Clinical trials: Synovitis of Knee
Synovial Diseases, Pigmented Villonodular Synovitis
Clinical Study of Magnetic Resonance Imaging and Deep Learning of Joint Synovial Disease
Through the high-throughput feature extraction of magnetic resonance images, the deep learning prediction model of joint synovial lesions is constructed used for the diagnosis, differential diagnosis and curative effect…
- Conditions
- Synovial Diseases, Pigmented Villonodular Synovitis, Gout, Rheumatoid Arthritis
- Trial name
- NCT04952896
- Testing
- Synovitis diagnosis
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Peking University Third Hospital
Osteoarthritis, Knee
Synovitis in Patients With Osteoarthritis
To study synovial membrane (SM) inflammation in suprapatellar fossa in advanced knee osteoarthritis (OA), and to correlate the pathological features with clinical findings.
- Trial name
- NCT05617573
- Testing
- Total knee arthroplasty due to advanced osteoarthritis.
- Where
- China
- Volunteers
- 272 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Knee Osteoarthritis, Medial Compartment Knee Osteoarthritis
A Study Evaluating the Safety, Efficacy, and Pharmacodynamic Effects of ABT-981 in Patients With Knee Osteoarthritis
A Phase 2a, multicenter, randomized, double-blind, parallel group, placebo-controlled study to evaluate the safety, tolerability, efficacy and pharmacokinetic/pharmacodynamic effect of ABT-981 in patients with symptomatic…
- Trial name
- NCT02087904
- Testing
- ABT-981
- Volunteers
- 350 people
- Sponsor
- AbbVie
Bursitis, Tendinitis
Efficacy and Safety of Etoricoxib/Betamethasone Combination in Acute Bursitis, Tendinitis and Synovitis
Phase III, multicenter, prospective, randomized, double-blind, parallel-group study to evaluate the efficacy and safety of a fixed-dose combination of etoricoxib/betamethasone compared with etoricoxib alone in patients with an…
- Conditions
- Bursitis, Tendinitis, Synovitis
- Trial name
- NCT07328022
- Testing
- Fixed Dose Etoricoxib + Betamethasone, Monotherapy Etoricoxib
- Where
- Mexico
- Volunteers
- 89 people
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Knee Osteoarthritis, Synovitis of Knee
A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis
This phase 2a trial is an international, multicenter, randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of one single intra-articular (IA) injection of 4P004 or placebo in: patients between…
- Trial name
- INFLAM MOTION (NCT07225829)
- Testing
- 4P004
- Where
- 22 sites in United States, Canada and 4 more
- Volunteers
- 130 people
- Sponsor
- 4Moving Biotech
Knee Osteoarthritis
Lipogems Prospective Study
The purpose of this study is to study the clinical outcomes and effects of the injection of fat-derived stem cells (the scientific name being "adipose derived autologous stem cell transplantation (ADAT)") as an addition to knee…
- Trial name
- NCT03922490
- Testing
- Lipogems Device PLUS debridement, Debridement only
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Hospital for Special Surgery, New York
Knee Osteoarthritis
Early Weight Bearing After Open Wedge High Tibial Osteotomy (OWHTO), Is it Worth?
The aim of our study is to evaluate the effect of early weight bearing after OWHTO on pain, function and return to normal lifestyle activity.
- Trial name
- NCT07583264
- Testing
- Early weight bearing post operative, Non weight bearing Post-operative
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Assiut University
Synovitis of Knee, Osteoarthritis, Knee
The Role of Synovitis in Osteoarthritis
To determine whether platelet-rich-plasma (PRP) or HA (hyaluronic acid)injection into synovitis in osteoarthritis(OA) knee can achieve improvement in knee function and reduce synovitis.
- Trial name
- NCT03167333
- Testing
- platelet rich plasma, Hyaluronic acid
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Knee Pain Chronic, Synovitis of Knee
Light Therapy on Pain and Synovitis
Background: Knee pain is a common complaint among middle-aged and older adults, often leading to reduced mobility and diminished quality of life.
- Conditions
- Knee Pain Chronic, Synovitis of Knee, Light Therapy
- Trial name
- NCT07057063
- Testing
- 810 nm Light Therapy
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 80 people
- Sponsor
- The Hong Kong Polytechnic University
Synovitis, Osteoarthritis
Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee
The purpose of this study is to determine the effect of a chondroitin sulphate conventional treatment on the degree of severity of synovitis, as measured by magnetic resonance in patients with knee OA with clinical synovitis.
- Conditions
- Synovitis, Osteoarthritis, Joint Diseases, Muskuloskeletal Diseases
- Trial name
- NCT00604539
- Testing
- Chondroitin sulphate (Condrosan)
- Where
- 4 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Bioiberica
Persistent Knee Joint Synovitis
Evaluation of The Efficacy And Safety of Intra-Articular Etanercept in Patients With Refractory Knee Joint Synovitis
To assess the therapeutic efficacy, of the clinical response of intraarticular (IA) etanercept (E) 12.5 mg or placebo (P: NaCl) injections into single knee arthritic joint of patients with refractory knee joint synovitis (KJS)…
- Trial name
- NCT00678782
- Testing
- etanercept
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- University of Padova
Osteoarthritis, Knee, Osteoarthritis, Hip
Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee
In this work the investigators will study the relationship between chronic musculoskeletal pain and abnormal blood flow (neovascularity) around the shoulder, hip and knee.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Osteo Arthritis Shoulders, Synovitis of Knee
- Trial name
- MRI (NCT05700682)
- Testing
- Shoulder/Hip/Knee Embolization with Embozene Microspheres
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Palo Alto Veterans Institute for Research
Knee Osteoarthritis, Effusion Synovial
Methotrexate in the Treatment of Advanced Knee Osteoarthritis With Effusion-synovitis
This multicentre randomized placebo-controlled clinical trial aims to evaluate whether methotrexate (MTX) has effects of relieving symptoms and reducing inflammation on advanced knee osteoarthritis (OA) with inflammatory…
- Conditions
- Knee Osteoarthritis, Effusion Synovial, Knee Pain
- Trial name
- NCT03815448
- Testing
- Methotrexate
- Where
- 11 sites in China
- Volunteers
- 215 people
- Sponsor
- Zhujiang Hospital
Knee Osteoarthritis, Knee Injuries
Dronabinol After Arthroscopic Surgery
The purpose of the proposed study is to evaluate the efficacy of dronabinol for postoperative pain after arthroscopic surgery of the knee.
- Conditions
- Knee Osteoarthritis, Knee Injuries, Meniscus Tear, Synovitis of Knee
- Trial name
- NCT05335252
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis (PVNS)
An Open-Label Study of Intra-articular AMB-05X Injections in Subjects With Tenosynovial Giant Cell Tumor of the Knee
AMB-051-01 is a multicenter study with an adaptive design that will enroll subjects with Tenosynovial Giant Cell Tumor (TGCT) of the knee for 12 weeks of multiple-dose, open-label treatment with intra-articular AMB-05X.
- Trial name
- NCT04731675
- Testing
- AMB-05X
- Where
- 6 sites in United States, Netherlands and 2 more
- Volunteers
- 11 people
- Sponsor
- AmMax Bio, Inc.
Arthritis of the Knee
Dosing of Intra-articular Triamcinolone Hexacetonide for Knee Synovitis in Chronic Polyarthritis
This prospective randomised controlled single blind trial comparing the relapse rate in 6 months for 20 mg versus 40 mg intraarticular triamcinolone hexacetonide (Lederspan®) for knee synovitis in patients with rheumatoid…
- Trial name
- NCT02437461
- Testing
- Triamcinolone hexacetonide
- Where
- Sweden
- Volunteers
- 159 people
- Sponsor
- Uppsala University
Osteo Arthritis of the Knee, Synovitis of Knee
Role of Methotrexate in Ultrasound Proven Synovitis in Primary Knee OA
Background: Osteoarthritis (OA) is a leading cause of disability worldwide, with limited treatment options and many patients suffering from chronic pain.
- Conditions
- Osteo Arthritis of the Knee, Synovitis of Knee, Methotrexate
- Trial name
- MTX in knee OA (NCT07161336)
- Testing
- Methotrexate (MTX)
- Where
- Bangladesh
- Volunteers
- 70 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh