Clinical trials: Symptoms and Signs
Adenomatous Polyp, Colorectal Cancer
Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI
The purpose of this study is to find out whether METFORMIN decreases protein markers in colorectal tissue. This is a phase IIA study of the pharmacodynamics, safety and tolerability of Metformin in decreasing colorectal mucosa in…
- Conditions
- Adenomatous Polyp, Colorectal Cancer, Obesity
- Trial name
- NCT01312467
- Testing
- metformin hydrochloride
- Where
- 4 sites in United States, Canada
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
Renal Calculi, Ureteral Calculi
Shockwave Lithotripsy (SWL) Under Selective, General Anesthesia.
SWL is widely used in the treatment of patients with renal and ureteral calculi. Several factors determine the success of extracorporeal shockwave lithotripsy (SWL) for kidney stones: stone size, stone location within the…
- Trial name
- NCT01008267
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Assaf-Harofeh Medical Center
Total Shoulder Arthroplasty
Exparel for Total Shoulder Arthroplasty
The primary objective of this study is to determine if Exparel leads to better pain scores at 24, 48 and 72 hours after Total Shoulder Arthroplasty (TSA) compared to a pain pump.
- Trial name
- NCT04364867
- Testing
- Exparel, Pain Pump
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Norton Healthcare
Triple-negative Breast Cancer, HER2-positive Breast Cancer
CT-based Radiomics of ALN pCR (ypN0) in Breast Cancer Undergoing NAC
This is a prospective, single-center, non-randomized, non-controlled observational study.
- Trial name
- NCT04457700
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Peking University
Intervertebral Disc Herniation, Stiffness; Spine
Cervical Changes by 4h of Hyper-buoyancy Flotation and Followed by 15 Mins 1g Re-loading
Study with the aim to see the effect on a space ground anaologue, Hyperbuoyancy Floatation (HBF) on cervical column.
- Trial name
- NCT05296200
- Testing
- Hyperbuoyancy Floatation
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Universidad Autonoma de Madrid
Chronic Obstructive Pulmonary Disease (COPD)
Effects of CPAP Level on Respiratory Mechanics and Central Drive in Patients With COPD
Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory disease characterized by airflow limitation that is progressive and not fully reversible.
- Trial name
- NCT02285400
- Testing
- CPAP level
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhujiang Hospital
Sarcopenia, Obesity
Investigating the Link Between Advanced Glycation End Products (AGEs) and Muscle Wasting in Sarcobesity
The study aims to explore whether a high level of AGEs (Advanced Glycation end products) derived from the diet may mediate diet-related muscle loss in Western-type diet, influencing the onset and progression of sarcopenia…
- Trial name
- Westernage (NCT06438900)
- Where
- Italy
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Nociceptive Pain
Cervical Neuromodulation and Nociceptive Processing
Several studies have demonstrated that direct currents delivered through the skin at the level of the lumbar spinal cord can influence spinal cord function.
- Trial name
- MICROVOLT (NCT05127200)
- Testing
- Starstim (Neuroelectrics)
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Pain Management, Total Hip Arthroplasty
Ultrasound-Guided Quadro-Iliac Plane Block for Pain Management After Total Hip Arthroplasty
This prospective, randomized, double-blind study evaluates the analgesic effectiveness of the ultrasound-guided Quadro-Iliac Plane (QIP) block in patients undergoing primary total hip arthroplasty.
- Trial name
- NCT07410000
- Testing
- Quadro-Iliac Plane (QIP) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa City Hospital
Blood Transfusion; Hemoglobinemia, Hypoxia
The Role of Central Venous Oxygen Saturation (ScvO2) as an Indicator of Blood Transfusion in the Critically Ill
Transfusion of red blood cells is an everyday practice in critical care with the primary aim of restoring adequate tissue oxygenation.
- Conditions
- Blood Transfusion; Hemoglobinemia, Hypoxia, Anemia
- Trial name
- NCT03138200
- Testing
- Blood transfusion
- Where
- 2 sites in Hungary
- Volunteers
- 160 people
- Sponsor
- Szeged University
Intensive Care Unit ICU, Intubation
The Effects of Endotracheal Suctioning on Pain and Serum Markers
The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients.
- Conditions
- Intensive Care Unit ICU, Intubation, Critical Illness, Mechanical Ventilation
- Trial name
- NCT06692400
- Testing
- endotracheal tube suctioning
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Loma Linda University
Atrial Fibrillation, Cardiac Rehabilitation
The Application of Internet+ Home-based Cardiac Rehabilitation in Atrial Fibrillation Patients After RFCA
Epidemiological reports show that the incidence of atrial fibrillation continues to increase. AF is the most common arrhythmia with high mortality and disability rate.
- Trial name
- NCT04414007
- Testing
- Internet+ home-based cardiac rehabilitation, Conventional rehabilitation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanjing Medical University
Colorectal Neoplasm, Gastric Neoplasm
A Phase I Study of S-1 Plus Irinotecan and Oxaliplatin in Advanced Gastrointestinal Malignancy
This study is an open-label, single center, and a dose-escalating phase I study to determine the maximal tolerated dose and the recommended dose of S-1 combined with irinotecan/oxaliplatin in patients with unresectable or…
- Conditions
- Colorectal Neoplasm, Gastric Neoplasm, Secondary
- Trial name
- TIROX (NCT00506207)
- Testing
- S-1, Irinotecan, Oxaliplatin
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- National Cancer Center, Korea
Opioid Consumption, Demographic Data
Single-level and Two-level Serratus Posterior Superior Intercostal Plan Block (SPSIPB)
Breast cancer is the most common malignancy in women; one of the mainstays of breast cancer treatment is surgery, and modified radical mastectomy is one of the standard treatments.
- Trial name
- NCT06751407
- Testing
- Single level SPSIPB, Two-level SPSIPB
- Volunteers
- 50 people
- Sponsor
- Ankara Etlik City Hospital
Erectile Dysfunction, Nocturia, Short Term Insomnia, Obstructive Sleep Apnea
Effects of Nightshift Work and Sleep Disturbances on Erectile Function
We aim to observe the unwanted effects of nightshift work and short term insomnia on erectile function of men aged between 25 to 60 years.
- Trial name
- NCT04707807
- Testing
- IIEF-5
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Hepatitis B Virus
Safety and Immunotherapeutic Activity of Cemiplimab in Participants With HBV on Suppressive Antiviral Therapy
The purpose of this study is to evaluate the safety and immunotherapeutic activity of cemiplimab in participants with hepatitis B virus (HBV) on suppressive antiviral therapy.
- Trial name
- NCT04046107
- Testing
- Cemiplimab
- Where
- 8 sites in United States, Brazil and 2 more
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Post-Traumatic Stress Disorder, Chronic Low Back Pain
Yoga and Mantram for Chronic Pain and PTSD
PTSD is prevalent among Veterans and is associated with physical and functional impairments in addition to PTSD symptoms. Veterans with PTSD experience more chronic pain and pain-related functional limitations than Veterans…
- Conditions
- Post-Traumatic Stress Disorder, Chronic Low Back Pain, Chronic Neck Pain
- Trial name
- NCT03816007
- Testing
- Yoga and Mantram Repetition, Veteran Calm
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- VA Office of Research and Development
Atrial Fibrillation, Sick Sinus Syndrome
PACE-AF: Prospective Analysis of Cardiac Electrostimulation and Atrial Fibrillation
PACE-AF is a prospective, observational patient registry designed to evaluate the impact of pacemaker algorithms on atrial fibrillation (AF) incidence, progression, and clinical outcomes in patients implanted with dual-chamber…
- Conditions
- Atrial Fibrillation, Sick Sinus Syndrome, Atrioventricular Block
- Trial name
- PACE-AF (NCT07279207)
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- Ilya Lukin
Disorder of Consciousness
Ketamine to Treat Patients With Post-comatose Disorders of Consciousness
The investigators will run a Randomized Clinical Trial with 30 patients with disorders of consciousness (DoC), with intravenous subanesthetic doses of ketamine. Patients will simultaneously undergo TMS-EEG.
- Trial name
- NCT05343507
- Testing
- Ketalar 50 MG/ML Injectable Solution
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University of Liege
Cerebrovascular Accident (CVA), Chronic Disease
Upper Limb Task-Oriented Rehabilitation With Robotic Exoskeleton for Hemiparetic Stroke Patients
The aim of this study is to evaluate the effects of an assisted rehabilitation treatment through a robotic exoskeleton device on the functional recovery in a group of patients with hemiparesis from lesion of the first motor…
- Conditions
- Cerebrovascular Accident (CVA), Chronic Disease, Stroke Rehabilitation
- Trial name
- RH-LEXOS (NCT03319992)
- Testing
- Upper Arm Rehabilitation Light Exoskeleton (RH-LEXOS)
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Scuola Superiore di Studi Universitari e di Perfezionamento Sant'Anna
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