Clinical trials: System Sclerosis
Dementia, Alzheimer Disease
The Swedish BioFINDER 2 Study
The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study (www.biofinder.se). BioFINDER 1 is used e.g.
- Conditions
- Dementia, Alzheimer Disease, Parkinson Disease, Lewy Body Disease
- Trial name
- BioFINDER2 (NCT03174938)
- Testing
- Flutemetamol F18 Injection, [18F]-RO6958948, Elecsys (Roche) Abeta42, Ttau and Ptau
- Where
- 2 sites in Sweden
- Volunteers
- 2,950 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Multiple Sclerosis
Study of Excretion Balance and Pharmacokinetics of [14C]-SAR442168 in Healthy Male Subjects
Primary Objective: To determine the excretion balance and systemic exposure of radioactivity after oral administration of [14C]-SAR442168.
- Trial name
- NCT04171310
- Testing
- SAR442168
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Sanofi
Multiple Sclerosis, Relapsing-Remitting
The Reliability, Validity, and Responsiveness of the Timed 360° Turn Test in Patients With Multiple Sclerosis
The aim of the study is to investigate reliability, validity, and responsiveness of the timed 360° turn test in patients with Multiple Sclerosis.
- Trial name
- NCT03718026
- Testing
- The timed 360° turn test
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Gazi University
Multiple Sclerosis, Stroke
Short Arm Human Centrifuge Therapeutic Training and Rehabilitation (GRACER1)
The study is a single blind randomized controlled trial (RCT) designed to examine the benefit of a short arm human centrifuge intervention program (SAHC) combined with exercise, compared to a standard of care (SOC) rehabilitation…
- Conditions
- Multiple Sclerosis, Stroke, Pulmonary Disease, Chronic Obstructive, Aged
- Trial name
- GRACER1 (NCT04369976)
- Testing
- ARTIFICIAL GRAVITY COMBINED WITH EXERCISE
- Where
- Greece
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Greek Aerospace Medical Association and Space Research
Multiple Sclerosis
DreaMS - Validation Study 1
Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) causing focal lesions of demyelination and diffuse neurodegeneration in the grey and white matter of the brain and spinal cord, leading…
- Trial name
- NCT05009160
- Testing
- dreaMS App R2.1
- Where
- 6 sites in Switzerland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Research Center for Clinical Neuroimmunology and Neuroscience Basel
Amyotrophic Lateral Sclerosis
DIAGALS: Relation Between Tar DNA Binding Protein(TDP)-43 et Nrf-2 in ALS: a Track to Improve Diagnosis and Prognosis of the Disease
In response to oxidative stress, cells activate the Nrf-2 pathway, which induces translation of its target genes and corresponding proteins involved in the antioxidant response.
- Trial name
- DIAGALS (NCT06230562)
- Testing
- Blood sample
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Multiple Sclerosis
Assessment of Immune Response in Multiple Sclerosis Patients With COVID-19/Vaccination Treated With Ofatumumab and Other Disease Modifying Therapies
Vaccine responses in patients treated with anti-CD20 antibodies (ocrelizumab and ofatumumab) or S1P receptor modulators (fingolimod and siponimod) were evaluated before and after third SARS-CoV-2 vaccination as part of an ongoing…
- Trial name
- NCT05950308
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis, NMO Spectrum Disorder
A Study of LP-168 in Healthy Volunteers
This is a Phase I study designed to assess the safety, tolerability and pharmacokinetics of LP-168 in healthy human volunteers.
- Trial name
- NCT05432713
- Testing
- LP-168 tablet
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Guangzhou Lupeng Pharmaceutical Company LTD.
Multiple Sclerosis, Optic Neuritis
Optical Coherence Tomography in Multiple Sclerosis Patients
To evaluate the ability of different spectral domain optical coherence tomography (OCT) devices, as well as different acquisition and analysis packages, to detect disease progression in patients with multiple sclerosis with and…
- Trial name
- NCT01774123
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Multiple Sclerosis
IL-11 in the Development of Multiple Sclerosis
Since the last submission, the investigator have further characterized the potential of IL--11 to induce encephalitogenic CD4+IL--17A+, IL--21+ and GM--CSF+ cells, which upon passive transfer induced severe RREAE with…
- Trial name
- NCT03735823
- Testing
- No intervention, just collect blood samples and CSF samples
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Scleroderma, Localized, Morphea
Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository
The Morphea in Adults and Children (MAC) cohort is the first registry for both children and adults with morphea (also known as localized scleroderma) in the country.
- Conditions
- Scleroderma, Localized, Morphea, Frontal Linear Scleroderma en Coup de Sabre, Scleroderma, Circumscribed
- Trial name
- MAC (NCT01808937)
- Testing
- Morphea
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Multiple Sclerosis, Cognition Disorders
Linking Cognitive Functioning to Multimodal Imaging in Multiple Sclerosis (MS)
Multiple sclerosis (MS) is the most common progressive neurologic disorder to occur in adults of working-age. Despite longstanding recognition of cognitive impairment as a symptom of MS, two obstacles in measurement have limited…
- Trial name
- NCT03723356
- Testing
- Siemens Biograph mMR (molecular MR), fMRI, Diffusion Spectrum Imaging (DSI)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Multiple Sclerosis
The Impact of Training on Sitting Time and Brain Volumes in Multiple Sclerosis.
The current study aims to investigate whether persons with Multiple Sclerosis (PwMS) compensate training time with more sedentary time and consequently blunt training effects.
- Trial name
- EXIMS (NCT04191772)
- Testing
- Periodized, home-based running program
- Where
- Belgium
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis
Telerehabilitation for Multiple Sclerosis
Multiple sclerosis (MS) is a neurodegenerative disease affecting the central nervous system and is a leading cause of disability in young adults. It often produces strength deficits.
- Trial name
- TRHBN (NCT06871072)
- Testing
- Telerehabilitation, Exercise program
- Where
- Spain
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Cadiz
Multiple Sclerosis
Dual Task Cost in the Upper Limb in Persons With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic, inflammatory, neurodegenerative disorder of the central nervous system, with more than 2.5 million people in the world.
- Trial name
- DTC (NCT02493166)
- Testing
- dual task cost (cognitive-motor interference)
- Where
- 4 sites in Belgium
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis
Reliability and Validity of the Glittre Activities of Daily Living Test in Multiple Sclerosis Patients
Patients with Multiple Sclerosis (MS) have reduced functional capacity due to clinical symptoms of the disease, resulting in decreased participation in daily living activities and reduced quality of life.
- Trial name
- NCT04182269
- Testing
- Measurement of functional exercise capacity
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Scleroderma
Optical Elastography of Systemic Sclerosis Skin
The goal of this study is to develop a new way to assess skin thickness in patients with scleroderma (systemic sclerosis). The study will test how well a new imaging method called optical coherence elastography (OCE) compares to…
- Trial name
- NCT02835196
- Testing
- Optical Elastography, Visual Assessment
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Systemic Sclerosis
Angiogenic/Angiostatic Mediators in Patients With Systemic Sclerosis
We propose to examine several angiogenic/angiostatic mediators in the skin and serum of subjects with SSc and compare it to levels found in the skin and serum of healthy subjects.
- Trial name
- NCT00668473
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Healthy, Prodromal Alzheimer's Disease
Exploring the Gut-Brain Axis in Ageing and Neurodegeneration
Neurodegenerative diseases are a major health concern due to their growing societal implications and economic costs. The identification of early markers of pathogenic mechanisms is one of the current main challenges.
- Conditions
- Healthy, Prodromal Alzheimer's Disease, Parkinson Disease, Multiple Sclerosis
- Trial name
- GutBrain (NCT05934188)
- Testing
- Magnetic Resonance Imaging, Neuropsychological protocol, Eating habits
- Where
- 3 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Relapsing Remitting Multiple Sclerosis
Productive Value of Sonographic Measurement of Optic Nerve in Transitional Multiple
1.to evaluate the potential role of the optic nerve diameter ( OND determined by ultrasonography and and visual nerve function by visual evoked potential as a biomarker of early axonal loss and disability in patients with…
- Trial name
- NCT06435962
- Testing
- sonography
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University