Clinical trials: Synaptic Plasticity
Acute Pain, Neuroplasticity
HD-tDCS: Effects on the Somatosensory System
The purpose of this study is to investigate the efficacy of high definition tDCS on different cortical targets in modulating the nociceptive system in the healthy subjects.
- Conditions
- Acute Pain, Neuroplasticity, Brain Modulation, Somatosensory Function
- Trial name
- NCT04165876
- Testing
- Primary Motor Cortex Stimulation, Dorsolateral Prefrontal Cortex Stimulation, Multimodal Stimulation (DLPFC+M1)
- Where
- Denmark
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Parkinson Disease
The Learning Effects of Attentional Strategy on Dual-task Walking in Patients With Parkinson's Disease: Behavioral Performance and Neural Plasticity
[year1] 1. To compare the effects of dual-task training with two different task priority instruction in people with Parkinson's disease and healthy controls on dual-task weight shifting performances. 2.
- Trial name
- NCT03895125
- Testing
- [year1] dual-task training with task priority strategy, [year2-3] dual-task training with internal and external focus
- Where
- Taiwan
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cerebrovascular Stroke
Noninvasive Brain Stimulation to Evaluate Neural Plasticity After Stroke
The purpose of this study is to examine how different areas in the brain interact with each other and how using brain imaging and brain stimulation approaches can influence these interactions.
- Trial name
- NCT02465034
- Testing
- Transcranial Magnetic Stimulation, Traditional Paired Associative Stimulation, Median Nerve Stimulation
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Emory University
Schizophrenia
Cerebral Reorganization in Schizophrenia
The purpose of this study is to reveal the specific effects of computer-aided cognitive training on cerebral reorganization in schizophrenia
- Trial name
- NCT01781000
- Testing
- Brain Fitness & Brain Training- Posit Science, Facial Affect Training- FAT, Treatment as usual
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Konstanz
Neuronal Plasticity
Simultaneous PET/MR Imaging of Human Brain Plasticity
Background: Neuronal plasticity is the brain's ability to continuously adapt to experiences and learning of new skills. Although this affects multiple characteristics of the brain such as structure, function and metabolism…
- Trial name
- NCT03485066
- Testing
- Tetris
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rupert Lanzenberger
Dyslexia, Aging Problems
Neuroplasticity of Multisensory Cortical Areas Induced by Musical Training: a Translational Approach (MusicPlast)
Exploiting recent methodological advancements, several neuroimaging studies suggested that multisensory integration emerges from a dynamic interplay of distributed regions operating in large-scale networks.
- Trial name
- MusicPlast (NCT03786185)
- Testing
- MusicPlast, MusicPlast Control
- Where
- Greece
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Stroke
Potentiation of Procedural Motor Learning in Health and Disease
The investigators plan to improve the learning of motor skills by pharmacological means (dopamine), and by noninvasive brain stimulation. They will study both healthy subjects and chronic stroke patients.
- Trial name
- NCT00126087
- Testing
- dopamine
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Spinal Cord Injuries
Spinal Cord Stimulation and Training
This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of…
- Trial name
- NCT05472584
- Testing
- Electrophysiology assessment - corticospinal tract, Electrophysiology assessment - reticulospinal tract, Electrophysiology assessment - spinal motoneuron
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Synaptic Plasticity
Roflumilast TMS-EEG Plasticity
Repetitive transcranial magnetic stimulation (rTMS) uses a magnetic field to non-invasively induce electrical function within the brain.
- Trial name
- NCT04369547
- Testing
- Transcranial Magnetic Stimulation, Roflumilast
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Calgary
Major Depressive Disorder
Impact of an Eight Week Exercise Intervention in Treating Major Depressive Disorder
To investigate the impact of a structured eight week exercise intervention as an add-on therapy in treating Major Depressive Disorder.
- Trial name
- NCT03191994
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Ontario Institute of Technology
Health Adult Subjects
Prefrontal Neuroplasticity and Coping Strategies in Healthy Population
The current study serves as a pilot for the GRF project "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS." The project examines whether intermittent theta-burst stimulation (iTBS)…
- Trial name
- NCT07433829
- Testing
- Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Morphine, Itch
A Relation of Morphine-induced Itch and Pain Processing
In This experiment, the investigators would like to test the two following hypotheses regarding the mechanisms by which opioids cause itch: 1.
- Trial name
- NCT04115462
- Testing
- Morphine, Histamine, Cowhage (Mucuna Pruriens)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Postural Balance, Neuronal Plasticity
Effect of Balance Training on White Matter Tracts in Healthy Elderly Population
Balance impairment increases the risk of falling and is associated with a fear of falling and immobility. Balance impairment can ultimately affect the morbidity of cardiovascular disease, cognitive impairment, and mortality…
- Conditions
- Postural Balance, Neuronal Plasticity, Elderly Population
- Trial name
- NCT05539690
- Testing
- Balance training
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
ACL Injury
Neuroplasticity Associated With Anterior Cruciate Ligament Injury
Activation of the brain for knee movement changes after anterior cruciate ligament (ACL) reconstruction. The brain activation profile after ACL reconstruction indicates a shift to a visual-motor control strategy, as opposed to a…
- Trial name
- NCT03654495
- Testing
- Exergame training, Usual Care Training
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Stroke
Exercise and Genotype in Sub-acute Stroke
This study will investigate the impact of cardiovascular exercise on brain plasticity among patients in sub-acute stages after stroke, and whether genotype modulates the response to this intervention.
- Trial name
- NCT05076747
- Testing
- Cardiovascular training, Standard Therapy
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- McGill University
Healthy
Effects of LSD on Neuroplasticity in Healthy Subjects
Neuroplasticity is the brain's ability to reorganize itself and adapt in response to changing environmental conditions or pathological stimuli.
- Trial name
- NCT05177419
- Testing
- Lysergic Acid Diethylamide
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Healthy Controls
Serotonin and Motor Plasticity
With this study, the investigators aim to test whether acute administration of selective serotonin reuptake inhibitors (SSRI) improves motor performance in a sequential motor learning task in comparison to placebo in healthy…
- Trial name
- NCT03162185
- Testing
- Escitalopram
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
Old Age; Dementia, Aging
Compensatory Brain Activity in Older Adults.
There are two important aspects in which the present project will allow to enrich our understanding of compensatory brain activity in older adults.
- Conditions
- Old Age; Dementia, Aging, Cognitive Decline
- Trial name
- BrainAct (NCT06235840)
- Testing
- working memory adaptive training, multi-domain non-adaptive control training
- Where
- Poland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Kazimierz Wielki University
Healthy Volunteers, General Anaesthesia
Neuroplasticity Induced by General Anaesthesia
The aim of this study is to use magnetic resonance imaging to explore and compare possible de novo neuroplastic changes induced by the isolated effects of the hypnotic agents sevoflurane and propofol, respectively.
- Conditions
- Healthy Volunteers, General Anaesthesia, Neuroplasticity
- Trial name
- DANA1 (NCT04125121)
- Testing
- Sevoflurane-propofol
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Signe Sloth Madsen
Motor Learning, Aging
OPTIMAL Motor Learning in Table Tennis: A fNIRS Study
This study investigates how OPTIMAL theory influences table tennis backhand learning in young, healthy older, and mild cognitively impaired older adults.
- Conditions
- Motor Learning, Aging, Coginitive Dysfunction
- Trial name
- NCT07914608
- Testing
- OPTIMAL theory-based Instruction, Conventional Instruction (Control)
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University