Clinical trials: Systemic Infection
Endotoxemia, Muscle Loss
Anabolic Potential of 3-hydroxybutyrate (3-OHB) and Whey Protein in a Human Catabolic Inflammatory Disease Model
This study aims to investigate the muscle anabolic potential of adding ketone (3-hydroxybutyrate) to whey protein compared with isocaloric, isonitrogenous whey protein in a human model of inflammatory catabolic disease.
- Conditions
- Endotoxemia, Muscle Loss, Catabolic State, Protein; Disease
- Trial name
- NCT04064268
- Testing
- Whey, 3-OHB + Whey
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hyperglycemia, Sepsis
Impact of Dopamine Infusion on Insulin Secretion in Healthy Subjects
This is a clinical study of a drug named dopamine and how it affects our bodies ability to make and secrete insulin. Insulin is a hormone made in the pancreas that helps our body regulate sugar levels.
- Trial name
- NCT02053935
- Testing
- Dopamine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Overweight, Microbiota
Effects of Maple Syrup on Gut Microbiota Diversity and Metabolic Syndrome
It has been suggested that the actual obesity epidemy is related to chronic overconsumption of added or free sugars. The increasing popularity of artificial sweeteners attest the population willingness to reduce added sugars…
- Conditions
- Overweight, Microbiota, Endotoxemia, Metabolic Syndrome
- Trial name
- NCT04117802
- Testing
- Maple syrup
- Where
- Canada
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Laval University
Sepsis, Severe Sepsis
Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis
In this study, the investigators will dynamically detect the expression of an immune regulator- T cell Ig and mucin domain protein 3 (Tim-3) in patient with sepsis.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02180009
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Corticosteroids, Covid19
Short Term Corticosteroids in SARS-CoV2 Patients
The investigators reviewed the charts of SARS-CoV-2 patients with pneumonia and moderate to severely elevated CRP and worsening hypoxemia who were treated with early, short-term dexamethasone.
- Conditions
- Corticosteroids, Covid19, SARS-CoV 2, Steroids
- Trial name
- NCT04445506
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Group B Streptococcus Carrier in Childbirth, Group B Streptococcal Infection, Late-Onset
Maternal, Neonatal and Infant Outcomes at Kawempe National Referral Hospital
Maternal immunisation is an evolving field that deserves special attention given its potential to have a significant positive impact on the health of women and children globally, and the potential safety and risk considerations…
- Conditions
- Group B Streptococcus Carrier in Childbirth, Group B Streptococcal Infection, Late-Onset, Group B Streptococcal Infection, Early-Onset, Group B Streptococcus Neonatal Sepsis
- Trial name
- PREPARE (NCT04653948)
- Where
- Uganda
- Volunteers
- 3,423 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Shock, Sepsis
Surrogate of Adequate Perfusion: Bladder Tissue Oxygen Monitoring
The extent and duration of tissue hypoxia is a major determinant of outcome following major, high-risk surgery and in critical illness.
- Conditions
- Shock, Sepsis, Surgery
- Trial name
- SoAP-BOx (NCT03935477)
- Testing
- WellBeing catheter
- Where
- United Kingdom
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Severe Pediatric Infectious Shock
Pediatric Immune Response to Infectious Shock
Infectious shocks are associated with high mortality rates (20-40%). Anti-inflammatory strategies based on the postulate that mortality related to sepsis is mainly due to an overwhelming pro-inflammatory immune response have…
- Trial name
- PedIRIS (NCT02848144)
- Testing
- blood samples, Collection of nosocomial infections
- Where
- France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Chronic Periodontitis, Bacteremia
Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy
There are not published studies evaluating the incidence, nature, magnitude and/or duration of bacteremia after periodontal treatment.
- Trial name
- AMX-Perio (NCT03354338)
- Testing
- Amoxicillin
- Where
- Colombia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad El Bosque, Bogotá
COVID-19, Cytokine Storm
Fluoxetine to Reduce Intubation and Death After COVID19 Infection
This project will test the efficacy of fluoxetine to prevent serious consequences of COVID-19 infection, especially death. Becoming sick with COVID-19 virus or any other serious respiratory condition is not fun.
- Trial name
- NCT04377308
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Toledo Health Science Campus
Toxic Shock Syndrome Staphylococcal
Phase I STEBVax in Healthy Adults
The main purpose of this study is to test the safety of a new vaccine, STEBVax, which may lead to a useful treatment for toxic shock syndrome.
- Trial name
- NCT00974935
- Testing
- Aluminum hydroxide, STEBVax vaccine
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Study of Controlled Human Malaria Infections to Evaluate Protection After Intravenous or Intramuscular Administration of PfSPZ Vaccine in Malaria-Naive Adults
Background: People bitten by mosquitoes carrying weakened malaria parasites could fight off the disease if later exposed to normal malaria parasites.
- Trial name
- NCT02015091
- Testing
- PfSPZ Vaccine
- Where
- 2 sites in United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sepsis, Severe Sepsis
Gram Type Infection-Specific Sepsis Identification Using Machine Learning
The focus of this study will be to conduct a prospective, randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a Gram type infection-specific…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03734484
- Testing
- InSight
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dascena
Sepsis
Cortisol Control of Human Inflammatory Responses to Endotoxin
The purpose of the research is to study a common and dangerous medical condition called 'septic shock' that often occurs in critically ill patients.
- Trial name
- NCT00396344
- Testing
- Çontrol, Hydrocortisone
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Sepsis, Viral Pneumonia
Discover the Immune Signature of Sepsis Caused by Acute Pulmonary Infection: A Cohort Study
The goal of this observational study is to describe the immune signature of acute pulmonary infection.The main questions it aims to answer are: 1. Nasal mucosal immune response in patients with influenza infection 2.
- Conditions
- Sepsis, Viral Pneumonia, Influenza, Upper Respiratory Tract Infection
- Trial name
- DISPLAY (NCT05612893)
- Testing
- pathogen
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Neonatal Sepsis
Role of Presepsin as a Novel Biomarker in Diagnosis of Neonatal Sepsis
-Introduction: Sepsis is a clinical syndrome that results from a deregulated inflammatory response to an infection. it is life-threatening entity causing millions of deaths worldwide, with variable clinical manifestations and…
- Trial name
- NCT06633770
- Testing
- proclcitonin and presepsin
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Sepsis
Immune Activation, Hypoxia and Vasoreaction in Sepsis of Pulmonary Versus Abdominal Origin
Sepsis remains a common entity in critical care patients with remarkable mortality. Pulmonary and abdominal infections (with subsequent sepsis) are the most common in the ICU.
- Trial name
- NCT01530932
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Obstetric and Perinatal Complications, Postpartum Hemorrhage
A Skills and Drills Intervention for Emergency Obstetrics and Neonatal Care at First Referral Units of North Karnataka
To evaluate the effectiveness of a First Referral Unit (FRU) Emergency Obstetric and Newborn Care (EmONC) skills and drills intervention, to estimate the appropriateness and effectiveness of referrals in intervention arm compared…
- Conditions
- Obstetric and Perinatal Complications, Postpartum Hemorrhage, Preeclampsia/Eclampsia, Obstructed/Prolonged Labor
- Trial name
- NCT01865656
- Testing
- Skills training, Emergency obstetric drills, Revised Case Sheets
- Volunteers
- 15,018 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Sepsis, Neonatal Mortality
Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates
The CLEAN (ChLorine to reduce Enteric and Antibiotic resistant infections in Neonates) cluster randomized controlled trial in western Kenya will evaluate the impact of a multi-component chlorination intervention in health care…
- Conditions
- Sepsis, Neonatal Mortality, Antibiotic Resistant Infection, Enteric Infections
- Trial name
- CLEAN (NCT06824350)
- Testing
- chlorination for water disinfection and surface disinfection, infection prevention and control messaging
- Where
- 2 sites in United States, Kenya
- Volunteers
- 45,450 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Malaria
Markers of T Cell Suppression: Associations With Malaria Infection and Antimalarial Treatment in Malian Children
Background: The disease malaria can cause very serious health problems. Researchers want to see if malaria affects the way T cells and vaccines work in the body.
- Trial name
- NCT02504918
- Where
- Mali
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)