Clinical trials: Systemic Infection
Acute Renal Failure, Sepsis
Acute Renal Failure in the Surgical Intense Care Units - NTUH-SICU-ARF (NSARF) Study
We examine the prognosis and etiology of postoperative acute renal failure
- Conditions
- Acute Renal Failure, Sepsis, Postoperative
- Trial name
- NCT00451373
- Testing
- CVVH and SLED, Vancomycin, Daptomycin
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Severe Sepsis
Effects of Acute Systemic Inflammation on Arterial Stiffness and Microcirculation.
This study aims to assess the effect of acute inflammation on arterial stiffness and microcirculation. Patients with severe sepsis will be compared with age-, sex- and cardiovascular risk factors-matched controls.
- Trial name
- IRIGA (NCT01556373)
- Testing
- NA : non interventional study
- Where
- 2 sites in France
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Shock, Septic, Sepsis
Efficacy and Safety of Therapy With IgM-enriched Immunoglobulin With a Personalized Dose vs Standard Dose in Patients With Septic Shock.
In patients with septic shock, low levels of circulating immunoglobulins are common and they are kinetic, particularly of immunoglobulin M (IgM), seems to be related with clinical outcome.
- Conditions
- Shock, Septic, Sepsis, Hypoglobulinemia
- Trial name
- IgM-FAT (NCT04182737)
- Testing
- IgM-enriched polyclonal immunoglobulins titer-based treatment, IgM-enriched polyclonal immunoglobulins Flat treatment
- Where
- Italy
- Volunteers
- 356 people
- Sponsor
- Massimo Girardis
Sepsis, Shock, Septic
Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis
Lipids and lipoproteins (cholesterol and lipid metabolites) are present in sepsis and are highly biologically active regulators of inflammation, but currently the changes in lipid and lipoprotein homeostasis during sepsis are not…
- Trial name
- NCT04576819
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Florida
Cytomegalovirus Retinitis, HIV Infections
A Phase I/II Open-Labelled Trial of Intravitreal Ganciclovir Salvage Therapy for AIDS Patients With Active CMV Retinitis Who Are Intolerant of Systemic Therapy
AMENDED: 04-12-91 Population of patients changed FROM those who are intolerant of systemic therapy with NON-sight-threatening CMV retinitis TO those AIDS patients intolerant of systemic therapy with CMV retinitis.
- Trial name
- NCT00000673
- Testing
- Ganciclovir
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Subarachnoid Hemorrhage (SAH)
Serum Procalcitonin
Systemic inflammatory response syndrome (SIRS) is characterized by changes in body temperature, heart rate, respiratory rate, or peripheral blood white cell count, and is often a heralding manifestation of blood infection (ie.…
- Trial name
- NCT00954551
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Sepsis, Septic Shock
Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa
Open-label phase 2a Randomized Controlled Trial (RCT) assessing the pharmacokinetics of two different doses of intravenous vitamin C given alongside vitamin B1 in adult medical patients with sepsis and hypotension.
- Conditions
- Sepsis, Septic Shock, HIV
- Trial name
- REVISTA-DOSE (NCT04999137)
- Testing
- Vitamin C, Vitamin B1
- Where
- 2 sites in Uganda
- Volunteers
- 60 people
- Sponsor
- Liverpool School of Tropical Medicine
Critical Illness, Selenium Deficiency
The Prognostic Impact of Selenium On Critical Surgical Patients
Selenium is an important trace element for human for its multiple roles such as the antioxidant activity. Previous evidences showed that critically ill patients may benefit from selenium supplement but the dose and results are…
- Conditions
- Critical Illness, Selenium Deficiency, Trace Element Deficiency, Acute Abdomen
- Trial name
- NCT04662242
- Testing
- Selenium Supplement, normal saline
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Pneumonia, Sepsis
Effects of Lumbrokinase DLBS1033 on D-Dimer, Interleukin-6, and Clinical Outcomes in Patients With Pneumonia and Sepsis
Pneumonia is a lung infection that can cause serious complications, especially when accompanied by sepsis. Sepsis can trigger excessive inflammation and abnormal blood clotting, potentially leading to organ damage and delayed…
- Conditions
- Pneumonia, Sepsis, Blood Coagulation Disorders
- Trial name
- NCT07892794
- Testing
- DLBS1033
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Sebelas Maret
Sepsis, Septic Shock
Investigation of the Role of Brain Natriuretic Peptide and Lactate in Early Goal-directed Therapy for Patients With Severe Sepsis and Septic Shock
B-type natriuretic peptide (BNP) is a cardiac neurohormone which rapidly released by the ventricle in response to myocardial stretch.
- Trial name
- NCT01539551
- Testing
- check BNP and lactate
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Septic Shock, Sepsis
Terlipressin in Septic Shock: Effects on Microcirculation
The present study was conducted as a prospective, randomized study to investigate the effects of vasopressin receptor agonists terlipressin and vasopressin on systemic hemodynamics and microcirculation in patients with…
- Trial name
- NCT00995839
- Testing
- continuous infusion of terlipressin, Arginine vasopressin, terlipressin bolus administration
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Critically Ill
Coated Devices to Decrease Infection in the Intensive Care Unit
Pilot explanatory, randomized, open label, controlled trial. Critically ill patients which will demand placement of invasive devices for organ support (endotracheal tube, central venous catheter and urinary Foley catheter) will…
- Trial name
- CRITIC (NCT03868241)
- Testing
- Coated devices, Control
- Where
- 6 sites in Brazil
- Volunteers
- 103 people
- Sponsor
- Hospital do Coracao
Sepsis, Maternal Sepsis
mSEP: Testing of Physiological and Immune-metabolic Blood Markers for Maternal Sepsis
A prospective observational cohort study investigating physiological parameters vs biological markers of whole blood in septic and non-septic pregnant woman to predict systemic immune health
- Conditions
- Sepsis, Maternal Sepsis, Maternal Sepsis During Labor, SIRS
- Trial name
- NCT05023954
- Testing
- Blood test
- Where
- United Kingdom
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Cardiff University
Bacteremia, Sepsis
Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care in Turkey
In this observational study, it is aimed to investigate the mortality and morbidity rates of hospital-acquired blood stream infections that are treated in intensive care units (ICU).
- Conditions
- Bacteremia, Sepsis, Hospital Acquired Condition
- Trial name
- NCT04304456
- Testing
- Treatment
- Volunteers
- 810 people
- Sponsor
- SCARE (Study group for carbapenem resistance)
Head Trauma, Polytrauma
Comparative Study for the Validity of Various Severity Scoring System
Scoring systems for use in intensive care unit (ICU) patients have been introduced and developed over the last 30 years. They allow an assessment of the severity of disease and provide an estimate of in-hospital mortality
- Conditions
- Head Trauma, Polytrauma, Pre-Eclampsia, Sepsis
- Trial name
- NCT04683094
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
Sepsis Syndrome, Systemic Inflammatory Response Syndrome
The Role of Myristic Acid in Serum for Early Diagnosis of Sepsis and Comparison With Selected Biomarkers of Sepsis
The aim of the study is to measure serum levels of myristic acid in septic patients and to compare them with myristic acid serum levels in patients with Systemic Inflammatory Response Syndrome of non infective etiology and in…
- Trial name
- NCT03314831
- Where
- Czechia
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome, Septic Shock
Early Continuous Renal Replacement Therapy for Pediatric Septic Shock
Septic shock is a major cause of morbidity and mortality in critically ill children. Continuous renal replacement therapy (CRRT) is increasingly used as adjunctive support in pediatric septic shock to improve hemodynamic…
- Trial name
- NCT07370753
- Where
- Vietnam
- Volunteers
- 50 people
- Sponsor
- National Children's Hospital, Vietnam
Anxiety Disorder, Cancer Survivor
Quality of Life in Younger Leukemia and Lymphoma Survivors
RATIONALE: Collecting information about the effect of hematologic cancer and its treatment on quality of life may help doctors learn more about the disease and plan the best treatment.
- Conditions
- Anxiety Disorder, Cancer Survivor, Fatigue, Leukemia
- Trial name
- NCT00956475
- Testing
- telephone-based intervention, questionnaire administration, assessment of therapy complications
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Case Comprehensive Cancer Center
Severe Sepsis, Septic Shock
Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis
Severe sepsis and septic shock are diseases of infectious origin with a high risk of death. The purpose of this study is to determine whether the intravenous application of selenium (given as sodium-selenite) can reduce mortality…
- Trial name
- SISPCT (NCT00832039)
- Testing
- sodium-selenite, Procalcitonin guided therapy
- Where
- 35 sites in Germany
- Volunteers
- 1,089 people
- Sponsor
- Kompetenznetz Sepsis
Maternal sepsIs
Selective Lipopolysaccharide Hemosorption in Maternal Sepsis
One of the major health problems in the world is sepsis, the number of cases of which, according to WHO, annually reaches 20-30 million. The prevalence and frequency of obstetric sepsis are quite pronounced.
- Trial name
- MINERVA (NCT05711901)
- Testing
- Efferon LPS
- Where
- 7 sites in Russia
- Volunteers
- 30 people
- Sponsor
- Efferon JSC
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