Clinical trials: Symptoms, Affective
Chronic Depression
Getting Biased Treatment Study: How Psychotherapy and Antidepressants Change Brain Activity in Chronic Depression
The purpose of this study is to determine how psychotherapy and pharmacotherapy respectively change brain activity in patients suffering from chronic depression.
- Trial name
- GETTY (NCT00596986)
- Testing
- Duloxetine, Cognitive Behavioural Analysis System of Psychotherapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
Rumination, Major Depressive Disorder
Decoding and Modulating Affective Brain States
The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS).
- Conditions
- Rumination, Major Depressive Disorder, Anxiety
- Trial name
- NCT05437705
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Inflammatory Bowel Diseases, Mild Cognitive Impairment
Cognitive Impairment and Affective Mood Disorders in Patients With IBD
The aim is to evaluate the presence of mild cognitive impairment (MCI) in patients with inflammatory bowel disease (IBD). This will be done by cognitive tests.
- Conditions
- Inflammatory Bowel Diseases, Mild Cognitive Impairment, Depression, Anxiety
- Trial name
- COGN-IBD-1 (NCT05760729)
- Testing
- Cognitive testing
- Where
- 3 sites in Romania
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Sleep Disturbance, Emotional Disturbance
Pilot Trial for Health Products on Mood and Sleep Quality
This is a pilot, single-site clinical trial that will follow a randomized, double-blinded, parallel-group, placebo-controlled design.
- Trial name
- NCT06579183
- Testing
- Vita Calm Mood Booster Formula (VCMBF), Vita Calm Deep Sleep Formula (VCDSF)
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Depression, Anxiety
The Effect of Selective Serotonin Reuptake Inhibitor (SSRI) Treatment on Affective Symptoms and Fertility Treatment Outcome in Women Undergoing in Vitro Fertilization (IVF)
Women undergoing IVF show a high prevalence of depressive and anxiety symptoms. Furthermore, stress has harmful consequences on IVF and pregnancy outcomes. An immunological cascade was suggested to be involved in the process.
- Conditions
- Depression, Anxiety, In Vitro Fertilization
- Trial name
- NCT00989053
- Testing
- escitalopram
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Perimenopausal Depression
Perimenopausal Effects of Estradiol on Reward Responsiveness
Using neuroimaging, the investigator will study the effects of estrogen on mood and brain function in perimenopausal women either with or without depression.
- Trial name
- PEERS (NCT02255175)
- Testing
- Estradiol, Progesterone
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Premenstrual Dysphoric Disorder
Premenstrual Hormonal and Affective State Evaluation (PHASE) Project
PHASE is designed to evaluate neuroactive hormone trajectories across the menstrual cycle and endocrine, autonomic, and subjective responses to psychosocial stress in women suffering from severe PMS (i.e., premenstrual dysphoric…
- Trial name
- PHASE Project (NCT03862469)
- Testing
- Individualized laboratory test
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Migraine, Alexithymia
Studio TIARA: Alessitimia ed Emicrania Cronica
The aim of this observational, cross-sectional study is to investigate the relationship between alexithymia and migraine frequency (considering alexithymia a condition that can influence the severity of the clinical phenotype of…
- Trial name
- TIARA (NCT06891053)
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Azienda Sanitaria Locale di Alessandria
Bipolar Disorder, Mood Disorder
Mindfulness in Mood Dysregulated Youth
Mindfulness group therapy can help children with mood irregularities and family history of bipolar disorder.
- Conditions
- Bipolar Disorder, Mood Disorder, Emotional Disturbance
- Trial name
- NCT02120937
- Testing
- MBCT-C Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Down Syndrome (Trisomy 21), Fragile X Syndrome (FXS)
The Neurocognitive Bases of Trust in Intellectual Disability
This project studies the neurocognitive basis of trust adjustment in intellectual disability (ID), a source of significant vulnerability for these patients, focusing on two target populations chosen for their specific social…
- Trial name
- BNConfDI (NCT07434037)
- Testing
- Confidence adjustment assessment, clinical assessment, Cognitive assessment
- Where
- France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Depression, Insulin Resistance
Endogenous Opioid Activity and Affective State in Insulin Resistant Women
Insulin resistance, a primary component of the metabolic syndrome, is an escalating phenomenon in the United States, and confers an increased risk of depression and mood disorder, particularly in women.
- Conditions
- Depression, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT02069379
- Testing
- Metformin
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Alexithymia, Emotion Regulation
Emotion Regulation Training, Nursing Student, and Alexithymia
This study aimed to investigate the effects of emotional regulation training, which is a prepared based on the cognitive behavioral approach, on alexithymia in nursing students.
- Trial name
- NCT06701097
- Testing
- Emotion regulation training
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Pain, Normal Physiology
Neural and Psychological Mechanisms of Pain Perception
Background: Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, not just pain.
- Conditions
- Pain, Normal Physiology, Healthy Volunteers
- Trial name
- NCT02446262
- Testing
- Instructions, Attention, Thermal Pain
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Seasonal Affective Disorder, Visual Impairment
Seasonal Affective Disorder and Visual Impairment
As a subtype of major depressive disorder, seasonal affective disorder (SAD) or winter depression causes severe reductions in both quality of life and productivity and results in high morbidity and frequent sick leave (1).
- Trial name
- NCT03403959
- Testing
- light therapy
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Psychiatric Centre Rigshospitalet
Depression, Anxiety
Affect Treatment for Depression and Anxiety (TAD Pilot)
The goal of this study is to determine whether subjects who do not show expected clinical improvement during the early course of positive affect treatment (PAT) would benefit from switching to an alternative psychosocial…
- Trial name
- NCT06488859
- Testing
- Positive Affect Treatment, Positive Affect Treatment and Negative Affect Treatment
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of California, Los Angeles
Anorexia Nervosa
Facial Emotion Recognition in Anorexia Nervosa
Altered emotional processing is reported in Anorexia Nervosa. However, this capability is generally measured through explicit measures, like self-report questionnaires and facial emotion recognition tasks.
- Trial name
- FER_AN (NCT06299293)
- Testing
- Facial Emotion Recognition Test
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Cerebellar Diseases
Emotional Communication Disorders in Cerebellar Disease
The cerebellum has been linked to cognitive and emotional functions and there is increasing evidence that damage to posterior portions of the cerebellum can result in frontal-executive, visuospatial, and verbal deficits…
- Trial name
- NCT02106819
- Testing
- Testing of emotional communication ability, magnetic resonance imaging (MRI) of the brain
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Florida
Depression
Cognitive and Affective Processes Online
This study will provide data for evaluating the psychometric characteristics of the tests assessing cognitive flexibility, including their (1) internal consistency, (2) feasibility and tolerability, their (3) convergent and…
- Trial name
- NCT05736471
- Testing
- Computational dissociation of the causes of cognitive rigidity in depression
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Major Depressive Disorder, Bipolar Disorder
An Eye Tracking Study of Affective Disorder Patients With Suicide Risk
This research tries to investigate the validity and reliability of eye-tracking technologies by using different paradigms (eg. free-view, pro-saccade and anti-saccade) which served as a novel way of evaluating suicide risk among…
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Suicide
- Trial name
- NCT03711045
- Testing
- eye-tracking
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Central South University
Anxiety, Depression
Affective Modulation of Positivity for Alcohol Use Disorder
The proposed study is a pilot study examining the feasibility and potential utility of administering a psychosocial intervention termed Affective Modulation of Positivity (AMP) for individuals suffering from co-morbid depression…
- Conditions
- Anxiety, Depression, Alcohol Use Disorder
- Trial name
- AMP-A (NCT04278365)
- Testing
- Positive affect training
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Laureate Institute for Brain Research, Inc.