Clinical trials: Sympathetic Disorder
High-risk Pregnancy
Leg Heating in Pregnant Women With Obesity
Obesity is a major risk factor for hypertensive disorders of pregnancy (HDP). The underlying mechanisms are largely unclear, but maternal vascular endothelial dysfunction is likely involved.
- Trial name
- NCT06932250
- Testing
- Leg heating
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Shoulder-hand Syndrome
Acupuncture for Post-stroke Shoulder-hand Syndrome
Shoulder-hand syndrome，a common complication of stroke patient，which is an important factor of limb function recovery.This research aims to observe the effect and safety of Acupuncture and Traditional Chinese medicine Combined…
- Trial name
- NCT02011854
- Testing
- rehabilitation, Acupuncture
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zouqin Huang
Hypertension
Effects of Thiazide Diuretics on Sympathetic Nervous System in Hypertension
Thiazide medications are often prescribed for individuals with high blood pressure, but research has shown that they may increase an individual's risk of developing diabetes.
- Trial name
- NCT00353652
- Testing
- Study#1: chlorthalidone (CTD), titrated dose, Study #1: spironolactone (SP), titrated dose, Study# 2 chlorthalidone (CTD), fixed dose
- Where
- 2 sites in United States
- Volunteers
- 166 people
- Sponsor
- University of Texas Southwestern Medical Center
Spinal Cord Injury
A Longitudinal Examination of Aging With a Spinal Cord Injury: Cardiovascular, Cerebrovascular and Cognitive Consequences
The general population is aging, today 12% of the United States population is older than 65 and it is estimated that by 2020 the number of people in the United States older than 65 will outnumber children younger than 5.
- Trial name
- NCT03023163
- Testing
- Longitudinal
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
COPD
Static Lung Hyperinflation and Sympathetic Nerve Activity-Associated Large Artery Stiffness in COPD Patients
The goal of this study is to evaluate the acute effects of a long-acting bronchodilator on pulmonary function, vascular function and muscle sympathetic nerve activity in individuals with COPD.
- Trial name
- NCT03611699
- Testing
- Umeclidinium / Vilanterol Dry Powder Inhaler
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Gary L. Pierce
Obesity, Polycystic Ovary Syndrome
Heat Therapy and Cardiometabolic Health in Obese Women
Traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression.
- Conditions
- Obesity, Polycystic Ovary Syndrome, Prehypertension, PreDiabetes
- Trial name
- CMH (NCT03644524)
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
Anxiety
Randomized, Single-blind Pilot Study Assessing the Effect of Cutaneous RESonance Stimulation SYMPAthetic and Parasympathetic Tone and Anxiety in Patients Admitted for Cardiac Surgery
Anxiety is a natural response to stress which peaks just before the surgery procedure. High levels of anxiety can increase postoperative pain and complications.
- Trial name
- RESC SYMPA (NCT07070986)
- Testing
- RESC, NSCS
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Hospices Civils de Lyon
Hypotension
Management Arterial Hypotension During Planned Caesarean Section, Intravenous Ephedrine/Phenylephrine Mixture Versus Intravenous Baby Noradrenaline
Comparison of two practices of obstetrical services between the CHU of Clermont Ferrand and the HFME Lyon-Bron in the management of arterial hypotension during an elective cesarean section
- Trial name
- ARTEMIS (NCT05513066)
- Where
- 2 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Hypertension
Renal Denervation for Complicated Hypertension
This is an observational proof of concept study investigating the safety and effectiveness of renal denervation to lower blood pressure in people whose blood pressure is not adequately controlled due to: intolerance to…
- Trial name
- RDNP-2012-03 (NCT01865253)
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 23 people
- Sponsor
- Baker Heart and Diabetes Institute
Prehypertension, Hypertension
Hypertension and Osteopathic Treatment
The goal of this study is to demonstrate the use of osteopathic manipulative therapy (OMT) in the effective management of hypertension.
- Conditions
- Prehypertension, Hypertension, Osteopathic Manipulation, Sympathetic Nervous System
- Trial name
- HOT (NCT02605551)
- Testing
- Osteopathic Manipulative Therapy, Lifestyle Modification
- Volunteers
- healthy volunteers welcome
- Sponsor
- Larkin Community Hospital
Hypertension
Renal Denervation for Resistant Hypertension
This is a study investigating the effectiveness of renal denervation in lowering blood pressure in people whose blood pressure is not adequately controlled despite treatment with 3 or more blood pressure lowering drugs.
- Trial name
- RDNP-2012-01 (NCT01865240)
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 5 people
- Sponsor
- Baker Heart and Diabetes Institute
Central Sympathetic Nervous System Diseases
Role of Sympathetic Activation in Ischemia Reperfusion Injury
This study is designed to assess the effect of forearm ischemia-reperfusion injury on sympathetic nerve activity. To determine whether reduced sympathetic responsiveness is a contributor to the protective effects of remote…
- Trial name
- NCT04479813
- Testing
- Moxonidine 0.2 MG
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Royal Perth Hospital
Early Menopause, Menopause
Influence of Early Menopause on Sympathetic Activation and Cardiovascular Function in Older Women
Women who enter menopause early are at a greater risk for developing cardiovascular disease later in life as compared to women with normal onset of menopause.
- Trial name
- NCT03692572
- Testing
- Nitrate supplementation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Heart Failure
Effects of Exercise Training on Mechanoreflex and Metaboreflex Control in Heart Failure Patients
The investigators hypothesize that exercise training would improve the mechanoreflex and metaboreflex control in heart failure patients.
- Trial name
- NCT01884142
- Testing
- Aerobic Exercise Training
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo General Hospital
Shoulder-hand Syndrome
The Treatment of Shoulder-hand Syndrome in Hemiplegia Patients
The purpose of this clinical study is to investigate effects of Kinesio taping (KT) combined with dry needling (DN) on myofascial trigger points (MTrPs) in post-stroke hemiplegic shoulder-hand syndrome (SHS).
- Trial name
- NCT07245472
- Testing
- Dry Needling, Kinesio Taping
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Handan Central Hospital
Hypertension, Cardiovascular Diseases
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
The main purpose of research is to examine and understanding the development of hypertension in obese adults with insulin resistance.
- Trial name
- NCT04715022
- Testing
- Ascorbic acid solution (American Regent Laboratories Inc.), Saline
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Kansas Medical Center
Hypertension, Chronic Kidney Disease
Impact of Sympathetic Renal Denervation- a Study in Patients After Renal Transplantation
The study is aiming to document the safety and effectiveness of renal denervation in patients after renal transplantation with hypertension.
- Conditions
- Hypertension, Chronic Kidney Disease, Renal Transplantation, Sympathetic Activity
- Trial name
- ISAR-denerve (NCT01899456)
- Testing
- Catheter-based renal denervation
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Technical University of Munich
Chagas Cardiomyopathy, Ventricular Arrythmia
Sympathetic Denervation by Video-assisted Thoracoscopy in Control of Cardiac Arrhythmias in Patients With Chagas Disease
Ventricular tachycardia (VT) is the main cause of sudden death in patients with structural heart diseases. The use of ICD (implantable cardio-defibrillator) could prevent sudden death, however, the occurrence of repetitive shock…
- Trial name
- NCT04239144
- Testing
- Bilateral sympathectomy, Catheter ablation
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo General Hospital
Spinal Cord Injury
Sympathetic-Somatomotor Coupling in Human Spinal Cord Injury
Significance: The long term objective of this study is to improve physical therapy and fitness programs in people with spinal cord injury.
- Trial name
- NCT02115685
- Testing
- Treadmill Training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Type 2 Diabetes, Diabetic Nephropathy
Role of Sleep Apnea and Sympathetic Activity in Resistant Hypertensive Patients.
Hypertension is highly prevalent in type 2 diabetic patients (NIDDM) with nephropathy, and is the single most important determinant of the rate of renal function loss.
- Conditions
- Type 2 Diabetes, Diabetic Nephropathy, Hypertension, Sleep Apnea
- Trial name
- SAS (NCT01875341)
- Testing
- NCPAP; Nasal continuous positive airway pressure., NCPAP Nasal Continuous Positive Airway Pressure-sub-therapeutic treatment group
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Ottawa Hospital Research Institute