Clinical trials: Symptoms, Cognitive
Childhood Apraxia of Speech, Speech Sound Disorders
Feasibility and Preliminary Effects of a Therapeutic Approach Using Ultrasound Visual Biofeedback in Children With AFI: a Pilot Randomized Clinical Trial.
The aim of this study is to evaluate the feasibility of the Ultrax protocol and estimate preliminary effects on articulatory precision, prosody, and speech motor planning.
- Trial name
- PICOS (NCT07087249)
- Testing
- Ultrasound Visual Feedback, Waitlist
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Aline Mara de Oliveira
Analgesia
A Study Investigating the Pharmacokinetic Profiles of Four Extended Release Paracetamol Formulations
A study investigating the pharmacokinetic profiles of four extended release paracetamol formulations
- Trial name
- NCT01568749
- Testing
- Paracetamol, Paracetamol formulation 1, Paracetamol Formulation 2
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
X-Linked Adrenoleukodystrophy, Adrenomyeloneuropathy
Safety and Pharmacodynamic Study of Sobetirome in X-Linked Adrenoleukodystrophy (X-ALD)
The purpose of this study is to assess the safety, tolerance, pharmacokinetics, and pharmacodynamics of sobetirome, a selective thyroid hormone analog, in adult male X-ALD patients.
- Trial name
- NCT01787578
- Testing
- Sobetirome
- Where
- United States
- Sponsor
- Thomas S. Scanlan
Chronic Low-back Pain
The Effects of Different Exercise Approaches in Patients With Chronic Low Back Pain
Identification of the effects of yoga, stabilization exercise and aerobic exercise approaches on physical and cognitive variables in individuals with low back pain.
- Trial name
- NCT04000685
- Testing
- Yoga exercise program, Spinal stabilization exercise program, Aerobic walking program
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Hacettepe University
Overweight, Obesity
The Effects of Including Almonds in a Weight Loss Trial
The purpose of this study is to determine whether inclusion of almonds in a weight loss regimen will augment the rate of weight loss, promote a greater fat mass/fat-free mass ratio of weight loss, improve blood pressure and…
- Trial name
- NCT02360787
- Testing
- Energy restriction, Almonds (15% kcal/day)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Purdue University
Cervical Pain, Lumbar Pain
EVALUATION OF THE TOLERABILITY AND BIOMEDICAL POTENTIAL OF A GARMENT CONTAINING PRINTED CERAMICS IN MUSCULAR PAIN
Today, a new revolution is underway in the textile industry with the introduction of new technologies that add special functions and properties to fabrics.
- Conditions
- Cervical Pain, Lumbar Pain, Muscular, Chronic Pain (Back / Neck)
- Trial name
- DZero (NCT07274293)
- Testing
- DZero
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- noiVita Srls
Delirium, Agitation
A Comparison of Dexmedetomidine and Haloperidol in Patients With Intensive Care Unit (ICU)-Associated Agitation and Delirium
The purpose of the study is to determine whether dexmedetomidine is a more effective medication than haloperidol in the treatment of agitation and delirium in patients receiving mechanical ventilation in an intensive care unit.
- Conditions
- Delirium, Agitation, Ventilator Weaning, Respiration, Artificial
- Trial name
- Dex (NCT00505804)
- Testing
- dexmedetomidine, haloperidol
- Volunteers
- 20 people
- Sponsor
- Austin Health
Anesthesia
Hypnoanalgesia for Dermatological Surgery in Children
This randomized clinical trial will evaluate the effect of hypnosedation on the need of sedation and analgesia in a pediatric population undergoing dermatological surgery, both during the procedure, and 24 hours after surgery.
- Trial name
- NCT04707014
- Testing
- Hypnosis, Attention-distracting techniques
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Complejo Hospitalario de Toledo
Aphasia, Primary Progressive
Effects of Transcranial Direct Current Stimulation (tDCS) on Inhibition and Brain Function in Primary Progressive Aphasia
Primary progressive aphasia (PPA) is a focal dementia characterized by primary impairment of language abilities and functional disturbances associated with language.
- Trial name
- Stim-APHA (NCT06473714)
- Testing
- tDCS
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Labor, Analgesia, Epidural
Effect of Timing on Efficacy of Morphine Analgesia After 2-chloroprocaine Anesthesia
Epidural chloroprocaine is often used in obstetrical anesthesia because of its fast onset and short duration. These properties make it an ideal drug to use for epidural anesthesia in patients undergoing postpartum tubal ligation.
- Trial name
- NCT00487084
- Testing
- Morphine-CP-saline (MCS), saline-2CP-morphine (SCM), saline-lidocaine-morphine (SLM)
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cesarean Section, Cesarean Delivery
Pain Management After Cesarean Section - A Before-and-After Cohort Study
Inadequate pain relief remains a challenge after Cesarean section (CS) and may significantly impair postoperative recovery. A recent Danish single-center study (n=100) revealed that 66% of elective CS patients experienced severe…
- Conditions
- Cesarean Section, Cesarean Delivery, Pain Management, Pain Management in Postoperative Care
- Trial name
- NCT06813638
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Nordsjaellands Hospital
Mucopolysaccharidosis II
A Study of Tividenofusp Alfa (DNL310) in Pediatric Participants With Hunter Syndrome
This is a multicenter, multiregional, open-label study to assess the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of tividenofusp alfa (DNL310), an investigational central nervous system (CNS)-penetrant enzyme…
- Trial name
- NCT04251026
- Testing
- tividenofusp alfa
- Where
- 7 sites in United States, Canada and 2 more
- Volunteers
- 47 people
- Sponsor
- Denali Therapeutics Inc.
Autism Spectrum Disorder, Complication of Prematurity
Correlation of CXCR4 Expression in Premature Infants With a Diagnosis of Autism at 24 Months
Preterm children are at increased risk for autism spectrum disorders, with an estimated rate of 10%. In the US, about 1 in 8 pregnancies ends with a premature birth.
- Trial name
- ASD-CXCR4 (NCT01686685)
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Schizophrenia, Schizoaffective Disorder
Brain Health and Exercise in Schizophrenia
To determine the effects of aerobic exercise on hippocampal volumes and severity of psychotic symptoms in a population of psychosis patients compared to healthy age/gender matched volunteers.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Poor Memory
- Trial name
- PEHP (NCT01392885)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BC Mental Health and Addictions Research Institute
Cognitive/Functional Effects, Malignant Neoplasm
Collaborative Targeted Case Management in Improving Functional Status in Patients With Stage III-IV Cancer
This randomized clinical trial studies collaborative targeted case management in improving functional status in patients with stage III-IV cancer.
- Conditions
- Cognitive/Functional Effects, Malignant Neoplasm, Pain
- Trial name
- NCT01721343
- Testing
- telephone-based intervention, case management, management of therapy complications
- Where
- United States
- Volunteers
- 516 people
- Sponsor
- Mayo Clinic
Delirium
Lived Experiences and Impact of Delirium in Critically Ill Children: a Qualitative Study
The investigators aim to conduct a qualitative study evaluating the long and short-term recollection and experiences of critically ill children with delirium as well as collect the lived experience of the caregiver and healthcare…
- Trial name
- NCT04168515
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Prader Willi Syndrome, Hyperphagia
Functional Connectome in Prader-Willi Syndrome: Neuroimaging and AI to Assess Therapeutic Impact
The goal of this observational study is to explore brain network changes and identify patterns related to hyperphagia, hormonal treatment effects, and cognitive deficits in adults with Prader-Willi Syndrome (PWS).
- Conditions
- Prader Willi Syndrome, Hyperphagia, Behavior Disorders
- Trial name
- NCT06900335
- Testing
- GH treatment (Somatropin), Eating
- Where
- Spain
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Physical Disability, Cognitive Dysfunction
Study on Cardiovascular Health, Nutrition and Physical Functioning in Older Adults in Spain
Population aging makes it necessary to identify factors related to unhealthy aging. The purpose of this study is to examine the association between ideal cardiovascular health, diet and other lifestyles and biological risk…
- Trial name
- Sen-ENRICAII (NCT03541135)
- Where
- Spain
- Volunteers
- 4,000 people
- Sponsor
- Universidad Autonoma de Madrid
Autism Spectrum Disorder, Intellectual Disability
TMS for the Investigation of Brain Plasticity in Autism Spectrum Disorders
The main purpose is to study brain plasticity (the changes that occur in the brain through experience) in individuals with autism spectrum disorder (ASD).
- Trial name
- NCT02836405
- Testing
- Transcranial Magnetic Stimulation
- Where
- 2 sites in United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Fatigue
Sleep and Training Aspects in Dialysis Fatigue - Exercise Intervention
The purpose of the current study is to investigate whether changes in patients' sleep quality and quantity will be followed by improvements in parameters related to physical and mental fatigue in patients receiving hemodialysis…
- Trial name
- StandFirm (NCT01721551)
- Testing
- Exercise, Usual Treatment
- Where
- 3 sites in Greece
- Volunteers
- 50 people
- Sponsor
- University of Thessaly