Clinical trials: System Lupus Erythematosus
Lupus Nephritis
Obe-cel in Severe, Refractory Systemic Lupus Erythematosus (SLE) With Active Lupus Nephritis (LN)
The purpose of this trial is to evaluate the efficacy and safety of obecabtagene autoleucel (obe-cel) administered once following lymphodepletion in participants with severe, refractory systemic lupus erythematosus (SLE) and…
- Trial name
- LUMINA (NCT07053800)
- Testing
- Obecabtagene autoleucel
- Where
- 16 sites in United States, Brazil and 3 more
- Volunteers
- 35 people
- Sponsor
- Autolus Limited
Lupus Erythematosus, Systemic
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of E6742 in Systemic Lupus Erythematosus Participants
The primary purpose of the study is to evaluate the safety and tolerability of multiple oral doses of E6742 in participants with systemic lupus erythematosus (SLE).
- Trial name
- NCT05278663
- Testing
- E6742
- Where
- 12 sites in Japan
- Volunteers
- 26 people
- Sponsor
- Eisai Co., Ltd.
Lupus, Dermatomyositis, Juvenile
Teams Engaged in Accessible Mental Health Interventions for Lupus Erythematosus and Dermatomyositis Stress
The objectives of this study are to determine if the 'Teams Engaged in Accessible Mental Health Interventions for Lupus Erythematosus and Dermatomyositis Stress' (TEAM-LEADS) intervention is feasible and acceptable to adolescents…
- Conditions
- Lupus, Dermatomyositis, Juvenile, Dermatomyositis, Lupus Erythematosus
- Trial name
- TEAM-LEADS (NCT06999109)
- Testing
- TEAM-LEADS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Systemic Lupus Erythematosus
Anti KU Antibodies and Its Relationship With Systemic Lupus Erythematosus
systemic lupus Erythematosus (SLE) is a multi system autoimmune disorder abroad spectrum of clinical presentations. Diagnosis of SLE depending on Systemic Lupus International Collaborating Clinics (SLICC) Criteria.
- Trial name
- NCT05900232
- Testing
- Anti _KU antibodies
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Systemic Lupus Erythematosus (SLE)
F182112 Phase Ib Clinical Study for the Treatment of Patients With Systemic Lupus Erythematosus
The investigational drug is an injectable recombinant humanized anti-BCMA/CD3 bispecific antibody (code: F182112) that can simultaneously target the immune effector cell antigen CD3 and the antigen BCMA.
- Trial name
- NCT07829614
- Testing
- F182112
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Lupus Erythematosus, Systemic, Lupus Glomerulonephritis
Mesenchymal Stromal Cells (MSC´s) in Renal Lupus
Phase II Clinical Trial to Assess the dose-response and Efficacy of Umbilical Cord-derived Mesenchymal Stromal Cells (MSCs) in Severe Renal Systemic Lupus Erythematosus (SLE).
- Trial name
- MSC-ROLE (NCT03917797)
- Testing
- MSC treatment, Standard of Care
- Where
- 2 sites in Chile
- Volunteers
- 39 people
- Sponsor
- Universidad de los Andes, Chile
Systemic Lupus Erythematosus
A Prospective, Single Arm, Open Label, Proof of Concept Clinical Study of Sulfasalazine in the Treatment of Active Systemic Lupus Erythematosus
The goal of this clinical trial is to learn if sulfasalazine is safe and feasible in the treatment of active lupus erythematosus (SLE).
- Trial name
- NCT06360068
- Testing
- Sulfasalazine Tablets
- Volunteers
- 20 people
- Sponsor
- Qiong Fu
Sjögren's Syndrome, Systemic Lupus Erythematosus
Objective Measurement Methods for Autoimmune Disease and Dry Eye Syndrome
To explore the association among TCM pattern, TCM tongue diagnosis and TCM pulse diagnosis for Autoimmune disease and Dry eye syndrome
- Conditions
- Sjögren's Syndrome, Systemic Lupus Erythematosus, Rheumatoid Arthritis, Systemic Sclerosis
- Trial name
- NCT03937271
- Testing
- Traditional Chinese Medicine pattern, Traditional Chinese Medicine tongue diagnosis, Traditional Chinese Medicine pulse diagnosis
- Where
- Taiwan
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Complication in Systemic Lupus Erythematosus
Long Non Coding RNA in Complications of Systemic Lupus
the precise role of RNA in setting of this complication in systemic lupus erythematosus (SLE) is largely unknown
- Trial name
- NCT03185767
- Testing
- blood sampling
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Systemic Lupus Erythematosus
A Study Evaluating the Effects of GLPG3970 Given as Oral Treatment for 12 Weeks in Adults With Systemic Lupus Erythematosus
This is a first exploration of GLPG3970 in subjects with active systemic lupus erythematosus (SLE) to evaluate the effect on disease biomarkers and to determine its pharmacokinetics (PK) profile, safety and tolerability, and…
- Trial name
- TAPINOMA (NCT04700267)
- Testing
- GLPG3970 film-coated tablet
- Where
- 14 sites in Bulgaria, Moldova and 3 more
- Volunteers
- 11 people
- Sponsor
- Lakefront Biotherapeutics NV
Systemic Lupus Erythematosus
A Pilot Study of CC-220 to Treat Systemic Lupus Erythematosus.
The purpose of this study is to determine whether CC-220 is effective for the treatment of skin, joint and serological manifestations of systemic lupus erythematosus.
- Trial name
- NCT02185040
- Testing
- CC-220
- Where
- 35 sites in United States
- Volunteers
- 42 people
- Sponsor
- Celgene
Systemic Lupus Erythematosus
Low-dose IL-2( Interleukin-2) Treatment in SLE
This clinical study will test the efficacy and safety of low dose IL-2 treatment in Systemic lupus erythematosus.
- Trial name
- NCT02084238
- Testing
- Interleukin-2
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
Systemic Lupus Erythematosus
A Study of Baricitinib in Participants With Systemic Lupus Erythematosus (SLE)
The reason for this long term study is to see how safe and effective the study drug known as baricitinib is in participants with systemic lupus erythematosus (SLE) who have completed the final treatment visit of study I4V-MC-JAHZ…
- Trial name
- SLE-BRAVE-X (NCT03843125)
- Testing
- Baricitinib
- Where
- 297 sites in United States, Argentina and 30 more
- Volunteers
- 1,147 people
- Sponsor
- Eli Lilly and Company
Lupus Erythematosus
Prognosis Assessment of the Increase of GADD34 Gene Expression for Patient Suffering From Systemic Lupus Erythematosus
Given that GADD34 has been described as a potential key regulator of pro-inflammatory cytokine production in human and elevated blood marker in SLE patients, this study aim to prove that the GADD34 RNA level in mononuclear blood…
- Trial name
- GADD34-LES (NCT02455089)
- Testing
- GADD34 RNA level measurement.
- Where
- 7 sites in France
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Systemic Lupus Erythematosus
Study of Ultra-Fast CD19 CAR-T Therapy for Refractory SLE
This is an investigator-initiated trial aimed at assessing the safety and efficacy of ultra-fast autologous CD19-targeted CAR-T cells in the treatment of refractory systemic lupus erythematosus.
- Trial name
- NCT07331467
- Testing
- CD19 CAR-T cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Refractory Autoimmune Diseases
A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases
The purpose of this study is to determine the safety, tolerability, optimal dose, and preliminary efficacy of BMS-986515, a healthy donor (HD) allogeneic CD19-targeted CART cell product, in participants with severe, refractory…
- Trial name
- NCT07115745
- Testing
- BMS-986515, Fludarabine, Cyclophosphamide
- Where
- 28 sites in United States, Australia and 8 more
- Volunteers
- 125 people
- Sponsor
- Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
Systemic Lupus Erythematosus
Transcutaneous Vagus Nerve Stimulation for the Treatment of Lupus
This is a 3-month double blinded randomized controlled study of transcutaneous electrical vagus nerve stimulation (tVNS) compared to a sham stimulation for the treatment of patients with active systemic lupus erythematosus (SLE).
- Trial name
- TRUST (NCT02917265)
- Testing
- TENS for vagus stimulation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Aikaterini Thanou
Systemic Lupus Erythematosus
Saphnelo Use in Females of Child-bearing Potential
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by substantial clinical burden-including organ damage, increased morbidity, and mortality-that often presents in young adulthood and…
- Trial name
- PRIMULA DUS (NCT07431775)
- Testing
- Anifrolumab
- Volunteers
- 26,000,000 people
- Sponsor
- AstraZeneca
Lupus Nephritis (LN), ANCA-Associated Glomerulonephritis
MSC303 Subcutaneous Injection for the Treatment of Immunologic Glomerular Disease.
This study will evaluate the safety and efficacy of MSC303 in patients with Immune glomerular diseases.
- Trial name
- MSC303 (NCT07000292)
- Testing
- Injection of MSC303
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Shanghai Changzheng Hospital
Lupus Nephritis
A Study of QLG1074 Combined With Background Therapy in Subjects With Active Lupus Nephritis
The purpose of this study is to assess the efficacy of QL1074 compared with placebo in achieving renal response after 52 weeks of therapy in subjects with Active Lupus Nephritis.
- Trial name
- NCT06406205
- Testing
- Voclosporin（QL1074）
- Where
- 10 sites in China
- Volunteers
- 270 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
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