Clinical trials: Sympathetic Activity
Hypertension
Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension
The purpose of this study is to better understand the role of the abdominal veins (splanchnic capacitance) and the sympathetic nervous system in human hypertension.
- Trial name
- NCT02425566
- Testing
- Trimethaphan, Nitroglycerin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Respiratory Muscle, Blood Pressure
Respiratory Muscle Contribution to Blood Pressure During Exercise
The investigators seek to understand how reflexes from the breathing muscles influence blood pressure during exercise. Furthermore, the investigators are determining if increasing breathing muscle strength (via inspiratory muscle…
- Conditions
- Respiratory Muscle, Blood Pressure, Exercise Capacity, Sympathetic Nerve Activity
- Trial name
- NCT03514823
- Testing
- Inspiratory Muscle Training (IMT), No Inspiratory Muscle Training (IMT)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy, Vasodilation
Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation
The purpose of this project is to examine the impact of increases in brain insulin on sympathetic nervous system activity, as well as peripheral and cerebral blood flow in humans.
- Conditions
- Healthy, Vasodilation, Insulin Resistance, Autonomic Dysfunction
- Trial name
- NCT05153395
- Testing
- Carbon dioxide breathing, Neurovascular Coupling, Human insulin
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Vasoconstriction, Vasodilation
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
The main purpose of this interventional study is to examine differences in resting blood pressure control between healthy males and females. The main questions it aims to answer are: 1.
- Trial name
- STARS (NCT05997732)
- Testing
- Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Sympathetic Nervous System
Sympathetic Nerve Activity and Strength Gains in Resistance Versus Concurrent Training
This study examines how the body's stress (sympathetic) nervous system responds to 8 weeks of either strength training alone or strength training combined with endurance (treadmill running) training in previously untrained young…
- Trial name
- SKNA-CT (NCT07680387)
- Testing
- Strength-only training, Concurrent training
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Autonomic Nervous System, Heart Rate Variability
Non-invasive Modulation of Autonomic Cardiac Nervous System
To demonstrate the effect of non invasive vagus nerve (VNS) stimulation on heart rate variability and MSNA signal.
- Conditions
- Autonomic Nervous System, Heart Rate Variability, Muscle Sympathetic Nerve Activity
- Trial name
- MSNA (NCT04057508)
- Testing
- Modulation of muscle sympathetic nerve activity
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Menopause
Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms
The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular…
- Trial name
- NCT06787066
- Testing
- Propranolol Hydrochloride, Phentolamine Injection
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity, Metabolic Syndrome X
The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids
The metabolic syndrome is associated with hyperdynamic circulation and sympathetic activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free fatty acids are responsible for this association.
- Trial name
- NCT00184899
- Testing
- Intravenous infusion of Intralipid/heparin, Intravenous infusion of Glycerol/heparin
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Exercise, Cognition
Sympathetic Nervous System Mediation of Acute Exercise Effects on Childhood Brain and Cognition
Today's children have become increasingly inactive and unfit, with >50% of children not meeting the recommended 60 min of moderate-to-vigorous physical activity.
- Trial name
- NCT03592238
- Testing
- Aerobic Exercise Intervention, Trier Social Stress Test for Children, Seated Rest
- Where
- United States
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Vasodilation, Vasoconstriction
Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.
This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.
- Trial name
- NCT05001048
- Testing
- Phenylephrine Hydrochloride, Cold Pressor Test, Isocapnic Acute Hypoxia
- Where
- 2 sites in Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Blood Pressure, Neurovascular Control
Meal Timing and Blood Pressure
Brain blood flow, blood pressure, and neurovascular control mechanisms will be measured in middle-aged adults before and after a brief intervention period.
- Trial name
- NCT04133701
- Testing
- Time-Restricted Feeding
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alcohol Drinking, Binge Drinking
Reducing Blood Pressure in Mid-life Adult Binge Drinkers
This study has two phases: Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers.
- Conditions
- Alcohol Drinking, Binge Drinking, Blood Pressure, Alcohol Abstinence
- Trial name
- NCT05522075
- Testing
- Exercise Training, Alcohol Abstinence Intervention
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Brain Blood Flow, Neurovascular Control
Cardiovascular and Neurovascular Regulation in GWI
Brain blood flow regulation and autonomic dysfunction will be measured in Veterans with and without Gulf War Illness who served in the Gulf War between 1990 and 1992.
- Trial name
- NCT04586049
- Testing
- MRI, Transcranial Doppler Ultrasound, Sympathetic Nerve Activity
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Diabetes Mellitus
Sympathetic Nerve Activity During Hypoglycemia and Exercise
The purpose of this study is to determine if either hypoglycemia or exercise cause differential responses in muscle and skin sympathetic nerve activity.
- Trial name
- NCT00608348
- Testing
- Hyperinsulinemic glucose clamp procedures, moderate exercise
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Cardiovascular Disease
Cardiometabolic Benefits of Omega-3 Polyunsaturated Fatty Acids
Omega 3 fatty acids have been shown to provide a number of cardiometabolic benefits in both healthy and at risk populations. Specifically, the daily consumption of fish oil supplements has been reported to reduce blood…
- Trial name
- TGIF (NCT03378232)
- Testing
- High EPA Supplement, High DHA Supplement
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Elevated Blood Pressure
Mindfulness and Neural Cardiovascular Control in Humans
This study evaluates the impact of mindfulness-based stress reduction (MBSR) on sympathetic nerve activity and arterial stiffness.
- Trial name
- NCT03626363
- Testing
- Stress Management
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Michigan Technological University
Nerve; Disorder, Sympathetic, Healthy
Skin Sympathetic Nerve Activity and Sympathetic Tone
There are many sympathetic hyperactivity diseases in the investigators' clinical practice. However, the conventional method to measure the sympathetic nerve activity had many limitations such as clinical application, data…
- Trial name
- NCT03243448
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Hypoglycemia
Hypoglycemia and Autonomic Nervous System Function
The goals of this proposal are to determine the effects of hypoglycemia on the autonomic nervous system.
- Trial name
- HypoANS (NCT01816893)
- Testing
- Hypoglycemic hyperinsulinemic clamp, Euglycemic hyperinsulinemic clamp
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Insulin Resistance, Autonomic Dysfunction
Role of Endothelin-1 Modulating Insulin-stimulated Blood Flow and Sympathetic Nervous System Activity in Obesity
The aim of this project is to determine role for ET-1 in individuals with obesity.
- Conditions
- Insulin Resistance, Autonomic Dysfunction, Obesity
- Trial name
- NCT05518422
- Testing
- Hyperinsulinemic, euglycemic infusion
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Down Syndrome, Autonomic Dysfunction
Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome
Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with widespread organ dysfunction, including abnormalities in the autonomic nervous system (ANS).
- Trial name
- DIVE (NCT07238465)
- Testing
- Cold Stress, Maximal Dynamic Exercise, Isometric Handgrip Exercise with Post-Exercise Muscle Ischemia
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver