Clinical trials: Symptoms, Behavioral
Sleep Problem, Suicidal Ideation
Sleep Treatment for Teens
The purpose of this research study is to test a brief (6-session), empirically supported, and highly disseminable version of digital (i.e., smartphone or web-based) cognitive behavioral therapy for insomnia (dCBT-I), called…
- Conditions
- Sleep Problem, Suicidal Ideation, Suicide, Attempted
- Trial name
- NCT05397353
- Testing
- Sleepio (TM)
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Rutgers, The State University of New Jersey
Stroke, Stroke Sequelae
Mindfulness Based Stress Reduction and Post-Stroke Cognition
The investigators don't fully understand how, regardless of the size or location in the brain, minor strokes can result in significant problems with focus, attention, and multi-tasking that prevent individuals from returning to…
- Conditions
- Stroke, Stroke Sequelae, Depression, Cognitive Impairment
- Trial name
- NCT04302493
- Testing
- Mindfulness Based Stress Reduction (MBSR), Stroke Support Group (SSG)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Suicidal Ideation
Peer Mentorship to Reduce Suicide Attempts Among High-Risk Adults
This is a single-blind, randomized controlled trial to test the effectiveness of a peer mentorship intervention (PREVAIL) for reducing suicide risk compared to enhanced usual care among participants (N=455) at high-risk for…
- Trial name
- PREVAIL (NCT03373916)
- Testing
- Peer mentorship, Enhanced Usual Care
- Where
- 3 sites in United States
- Volunteers
- 455 people
- Sponsor
- University of Michigan
Agitation, Dementia
Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY II)
A study to determine the safety and efficacy of BXCL501 dosing for episodes of agitation associated with dementia when they occur (given as needed [PRN]), for a maximum of 28 doses within a 12-week treatment period.
- Trial name
- NCT05271552
- Testing
- BXCL501
- Where
- 11 sites in United States
- Volunteers
- 151 people
- Sponsor
- BioXcel Therapeutics Inc
TBI, Anxiety
Cranial Electrotherapy Stimulation (CES) Therapy
The primary aim of this proposed study is to gather preliminary data for CES use in treating PTSD and anxiety symptoms in OEF/OIF Veterans with PTSD and a history of TBI.
- Conditions
- TBI, Anxiety, PTSD, Depression
- Trial name
- CES (NCT02453347)
- Testing
- CES Therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pediatric Obesity, Mobile Technology
An Addiction-Based Mobile Health Weight Loss Intervention With Coaching
The proposed multi-site randomized control trial (RCT) will test the effectiveness of an addiction-based weight loss intervention, embodied first as a smartphone app with telephone coaching and second as an identical approach…
- Conditions
- Pediatric Obesity, Mobile Technology, Addiction
- Trial name
- NCT03500835
- Testing
- App, Coaching, Clinic: Modified KidsNFitness
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- Children's Hospital Los Angeles
Breast Cancer, Gynecologic Cancer
Prasterone (Dehydroepiandrosterone) in Treating Postmenopausal Cancer Survivors With Vaginal Symptoms
RATIONALE: Dehydroepiandrosterone (DHEA) may help relieve vaginal symptoms in female cancer survivors. PURPOSE: This randomized phase III trial studies DHEA to see how well it works compared to placebo in treating postmenopausal…
- Trial name
- NCT01376349
- Testing
- prasterone
- Where
- 280 sites in United States
- Volunteers
- 464 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Nicotine Dependence
Pilot Study of Tolcapone in Smokers
The goals of this within-subject pilot study are: (1) assess the feasibility and safety of administering the Catechol-O-Methyl-Transferase (COMT) inhibitor, tolcapone, to smokers, and (2) explore whether tolcapone may reduce…
- Trial name
- NCT01202955
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Pennsylvania
Overweight, Obesity
Toddler Overweight Prevention Study Among Low-Income Families
The hypothesis is that toddlers with parents who are randomized to a parenting intervention and toddlers with parents who are randomized to the maternal intervention focused on maternal diet and physical activity will be more…
- Conditions
- Overweight, Obesity, Depression
- Trial name
- TOPS (NCT02615158)
- Testing
- Maternal Physical Activity and Nutrition, Parenting, Child Safety
- Where
- 2 sites in United States
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Major Depressive Disorder
Efficacy and Safety of Vortioxetine (Lu AA21004) in Treating Adults With Major Depressive Disorder
The purpose of this study is to determine the efficacy and safety of once daily vortioxetine (Lu AA21004) in adults with major depressive disorder.
- Trial name
- NCT00672958
- Testing
- Vortioxetine
- Where
- 33 sites in United States, Canada and 1 more
- Volunteers
- 600 people
- Sponsor
- Takeda
Acute Coronary Syndrome, Depression
Comparison of Depression Interventions After Acute Coronary Syndrome
Patients will be consented and screened within 2 to 6 months of the index ACS. Patients who have elevated depression (BDI>=15 or BDI>=10 assessed twice over two week period) and who continue to meet all of the trial's eligibility…
- Trial name
- CODIACS (NCT01032018)
- Testing
- Problem Solving Therapy, Sertraline, citalopram, or bupropion, Standard care
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Columbia University
Depressive Disorder, Depression
A Study of Flexible-dose Brexpiprazole as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder, the Delphinus Trial
To compare the efficacy of brexpiprazole (flexible dose) with placebo as adjunctive therapy to an assigned open label antidepressant therapy (ADT) in the proposed subject population with MDD.
- Conditions
- Depressive Disorder, Depression, Depressive Disorder, Major, Mood Disorders
- Trial name
- NCT01727726
- Testing
- Brexpiprazole, Seroquel XR
- Where
- 76 sites in United States, Canada and 5 more
- Volunteers
- 2,182 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Depression
A Study to Evaluate the Efficacy, Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant Depression
The purpose of this study is to evaluate the efficacy of fixed dosed intranasal esketamine compared to intranasal placebo, as an add-on to an oral antidepressant in Japanese participants with treatment-resistant depression (TRD)…
- Trial name
- NCT02918318
- Testing
- Intranasal esketamine (28 mg), Intranasal esketamine (56 mg), Intranasal esketamine (84 mg)
- Where
- 43 sites in Japan
- Volunteers
- 202 people
- Sponsor
- Janssen Pharmaceutical K.K.
Stress, Diabetes Mellitus, Type 2
Decreasing Stress in Diabetes
The purpose of this study is to conduct a randomized controlled trial (RCT) to determine the effects of an online 6-month Mindfulness-based stress reduction (MBSR) intervention compared to an active control Stress Management…
- Conditions
- Stress, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- De-Stress (NCT04016415)
- Testing
- Mindfulness Based Stress Reduction, Stress Management Education
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- Milton S. Hershey Medical Center
Depression, HIV
SSRI Effects on Depression and Immunity in HIV/AIDS
This is a 10 week, double-blind, placebo controlled trial to evaluate SSRI (Selective Serotonin Reuptake Inhibitor) effects for treatment of depression in HIV/AIDS with a focus on innate immunity and inflammation.
- Conditions
- Depression, HIV, AIDS
- Trial name
- NCT02620150
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Pennsylvania
Apathy, Diabetes
The Role of Apathy in Glycemic Control
In spite of several new medications and insulins for the control of blood sugars in patients with diabetes, a large number of patients do not have good control.
- Trial name
- NCT00844090
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- US Department of Veterans Affairs
COPD, Heart Failure
Personalized Experiences to Inform Improved Communication for Minorities With Life Limiting Illness
The purpose of this research is to develop patient-centered palliative care interventions to improve patient-provider communication and Quality of Life (QoL) of ethnic and racial minority patients living with life-limiting…
- Conditions
- COPD, Heart Failure, Cancer
- Trial name
- NCT03391115
- Testing
- Storytelling Intervention for Patient Participants, Storytelling Intervention for Nurse Participants
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Anorexia Nervosa/Bulimia, Anorexia in Adolescence
Oral Naltrexone In Pediatric Eating Disorders
The objective of this study is to evaluate the effectiveness of oral naltrexone tablets in pediatric and adolescent eating disorders, in particular anorexia nervosa and bulimia nervosa, as compared to placebo.
- Conditions
- Anorexia Nervosa/Bulimia, Anorexia in Adolescence, Anorexia Nervosa, Atypical, Anorexia Nervosa, Binge Eating/Purging Type
- Trial name
- ONPED (NCT05073679)
- Testing
- Naltrexone Hydrochloride, Control
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Rosemary Claire Roden
Depression, Menopause
Vortioxetine for Menopausal Depression
The broad goal of this study was to examine the efficacy and tolerability of vortioxetine (flexible dose) for the treatment of major depressive disorder (MDD) in symptomatic women around the menopausal transition.
- Conditions
- Depression, Menopause, Vasomotor Disturbance, Hot Flashes
- Trial name
- NCT02234362
- Testing
- vortioxetine
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Massachusetts General Hospital
Anxiety, Depression
Collaborative Care for Women Veterans
Implementation of Tailored Collaborative Care for Women Veterans (CCWV) was designed to enhance primary care-mental health integration for women Veterans by tailoring services to women Veterans' and providers' needs and providing…
- Conditions
- Anxiety, Depression, Stress Disorders, Post Traumatic
- Trial name
- CCWV (NCT02950961)
- Testing
- Collaborative Care for Women Veterans
- Where
- 3 sites in United States
- Volunteers
- 153 people
- Sponsor
- VA Office of Research and Development
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