Clinical trials: Synaptic Plasticity
Schizophrenia
Glutamate, Learning, and Working Memory
Impairments in plasticity and working memory in schizophrenia have been hypothesized to reflect dysfunction at the N-methyl-D-aspartate glutamate receptor (NMDAR).
- Trial name
- NCT02769936
- Testing
- D-cycloserine
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Stroke, Chronic, Aging
AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions
The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors.
- Conditions
- Stroke, Chronic, Aging, Cognitive Decline, Motor Dysfunction
- Trial name
- AMPLIFI (NCT06950060)
- Testing
- High intensity cycling, Low-intensity cycling, Health education session
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Depression, Healthy
Comparison of Measures of Plasticity
Neuroplasticity refers to the ability of the nerve cells to modify their structure or function in response to injury or insult, or other environmental stimuli, with these changes outlasting the period of exposure.
- Trial name
- NCT01317303
- Testing
- cTBS-PAS25, cTBS-iTBS, PAS25
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales
Healthy Young Adults
iTBS Effect on M1 Plasticity, Blood Glucose, and Cardiovascular Response
Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols.
- Trial name
- NCT06043076
- Testing
- TMS
- Where
- Malaysia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Mild Cognitive Impairment
Vision-based Speed of Processing Cognitive Training and Mild Cognitive Impairment
This project seeks to identify neural changes that occur in adults with mild cognitive impairment (MCI) after engagement in computerized cognitive training.
- Trial name
- NCT02559063
- Testing
- Vision-based speed of processing training, Mental leisure activities
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Cortical Excitability, Healthy
Assessing the Effects of Hormones on Noninvasive Transcranial Stimulation
This study is investigating how two types of non-invasive brain stimulation, transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS), affect brain activity, and whether combining them produces…
- Conditions
- Cortical Excitability, Healthy, TMS, Menstrual Cycle
- Trial name
- NCT07635017
- Testing
- Transcranial Electrical Stimulation, Transcranial Magnetic Stimulation, TES + TMS
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Carnegie Mellon University
Amelia of Upper Limb
Computer-aided and Mental Trainings Induced Plasticity of Sensorimotor Cortex in Patients Born Without Upper Limbs
This project will explore a potentially powerful trainings that may be administered before upper extremity transplantation to induced plasticity of sensorimotor cortex in humans with congenital absence of upper limbs.
- Trial name
- NCT04048083
- Testing
- Mental trainings, Computer-aided trainings, Computer-aided and mental trainings
- Where
- Poland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Sedentary Behavior
Cognition and Neuroplasticity Sedentary Adults After 8 Weeks of Aerobic Exercise
The overall goal of the proposed study is to evaluate the effects of an 8-week aerobic exercise program on cognition and determine the relationship between cognitive improvements and Transcranial Magnetic Stimulation (TMS)…
- Trial name
- NCT03804528
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Miami
Brain Function, Cerebral Palsy
7T Anatomo-functional Characterization of Structures in the Action Observation Network
The goal of this study is to explore the anatomical-functional characteristics of the AON circuit (with particular interest for subcortical areas and the cerebellum), and the cortico-subcortical connectivity of the nodes of the…
- Trial name
- 7T-ATHENA (NCT06826287)
- Testing
- 7T MR exam, clinical assessment
- Where
- 2 sites in Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Healthy
Assessing the Stability of Transcranial Magnetic Stimulation Plasticity Responses
The overall goal of this proposed study is to assess the reliability of plasticity measured by transcranial magnetic stimulation (TMS) interleaved with intermittent theta-burst stimulation plasticity measures and to assess the…
- Trial name
- NCT03034629
- Testing
- Short-term aerobic exercise
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Miami
Depression
Modulation of Visually Evoked Potentials by an Antidepressant
12 normal healthy controls will be treated with 50 mg sertraline once daily for three weeks. Early amplitudes of visually evoked potentials will be examined at day 0, 10 and 21 and statistically compared.
- Trial name
- NCT00263133
- Testing
- Sertraline
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital Freiburg
Cognitive Health, Healthy Aging
Successful Aging and Enrichment (SAGE)
Progress has been made in understanding the impact of different kinds of structured intervention programs in improving cognitive processing and performance in older adults, and in determining whether there is electrophysiological…
- Trial name
- SAGE (NCT05128396)
- Testing
- Cognitive Stimulation, Mindfulness training, Physical Activity
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Stroke With Hemiparesis
Transfer of Grasp Control Across Hands After Stroke
The purpose of this study is to examine if the strong hand can assist in the recovery of muscle function in the weak hand after a stroke.
- Trial name
- NCT00589368
- Testing
- Transfer of grasp control across hands
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Aging Hands
Neural Substrates Underlying Adaptations in Manual Dexterity of Older Adults
Age-related declines in motor function can compromise independence and quality of life. This project examines how practice and somatosensory stimulation reshape the neural control of hand muscles in older adults, leveraging…
- Trial name
- NCT07011160
- Testing
- Transcutaneous electrical nerve stimulation (TENS), Familiarization
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Delirium
Perioperative Cognitive Protection - Cognitive Exercise and Cognitive Reserve (The Neurobics Trial)
Many individuals experience an acute change in thinking and reasoning skills after surgery. This is called post-operative delirium (PD). PD symptoms typically start 1-3 days after surgery.
- Trial name
- NCT02230605
- Testing
- Mini-Mental State Examination, Self-Administered Gerocognitive Examination, Geriatric Depression Scale
- Where
- United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Healthy Young Adult, Neurophysiology
Motor Cortex Plasticity Response to Theta-Burst Stimulation After Ketone Monoester Supplementation
Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols.
- Trial name
- KME-TBS (NCT06799260)
- Testing
- Ketone Monoester (KME), iTBS, cTBS
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Healthy
Efficacy and Safety of Acute Topical and Aromatic Essential Oil-Based Products for Cognitive Support
This study will evaluate whether the InTune product system may help support attention, memory, focus, and other thinking skills in healthy adults ages 18-64.
- Trial name
- ITS (NCT07623811)
- Testing
- Cognitive Support System
- Where
- United States
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- dōTERRA International
Alzheimer's Disease
Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin
Background: Normal aging, as well as dementias such as Alzheimer s disease, can cause changes in the brain that affect memory, attention, and thinking.
- Trial name
- NCT07721467
- Testing
- Psilocybin, Cognitive Training
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Schizophrenia
Effects of Acute Nicotine Treatment on Neuroplasticity and Memory in Patients With Schizophrenia
Patients with schizophrenia display cognitive impairments, such as reduced attention and problems with memory. Available medications for schizophrenia poorly alleviate memory problems however, research indicates that nicotine…
- Trial name
- NIC-PAS (NCT01465074)
- Testing
- Nicotine polacrilex, Regular chewing gum; Dentyne Ice, Wrigely´s Mint Gum
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Cognitive Impairment, Bipolar Disorder
Effects of Altitude-like Cognition Training on Neuroplasticity and Cognitive Functions
The goal of this clinical trial is to investigate the effects of a three-week altitude-like cognition training intervention in healthy individuals (substudy 1) and symptomatically stable patients with mood disorders (depression…
- Conditions
- Cognitive Impairment, Bipolar Disorder, Depression
- Trial name
- ALTIBRAIN (NCT06121206)
- Testing
- Altitude-like hypoxia (12% O2), Normoxia (20% O2), Cognitive training
- Where
- Denmark
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital