Clinical trials: System Sclerosis
Multiple Sclerosis
Fatigability in Persons With Multiple Sclerosis: Inputs From Cognition, Walking and Coordination
Walking impairments occur in 93% of persons with MS (pwMS) within 10 years of diagnosis. Besides the impact of muscle weakness or hypertonia, one is increasingly aware about the symptom of fatigability.
- Trial name
- NCT05412043
- Testing
- Dance therapy, Psychometric properties (Validity, Reliability) of interlimb coordination- and cognitive-fatigability
- Where
- 2 sites in Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis, Alzheimer's Disease
PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
The specific aims of the study are: Primary: To determine the presence and regional distribution of microglial activation, as assessed by Fluorine-18 (18F) labeled "Peripheral Benzodiazepine Receptor 06" (PBR06) -PET, in subjects…
- Trial name
- MAPET (NCT02649985)
- Testing
- [F-18]PBR06, [C-11]PBR28
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Spasticity
A Prospective Study of Spasticity in Individuals With Multiple Sclerosis
This study is expected to contribute to the body of knowledge on the benefits of individuals with MS taking glatiramer acetate (Copaxone®).
- Trial name
- NCT01111435
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Fraser, Cira, Ph.D., RN, ACNS-BC
Systemic Sclerosis, Caregivers
Systemic Sclerosis' Relatives Reflex
Systemic sclerosis (SSc) is a rare, serious disease that is part of chronic inflammatory rheumatism. It requires multidisciplinary care and a specific therapeutic patient education program.
- Trial name
- RelativReflex (NCT04917146)
- Testing
- Self-administered questionnaires for relatives (caregivers=CG)
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis, Fatigue
Fatigue in Multiple Sclerosis: Evaluated With 3 MRI and Transcranial Magnetic Stimulation
The purpose of this study is to investigate fatigue in patients with multiple sclerosis (MS) and to determine the correlation between the symptom and cerebral changes.
- Trial name
- NCT00342381
- Testing
- 3,4-diaminopyridine
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Amyotrophic Lateral Sclerosis
Study of Dopamine and Serotonin Transporters in Patients With Amyotrophic Lateral Sclerosis and Controls
The purpose of this study is to study the transporters of serotonin and dopamine in ALS patients in relation with the clinical phenotype, i.e., patients without stiffness, patients with pyramidal stiffness, patients with mixed…
- Trial name
- DOSERAL (NCT01160263)
- Testing
- SPECT : 123 I-FP-CIT (DATSCAN) and 123I-ADAM
- Where
- 2 sites in France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Systemic Sclerosis
Neuropsychiatric Scleroderma Study: Systematic Evaluation of Neuropsychiatric Involvement in Systemic Sclerosis
Systemic sclerosis is a rare disease with vascular involvement and systemic fibrosis. This disease is usually thought to spare central nervous system.
- Trial name
- NeuroScS (NCT01488214)
- Testing
- Magnetic resonance Imaging
- Where
- 4 sites in France
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Multiple Sclerosis, Optic Neuritis
Effect of Transorbital Electrical STIMulation of Optic Nerve on Remyelination After an Acute Optic Neuritis
In light of experimental models showing that neuronal electrical activity is crucial for the remyelination process, we hypothesize that maintenance of electrical axonal activity in the early stages of optic neuritis may promote…
- Trial name
- ONSTIM (NCT04042363)
- Testing
- Transorbital electrical stimulation (Eyetronic Next Wave 1.1)
- Where
- 2 sites in France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Alzheimer Disease, Frontotemporal Dementia
Proteinopathies Expression in Skin of Neurodegenerative Disorders
The goal of this observational study is to compare the aggregation pattern of proteinopathies (alpha-synuclein, amyloid-beta, phosphorylated tau and transactive response DNA -binding protein 43 [TDP43]) in skin biopsies of…
- Conditions
- Alzheimer Disease, Frontotemporal Dementia, Parkinson Disease, Atypical Parkinsonism
- Trial name
- NCT06528964
- Testing
- Immunohistochemistry and immunofluorescence
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Systemic Sclerosis
Stimulatory Autoantibodies to the Platelet-Derived Growth Factor Receptor (PDGFR) in Patients With Systemic Sclerosis
This study is to determine if subjects with .systemic sclerosis have stimulatory autoantibodies to the PDGF receptor and to confirm activation (phosphorylation) of the PDGF receptor in skin sites with varying degrees of skin…
- Trial name
- NCT00667134
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Multiple Sclerosis
The Reliability and Validity of the L-test in Patients With Multiple Sclerosis
Walking safely inside or outside is an important function in patients with Multiple Sclerosis (PwMS) that affects their daily life activity and participation.
- Trial name
- NCT05641714
- Testing
- L test, Timed Up and Go test, 10 meter walk test
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Gazi University
Multiple Sclerosis
Glucose Consumption in MS Using [F-18]FDG-PET
Given the need for better diagnostic imaging techniques in multiple sclerosis (MS), the study aims to investigate the utility of [F-18]FDG positron emission tomography (PET) in MS.
- Trial name
- NCT07087106
- Testing
- [F-18]FDG
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Multiple Sclerosis
Plantar Pressure Distribution in Patient With Multiple Sclerosis
Fifty patients who were referred to receive physiotherapy and 20 healthy volunteers will be participants of the study.Participants with multiple sclerosis will evaluate with the following assessment tools: Modified Ashworth scale…
- Trial name
- NCT02947906
- Testing
- No intervention
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Assessing Motor Neuron Disease Mechanisms by Threshold Tracking Transcranial Magnetic Stimulation and Magnetic Resonance Spectroscopy
Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease, which cases the death of neurons controlling the voluntary muscles.
- Conditions
- Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Cortical Excitability
- Trial name
- NCT03664206
- Testing
- MRS, conventional TMS and treshold tracking TMS
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sándor Beniczky
Multiple Sclerosis
Analyze the Myelin-TRAP as Diagnostic Tool in Multiple Sclerosis
The objective of this project is to characterize the response TRAP positive patients with Multiple Sclerosis (MS) and to evaluate the sensitivity and specificity of the method in order to develop a second time as a diagnostic…
- Trial name
- TRAP-Myéline (NCT01723631)
- Testing
- Trap Myelin Test
- Where
- 11 sites in France
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Multiple Sclerosis, Fatigue
The Impact of Exercise Training on Living Quality in Multiple Sclerosis Individuals
The most common symptom displayed in patients with multiple sclerosis (MS) is a pronounced sense of fatigue that can have negative effect on functional ability and quality of life (QOL).
- Conditions
- Multiple Sclerosis, Fatigue, Mental Status Change, Physical Disability
- Trial name
- NCT03222596
- Testing
- Exercise training
- Where
- Croatia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
Hypertension, Heart Failure
LSFG-SKIN, Laser Speckle Flowgraphy
The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or…
- Conditions
- Hypertension, Heart Failure, Vascular Ischemia, Burns
- Trial name
- NCT03660618
- Testing
- laser speckle flowgraphy
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Amyotrophic Lateral Sclerosis (ALS)
Circulating Biomarker for Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis (ALS) is a rare disease with a worldwide incidence of 2-3 cases per 100,000 individuals/year and it is characterized by progressive neurodegeneration of motor neurons.
- Trial name
- NCT03088839
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Clinically Isolated Demyelinating Syndromes, Multiple Sclerosis
Prospective Longitudinal 1-year Study of the Correlation Between Cognitive Functioning in Patients With Clinically Isolated Syndrome Suggestive of Multiple Sclerosis and Disconnection in the Brain Assessed by MRI
Clinically isolated demyelinating syndromes (CIS) can evolve into multiple sclerosis (MS). Cognitive deficiencies could occur at this early stage and concern mainly information processing speed (IPS) and their mechanisms are not…
- Conditions
- Clinically Isolated Demyelinating Syndromes, Multiple Sclerosis, Cognitive Deficiencies, Brain MRI
- Trial name
- SCI-COG (NCT01865357)
- Testing
- Brain MRI - Clinical and cognitive evaluation, Eye movement
- Where
- France
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Nonalcoholic Steatohepatitis (NASH), Primary Sclerosing Cholangitis (PSC)
Subcutaneous Doses of CM-101 as a Treatment for Medical Conditions Involving Inflammatory and Fibrotic Mechanisms in Healthy Male Subjects
CM-101 is developed as treatment for medical conditions involving inflammatory and fibrotic mechanisms such as non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) and systemic sclerosis (SSc).
- Conditions
- Nonalcoholic Steatohepatitis (NASH), Primary Sclerosing Cholangitis (PSC), Systemic Sclerosis (SSc)
- Trial name
- NCT06037577
- Testing
- CM-101
- Where
- Israel
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- ChemomAb Ltd.