Clinical trials: Swallowing Disorder, active
Esophageal Achalasia
Per Oral Endoscopic Myotomy (POEM) and Prolonged Dilatation (PRD) for Achalasia
Achalasia is an esophageal motility disorder, which leads to clinical symptoms such as dysphagia, regurgitation, chest pain and consecutive weight loss.
- Trial name
- POETA (NCT02518542)
- Testing
- Endoscopic intervention A, Endoscopic intervention B, Endoscopic intervention C
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Vienna
Gut-Brain Disorders, GERD Without Erosive Esophagitis
Neuroregulators for the Treatment of Diseases Associated With Esophageal-brain-gut Axis Communication Abnormalities.
Gastroesophageal reflux disease (GERD) poses a challenging medical condition to manage, with up to 40% of patients showing refractory to standard medical intervention, which usually begins with a proton pump inhibitor (PPI).
- Trial name
- NCT06778824
- Testing
- Takepron, Zoloft 50Mg Tablet, Imipramine Pill
- Where
- Taiwan
- Volunteers
- 610 people
- Sponsor
- Hualien Tzu Chi General Hospital
Brain Injury, Cognitive Impairment
Somatic and Ear Acupuncture for Dysphagia Rehabilitation and Decannulation After Severe Acquired Brain Injuries
The goal of this interventional, randomized, controlled, double-blind pilot study is to assess the superiority of Acupuncture and Auriculotherapy, in addition to conventional speech therapy rehabilitation, for the treatment of…
- Conditions
- Brain Injury, Cognitive Impairment, Deglutition Disorder
- Trial name
- REDACT (NCT06888219)
- Testing
- Acupuncture and Auricolotherapy, Conventional logopedic rehabilitation
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Symptomatic Non-erosive Gastroesophageal Reflux Disease
A Study to Evaluate the Efficacy and Safety of Vonoprazan 10 mg Compared to Placebo for Relief of Episodic Heartburn in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux Disease Through 24 Weeks
The main objective is to assess the efficacy of vonoprazan (10 mg as needed) compared to placebo (as needed) in relief of episodic heartburn at 2 hours that is sustained for 24 hours over 12 weeks of treatment in participants…
- Trial name
- NCT07752407
- Testing
- Vonoprazan
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Phathom Pharmaceuticals, Inc.
Gastroesophageal Reflux Disease
A Post-market Registry to Assess Safety and Performance of RefluxStop™ in the Treatment of GERD in General Hospital Practice
A post-market retrospective and prospective, open label, multicenter, single-arm registry study using standard clinical procedures to record available and/or new data to evaluate the safety and performance of RefluxStop™ for the…
- Trial name
- RESTORE500 (NCT07004439)
- Testing
- RefluxStop™ implantation
- Where
- 5 sites in Germany, Spain
- Volunteers
- 500 people
- Sponsor
- Implantica CE Reflux Ltd.
Gastroesophageal Reflux Disease (GERD), Gastroesophageal Reflux (GER)
Development of Machine Learning Models to Predict Postoperative GERD Symptom Resolution After Laparoscopic Nissen Fundoplication
This study aims to develop machine learning models to predict postoperative gastroesophageal reflux symptom resolution after laparoscopic Nissen fundoplication using Elastic Net regression and synthetic minority oversampling…
- Trial name
- NCT06862037
- Testing
- Laparoscopic Nissen fundoplication
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Korea University Anam Hospital
Dysphagia, Critical Illness
Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation Trial
This research study is investigating the efficacy and implementation of expiratory muscle strength training (EMST), standard of care dysphagia treatment, and intensive dysphagia treatment in critically ill adults in the acute…
- Trial name
- NCT07736105
- Testing
- Expiratory muscle strength training (EMST), Standard of Care Dysphagia Treatment, Intensive Dysphagia Treatment
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
Dysphagia
Translation and Validation of a Swallowing Assessment Scale for Neurogenic Dysphagia
The Munich Swallowing Score (MUCSS) is a tool that evaluates saliva, liquid, and food swallowing abilities using two scales: one for saliva/secretions (MUCSS-S) and one for nutrition (MUCSS-N).
- Trial name
- SCALA_DISF (NCT07503145)
- Testing
- Clinical assessment tool
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Deglutition Disorders
A New Ultrasound Score for Swallowing Disorders Diagnosis in Difficult-to-wean Tracheostomised Patients
Swallowing Disorders (SD) is commonly observed in intensive care unit (ICU) patients. Disruption to the upper airway by way of a tracheostomy may lead to physiological and/or biomechanical changes to the swallow, thereby…
- Trial name
- SHUBACA (NCT06630013)
- Where
- 4 sites in France
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Hopital Forcilles
GERD, Gastroesophageal Reflux
Compassionate Use of Domperidone for Refractory Gastroparesis
The purpose of this program is to allow the use of domperidone in children from 12 to 21 years of age with symptoms related to motility disorders and Gastroesophageal reflux disease (GERD) who have failed all the standard…
- Conditions
- GERD, Gastroesophageal Reflux, Gastroparesis
- Trial name
- NCT04699591
- Testing
- Domperidone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jose Cocjin
Gastroesophageal Reflux, Infant, Newborn, Diseases
Treatment of Gastroesophageal Reflux Disease in Infants
Gastroesophageal reflux disease in infants is not fully understood. Infants are prescribed medical treatments that may not be effective or that contribute to adverse side effects and lead to concerns and expenses for the parents…
- Trial name
- NCT06255886
- Testing
- Protein pump inhibitor., Mother or infant diet
- Where
- 3 sites in Denmark
- Volunteers
- 96 people
- Sponsor
- Odense University Hospital
GERD (Gastroesophageal Reflux Disease), NERD
New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial)
The goal of this randomized, double-blind, single-center clinical trial RELEIF is to learn if medical devices work to decrease symptoms of gastroesophageal reflux disease (GERD) in adults' patients.
- Conditions
- GERD (Gastroesophageal Reflux Disease), NERD, Heartburn, Regurgitation, Gastric
- Trial name
- RELIEF (NCT07624383)
- Testing
- Esophageal barrier medical device
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Cellmedis
Parkinson Disease, Dysphagia
Rehabilitation of Airway Protection in Parkinson's Disease
Airway protective disorders are a prevalent and progressive consequence of Parkinson's Disease (PD), and often result in aspiration pneumonia which is the leading cause of death in PD.
- Trial name
- NCT05700825
- Testing
- Expiratory Muscle Strength Training + Cough Skill Training
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Teachers College, Columbia University
Neuromotor Dysphagia After Acute Stroke
The Cooling Sensation Safe Deglution Study
Dysphagia is a common complication in patients who have suffered a cerebrovascular accident (CVA), with an incidence ranging from 29% to 81%.
- Trial name
- NCT06936501
- Testing
- Traditional flavor ONS (vanilla or strawberry, by choice), Refreshing and stimulating flavor ONS (mango-peppermint or lemon-mint, by choice)
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Swallowing-induced Pain
Doxepin Solution for Alleviation of Stubborn Breakthrough Pain Induced by Swallowing in Patients Receiving Radiotherapy for Nasopharyngeal Carcinoma
The goal of this clinical trial is to explore the effectiveness and adverse reactions of doxepin solution spray for alleviation of stubborn breakthrough pain induced by swallowing in patients receiving radiotherapy for…
- Trial name
- NCT06017895
- Testing
- doxepin solution
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Eosinophilic Esophagitis (EoE)
Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE)
The goal of this study is to research Dupilumab, an FDA approved medication in treating patients diagnosed with Eosinophilic esophagitis (EoE). The drug works by controlling allergic inflammation of the esophagus.
- Trial name
- NCT06665971
- Testing
- Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Gastro Esophageal Reflux
Observational Registry of Transoral Incisionless Fundoplication (TIF) for Gastroesophageal Reflux Disease (GERD)
This observational registry aims to: 1) record the TIF interventions in patients with esophageal or extra-esophageal symptoms; 2) to monitor the therapy response through the clinical experience in terms of effect on the use and…
- Trial name
- TIF/2021 (NCT05066594)
- Testing
- Transoral incisionless fundoplication
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Esophageal Achalasia, Esophageal Motility Disorders
POEM Versus Laparoscopic Heller Myotomy With Dor Fundoplication for Esophageal Achalasia
Achalasia is a disorder of the esophagus in which the muscular valve between the esophagus and the stomach fails to relax, and the body of the esophagus loses its normal coordinated squeezing movement.
- Conditions
- Esophageal Achalasia, Esophageal Motility Disorders, Gastroesophageal Reflux
- Trial name
- POEM-HD (NCT07814027)
- Testing
- Peroral endoscopic myotomy, Laparoscopic Heller myotomy with Dor fundoplication
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Minia University
Gastro Esophageal Reflux
Prevalence of Symptomatic Gastroesophageal Reflux Disease in Czech Children (Czech GERDKids)
This study aims to determine the prevalence of symptomatic gastroesophageal reflux disease (GERD) in children aged 8-9 years and 12-13 years in the Czech Republic.
- Trial name
- Czech GERDKids (NCT07482969)
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Motol
Dysphagia, Achalasia, Esophageal
Evolution of the Chicago Classification: Bridging Physiology and Mechanics
Swallowing difficulties are extremely common and result in substantial morbidity, reduction in the quality of life, and mortality related to malnutrition and complications from regurgitation and aspiration.
- Conditions
- Dysphagia, Achalasia, Esophageal, Ineffective Esophageal Motility
- Trial name
- NCT06883175
- Testing
- FLIP, HRM, Prucalopride
- Where
- United States
- Volunteers
- 575 people
- Sponsor
- Northwestern University