Clinical trials: System Lupus Erythematosus
Telitacicept, Systemic Lupus Erythematosus
Effect of Telitacicept on Transitional Regulatory B Cells in Patients With Systemic Lupus Erythematosus
The effect of Telitacicept treatment on the changes of transitional regulatory B lymphocyte T1, T2B cell subsets and plasma blasts and the expression levels of cytokines IL-10, IL-35, April and BAFF in SLE.
- Conditions
- Telitacicept, Systemic Lupus Erythematosus, Therapy
- Trial name
- NCT06137053
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Yanfeng Hou
Systemic Lupus Erythematosus
Safety of Estrogens in Lupus: Hormone Replacement Therapy
Safety of Estrogens in Lupus Erythematosus - National Assessment (SELENA) is a study to test whether postmenopausal women with systemic lupus erythematosus (SLE, or lupus) can safely use the hormone estrogen.
- Trial name
- NCT00000419
- Testing
- Premarin and Provera
- Where
- 16 sites in United States
- Volunteers
- 350 people
- Sponsor
- NYU Langone Health
Systemic Lupus Erythematosus (SLE)
GENetic & Immunologic Abnomalies in Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease for which the aetiology includes genet-ic and environmental factors. It is rare in children as compared to adults.
- Trial name
- GENIAL (NCT01992666)
- Testing
- Blood sampling
- Where
- 26 sites in France
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Macrophage Activation Syndrome, Secondary Hemophagocytic Lymphohistiocytosis
Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE
The purpose of this study is to assess the safety, tolerability and efficacy of emapalumab in children and adults with macrophage activation syndrome (sHLH/MAS) in Still's disease (including systemic juvenile idiopathic arthritis…
- Conditions
- Macrophage Activation Syndrome, Secondary Hemophagocytic Lymphohistiocytosis, Still Disease, Systemic Lupus Erythematosus
- Trial name
- EMERALD (NCT05001737)
- Testing
- Emapalumab
- Where
- 44 sites in United States, Belgium and 11 more
- Volunteers
- 33 people
- Sponsor
- Swedish Orphan Biovitrum
Lupus Nephritis
Fibroblast Activating Protein Inhibitor PET Imaging in Lupus Nephritis
Abnormal high expression of fibroblast activating protein (FAP) has been found in inflammatory reactions and benign fibrosis tissue.
- Trial name
- NCT05845151
- Testing
- 68Ga-FAPI-04 PET
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ruijin Hospital
Systemic Lupus Erythematosus With or Without Clinical Activity
Anti-nucleosome B Lymphocytes in Lupus
Lupus disease is characterized by the production of pathogenic autoantibodies, which participate in end-organ damages. The phenotype of B cells producing the pathogenic autoantibodies in lupus patients is today unknown.
- Trial name
- NCT01889654
- Testing
- Venous blood sampling
- Where
- France
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Systemic Lupus Erythematosus
Screening Biomarkers for Severe Lupus Based on Multi-omics Studies
In order to achieve accurate diagnosis and treatment of the disease, we performed RNA sequencing and ATAC(Assay for Transposase Accessible Chromatin) chromatin open sequencing in lupus patients in the early stage.
- Trial name
- NCT05539001
- Where
- China
- Volunteers
- 152 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Lupus Erythematosus
Longitudinal Study of Quality of Life and Activity in Systemic Lupus Erythematosus
Systemic lupus erythematosus is a complex disease whose evaluation in everyday practice and in clinical research requires several aspects to be taken into account, in particular the impact of disease activity on quality of life.
- Trial name
- EQUAL (NCT01904812)
- Testing
- Questionnaire about quality of life and satisfaction
- Where
- France
- Volunteers
- 356 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Adolescent Lupus Nephritis, Pediatric Lupus Nephritis
Long-Term Voclosporin Treatment in Adolescent and Pediatric Subjects With Lupus Nephritis
The purpose of this study is to assess the long-term safety and tolerability of voclosporin for up to an additional 12 months following completion of treatment in the AUR-VCS-2020-03 study (VOCAL) in adolescent and pediatric…
- Trial name
- VOCAL-EXT (NCT05962788)
- Testing
- voclosporin
- Where
- 6 sites in United States, Colombia and 3 more
- Volunteers
- 4 people
- Sponsor
- Aurinia Pharmaceuticals Inc.
Systemic Lupus Erythematosus, Sjogren's Syndrome
Clinical Performance of BioCLIA Ro60
The study is to evaluate the clinical performance of BioCLIA Ro60 for measuring the autoantibody in autoimmune disease patients.
- Trial name
- NCT03204448
- Testing
- BioCLIA Ro60
- Where
- United States
- Sponsor
- HOB Biotech Group
Systemic Lupus Erythematosus, Antiphospholipid Antibody Syndrome
Pilot Study of Cyclophosphamide in Patients With Life-Threatening Systemic Lupus Erythematosus or Antiphospholipid Antibody Syndrome
OBJECTIVES: I. Determine the induction of durable remission in patients with life-threatening systemic lupus erythematosus or antiphospholipid antibody syndrome treated with cyclophosphamide. II.
- Trial name
- NCT00010400
- Testing
- Cyclophosphamide, filgrastim
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University
Systemic Lupus Erythematosus (SLE)
A Study of CAR-T Cells in Subjects With Systemic Lupus Erythematosus
The purpose of this study is to assess the safety and efficacy of CAR-T cell therapy in Subjects with SLE.
- Trial name
- NCT06900764
- Testing
- CAR-T cell
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Systemic Lupus Erythematosus
An Open Label Study to Evaluate Daratumumab in Participants With Moderate to Severe Systemic Lupus Erythematosus
This is a monocenter, open-label Phase II trial for refractory SLE patients currently on stable background immunosuppressive therapy. Treatment in this trial will be daratumumab weekly for a period of 8 weeks.
- Trial name
- DARALUP (NCT04810754)
- Testing
- Daratumumab Injection
- Volunteers
- 10 people
- Sponsor
- Charite University, Berlin, Germany
Lupus Nephritis, Systemic Lupus Erythematosus (SLE)
Assessing Residual Inflammation and Macrophage Presence in Lupus Nephritis After 3 Months of Intensified Treatment With Prednisolone, Mycofenolate Mofetil and Voclosporin as Compared to Mycofenolate Mofetil and Prednisolone
The goal of this clinical trial is to learn how different treatments affect immune cells in the kidney in people with active lupus nephritis (LN), a kidney manifestation of systemic lupus erythematosus (SLE).
- Trial name
- MAPLE (NCT07760480)
- Testing
- Kidney Biopsy, Voclosporin (LUPKYNIS), Blood, feces and urine sample collection
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Lupus Nephritis
A Pharmacoeconomic Study Comparing the Use of Mycophenolate Mofetil or Cyclophosphamide as Induction Therapy in Lupus Nephritis Patients in Egypt
The aim of this study is to conduct a pharmacoeconomic analysis to compare the use of Mycophenolate Mofetil or i.v. Cyclophosphamide as induction therapy from a third party payer perspective in LN patients in the Egyptian context
- Trial name
- NCT05195086
- Testing
- endoxan, cellcept
- Where
- Egypt
- Volunteers
- 122 people
- Sponsor
- Nada Magdy Mansour
Systemic Lupus Erythematosus
Efficacy and Immunological Evaluation of Belimumab Plus Low Dose IL-2 in the Treatment of Systemic Lupus Erythematosus
The purpose of this study was to explore the clinical and immunological efficacy of belimumab plus low dose IL-2 in systemic lupus erythematosus.
- Trial name
- NCT05262686
- Testing
- Belimumab, Interleukin-2
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Peking University People's Hospital
Fetal Growth Retardation
SLE Therapy Changes in Pregnancy and Relation to Pregnancy Outcome
to review the changes to SLE medications during pregnancy including adherence and non-adherence to the medications and correlate these to the pregnancy outcome and post-partum course of the disease.
- Trial name
- NCT05176041
- Testing
- Naser Al-Husban
- Volunteers
- 156 people
- Sponsor
- University of Jordan
Lupus Nephritis (LN)
The Role of Transforming Growth Factor- Beta (TGF- β) Expression in Renal Biopsy of Lupus Nephritis Patients
To investigate the possible role of TGF-β expression in renal biopsy and it's relation with fibrosis, activity and chronicity indices
- Trial name
- NCT07823556
- Testing
- renal biopsy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
System Lupus Erythematosus
A Study of SCTB35 in Patients with Systemic Lupus Erythematosus
This study is a multicenter Phase Ib/II clinical trial aimed at evaluating the safety, tolerability and efficacy of SCTB35 in patients with systemic lupus erythematosus (SLE).
- Trial name
- NCT06841042
- Testing
- SCTB35 injection
- Where
- 14 sites in China
- Volunteers
- 168 people
- Sponsor
- Sinocelltech Ltd.
Lupus Erythematosus
Identification of Modifiable Sleep-related Factors in Patients With Systemic Lupus Erythematosus.
Background: Sleep quality is a key determinant of physical and mental health, with important implications for immune regulation, psychological well-being, and overall quality of life.
- Trial name
- NCT07483541
- Testing
- Adults with systemic lupus erythematosus
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Investigación en Hemofilia y Fisioterapia
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