Clinical trials: Sympathectomy
Pediatric Thoracoscopy
Retrolaminar Block for Pediatric Thoracoscopic Sympathectomy
Thoracoscopic sympathectomy is a rapid and simple technique associated with rare complications, but it is associated with severe postoperative pain that makes breathing and coughing difficult resulting in increased occurrence of…
- Trial name
- NCT04688918
- Testing
- Retrolaminar block, paravertebral group
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Hypertension
Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy
Non-randomized study of 5 subjects that have been selected for prophylactic open surgery due to abdominal aortic aneurysm. During surgery the renal arteries are identified and subjected to about 60 seconds each of freezing by…
- Trial name
- PRASDEN (NCT02345603)
- Testing
- Cryo-therapy
- Where
- Sweden
- Volunteers
- 9 people
- Sponsor
- University Hospital, Linkoeping
Hypertension, Renal
RDN Fesibility Study
Renal sympathetic denervation (RDN) was considered an effective alternative for patients whose blood pressure (BP) is not optimally controlled.
- Trial name
- NCT05743894
- Testing
- Symplicity Spyral RENAL DENERVATION (RDN) SYSTEMTM Livewire™ Reflexion™ Catheter
- Where
- 2 sites in Hong Kong
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
Spinal Anesthesia Evaluation
Regional Hemodynamic Parameter Changes After Spinal Anesthesia
Spinal anesthesia is a regional anesthesia method used for surgical procedures generally involving the lower abdominal area, perineum, and lower extremities.
- Trial name
- NCT05332379
- Testing
- Pulsed Wave Doppler USG examination
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Marmara University
Heart Failure
Study of Renal Denervation in Patients With Heart Failure
Congestive heart failure is a common disorder in which the heart cannot pump enough blood to meet the needs of the rest of the body.
- Trial name
- PRESERVE (NCT01954160)
- Testing
- Symplicity Renal Denervation
- Where
- 12 sites in United States
- Volunteers
- 5 people
- Sponsor
- Adrian Hernandez
Hyperhidrosis, Quality of Life
Objective Evaluation of Patients With Palmar Hyperhidrosis Submitted to Two Levels of Sympathectomy: T3 and T4.
Compare the results obtained with video-assisted sympathectomy performed in two distinct levels ganglionic (third versus fourth thoracic ganglion) for the treatment of palmar hyperhidrosis, through a blind randomized clinical…
- Trial name
- NCT01140659
- Testing
- Video-assisted sympathectomy
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Erector Spinae Plane Block, Children
Erector Spinae Plane Block for Children Undergoing Thoracoscopic Sympathectomy
This study aims to evaluate the influence of ultrasound-guided erector spinae plane block on postoperative pain and diaphragmatic dysfunction in pediatric patients undergoing thoracoscopic sympathectomy.
- Conditions
- Erector Spinae Plane Block, Children, Thoracoscopic Sympathectomy
- Trial name
- NCT06984874
- Testing
- Erector spinae plane block, General anesthesia
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Excessive Sweating of the Hands
Phenol With Fluoroscopy Guided Radiofrequency Ablation of T2-T3in Palmar Hyperhidrosis.
Primary hyperhidrosis is a disorder characterized by excessive and chronic sweating in the absence of a sweating trigger. The disorder can be severe and interfere with normal daily activities of the patients.
- Trial name
- NCT03506828
- Testing
- Surgical sympathectomy, Radiofrequency ablation with phenol injection
- Where
- Egypt
- Volunteers
- 82 people
- Sponsor
- Mansoura University
Chagas Cardiomyopathy, Ventricular Arrythmia
Sympathetic Denervation by Video-assisted Thoracoscopy in Control of Cardiac Arrhythmias in Patients With Chagas Disease
Ventricular tachycardia (VT) is the main cause of sudden death in patients with structural heart diseases. The use of ICD (implantable cardio-defibrillator) could prevent sudden death, however, the occurrence of repetitive shock…
- Trial name
- NCT04239144
- Testing
- Bilateral sympathectomy, Catheter ablation
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo General Hospital
Hypertension
The Effect of Renal Denervation on Biological Variables
Hypertension is a major and growing public health concern. Chronic elevation of sympathetic nervous system (SNS) activity has been identified as a major contributor to the complex pathophysiology of (essential) hypertension.
- Trial name
- NCT01427049
- Testing
- renal denervation
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- UMC Utrecht
Post-Mastectomy Chronic Pain Syndrome
Radiofrequency Thoracic Sympathectomy for Chronic Postmastectomy Pain; Randomized Placebo Controlled Study
Postmastectomy pain syndrome (PMPS) is a neuropathic pain that can follow surgical treatment for breast cancer, The antineuropathic medications (antidepressants and anticonvulsants) are disappointing and have low success rate.
- Trial name
- NCT03494426
- Testing
- radiofrequency thoracic sympathectomy, pregabalin ,tramadol,and tricyclic antidepressants
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Hypertension
Safety and Efficacy Study of Renal Artery Ablation in Resistant Hypertension Patients
This is a prospective, multicenter, feasibility study on the safety and efficacy of renal denervation in patients with resistant hypertension.
- Trial name
- EnligHTN-I (NCT01438229)
- Testing
- St. Jude Medical renal artery ablation system: RF ablation generator (IBI 1500T11.5) and Renal artery ablation catheter (DS3D001, DS3D002)
- Where
- 4 sites in Australia, Greece
- Volunteers
- 47 people
- Sponsor
- Abbott Medical Devices
Sudden Cardiac Death, Ventricular Tachycardia
Cardiac Sympathetic Denervation for Prevention of Ventricular Tachyarrhythmias
The purpose of this research study is to examine the effect of cardiac sympathetic denervation (CSD) surgery on life threatening abnormal heart rhythms called ventricular tachycardia or ventricular fibrillation that can lead to…
- Conditions
- Sudden Cardiac Death, Ventricular Tachycardia, Ventricular Fibrillation, Cardiomyopathy
- Trial name
- PREVENT VT (NCT01013714)
- Testing
- Cardiac Sympathetic Denervation (CSD), Routine Care
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Adult Polycystic Kidney Disease
Renal Sympathetic Denervation for Reduction of Pain and Improvement of Insulin Sensitivity in Adult Polycystic Kidney Disease
In patients with polycystic kidney disease, pain may be resistant to drug therapy and may reduce quality of life. This study investigate the effect of renal denervation on this pain.
- Trial name
- NCT02062671
- Testing
- renal denervation
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Odense University Hospital
Ventricular Tachycardia
REnal SympathetiC Denervation to sUpprEss Tachyarrhythmias in ICD Recipients
The objective of this trial is to determine the efficacy and safety of adjunctive catheter-based renal sympathetic denervation (RSDN) in the primary prevention of implantable cardioverter defibrillator (ICD) therapy in patients…
- Trial name
- RESCUE (NCT01747837)
- Testing
- Boston Scientific Vessix Renal Denervation System
- Where
- 4 sites in United States, Czechia and 1 more
- Volunteers
- 48 people
- Sponsor
- Vivek Reddy
Sudden Cardiac Death
Is Left Stellate Ganglionectomy Beneficial to Patients With Life Threatening Ventricular Arrhythmias
The purpose of this study is to determine whether the incidence of recurrent life threatening ventricular arrhythmias in patients with an implanted cardiac defibrillator (ICD) can be reduced if a surgical left stellate…
- Trial name
- Reduce-SCD (NCT02113722)
- Testing
- Left cardiac sympathetic denervation, Standard of Care
- Where
- Australia
- Sponsor
- Cindy Hall
Hypertension, Renal
Transcatheter Renal Artery Sympathetic Denervation Observational Study
Hypertension is a common health problem that affects millions of people in the world. Poorly controlled blood pressure (BP) leads to cardiovascular, cerebrovascular and renal complications.
- Trial name
- NCT05744986
- Testing
- SYMPICITY Spyral RENAL DENERVATION (RDN) SYSTEMTM
- Where
- 2 sites in Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Hypertension, Resistant to Conventional Therapy
Effect of Renal Sympathetic Denervation on Resistant Hypertension and Cardiovascular Hemodynamic in Comparison to Intensive Medical Therapy Utilizing Impedance Cardiography
The purpose of this study is to demonstrate that Renal Sympathetic Denervation (RDN) improves the control of blood pressure (BP) in patients with treatment-resistant hypertension, as compared to intensive medical therapy (IMT)…
- Trial name
- OsloRDN (NCT01673516)
- Testing
- The SymplicityTM Renal Denervation System, The HOTMAN® System
- Where
- Norway
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Dilated Cardiomyopathy, Ischemic Cardiomyopathy
Left Cardiac Sympathetic Denervation for Cardiomyopathy Feasibility Pilot Study
A randomized controlled trial to test the potential safety and efficacy of LCSD in patients with heart failure due to non-ischemic and ischemic cardiomyopathy at the University of Cape Town.
- Conditions
- Dilated Cardiomyopathy, Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
- Trial name
- LCSD (NCT03071653)
- Testing
- Left Cardiac Sympathetic Denervation (LCSD), Optimal Medical Therapy
- Where
- South Africa
- Volunteers
- 30 people
- Sponsor
- University of Cape Town
Hyperhidrosis Due to Autonomic Dysregulation (Disorder)
Extended Versus Limited Thoracoscopic Sympathectomy: Its Impact on Palmar and Plantar Hyperhidrosis
Conclusions: In the context of palmar and plantar hyperhidrosis, extended thoracoscopic sympathectomy seemed to be preferred over limited thoracoscopic sympathectomy due to better overall outcomes and minimal time for hospital…
- Trial name
- NCT06219655
- Testing
- thoracoscopic sympathectomy
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mansoura University