Clinical trials: Sympathetic Disorder
Sympathetic Nervous System Diseases, Sympathetic Nervous Structure Injury
Hydroxyephedrine PET/CT in Sympathetic Nervous System Disease
To evaluate the potential usefulness of 11C/18F-HED positron emission tomography/ computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various Tau-related disease patients.
- Conditions
- Sympathetic Nervous System Diseases, Sympathetic Nervous Structure Injury, Sympathetic Nerve Injury
- Trial name
- NCT06951984
- Testing
- 11C/18F-HED
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Healthy, Autonomic Nervous System Diseases
Prevalence of Chapman Reflex Points in Medical Students and Their Association With Visceral Symptoms
Chapman Reflex Points (CRPs) are small palpable nodules found within connective tissue that have traditionally been associated with dysfunction of internal organs and the autonomic nervous system.
- Conditions
- Healthy, Autonomic Nervous System Diseases, Lymphatic Diseases, Somatic Dysfunction
- Trial name
- NCT07691112
- Testing
- Chapman Reflex Point Examination
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The Touro College and University System
Post-traumatic Stress Disorder, Prehypertension
Sympathetic Overactivity in Post-traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a highly prevalent anxiety disorder that is associated with an increased risk of cardiovascular (CV) disease and hypertension.
- Trial name
- SO-PTSD (NCT01627301)
- Testing
- Device-Guided Breathing (DGB), Transcutaneous Vagal Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Emory University
Neuropathic Pain, Reflex Sympathetic Dystrophy
Effects of Vaporized Marijuana on Neuropathic Pain
This study theorized that a low dose of vaporized cannabis could alleviate nerve injury pain.
- Conditions
- Neuropathic Pain, Reflex Sympathetic Dystrophy, Peripheral Neuropathy, Post-herpetic Neuralgia
- Trial name
- NCT01037088
- Testing
- Mild dose cannabis, Low dose cannabis, Cannabis
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, Davis
Cardiomyopathy
Characterization of Sympathetic Nerve Activity in Stress Cardiomyopathy
Stress (Takotsubo) cardiomyopathy (SC) is a peculiar form of acute, reversible myocardial dysfunction predominantly affecting the apical and mid left ventricular segments.
- Trial name
- NCT01048125
- Testing
- Sympathetic Nerve Activity, Mental Stress Test (Color Word Test), The Modified Oxford Technique for Baroreflex Sensitivity
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hypertension,Essential
Brain BOLD fMRI in Hypertensive and Normotensive Participants
This study will explore the brainstem activity in response to stress in hypertensive patients and normotensive subjects. In addition, it will evaluate if the response in hypertensive patients can be modulated by blocking the…
- Trial name
- BRAIrdN (NCT03473275)
- Testing
- Cold Pressor test, PinPrick test
- Where
- Switzerland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Hypertension
Pathological Mechanism Study of Aerobic Exercise Regulating Cold Stress-induced Hypertension Via the Thermosensitive Target-mediated Sympathetic Nerve Pathway
This study focuses on the specificity of thermosensitive targets in populations with hypertension in cold regions, identifies core targets through transcriptome sequencing and clinical validation, and clarifies the regulatory…
- Trial name
- NCT07666607
- Testing
- Exercise exposure
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Wang Jingfeng
Atrial Fibrillation
Renal Nerve Denervation After Pulmonary Vein Isolation for Persistent Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia and it is associated with significant morbidity and mortality. Electrical isolation of the pulmonary vein (PVI) by radiofrequency energy or cryoablation has been shown to be…
- Trial name
- NCT03246568
- Testing
- Renal Nerve Denervation, Pulmonary vein isolation
- Where
- Hong Kong
- Volunteers
- 3 people
- Sponsor
- Chinese University of Hong Kong
Hypertension
Effects of Electrical Baroreflex Stimulation on Sympathetic Activity, Renal Hemodynamics, and Insulin Sensitivity
Electrical stimulation of carotid baroreceptors (baropacing) acutely decreases arterial pressure in patients with refractory hypertension.
- Trial name
- CVRX-ReSy (NCT01355510)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Hannover Medical School
Central Sympathetic Nervous System Diseases
Role of Sympathetic Activation in Ischemia Reperfusion Injury
This study is designed to assess the effect of forearm ischemia-reperfusion injury on sympathetic nerve activity. To determine whether reduced sympathetic responsiveness is a contributor to the protective effects of remote…
- Trial name
- NCT04479813
- Testing
- Moxonidine 0.2 MG
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Royal Perth Hospital
Hypertension, Renal
Transcatheter Renal Artery Sympathetic Denervation Observational Study
Hypertension is a common health problem that affects millions of people in the world. Poorly controlled blood pressure (BP) leads to cardiovascular, cerebrovascular and renal complications.
- Trial name
- NCT05744986
- Testing
- SYMPICITY Spyral RENAL DENERVATION (RDN) SYSTEMTM
- Where
- 2 sites in Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Preeclampsia
Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia
A history of preeclampsia is associated with a low plasma volume and higher sympathetic activity. Methyldopa will suppress sympathetic activity to normal values.
- Trial name
- NCT00117546
- Testing
- alpha methyldopa
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Radboud University Medical Center
Insulin Resistance, Blood Pressure
Denervation of the REnal Artery in Metabolic Syndrome
The current prevalence of hypertension as part of the metabolic syndrome is substantial and is increasing with the rise of obesity worldwide.
- Trial name
- DREAMS (NCT01465724)
- Testing
- Renal denervation
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- UMC Utrecht
Hypoxia, Sleep Apnea
Intermittent Hypoxia 2: Cardiovascular and Metabolism
The purpose of this study is to compare cardiovascular physiological adaptation to intermittent hypoxia (IH) of nonobese healthy subjects. The exposure will be two periods of two weeks (IH versus exposure "placebo hypoxia").
- Conditions
- Hypoxia, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- IH2 (NCT02058823)
- Testing
- Valsartan, Amlodipine
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Renal Failure Chronic Requiring Hemodialysis, Haemodialysis-induced Symptom
Mechanisms of Intradialytic Hypertension
Patients with end-stage renal disease (ESRD) are at significantly higher risk for death due to cardiovascular disease. Those with paradoxical increases in blood pressure (BP) during hemodialysis (HD), defined as intradialytic…
- Conditions
- Renal Failure Chronic Requiring Hemodialysis, Haemodialysis-induced Symptom, Hypertension
- Trial name
- MID-H (NCT01947673)
- Testing
- Mindfulness Meditation, Health Education
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Emory University
Complex Regional Pain Syndrome Type I of the Upper Limb, Unilateral Limb Pain of Other Origin
Correlation Between 3 Phase Bone Scintigraphy and Pressure Pain Thresholds in Patients With Complex Regional Pain Syndrome (CRPS)
The aim of the study is to investigate the correlation between increased bone metabolism in the 3 phase bone scintigraphy (TPBS) and decreased pressure pain thresholds in patients with complex regional pain syndrome (CRPS) of the…
- Conditions
- Complex Regional Pain Syndrome Type I of the Upper Limb, Unilateral Limb Pain of Other Origin, Healthy Subjects
- Trial name
- NCT01623141
- Testing
- Pressure Pain measurement
- Where
- Germany
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Complex Regional Pain Syndrome Type I of the Upper Limb
Contribution of Immersive Virtual Reality to a Standardized Rehabilitation Program for Upper Limb Chronic Pain: A Single-Case Experimental Design Study
Background: Chronic pain represents a significant public health concern, given its high prevalence and the substantial impact it has on the quality of life of many individuals affected.
- Trial name
- ReVIDoC (NCT06523361)
- Testing
- H'ability
- Where
- 2 sites in France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Angers
Autonomic Dysfunction
Cervicothoracic Sympathetic Block Evaluation for Post COVID Condition
Post-COVID Condition (PCC) affects roughly 2.1 million Canadians, carrying an annual economic burden of CAD $7.8-50.6 billion. It presents across multiple organ systems with symptoms including fatigue, brain fog, palpitations…
- Trial name
- CeASE (NCT07468604)
- Testing
- 5 mL of 0.25% bupivacaine with epinephrine (1:200,000)
- Where
- 2 sites in Canada
- Volunteers
- 78 people
- Sponsor
- University Health Network, Toronto
RSD (Reflex Sympathetic Dystrophy), Algodystrophy
Prophylactic Administration of Vitamin C in Wrist Fractures
Complex Regional Pain Syndrome or posttraumatic dystrophy is a pain syndrome which develops after a trauma, surgery or for unknown reason. The incidence after wrist fractures varies in literature from 2 - 37%.
- Conditions
- RSD (Reflex Sympathetic Dystrophy), Algodystrophy, CRPS Type I
- Trial name
- NCT00296868
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Stichting Achmea Slachtoffer en Samenleving
Complex Regional Pain Syndrome (RSD)
A Study of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS)
This is a multicenter, open-label study in adult subjects with Type 1 Complex Regional Pain Syndrome. Subjects diagnosed with unilateral Type 1 CRPS will be enrolled sequentially to receive CC-5013 10 mg/day orally.
- Trial name
- CRPS (NCT00067743)
- Testing
- Lenalidomide
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- Celgene Corporation