Clinical trials: Systemic Infection
Sepsis, Sepsis Bacterial
A Validation Study of the Lab Clasp Device: A Point of Care Sepsis Risk Monitor
The overall purpose of this study is to demonstrate the usability of a clinical-grade device in the form of a finger clasp similar to a pulse oximeter for monitoring lactate values, by comparing its performance in reading…
- Conditions
- Sepsis, Sepsis Bacterial, Lactate Blood Increase, Infectious Disease
- Trial name
- NCT04796285
- Testing
- Lab Clasp
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sepsis, Endotoxemia, Immunosuppression
The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor Cells
We will investigate whether human endotoxemia induces changes in human bone marrow cells and their downstream effector cells. To comprehensively investigate underlying mechanisms behind functional and transcriptional changes in…
- Trial name
- LPS-BM (NCT05570643)
- Testing
- LPS
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Septic Shock
Methylene Blue in Early Septic Shock
Septic shock is a subset of sepsis characterized by a decrease in vascular tone, which contributes to impaired regional blood flow distribution, and leads to organic failure.
- Trial name
- SHOCKEM-Blue (NCT04446871)
- Testing
- 0.9% sodium chloride, Methylene Blue
- Where
- Mexico
- Volunteers
- 91 people
- Sponsor
- Hospital Civil de Guadalajara
Hemodialysis
HeRO Vascular Access Device Bacteremia Study
The purpose of this study is to compare the safety and effectiveness of the HeRO Vascular Access Device in access challenged (e.g., catheter-dependent) hemodialysis patients.
- Trial name
- NCT00889564
- Testing
- HeRO Vascular Access Device
- Where
- 7 sites in United States
- Volunteers
- 38 people
- Sponsor
- Merit Medical Systems, Inc.
Bacteremia, Gram-Negative Bacterial Infections
Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis
The impact of continuous veno-venous haemofiltration (CVVH) on sepsis-induced multiple organ failure severity is controversial. We thus sought to assess the effect of early application of haemofiltration on the degree of organ…
- Conditions
- Bacteremia, Gram-Negative Bacterial Infections, Gram-Positive Bacterial Infections, Pneumonia, Bacterial
- Trial name
- NCT00406198
- Testing
- venovenous hemofiltration
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Hopital Lariboisière
Critical Illness, Acute Respiratory Distress Syndrome
TelePORT Pilot Study
Although more than 50% of survivors of critical illness experience one or more post-intensive care syndrome (PICS) problems, there are still no validated interventions for the management of PICS.
- Conditions
- Critical Illness, Acute Respiratory Distress Syndrome, Septic Shock
- Trial name
- TelePORT (NCT03926533)
- Testing
- Telehealth
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Vanderbilt University
Diet, Healthy, Food
The PASTDUe Nutrition Ecosystem Project (PASTDUe)
This is a research study to determine if a particular method of providing nutrition improves the clinical outcomes of patients in the intensive care unit (ICU) who have undergone abdominal surgery and would require nutrition…
- Conditions
- Diet, Healthy, Food, Nutrition, Intensive Care
- Trial name
- PASTDUe (NCT05127109)
- Testing
- Nutrition Ecosystem pathway, Comparator
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Sepsis
Antimicrobial Stewardship Reduces MDRO Isolates in Critically Ill Patients
Antimicrobial exposure is known to reduce the selection for various drug-resistant organisms. Numerous studies have demonstrated the association between antimicrobial use and MDR bacteria detection.
- Trial name
- NCT02128399
- Volunteers
- 978 people
- Sponsor
- Jianfeng Xie
Sepsis
SHOCK US STUDY: Fluid Responsiveness in Sepsis Measured by Ultrasonography
The study aim is to examine point-of-care ultrasound findings, reliability, and ease of performance in association with fluid responsiveness for patients with severe sepsis and septic shock.
- Trial name
- NCT02170233
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Yale University
Septic Shock, Intracranial Hypertension
Study SOLACE SEPSIS
A Pilot, Randomized, Double-Blinded, Controlled Study of Hemodynamic and Acid Base Effects of 0.5M Sodium Lactate and 3% Saline Solutions in Septic Shock Patients
- Trial name
- MJIP1_0 (NCT06634069)
- Testing
- Sodium Lactate, 3% NaCl
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Pilsen
Sepsis
Pharmacokinetics and Pharmacodynamics of High Dose Ceftriaxone in Patients With Sepsis
As the general treatment method for infectious diseases is to prescribe antibiotics which can be complete at the empirical treatment with the control of the sources of infection, the types of antibiotics that contain the broad…
- Trial name
- NCT07245966
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Prince of Songkla University
Septic Shock
Plasmaexchange in Early Septic Shock
Sepsis is defined by the occurrence of a systemic inflammatory response syndrome (SIRS) in the context of infection. Unfortunately, its incidence appears to be rising, and the mortality of septic shock remains extraordinary high…
- Trial name
- EXCHANGE (NCT03065751)
- Testing
- Plasmaexchange
- Where
- Germany
- Volunteers
- 352 people
- Sponsor
- Hannover Medical School
Vitamin C, Postoperative
Role of Vitamin C Infusion in Postoperative Mechanically Ventilated Neonates With Sepsis
This study aims to evaluate the effect of intravenous vitamin C infusion on septic mechanically ventilated full-term neonates who underwent surgical interventions regarding mechanical ventilation parameters, time to wean, and the…
- Conditions
- Vitamin C, Postoperative, Mechanically Ventilation, Sepsis
- Trial name
- NCT06780345
- Testing
- Vitamin C
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Sepsis
Procalcitonin Monitoring May Decrease Antibiotic Use in the Intensive Care Unit
Sepsis is common and is associated with significant mortality, morbidity and health-care costs. Unfortunately, its diagnosis is not straightforward because its signs and symptoms are neither specific nor sensitive; in addition…
- Trial name
- NCT01085994
- Testing
- Literature search
- Where
- Greece
- Sponsor
- University of Athens
Oxidative Stress, Septic Shock
Clinical Trial of Antioxidant Therapy in Patients With Septic Shock
Sepsis and septic shock are public health problems worldwide that represents an excessive cost for health systems. Despite the great technological and research advances, mortality can reach up to 80% in patients with multiple…
- Trial name
- NCT03557229
- Testing
- Melatonin 5 mg, Vitamin C 1 GM Oral Tablet, Vitamin E 400 UNT
- Where
- Mexico
- Volunteers
- 131 people
- Sponsor
- American British Cowdray Medical Center
Sepsis, Septic Shock
Observational Trial on Cytokine Adsorption in Sepsis
To determine the specific population of critically ill septic patients who benefit most from cytokine adsorption therapy with the HA-380 cartridge.
- Conditions
- Sepsis, Septic Shock, Multiple Organ Failure
- Trial name
- OuTCASt (NCT04306419)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
AIDS-related Peripheral/Systemic Lymphoma, AIDS-related Primary CNS Lymphoma
17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Advanced Epithelial Cancer, Malignant Lymphoma, or Sarcoma
Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. This phase I trial is studying the side effects and best dose of 17-N-allylamino-17-demethoxygeldanamycin in…
- Conditions
- AIDS-related Peripheral/Systemic Lymphoma, AIDS-related Primary CNS Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma
- Trial name
- NCT00004241
- Testing
- tanespimycin, pharmacological study
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Pneumocystis Jirovecii Infection, Pneumocystis
Prospective Observational Study on the Incidence of Opportunistic Fungal Infections
Corticosteroids exposure is a common risk factor for invasive fungal infections. Systemic corticosteroid therapy treats several medical conditions, including rejection in solid organ transplant recipients, malignancy, and…
- Conditions
- Pneumocystis Jirovecii Infection, Pneumocystis, Cryptococcosis, Candidiasis
- Trial name
- NCT05707156
- Where
- United States
- Volunteers
- 12,032 people
- Sponsor
- University of Colorado, Denver
Zinc in Pediatric Sepsis
Zinc Supplementation in Pediatric Sepsis
a single blinded randomized controlled clinical trial that was conducted to evaluate the role of zinc supplementation in improving the outcome of infants and children with sepsis in pediatric intensive care unit.
- Trial name
- NCT05366595
- Testing
- oral zinc sulfate
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Sepsis
Pilot Trial of External Warming in Septic Patients
The purpose of this study is to determine whether externally warming critically ill afebrile adult septic patients will improve indices of immune function and/or clinical outcomes.
- Trial name
- NCT02706275
- Testing
- External warming
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
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