Clinical trials: Systemic Immune-inflammation Index
Diabetic Ketoacidosis
Association of Systemic Immune-inflammation Index and Severity of Diabetic Ketoacidosis in Type 1 Diabetes Mellitus
Diabetic ketoacidosis (DKA) is the most serious metabolic complication of type 1 diabetes mellitus (T1DM). Insulin deficiency and inflammation play a role in the pathogenesis of DKA.
- Trial name
- NCT06251895
- Testing
- DKA protocol
- Where
- Kuwait
- Volunteers
- 241 people
- Sponsor
- Jahra Hospital
Postoperative Pain Management, Laparoscopic Hysterectomy
Intrathecal Morphine Versus Trocar-Site and Intraperitoneal Bupivacaine for Quality of Recovery After Laparoscopic Hysterectomy
This study aims to compare the effects of intrathecal morphine with trocar-site infiltration and intraperitoneal bupivacaine on postoperative pain control, quality of recovery, and inflammatory response in patients undergoing…
- Conditions
- Postoperative Pain Management, Laparoscopic Hysterectomy, Postoperative Recovery
- Trial name
- ITM-LH-QoR (NCT07232108)
- Testing
- Intrathecal Morphine, Trocar-Site Bupivacaine Infiltration, Intraperitoneal Bupivacaine spray
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ataturk University
Inflammation, Neutrophil
SIII and Spontaneous Regression in Lumbar Disc Herniation
This study aimed to investigate the role of the Systemic Immune-Inflammatory Index (SIII) in patients with lumbar disc herniation (LDH) and to evaluate its potential clinical relevance in relation to treatment modality.
- Conditions
- Inflammation, Neutrophil, Lymphocyte, Neurosurgery
- Trial name
- SIII-LDH (NCT07367503)
- Testing
- Lumbar disc herniation treatment, Lumbar disc herniation surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Rhinoplasty
Effect of Systemic Inflammatory Index and Systemic Immune Inflammation Index on Ecchymosis, Bleeding and Edema
Rhinoplasty is a cosmetic surgical procedure that is widely applied today and is characterized by edema in the postoperative period.
- Trial name
- NCT06649370
- Testing
- Hypotensive Drugs and/or Vasoactive Drugs
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Diabetic Kidney Disease, Diabetic Nephropathies
Systemic Immune-Inflammation Index and Platelet Parameters in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is a frequent microvascular complication in individuals with type 2 diabetes mellitus (T2DM) and a major cause of chronic kidney failure worldwide.
- Conditions
- Diabetic Kidney Disease, Diabetic Nephropathies, Type 2 Diabetes Mellitus, Albuminuria
- Trial name
- NCT07773467
- Volunteers
- 120 people
- Sponsor
- Assiut University
Covid19, Corona Virus Infection
Effect of Pentoxifylline on Prognosis of Coronavirus Disease 2019 (COVID- 19) Infection
Coronavirus disease 2019 (COVID-19) remains a threatening pandemic, due to its rapid transmission, uncertain risk factors for progression that lead to its lethality and yet unsatisfactory antiviral therapy or prophylaxis.
- Conditions
- Covid19, Corona Virus Infection, Cytokine Storm
- Trial name
- NCT04739345
- Testing
- Pentoxifylline
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Ain Shams University
Schizophrenia, Physical Exercise
Physical Exercise on Simple Inflammatory Markers, Systemic Immune Inflammation Index, and Systemic Immune Response Index
Mental health is defined as a state of well-being in which a person can realize their talents, cope with the normal stresses of life, and support society by working efficiently and productively.
- Trial name
- NCT06574893
- Testing
- physical exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Acute Lymphoblastic Leukemia
Systemic Inflammation Response Index and C-Reactive Protein to Albumin Ratio in Acute Lymphoblastic Leukemia
the goal of this observational study is Assesment of systemic inflammatory index (SII) , system inflammation response index (SIRI) and CRP Albumin ratio(CAR) as biomarkers for ALL prognosis.
- Trial name
- NCT06674850
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Assiut University
Gastric Cancer
Impact of Robotic Surgery on Systemic Immune-inflammation Index
Robotic surgery has been gaining attention because of the physical and metabolic morbidity of the conventional open technique.The systemic immune-inflammation index(SII) has emerged as a recent and more reliable biomarker.In our…
- Trial name
- NCT06811753
- Testing
- robotic surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Acute Pancreatitis, Pancreatitis
CBC-Derived Inflammatory Indices in Acute Pancreatitis
This prospective observational study aims to evaluate the prognostic value of complete blood count (CBC)-derived inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and…
- Trial name
- NCT07793734
- Volunteers
- 109 people
- Sponsor
- Assiut University
Acute, Pancreatitis
Prediction of Acute Pancreatitis Outcome
Aim of study prediction of acute pancreatitis outcome by using cheap and available laboratory resources
- Trial name
- NCT06653205
- Volunteers
- 47 people
- Sponsor
- Assiut University
Asthma Control
NLR, ELR and SII Index as Biomarkers of Asthma Control
This is Case control study aims to study Neutrophil-to-Lymphocyte Ratio (NLR), Eosinophil-to-Lymphocyte Ratio (ELR), and Systemic Immune Inflammation (SII) Index as Biomarkers of Asthma Controlin adult patients with bronchial…
- Trial name
- NCT07730047
- Testing
- Complete blood count
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shaimaa Ali Mohammed
Critical Illness, Intensive Care Unit Delirium
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis.
- Conditions
- Critical Illness, Intensive Care Unit Delirium, Neurocognitive Deficit, Microbiome,immune Function, Critically Ill
- Trial name
- MS-ICU (NCT06749483)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Human Immunodeficiency Virus (HIV), Cardiovascular Risk Factor
Reducing Systemic Inflammation in People on Antiretroviral Therapy
This randomized, open-label clinical trial will evaluate whether adding fostemsavir to current antiretroviral therapy can reduce the risk of cardiovascular disease in people with well-controlled HIV.
- Trial name
- RESTART (NCT07030920)
- Testing
- Fostemsavir
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Critical Illness, Sepsis
Systemic Immune-Inflamation Index and Mortality in ICU Patients
Systemic Immune-Inflammation Index (SII) is a hemogram-derived biomarker reflecting the balance between systemic inflammation and immune response.
- Trial name
- NCT07493759
- Testing
- Systemic Immune-Inflammation Index (SII)
- Where
- Turkey (Türkiye)
- Volunteers
- 570 people
- Sponsor
- Ataturk University
Axial Spondyloarthritis
New Biomarkers in Axial Sypondyloarthropathy; SII and SIRI
investigators aimed to evaluate the relationship between Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) and disease activity in patients with axial spondyloarthropathy (SpA).
- Trial name
- NCT05914532
- Testing
- lab testing
- Where
- Turkey (Türkiye)
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Immunotherapy Gastrict Cancer, Inflammation Biomarkers
Evaluate the Prognostic Significance of Changes in the Systemic Immune-Inflammation Index in Patients with AGC Treated with ICI Therapy.
The SIIR during neoadjuvant therapy can serve as a specific biomarker for predicting the efficacy of immunotherapy in patients with advanced gastric cancer.
- Conditions
- Immunotherapy Gastrict Cancer, Inflammation Biomarkers, Gastric Cancers
- Trial name
- NCT06706466
- Testing
- observational study
- Where
- China
- Volunteers
- 410 people
- Sponsor
- Chang-Ming Huang, Prof.
AKI in Cirrhosis
SII in AKI With Cirrhosis
Acute Kidney Injury (AKI) is a common and serious complication in patients withAcute Kidney Injury (AKI) is a common and serious complication in patients with liver cirrhosis, affecting up to 20-50% of hospitalized cirrhotics and…
- Trial name
- NCT07452484
- Testing
- No intervention needed, SII, Serial systemic immune inflammation index
- Volunteers
- 100 people
- Sponsor
- Sohag University
Acute Aortic Dissection, Surgery (Cardiac)
Immune-Inflammatory Markers in Aortic Dissection
Identifying early on which patients with acute aortic dissection require closer monitoring may help with care planning. If simple, inexpensive values obtained from routine blood tests can provide additional information for…
- Conditions
- Acute Aortic Dissection, Surgery (Cardiac), Systemic Immune-inflammation Index, Postoperative Death
- Trial name
- NCT07683260
- Where
- Turkey (Türkiye)
- Volunteers
- 127 people
- Sponsor
- Bursa City Hospital
Knee Osteoarthritis, Osteoarthritis
Blood Cell Ratios as Predictors of Response to Platelet-Rich Plasma in Knee Osteoarthritis
Intra-articular platelet-rich plasma (PRP) injection is a widely used treatment for knee osteoarthritis, but patients respond to it very differently and there is currently no simple, inexpensive way to predict who will benefit.
- Trial name
- PRP-NLR (NCT07617233)
- Where
- Cyprus
- Volunteers
- 120 people
- Sponsor
- Utku Gürhan