Clinical trials: Syncope and Collapse
Autonomic Nervous System Diseases
PET Scan in Patients With Neurocardiologic Disorders
This study is designed to use PET scans in order to measure activity of the sympathetic nervous system. The sympathetic nervous system is the portion of the nervous system that maintains a normal supply of blood and fuel to…
- Trial name
- NCT00001418
- Where
- United States
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
We and others have shown that many younger patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have orthostatic intolerance (OI), i.e., they can't tolerate prolonged standing.
- Conditions
- Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Systemic Exertion Intolerance Disease (SEID), Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT02854683
- Testing
- Normal Saline, Oral Rehydration Solution
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Syncope
Evaluation of Chronic Orthostatic Intolerance
This study will conduct tests with patients with primary chronic orthostatic intolerance (COI) to learn more about this disorder of the autonomic nervous system.
- Trial name
- NCT00069693
- Where
- 3 sites in United States, Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Ventricular Ejection Fraction, LVF
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF)…
- Conditions
- Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement
- Trial name
- EFACT (NCT06699056)
- Testing
- 15-minutes of sitting during COR ECG Acquistion
- Where
- 8 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Cardiovascular Diseases, Cardiovascular Diseases Risk
Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways
Cor360 is an observational study evaluating whether extended wearable electrocardiogram (ECG) data can support broad-spectrum cardiac phenotyping and risk assessment beyond conventional single-purpose ambulatory rhythm…
- Conditions
- Cardiovascular Diseases, Cardiovascular Diseases Risk, Cardiac Conduction System Disease, Bundle/Fascicular Abnormalities
- Trial name
- Cor360 (NCT07775976)
- Testing
- COR Wearable ECG Monitoring, Cor360 Clinician-Facing Decision-Aid Reporting
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Syncope
Heat Stress and Volume Administration
Heat stress reduces the central blood volume and causes orthostatic intolerance. The hypothesis is that infusion of volume may reduce effects of orthostatic stress during heat stress.
- Trial name
- NCT00714766
- Testing
- Intravascular volume administration
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Fainting, Presyncope
Evaluation of the Efficiency of Hydration by Isotonic Solution in the Prevent of the Fainting Whole Blood Donors
Blood donation is a generous act carried out by healthy male and female volunteer donors. The safety of blood donation in France is based on rigorous well documented biological and medical criteria, in particular concerning the…
- Conditions
- Fainting, Presyncope, Syncopal Episode
- Trial name
- EVASION (NCT02075099)
- Testing
- tensing exercises, No tensing exercises
- Where
- 2 sites in France
- Volunteers
- 4,825 people, healthy volunteers welcome
- Sponsor
- Etablissement Français du Sang
Presyncope, Syncope
Oral Water Hydration to Prevent Post-Vaccination Presyncope
This is a randomized controlled open-label trial. During the study, adolescents and young adults scheduled to receive at least one intra-muscular (IM) vaccine will receive either oral water hydration in addition to standard care…
- Trial name
- NCT02353390
- Testing
- Oral Water Hydration
- Where
- 2 sites in United States
- Volunteers
- 1,820 people, healthy volunteers welcome
- Sponsor
- Duke University
Atrial Fibrillation, Syncope
LUX-Dx Insertable Cardiac Monitor Remote Programming and Performance Study
The LUX-Dx PERFORM Study had two primary objects which were (1) to characterize, in a general patient population, the utilization of the remote programming feature of the Boston Scientific (BSC) Insertable Cardiac Monitor (ICM)…
- Conditions
- Atrial Fibrillation, Syncope, Cryptogenic Stroke
- Trial name
- LUX-Dx PERFORM (NCT04732728)
- Where
- 24 sites in United States
- Volunteers
- 727 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Vasovagal Syncope (VVS), Presyncope
A Warning Red Flag Classification System to Predict Risk of Vasovagal Event During Office Hysteroscopy
The goal of this pilot cross sectional study is to identify participants at risk of vasovagal reaction/syncope(VVR/VVS) during office hysteroscopy.
- Trial name
- FLAG-VS (NCT07030218)
- Testing
- Office hysteroscopy
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tanvir Hospital
Healthy Amateur Divers
Effects of Voluntary Neck Extension on Cerebral Blood Flow, in Breath-hold Divers Ending an Apnoea of Two Minutes or More.
The aim of this study is to demonstrate the effect of the voluntary neck extension in the occurrence of an increase in the pulsatility index of the right internal carotid artery in the amateur diver, realizing an apnea of two…
- Trial name
- APNECK (NCT03210857)
- Testing
- apnea performing
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Asthma, Syncope
Vagal Nerve Stimulation Assessed by the Diving Reflex: An Investigation Into Mechanisms of Asthma Death
The investigators' hypothesis is that dysregulation of autonomic function, as revealed during a simulated dive reflex, may result in an attenuation of the heart rate response to a greater degree in asthmatics who collapse during…
- Trial name
- NCT02083029
- Testing
- Simulated dive reflex
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Syncope, Vasovagal
Cardioneuroablation for Reflex Syncope and Exercise Capacity
Cardioneuroablation (CNA) is a new promising method to treat reflex syncope which is due to vagally-induced functional sinus arrest or atrio-ventricular block (AVB).
- Trial name
- Roman3 (NCT06440291)
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre of Postgraduate Medical Education
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Orthostatic Hypotension, Syncope
The Effect of Water Carbonation on Orthostatic Tolerance
The primary purpose of this investigation is to determine whether water carbonation can improve orthostatic tolerance in healthy control volunteers.
- Conditions
- Orthostatic Hypotension, Syncope, Vasovagal Syncope
- Trial name
- NCT05621460
- Testing
- 500mL carbonated water, 500mL still water, 50mL still water
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Cardiac Arrhythmia, Syncope
Comparative Study of the Sternal Patch System With a Conventional Holter Recorder
This study will be a comparison of two externally worn recording systems for documentation of cardiac arrhythmias in symptomatic patients or patients at risk for arrhythmia.
- Trial name
- NCT04241692
- Testing
- CarnationTM Ambulatory Monitoring Sternal ECG Patch System, Conventional 24-Hour 7 Lead Holter Monitor Recorder
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Drug Resistant Epilepsy, Drop Seizures
Novel Helmet Design in Patients With Seizures
This is a two-part study that aims to determine the reliability and safety of the use of the Hövding inflatable helmet in seizures, as evidenced by the deployment of the helmet during seizures, and qualitative patient reporting.
- Conditions
- Drug Resistant Epilepsy, Drop Seizures, Generalized Tonic Clonic Seizure, Complex Partial Seizure
- Trial name
- NCT03443388
- Testing
- Hövding inflatable helmet
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Michael A. Gelfand, MD, PhD
Syncope
Autonomous Syncope Onset Prediction and Prevention
syncope prediction on tilt table
- Trial name
- NCT02684539
- Testing
- tilt table Erigo®
- Volunteers
- healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Postural Tachycardia Syndrome (POTS), Vasovagal Syncope (VVS)
Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Vasovagal Syncope (VVS)
Vasovagal syncope (VVS, simple faint) is the most common cause of transient loss of consciousness and represents the acute episodic form of orthostatic intolerance (OI).
- Conditions
- Postural Tachycardia Syndrome (POTS), Vasovagal Syncope (VVS), Fainting
- Trial name
- NCT02558972
- Testing
- Northera (Droxidopa)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- New York Medical College