Clinical trials: Sympathectomy
CREST Syndrome, Peripheral Vascular Disease
Exparel as a Nerve Block for Severe Hand Pain
The purpose of this study is to investigate whether the use of the study drug (Exparel) is safe and effective for treating circulation problems and pain in the hand or fingers.
- Conditions
- CREST Syndrome, Peripheral Vascular Disease, Raynaud Disease, Scleroderma, Diffuse
- Trial name
- NCT02374320
- Testing
- liposomal bupivacaine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Jose Soberon, MD
Resistant Hypertension
Renal Sympathetic Denervation by Iberis System in Patients With Uncontrolled Hypertension - Iberis-HTN Registry
The purpose of this study is to document safety and efficacy of renal sympathetic denervation treatment in subjects with uncontrolled hypertension by using Iberis renal denervation system.
- Trial name
- Iberis (NCT02295683)
- Testing
- Renal Denervation
- Where
- 2 sites in Serbia, Spain
- Volunteers
- 18 people
- Sponsor
- Terumo Europe N.V.
Therapy Resistant Arterial Hypertension
Arterial Stiffness as a Predictor of Response to Renal Sympathetic Denervation
This trial is designed to establish invasive and non-invasive measures of arterial stiffness as potential predictors of treatment response to renal sympathetic denervation
- Trial name
- EFFECTIVENES (NCT02772939)
- Testing
- Renal sympathetic denervation (RDN)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Heart Center Leipzig - University Hospital
Chagas Cardiomyopathy, Ventricular Arrythmia
Sympathetic Denervation by Video-assisted Thoracoscopy in Control of Cardiac Arrhythmias in Patients With Chagas Disease
Ventricular tachycardia (VT) is the main cause of sudden death in patients with structural heart diseases. The use of ICD (implantable cardio-defibrillator) could prevent sudden death, however, the occurrence of repetitive shock…
- Trial name
- NCT04239144
- Testing
- Bilateral sympathectomy, Catheter ablation
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo General Hospital
Hypertension, Resistant to Conventional Therapy
Renal Sympathetic Denervation and Potential Effects on Glucose Metabolism and Cardiovascular Risk-Factors
The Re-Shape CV-Risk Study is a clinical study where renal adrenergic denervation (RDN) is done in high risk patients with treatment-resistant hypertension.
- Trial name
- Re-Shape (NCT01630928)
- Testing
- Renal sympathetic denervation
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital of North Norway
Hypertension, Hypertensive Heart Disease
Renal Sympathetic Denervation Prevents Atrial Fibrillation in Patients With Hypertensive Heart Disease: a Pilot Study
The autonomic nervous system plays an important role in the precipitation of AF in structurally-abnormal hearts. Restoration of autonomic imbalance may therefore prevent new-onset AF.
- Conditions
- Hypertension, Hypertensive Heart Disease, Atrial Fibrillation, Autonomic Imbalance
- Trial name
- RDPAF (NCT01990911)
- Testing
- Renal denervation, Medical therapy
- Where
- South Africa
- Volunteers
- 80 people
- Sponsor
- Pace Clinic
Aorticorenal Ganglion, Renal Sympathetic Denervation
Renal Sympathetic Denervation Combined With Aorticorenal Ganglion Ablation for Treatment of Hypertension
The purpose of this prospective cohort proof-of-concept trial is to compare the efficacy and safety of renal sympathetic denervation (RSD) plus aorticorenal ganglion ablation versus RSD alone in the treatment of uncontrolled…
- Conditions
- Aorticorenal Ganglion, Renal Sympathetic Denervation, Autonomic Regulation, Hypertension
- Trial name
- NCT06864962
- Testing
- Renal sympathetic denervation, Renal sympathetic denervation plus aorticorenal ganglion ablation
- Where
- 2 sites in China
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Heart Failure
Renal Denervation in Heart Failure Patients With Preserved Ejection Fraction (RESPECT-HF)
Investigators will test a new approach to a form of heart failure (HF) with no current treatment proven to reduce death rates or hospitalisations.
- Trial name
- RESPECT-HF (NCT02041130)
- Testing
- Renal Denervation
- Where
- 7 sites in Australia, New Zealand and 1 more
- Volunteers
- 144 people
- Sponsor
- National University Hospital, Singapore
Chronic Heart Failure
Renal Sympathetic Denervation for Patients With Chronic Heart Failure
To study whether renal sympathetic denervation(RSD) RSD can slow the progression of CHF and reduce the rate of all-cause mortality effectively and securely.
- Trial name
- RSD4CHF (NCT01790906)
- Testing
- RSD, Conventional therapy
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pneumothorax Iatrogenic Postprocedural
Clinical Value of Routine Chest Radiography and Point-of-Care Lung Ultrasound Following Ambulatory Thoracic Sympathectomy
The goal of this observational study is to find out whether routine chest X-rays after surgery actually change patient care, and whether lung ultrasound could be a suitable alternative for detecting important postoperative…
- Trial name
- LUNG_US_SIMP (NCT07854340)
- Where
- Chile
- Volunteers
- 200 people
- Sponsor
- Clinica Alemana de Santiago
Hyperhidrosis
Cardiac Autonomic Changes After Endoscopic Thoracic Sympathectomy For Essential Palmar Hyperhidrosis
Essential palmar hyperhidrosis (EPH) is a pathological condition of excessive sweating of the hands due to an unexplained over-activity of the T2 and T3 sympathetic fibers.
- Trial name
- NCT02733497
- Testing
- Sympathectomy, Sympathicotomy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Resistant Hypertension, Uncontrolled Hypertension
Rapid Renal Sympathetic Denervation for Resistant Hypertension II
This is a global, multi-center, prospective, randomized, controlled study of the safety and effectiveness of renal denervation with the OneShot Renal Denervation System in patients with uncontrolled hypertension.
- Conditions
- Resistant Hypertension, Uncontrolled Hypertension, Renal Artery Ablation
- Trial name
- RAPID II (NCT01939392)
- Testing
- Renal Denervation (OneShot™ Renal Denervation System)
- Where
- Italy
- Sponsor
- Medtronic Endovascular
Uncontrolled Essential Hypertension
Ultrasound Ablation for Essential Hypertension（FIM）
To evaluate the safety and feasibility of disposable intravascular ultrasound ablation catheter and ultrasound ablation instrument in the treatment of essential hypertension.
- Trial name
- NCT05795829
- Testing
- disposable intravascular ultrasound ablation catheter and ultrasound ablation instrument
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Lepu Medical Technology (Beijing) Co., Ltd.
Post Mastectomy Pain Syndrome, Chronic Pain Following Surgical Procedure for Cancer
Super-voltage PRF of Stellate Ganglion Versus Super-voltage PRF of T2 T3 Sympathetic Ganglia in Managing PMPS.
The aim of this study is to compare the effectiveness of super-voltage pulsed radiofrequency of stellate ganglion and super-voltage pulsed radiofrequency of T2-T3 sympathetic ganglia in the treatment of postmastectomy pain…
- Trial name
- PMPS PRF (NCT07675096)
- Testing
- Group S : Stellate Ganglion supervoltage pulsed radiofrequency, Group T : T2-T3 chains supervoltage pulsed radiofrequency.
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute, Egypt
Hypertension, Resistant, Sympathectomy
Procedural Sedation in Renal Sympathetic Denervation
This retrospective, single-center study investigates the effects of two different sedation regimens-dexmedetomidine versus fentanyl-propofol-on clinical outcomes in patients undergoing catheter-based renal sympathetic denervation…
- Conditions
- Hypertension, Resistant, Sympathectomy, Conscious Sedation, Procedural Sedation and Analgesia
- Trial name
- NCT07293273
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Ebru Girgin Dinc
Parkinson Disease, Neuroendocrine Tumors
124I-MIBG Tracer Evaluation of Myocardial Sympathetic Denervation and Assessment of Neuroendocrine Tumors.
The Feasibility of Novel 124I-MIBG Tracer in Evaluation of Myocardial Sympathetic Denervation and Assessment of Neuroendocrine tumors. Comparison with 123I-MIBG.
- Trial name
- NCT01931488
- Testing
- MIBG label with I123 or I124, SPECT imaging
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Refractory Hypertension
Renal Sympathetic Denervation in Mild Refractory Hypertension
The purpose of this study is to examine the benefit of renal sympathetic denervation in patients with mild refractory hypertension
- Trial name
- NCT01656096
- Testing
- Renal sympathetic denervation (Symplicity ablation catheter, Medtronic Inc. Minneapolis, Minnesota, USA)
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- University of Leipzig
Sudden Cardiac Death
Is Left Stellate Ganglionectomy Beneficial to Patients With Life Threatening Ventricular Arrhythmias
The purpose of this study is to determine whether the incidence of recurrent life threatening ventricular arrhythmias in patients with an implanted cardiac defibrillator (ICD) can be reduced if a surgical left stellate…
- Trial name
- Reduce-SCD (NCT02113722)
- Testing
- Left cardiac sympathetic denervation, Standard of Care
- Where
- Australia
- Sponsor
- Cindy Hall
Hyperhidrosis Primary Focal Palms
Compensatory Sweating After Unilateral Sympathectomy on the Dominant Side or Bilateral Sequential Sympathectomy
The standard treatment for palmar hyperhidrosis is bilateral sequential thoracic sympathectomy. High rates of compensatory sweating due to the surgical procedure are described in the literature.
- Trial name
- Universusbi (NCT03921320)
- Testing
- Bilateral sequential sympathectomy, Unilateral sympathectomy, Contralateral sympathectomy
- Where
- 10 sites in Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS
POLish Registry of CArdioneuroablation and CArdioneuromodulation
The multicentre observational study POL-CA involves a wide spectrum of patients with a history of syncopy. The study recruits patients with diagnosed vasovagal syndrome, cardioinhibitory carotid sinus syndrome, symptomatic sinus…
- Conditions
- Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS, Symptomatic Sinus Bradycardia SB or Atrioventricular Block AV, Postural Orthostatic Tachycardia Syndrome POTS
- Trial name
- POL-CA (NCT07196397)
- Testing
- cardioneuroablation, SN sparing hybrid ablation, Cardiac sympathetic denervation
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- SABAMED Medical Center Ltd.