Clinical trials: Symptoms and Signs
Cellulite, Edematous Fibrosclerotic Panniculopathy (EFP)
Impact of CCH Treatment of Buttock and Thigh Cellulite in Adult Women
This is a single center, open-label, Phase 2a study to assess the photonumeric scale, morphological, and histopathological changes associated with Collagenase Clostridium Histolyticum (CCH) in adult women with moderate or severe…
- Trial name
- NCT04209530
- Testing
- EN3835
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Sepsis
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Dose Exploration Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetic Characteristics of STC314 Injection Administered Intravenously in Sepsis Patients
One study evaluated the efficacy and safety of intravenous STC314 injection in patients with sepsis Sex and pharmacokinetic profiles of a multicenter, randomized, double-blind, placebo-controlled II Phase I dose exploration…
- Trial name
- Sepsis (NCT06548854)
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Grand Medical Pty Ltd.
Obesity, Overweight
The Effect of Mashed Potato Composition on Food Intake, Satiety and Blood Glucose
Potato is one of the world's most popular foods and is widely accepted as a staple food. The objective of this study is to determine the effect of consuming instant mashed potatoes with and without fat on glycemic response…
- Conditions
- Obesity, Overweight, Diabetes, Metabolic Syndrome
- Trial name
- NCT02009254
- Testing
- Dietary treatment
- Sponsor
- University of Toronto
Healthy
Effect of Neutralization of Endogenous Acid Production on BMD and Bone Microarchitectural
Hypothesis: Neutralization of acid production induced by the Western diet with oral administration of potassium citrate increases bone mineral density and bone mass as well as skeletal muscle mass and strength in elderly people…
- Trial name
- NCT00509405
- Testing
- potassium citrate
- Where
- Switzerland
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Baselland Bruderholz
Recent Acute Myocardial Infarction
Impact of the Obstructive Sleep Apnea Syndrome (OSAS) on the Ventricular Remodeling After Acute Myocardial Infarction
Coronary artery disease is a common and serious disease, the leading cause of death worldwide. Obstructive sleep apnea syndrome (OSAS) is common and often under-diagnosed in coronary artery disease where it could be involved in…
- Trial name
- SAS-IDM (NCT02439294)
- Testing
- Without Obstructive Sleep Apnea (syndrome), Mild or moderate Obstructive Sleep Apnea (syndrome), Severe Obstructive Sleep Apnea (syndrome)
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Montpellier
Intra Abdominal Infections
Soluble Immune Checkpoints in Intra-Abdominal Infections
Intraabdominal infections is a life-threatening syndrome with a high incidence and a significant economic burden. The early-stage cytokine storm and the late-stage immunosuppression contribute to the mortality of sepsis.
- Trial name
- NCT07689266
- Testing
- Soluble Immune checkpoint levels
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Prediabetic State, Body Weight
Development of PI-ML Algorithm for Prediction of the Real-time Risk for Developing Pre-diabetes
In this prospective, non-randomized, monocentric study, data will be collected from otherwise healthy individuals with overweight/obese grade I to increase data availability in the pre-diabetes field (impaired glucose…
- Conditions
- Prediabetic State, Body Weight, Overweight or Obesity, Life Style, Healthy
- Trial name
- PRAESIIDIUM (NCT06195566)
- Where
- Latvia
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Jelizaveta Sokolovska
Peptic Ulcer Hemorrhage
China Survey of Peptic Ulcer Bleeding
This will be a multicenter prospective observational study carried out in China. The investigators will collect data in a pre-specified Case Report Form.
- Trial name
- PUB (NCT01241266)
- Where
- 31 sites in China
- Volunteers
- 1,044 people
- Sponsor
- AstraZeneca
Total Intravenous Anesthesia
The Effect of Mild Hypercapnia During Anesthetic Emergence on Recovery Time From TIVA
We hypothesized that patients with mild hypercapnia during anesthetic emergence after TIVA had a shorter recovery time than patients with normal blood carbonate levels.
- Trial name
- NCT05401266
- Testing
- mild hypercapnia
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Neck Pain
Risk Factors and Risk Profiles for Persistent Neck Pain in Young Adults: Results From the HUNT Study
Neck pain is one of the most prevalent musculoskeletal disorder in Norway among older adolescents and young adults. Despite this, little research exist on risk factors for neck pain in the transitional life phase from adolescence…
- Trial name
- NCT04201366
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 8,562 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Lung Transplant; Pain
Evaluating the Impact of Cryo-analgesia on Recovery After Double Lung Transplantation
The goal of this pilot trial is to learn whether the use of cryo nerve block and its effect on sensation in the chest alters recovery after bilateral lung transplantation, and to which extent these parameters are influenced.
- Trial name
- CRyoLTRiX (NCT06959056)
- Testing
- cryo nerve block at T3-T8 intercostal nerves bilaterally
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Gasthuisberg
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Cyclosporine Drug Interaction on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers. Drug-Drug Interaction 2 (DDI2) Study
The main goal of this pharmacokinetic study in healthy volunteers is to evaluate the potential effect of cyclosporine (probe inhibitor of P glycoprotein [P-gp] and breast cancer resistance protein [BCRP] transporters) on CHF6001…
- Trial name
- DDI2 (NCT06892756)
- Testing
- CHF6001 dry powder inhaler (DPI), Cyclosporine, CHF6001 DPI
- Where
- Bulgaria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Retrograde Intrarenal Surgery, Stone, Kidney
Homework in Retrograde Intrarenal Surgery
To evaluate the effectiveness of this homework on stone clearance rates after retrograde intrarenal surgery (RIRS) by instructing the patient in the home environment and suggesting percussion and movement/position changes to…
- Trial name
- NCT06795256
- Testing
- Percussion and position change in retrograde intrarenal surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Adiyaman University
Pelvic Organ Prolapse (POP)
Evaluation of Sexual Function and Quality of Life Tests in Patients Who Underwent Manchester Operation for Pelvic Organ Prolapse
Pelvic organ prolapse is a condition that affects sexual health and quality of life at all ages. The efficacy of the Manchester operation planned in appropriate patients and its effects on the sexual function and quality of life…
- Trial name
- NCT06975956
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Chronic Pain, Insomnia
The Efficacy of CALPXT96™in Improving Sleep Quality in Patients With Chronic Non-cancer Pain
California Poppy has been traditionally used in Herbal Medicine as an analgesic, mild sedative and/or sleep aid. However there are no human clinical trial data to support its use.
- Trial name
- CALPXT96 (NCT02232256)
- Testing
- CALPXT96
- Where
- Canada
- Sponsor
- 9305-9954 Quebec Inc
Muscle Loss, Extracellular Fluid Alteration
Ultrasound Detection of Body Composition in Critical Care
Objective assessment of the Changes in body composition of critically ill patients is very valuable. Ultrasound stands as a solution due to its portability, bedside availability, and radiation-free technology.
- Conditions
- Muscle Loss, Extracellular Fluid Alteration, Critical Illness, Pregnancy Complications
- Trial name
- NCT06728722
- Testing
- ultrasound detection of body composition
- Where
- Egypt
- Volunteers
- 121 people
- Sponsor
- Ain Shams University
Spastic Diplegia
Phase II Randomized Study of Selective Dorsal Rhizotomy and Physiotherapy Vs Physiotherapy Alone for Spastic Diplegia
OBJECTIVES: I. Assess the efficacy and safety of selective dorsal rhizotomy and physiotherapy compared with physiotherapy alone in improving gross motor function and reducing spasticity in children with spastic diplegia.
- Trial name
- NCT00004751
- Testing
- Surgery, Physical therapy
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Hepatitis B
Study to Evaluate the Efficacy and Safety of AHB-137 in Treatment-naive Participants With Chronic Hepatitis B (CHB)
The study is to evaluate the efficacy and safety of AHB-137 in CHB participants. The total duration of the study, including screening phase, treatment phase and follow-up phase.
- Trial name
- NCT06829329
- Testing
- AHB-137, NAs
- Where
- 6 sites in China
- Volunteers
- 105 people
- Sponsor
- Ausper Biopharma Co., Ltd.
Overweight and Obesity
Familial Overweight: Comparing Use of Strategies
The purpose of this study is to compare the efficacy of two different approaches (prescribed \& self-directed) to the treatment of childhood obesity and their relative impact on child weight status, physical activity, and diet.
- Trial name
- FOCUS (NCT00746629)
- Testing
- FOCUS
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Renal Calculi
Tip-flexible Semi-rigid Ureterorenoscope Versus Flexible Ureteroscopy in Renal Calculi
This study evaluates the safety and efficacy of the novel tip-flexible semi-rigid ureterorenoscope for the treatment of renal calculi using a prospective, randomized multicentre trial design.
- Trial name
- NCT02426931
- Testing
- the tip-flexible ureterorenoscope, the classic flexible ureteroscope
- Volunteers
- 280 people
- Sponsor
- Ling Li, MD
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