Clinical trials: System Sclerosis
Neurologic Diseases, Hemiparesis
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one…
- Conditions
- Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies
- Trial name
- NCT04798378
- Testing
- Neurosleeve
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Systemic Lupus Erthematosus, Sjogren's Syndrome
Mass Spectrometry-based Immune Profiling in Autoimmune Diseases
Based on mass spectrometry flow method, this study analyzed the typing of new T, B, NK and DC cell subsets in peripheral blood of common autoimmune diseases and their correlation with disease activity, aiming at establishing an…
- Conditions
- Systemic Lupus Erthematosus, Sjogren's Syndrome, Inflammatory Myopathies, Systemic Sclerosis (SSc)
- Trial name
- NCT07188285
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Neuronal Plasticity, Multiple Sclerosis
Brain Activity Changes Following Neuroproprioceptive Physiotherapy in Multiple Sclerosis
Imaging methods bring new possibilities for describing the brain plasticity processes that underly the improvement of clinical function after physiotherapy in people with multiple sclerosis (pwMS).
- Conditions
- Neuronal Plasticity, Multiple Sclerosis, Rehabilitation
- Trial name
- NCT04448444
- Testing
- Motor Program Activating Therapy, Vojta reflex locomotion
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Amyotrophic Lateral Sclerosis
Italian Validation of the Beaumont Behavioural Inventory (BBI)
Up to 50% of patients affected with amyotrophic lateral sclerosis (ALS) can show behavioral dysfunctions within the spectrum of frontotemporal degenerations (FTD) - namely, apathy, disinhibition, loss of sympathy/empathy…
- Trial name
- BBI (NCT04440644)
- Testing
- BBI
- Where
- Italy
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Neurodegenerative Disease, Behavioral Variant Frontotemporal Dementia (bvFTD)
Tracking and Predicting How Brain Damage Spreads in Neurodegenerative Diseases
Neurodegenerative diseases, including frontotemporal lobar degeneration (FTLD) spectrum syndromes, are characterized by the accumulation of insoluble protein aggregates in the central nervous system.
- Conditions
- Neurodegenerative Disease, Behavioral Variant Frontotemporal Dementia (bvFTD), Primary Progressive Aphasia(PPA), Progressive Supranuclear Palsy(PSP)
- Trial name
- NCT07567664
- Testing
- 3 Tesla MRI without contrast medium, Blood sample for genetic analysis, Cerebrospinal fluid sampling (CSF)
- Where
- Italy
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Multiple Sclerosis
Exercise Therapy in Multiple Sclerosis
Exercise or active rehabilitation is a non-pharmacological approach increasingly used for people with Multiple Sclerosis (MS), in support of disease-modifying therapies (DMTs), with the aim of improving the quality of life and…
- Trial name
- RehaMS (NCT04294979)
- Testing
- Physical Therapy
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Amyotrophic Lateral Sclerosis
PRE-Symptomatic Studies in Amyotrophic Lateral Sclerosis
The goal of PRESS-ALS is to study the earliest manifestations of disease in people with early ALS in whom some areas of the body are not yet affected.
- Trial name
- PRESS-ALS (NCT01508962)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Miami
Multiple Sclerosis, Quality of Life
Impact of Exercise on "Invisible" Symptoms and Quality of Life in Multiple Sclerosis Individuals
Patients with multiple sclerosis (MS) struggle on a daily basis with accompanying, "Invisible" symptoms like primary fatigue, pain and emotional-cognitive disorders.
- Conditions
- Multiple Sclerosis, Quality of Life, Motivation, Pain
- Trial name
- NCT03768830
- Testing
- Exercise training
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Rijeka
Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System
Pathologic-MRI Findings in Atypical IIDD
Our objective is to describe the pathologic and MRI findings in a series of patients with presumed demyelinating lesion of the central nervous system.
- Trial name
- IIDD (NCT03121105)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Multiple Sclerosis
Multimodal Imaging of MS Reveals the Smoldering Inflammation
To evaluate active MS plaque evolution with conventional MRI, QSM-post processing, TSPO-PET imaging and P2X7-PET imaging.
- Trial name
- PLAQ-MS (NCT04126772)
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Multiple Sclerosis
Anti-Inflammatory Type II Monocyte Induction by Glatiramer Acetate (Copaxone) Treatment of Multiple Sclerosis
The purpose of this study is to determine whether glatiramer acetate (Copaxone) will induce anti-inflammatory type II monocyte development during treatment of MS, and if these antigen presenting cells (APC) will promote Th2 and…
- Trial name
- NCT00819195
- Testing
- Glatiramer acetate
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Multiple Sclerosis
A Database Study to Estimate the Risk of Multiple Sclerosis Following Vaccination With Arepanrix™ in Manitoba, Canada
The purpose of this database study is to assess if Arepanrix™ vaccination during the 2009 pandemic was associated with an increased risk of multiple sclerosis (MS) in Manitoba, Canada.
- Trial name
- H1N1-014VS (NCT02367222)
- Testing
- Exposed to Arepanrix™ Cohort, Unexposed to Arepanrix™ Cohort
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Multiple Sclerosis (MS), Clinically Isolated Syndrome (CIS)
Pregnancy Cohort in Multiple Sclerosis (MS)
Multiple sclerosis (MS) is a common inflammatory demyelinating disorder of the central nervous system frequently affecting females in their reproductive phase of life.
- Trial name
- NCT05010902
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Multiple Sclerosis
Spinal Cord Analysis in Multiple Sclerosis
Research project in which patients with Multiple Sclerosis (MS) are examined clinically and with magnetic resonance imaging (MRI). To evaluate spinal cord (SC) grey and white matter changes (incl.
- Trial name
- NCT03841903
- Testing
- spinal cord MRI
- Where
- Switzerland
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Multiple Sclerosis, 3D Gait Analysis
Gait Analysis in Multiple Sclerosis Patients
In the literature, the results of vestibular rehabilitation treatment applied in patients with Multiple Sclerosis (MS) have been investigated in detail under the headings such as fatigue, physical activity level, and quality of…
- Conditions
- Multiple Sclerosis, 3D Gait Analysis, Vestibular Rehabilitation
- Trial name
- NCT05299151
- Testing
- Vestibular exercises, Standard neurorehabilitation exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Istanbul Kültür University
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging.
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), Alzheimer Disease
- Trial name
- MESO7 (NCT07202494)
- Testing
- Imaging Techniques (MRI 3T & 7T, Functional, Structural, and Metabolic Imaging)
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Multiple Sclerosis
Single-Dose Study of a New Formulation of BIIB061
The primary objective of the study is to assess the pharmacokinetic (PK) profile of BIIB061 in the new oral formulation in the fasted state in healthy male and female volunteers.
- Trial name
- NCT02521545
- Testing
- BIIB061
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Biogen
Central Nervous System (CNS) Demyelinating Disease, Multiple Sclerosis
Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of BIIB033 in Healthy Japanese Participants
The primary objective of this study is to assess the safety and tolerability of a single dose and multiple doses of BIIB033 administered to healthy adult Japanese participants.
- Trial name
- NCT02641041
- Testing
- BIIB033
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Biogen
Amyotrophic Lateral Sclerosis
Stratification of Presymptomatic Amyotrophic Lateral Sclerosis: the Development of Novel Imaging Biomarkers
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disorder with no effective disease-modifying therapies at present. The disease is sporadic in 90 % of the ALS patients.
- Trial name
- STRATALS (NCT05358431)
- Testing
- Neuroimaging and electrophysiology
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Positron-Emission Tomography, Multiple Sclerosis
Evaluation of the Positron Emission Tomography (PET) Tracer ZK 6032924 in Patients With Multiple Sclerosis Compared to Healthy Volunteers
PET (positron emission tomography) imaging with BAY85-8101 for investigation in patients with Multiple Sclerosis compared to healthy volunteers
- Trial name
- NCT01031199
- Testing
- F-18 FEDAA1106 (BAY85-8101)
- Where
- 2 sites in Australia, Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bayer