surgery
- Trial name
- NCT05776758
- Testing
- cisplatin based neoadjuvant chemotherapy, Radical cystectomy alone
- Where
- Italy
- Volunteers
- 236 people
- Sponsor
- Regina Elena Cancer Institute
Colorectal Cancer
Endoscopic Versus Surgical Treatment for T1 Colorectal Cancer
The implementation of population screening programs for colorectal cancer (CRC) has led to a considerable increase in the prevalence T1 CRC originating on polyps amenable by endoscopy.
- Trial name
- EpiT1 (NCT04150081)
- Testing
- Surgery or Endoscopic treatment
- Where
- Spain
- Volunteers
- 1,400 people
- Sponsor
- Hospital Clinic of Barcelona
Breast Cancer
Combination Chemotherapy With or Without Darbepoetin Alfa in Treating Women With Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00309920
- Testing
- darbepoetin alfa, cyclophosphamide, docetaxel
- Where
- 47 sites in Germany
- Volunteers
- 1,234 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Epithelial Ovarian Cancer, Fallopian Tube Cancer
Stratified Evaluation of PDS and NACT-IDS in Ovarian Cancer (FOCUS)
The purpose of this study is to answer the fundamental question 'The Optimal Timing of Surgery' in advanced ovarian cancer patients with different tumor burden, and to perform translational study.
- Conditions
- Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- NCT04515602
- Testing
- Primary debulking surgery, Neoadjuvant chemotherapy, PARPi
- Where
- 4 sites in China
- Volunteers
- 410 people
- Sponsor
- Shanghai Gynecologic Oncology Group
Colonic Cancer, Unresectable Metastasis Originating in Colonic Cancer
Resection vs no Resection of the Primary in Colorectal Cancer With Unresectable Metastases
Main outcome: Assess the impact of cancer-related survival at 2 years in patients with unresectable metastatic colorectal cancer treated with chemotherapy alone versus surgery followed by chemotherapy. To assess overall survival.
- Trial name
- CCRe-IV (NCT02015923)
- Testing
- Colonic resection, Chemotherapy- scheme
- Where
- 22 sites in Spain
- Volunteers
- 107 people
- Sponsor
- Hospital Universitari de Bellvitge
Circulating Tumor Cell, HNSCC
Using a 3D Culture Model for Circulating Tumor Cells Combined With Molecular Bioassays in Patients With HNSCC Cancer
Cancer has been a significant cause of human death in the recent two decades, although detection, diagnosis, and cancer treatments improved and evolved rapidly.
- Trial name
- NCT06755762
- Testing
- Organoid 3D culture
- Where
- Taiwan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Serum Biomarker, Pancreatic Cancer
sCD8, as a Novel Biomarker for Pancreatic Cancer
Early detection and early treatment is the most important issue to improve the long-term survival of pancreatic cancer patients.
- Trial name
- NCT05500027
- Testing
- serum test
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Lymphedema of Face, Head and Neck Cancer
Assessing Impact of Early Physiotherapy on Lymphatic Dysfunction in Head and Neck Cancer Survivorship
The goal of this clinical trial is to learn if treating the lymphatics in head and neck cancer survivors before clinical diagnosis of lymphedema will prevent its development or progression.
- Trial name
- NCT05937269
- Testing
- Near-infrared fluorescence lymphatic imaging, advanced pneumatic compression therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The University of Texas Health Science Center, Houston
Metastatic Liver Cancer, Secondary Liver Cancer
Study Comparing Radio Frequency Ablation Plus Chemotherapy and Chemotherapy Alone in Patients With Secondary Liver Metastases
The purpose of this study is to determine whether patients treated with Radiofrequency Ablation (RFA) in conjunction with chemotherapy have a better overall survival rate than patients treated with chemotherapy alone.
- Conditions
- Metastatic Liver Cancer, Secondary Liver Cancer, Liver Neoplasm
- Trial name
- Prometheus (NCT00510627)
- Testing
- Radiofrequency Ablation (RFA), Chemotherapy
- Where
- 2 sites in United States
- Sponsor
- Boston Scientific Corporation
Nutrition in Cancer Survival and Treatment
Delivery of Nutritional Services in Nicaragua
This study investigates nutritional status, at predefined points in therapy, and the association with outcomes in children and adolescents undergoing treatment for cancer in institutions under Asociación de Hemato-Oncología…
- Trial name
- NCT04031586
- Where
- Nicaragua
- Volunteers
- 50 people
- Sponsor
- Columbia University
Breast Neoplasm Female, Surgery
Locoregional Surgery of the Primary Tumor in de Novo Stage IV Breast Cancer Patients
Current guidelines lack definitive evidences about the relative benefits of locoregional surgery for the primary tumor in de novo stage IV breast cancer.
- Conditions
- Breast Neoplasm Female, Surgery, Advanced Breast Cancer
- Trial name
- SYSBTC-001 (NCT04456855)
- Testing
- Locoregional surgery
- Where
- 3 sites in China
- Volunteers
- 358 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Survivorship, Cancer
Telephone-Based Intervention to Treat Depression and Anxiety in Hispanic Cancer Survivors
The purpose of this research is to assess the feasibility of administering a telephone-based intervention to treat depression and anxiety in Hispanic cancer survivors.
- Conditions
- Survivorship, Cancer, Depression, Anxiety
- Trial name
- NCT04430335
- Testing
- Telephone interview, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Wake Forest University Health Sciences
Non Hodgkin Lymphoma (NHL)
Non-Hodgkin Lymphoma - Observational Epidemiological and Clinical Study (NiHiL)
The Czech National Lymphoma Registry (NiHiL) was founded to monitor epidemiologic data and improve the diagnostic evaluation and quality of treatment of patients with non-Hodgkin´s lymphoma (NHL).
- Trial name
- NCT03199066
- Where
- Czechia
- Volunteers
- 20,000 people
- Sponsor
- Czech Lymphoma Study Group
Melanoma (Skin), Melanoma, Stage II, Stage I
Evaluation of a Personalised Survivorship Care Plan App for Patients With Melanoma
A multicentre randomised controlled trial (RCT) will be conducted to evaluate the effectiveness of the digital personalised Melanoma Survivorship Care Plan (SCP) app.
- Conditions
- Melanoma (Skin), Melanoma, Stage II, Stage I, Melanoma Stage, Survivorship
- Trial name
- Melanoma SCP (NCT06643286)
- Testing
- Digizorg Melanoma app
- Where
- 4 sites in Netherlands
- Volunteers
- 180 people
- Sponsor
- Erasmus Medical Center
Multiple Myeloma
Pamidronate Prophylaxis in Multiple Myeloma 30 mg/Month Versus 90 mg/Month
Multiple myeloma is a malignant hematological disease dominated by monoclonal plasma cells in the bone marrow. Major symptoms are related to the bones due to an increased bone resorption and a decreased bone formation leading to…
- Trial name
- NCT00376883
- Testing
- pamidronate
- Where
- 14 sites in Denmark, Norway and 1 more
- Volunteers
- 500 people
- Sponsor
- Nordic Myeloma Study Group
Cancer, Quality of Life
Effectiveness of the Advocate Lutheran General Survivorship Center Programs
The objective of this observational study is to assess the effectiveness of the Advocate Lutheran General Survivorship Center's Programs by measuring the following outcomes of interest on participating patients: 1.
- Trial name
- NCT02660996
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences
Carcinoma, Hepatocellular
Multimetabolic 18F-Fluorodeoxyglucose (FDG) and 18F-Fluorocholine (FCH) Positron Emission Tomography (PET) as an Early Predictive Factor of Overall Survival in Patients With Advanced Hepatocellular Carcinoma Treated With Sorafenib
Hepatocellular carcinoma (HCC) is the third cause of death by cancer. For patients with inoperable advanced HCC, systematic therapy with Sorafenib, a multikinase inhibitor that has both antiangiogenic and antiproliferative…
- Trial name
- PREMETHEP (NCT02847468)
- Testing
- FDG Positron Emission Tomography, FCH Positron Emission Tomography
- Where
- France
- Volunteers
- 61 people
- Sponsor
- Centre Georges Francois Leclerc
Stomach Neoplasms, Aged
Prediction Model for Advanced Gastric Cancer in Elderly
This study aims to develop and validate a Nomogram (mCNS) model for predicting long-term survival in elderly patients following curative resection for advanced gastric cancer.
- Trial name
- NCT06467591
- Where
- China
- Volunteers
- 1,436 people
- Sponsor
- Chang-Ming Huang, Prof.
Cancer
Differences in Trends Malignant Germ Cell Tumors in Males and Females: A SEER Population-based Study
Differences in 30-year Trends in Incidence and Survival for Malignant Germ Cell Tumors in Males and Females.
- Trial name
- NCT00322790
- Where
- United States
- Sponsor
- New Mexico Cancer Research Alliance
Colorectal Cancer
The Norwegian Dietary Guidelines and Colorectal Cancer Survival Study
The current study is designed to gain a better understanding of the role of a healthy diet aimed at dampening inflammation and oxidative stress on long-term disease outcomes and survival in colorectal cancer patients.
- Trial name
- CRC-NORDIET (NCT01570010)
- Testing
- Norwegian food based dietary guidelines
- Where
- 3 sites in Norway
- Volunteers
- 503 people
- Sponsor
- University of Oslo
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