Clinical trials: System Sclerosis
Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System
Pathologic-MRI Findings in Atypical IIDD
Our objective is to describe the pathologic and MRI findings in a series of patients with presumed demyelinating lesion of the central nervous system.
- Trial name
- IIDD (NCT03121105)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Motor Neuron Disease
Brain Function in Primary Lateral Sclerosis
This study will examine whether the motor cortex (the part of the brain that controls movement) works properly in patients with primary lateral sclerosis (PLS), a disorder in which voluntary movements are very slow.
- Trial name
- NCT00071435
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Sclerosis
Correlation Between Relapses in Multiple Sclerosis (MS) and Vitamin D Intake
The correlation between relapses in MS and vitamin D intake will be examined.
- Trial name
- NCT01994018
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- OSF Healthcare System
Multiple Sclerosis, Stroke
A Comprehensive Assessment of Trunk, Scapula and Upper Limb in Neurological Patients. Reliability, Validity and Interrelatedness
The study aimed to provide insights in the coordination between trunk, shoulder and upper limb while reaching. Two main phases are present in this study: In phase A: the psychometric properties of two tests: Clinical Scapular…
- Trial name
- NCT04908891
- Testing
- Clinical Scapular protocol (ClinScaP), the prevalence of trunk, scapula and upper limb impairments., the interaction between trunk, scapula and upper limb impairments.
- Where
- 4 sites in Belgium
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Amyotrophic Lateral Sclerosis (ALS)
PET Imaging in ALS Patients
This is a pilot study to evaluate a potential imaging biomarker for aiding diagnosis and monitoring progression of ALS, based on a well established basic science pathway, published human autopsy data, preliminary data in ALS…
- Trial name
- NCT02236897
- Testing
- PET Scanning
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Autoimmune Diseases of the Nervous System, Neuromyelitis Optica Spectrum Disorder
Biomarkers in Autoimmune Disease of Nervous System
Neurological autoimmune diseases are a group of disorders characterized by the abnormal immune response attacking the nervous system, including the brain, spinal cord and peripheral nerves.
- Conditions
- Autoimmune Diseases of the Nervous System, Neuromyelitis Optica Spectrum Disorder, Multiple Sclerosis, Guillain-Barre Syndrome
- Trial name
- NCT06502015
- Testing
- biomaker levels
- Where
- China
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Multiple Sclerosis
Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
Studies performed under 89-N-0045 are designed to examine the natural history of multiple sclerosis (MS) using MRI and immunological measures.
- Trial name
- NCT00001248
- Where
- United States
- Volunteers
- 3,750 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Amyotrophic Lateral Sclerosis, Alzheimer Disease
Study of the Role of G72 in Amyotrophic Lateral Sclerosis: Biomarker Discovery and Mechanism Investigation
G72 gene is located on the common linkage locus in bipolar disorder and schizophrenia, and it encodes D-amino acid oxidase activator (DAOA).
- Conditions
- Amyotrophic Lateral Sclerosis, Alzheimer Disease, Parkinson's Disease
- Trial name
- NCT01378026
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Multiple Sclerosis
Deciphering the Role of the Gut Microbiota in Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory disease that affects the nervous system and results in a wide range of signs and symptoms including physical and cognitive problems.
- Trial name
- NCT02580435
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Relapsing-Remitting Multiple Sclerosis
Impact of Natalizumab Versus Fingolimod in Relapsing-Remitting Multiple Sclerosis (RRMS) Participants
The primary objective of this study is to assess the effect of natalizumab compared to fingolimod on the evolution of new on-treatment T1-gadolinium-enhancing (Gd+) lesions to persistent black holes (PBH) over 52 weeks.
- Trial name
- REVEAL (NCT02342704)
- Testing
- natalizumab, fingolimod
- Where
- 42 sites in United States, Australia and 7 more
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Biogen
Amyotrophic Lateral Sclerosis
Dexpramipexole SAD/MAD Study
This Phase 1 study will explore the safety, tolerability, and pharmacokinetics of single doses ranging from 300 to 600 mg and multiple daily doses ranging from 225 mg to 300 mg BID dexpramipexole in healthy volunteers.
- Trial name
- NCT01449578
- Testing
- Dexpramipexole
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Knopp Biosciences
Relapsing Remitting Multiple Sclerosis, Fatigue
Correlation Between Daily Physical Activity and Disability, Fatigue, Cognition and Quality of Life in MS Patients
The main purpose of the study is to assess the fatigue, cognition, quality of life and disability correlation to MS-patients daily physical activity.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Fatigue, Quality of Life, Physical Activity
- Trial name
- PAMS (NCT04115930)
- Testing
- Physical Activity measurement:
- Where
- 4 sites in Finland
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Multiple Sclerosis
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VT7208 in Healthy Participants and MS Patients
Part 1 of this study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of VT7208 in healthy volunteers.
- Trial name
- NCT07085507
- Testing
- VT7208
- Where
- Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vidya Therapeutics Inc
Multiple Sclerosis
STAT4 in Multiple Sclerosis by PCR and Flow Cytometry
1. To determine the level of STAT4 expression in different cases of multiple sclerosis and its relation to disease severity . 2. compare the sensitivity and specificity of STAT4 levels using both PCR and flow cytometry.
- Trial name
- NCT03893344
- Testing
- detection of STAT4 gene
- Where
- Egypt
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Assiut University
Multiple Sclerosis
Microbiome Benchmarking to Identify Perturbations in Multiple Sclerosis II
The goal of this longitudinal study is to (1) explore the association between the gut microbiota and inflammatory disease activity in early onset multiple sclerosis, (2) investigate whether/how gut microbial composition vary when…
- Trial name
- NCT03797937
- Testing
- Magnetic resonance imaging (MRI)
- Where
- 2 sites in Belgium
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National MS Center Melsbroek
Multiple Sclerosis, Fatigue
Physiological Responses in Experimentally Induced Cognitive Fatigue in People With Multiple Sclerosis (MS)
The current study will add to the current knowledge by combining several electrophysiological techniques to examine the relationship between physiological responses and cognitive fatigue and daily activity performance in a…
- Conditions
- Multiple Sclerosis, Fatigue, Stress
- Trial name
- PREFIMS (NCT05003375)
- Testing
- High-challenging cognitive protocol to provoke stress and (cognitive) fatigue
- Where
- 2 sites in Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Multiple Sclerosis
Role of Microglia in the Pathogenesis of Progressive Multiple Sclerosis
Our aim is to evaluate whether translocator binding protein (TSPO)-imaging correlates to Expanded Disability Status Scale (EDSS) and other disease progression-related clinical and paraclinical parameters in a homogenous cohort of…
- Trial name
- PROMS (NCT03134716)
- Where
- Finland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Amyotrophic Lateral Sclerosis
Relationship Between Neurological Disability and Visual Impairment in Patients With ALS or Friedreich's Ataxia
The aim of this study is to obtain an early biomarker of amyotrophic lateral sclerosis and Friedreich's Ataxia which allows to diagnose the disease in an initial stage and to follow up the patient with optic coherence tomography…
- Trial name
- NCT03285204
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Jose Luis Urcelay Segura
Amyotrophic Lateral Sclerosis, Neurodegenerative Disease
EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular condition characterized by weakness, muscle wasting, fasciculations and increased reflexes.
- Conditions
- Amyotrophic Lateral Sclerosis, Neurodegenerative Disease, Motor Neuron Disease
- Trial name
- BCI (NCT00718458)
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Drexel University College of Medicine
Scleroderma
The Effects of Botulinum Toxin on Oral Aperture in Patients With Scleroderma
This study will evaluate the use of botulinum toxin for microstomia (also known as reduced oral aperture) in scleroderma patients.
- Trial name
- NCT04523506
- Testing
- Botulinum toxin(Botox)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center