Clinical trials: Systemic Infection
Septic Shock
Assessment of Microcirculatory Dysfunction in Septic Shock Patients by OCTA
Purpose and rationale: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis and septic shock are major public health problems killing one in every three patients.
- Trial name
- SshOCTA (NCT04593212)
- Testing
- Optical Coherence Tomography Angiography
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital da Luz, Portugal
Disease, Viral, Cytokine Release Syndrome
Th1/Th2/Th17/TREG and TLRs Activation/KIR for COVID 19 Prediction of Outcome
To ascertain globally the changes in the cytokines involved and TLRs/KIR activation in patients admitted to the hospital with a COVID-19 diagnosis, and the changes after initiation of the different therapies
- Conditions
- Disease, Viral, Cytokine Release Syndrome, TLRs
- Trial name
- Resistir (NCT04403061)
- Testing
- Cytokines measurement, Cellular response, TLRs activation measurement
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Asociacion para el Estudio de las Enfermedades Infecciosas
Sepsis, Infections
Improving Therapeutic Drug Monitoring and Dosing for Vancomycin in Young Infants With Infections (VANCAPP) (Part 2)
A challenge to intermittent vancomycin dosing in young infants is the avoidable delay caused by the need to wait until steady state (i.e.
- Conditions
- Sepsis, Infections, Bacteremia
- Trial name
- VANCAPP (NCT05770622)
- Testing
- First-dose trough dose adjustment calculator - using early TDM (first-dose trough) to determine an early dose adjustment if the predicted steady-state trough is outside of target range (10-20mg/L)
- Where
- 4 sites in Australia
- Volunteers
- 40 people
- Sponsor
- Murdoch Childrens Research Institute
Sepsis, Atrophy
HO-1 and Muscle Mitochondrial Dysfunction in Sepsis
The current project was designed to examine dynamic changes in muscle wasting during sepsis. Researchers will focus the mitochondrial dysfunction of muscle cells and investigate the role of HO-1 in it.
- Trial name
- NCT02359240
- Testing
- therapy according to SSC guidelines and muscle biopsy, standard surgery for femoral fracture and muscle biopsy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Changhai Hospital
Covid19
Vitamin D, Omega-3, and Combination Vitamins B, C and Zinc Supplementation for the Treatment and Prevention of COVID-19
The NUTROVID Factorial Trials The purpose of the NUTROVID-Prevent and NUTROVID-Treat Factorial Trials is to determine whether Vitamin B Complex, Vitamin C, and Zinc; Vitamin D; and Omega3, taken at dosages approximating…
- Trial name
- NUTROVID (NCT04828538)
- Testing
- Vitamin D, Omega DHA / EPA, Vitamin C, Vitamin B complex and Zinc Acetate
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hospital de la Soledad
Sepsis
Beta-Lactam InfusioN Group Study
The purpose of this study is to find out whether continuous infusion of beta-lactam antibiotics or intermittent infusion or beta-lactam antibiotics, offers more health advantages to patients or if there is no difference.
- Trial name
- BLING III (NCT03213990)
- Testing
- Continuous infusion, Intermittent infusion
- Where
- 103 sites in Australia, Belgium and 5 more
- Volunteers
- 7,203 people
- Sponsor
- The George Institute
Burns, Sepsis
The Impact of Continuous Renal Replacement Therapy on the Outcomes of Burn Patients With Early Phase of Sepsis
The purpose of this study is to determine if early application of CRRT will result in an improvement of clinical outcomes of burn patients during the early phase of sepsis
- Trial name
- CRRT (NCT01501097)
- Testing
- Continuous Renal Replacement Therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Southwest Hospital, China
COVID-19
Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults
A Double-blind, Randomized, Controlled, Phase 2a Study to Evaluate the Safety and Tolerability of a Newcastle Disease Virus-based Mucosal Vaccine (NDV-HXP-S-KP.2) Relative to an Approved Systemic mRNA Vaccine in Previously…
- Trial name
- NCT07215520
- Testing
- NDV-HXP-S-KP.2, COVID-19 mRNA Vaccine
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CastleVax Inc.
Critical Illness, Sepsis
Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial
This is a prospective, unmasked, randomized, multicenter clinical trial evaluating the impact of point-of-care large language model (LLM)-based decision support on diagnostic accuracy and clinical outcomes in adult medical…
- Conditions
- Critical Illness, Sepsis, Acute Respiratory Failure (ARF), Multi-organ Failure
- Trial name
- POC-AI-ICU (NCT07293078)
- Testing
- Point-of-care large language model decision support (ChatGPT-5)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- MetroWest Artificial Intelligence Research Workgroup
Biomarkers, Acute Kidney Injury
Vancomycin Exposure and Biomarker Tracking Using Real-time Monitoring of Interstitial Fluid
The goal of this observational study is to understand whether a wearable sensor (the Nutromics Sensor Device) can accurately measure drug and biomarker levels in the fluid just under the skin (interstitial fluid), instead of…
- Conditions
- Biomarkers, Acute Kidney Injury, Sepsis
- Trial name
- VENTURE (NCT07893223)
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Nutromics
Sepsis, Severe Sepsis
Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis
This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock, Multi-organ Failure
- Trial name
- NCT01315782
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center, Houston
Septic Shock
Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock?
The main objective of this study is to evaluate in a population of patients with septic shock receiving 500 ml crystalloid over 10 minutes, the proportion of patients classified as "responders" to the fluid challenge (increase of…
- Trial name
- FC-Rev (NCT02116413)
- Testing
- Fluid challenge, Cardiac ultrasound
- Where
- 9 sites in France
- Volunteers
- 145 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Severe Sepsis, Septic Shock
Mannheim Register of Sepsis and Septic Shock
The study aims to investigate clinically and prognostically relevant parameters in patients with sepsis and septic shock within a monocentric observational clinical register.
- Trial name
- MARSS (NCT05231720)
- Where
- 2 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Universitätsmedizin Mannheim
Septic Shock
Clinical Trial Comparing Noradrenaline (NA) Plus Placebo Versus Noradrenaline Plus Terlipressin (TP) in Septic Shock
Septic shock is a major health problem. In the clinical practice guidelines of the Surviving Sepsis Campaign is recommended to add vasopressin (VP) or epinephrine in case of not reaching the goal of mean arterial pressure (MAP)…
- Trial name
- NCT05207280
- Testing
- Noradrenaline plus Terlipressin
- Where
- 10 sites in Spain
- Volunteers
- 152 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Sepsis
Role of the Kallikrein-kinin System in Septic Cardiomyopathy
The purpose of this study is to investigate whether there are differential expressions of molecules in the kallikrein-kinin system (KKS) pathway in septic cardiomyopathy, and to analyze their regulatory mechanisms and gene…
- Trial name
- NCT06080282
- Testing
- Ulinastatin
- Where
- China
- Volunteers
- 567 people
- Sponsor
- Qin Zhang
Septic Shock
Impact of Early Goal-Directed Therapy to Perfusion and Metabolism of Brain
Early goal directed therapy (EGDT) is an effective treatment for patients with septic shock, which is widely used in clinic. Fluid resuscitation can significantly reduce the mortality of patients with septic shock and improve the…
- Trial name
- NCT02706379
- Testing
- Local cerebral oxygen saturation
- Volunteers
- 26 people
- Sponsor
- Southeast University, China
Bacteremia Due to Staphylococcus Aureus
Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia
The aim of this study is to compare the efficacy of daptomycin treatment versus vancomycin treatment in the treatment of methicillin resistant staphylococcus aureus (MRSA) bloodstream infections (BSI) due to isolates with high…
- Trial name
- NCT01975662
- Testing
- Daptomycin, Vancomycin
- Where
- Singapore
- Volunteers
- 14 people
- Sponsor
- Singapore General Hospital
Sepsis, Septic Shock
Lactate Kinetics in Septic Shock
Lactate kinetics will be studied in hospitalized septic patients using a bolus injection of stable isotopically labeled lactate.
- Trial name
- LKISS (NCT05349370)
- Testing
- Isotopically labeled lactate
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska University Hospital
Sepsis
Pharmacokinetics and Pharmacodynamics of Ceftazidime in Pediatric ICU Patients
Mortality benefit has been proven with early antibiotic administration in sepsis. Antimicrobial therapy should be based on early achievement of effective drug concentrations by optimizing the pharmacokinetic/pharmacodynamics of…
- Trial name
- NCT03133910
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Early Onset Sepsis, Preterm Neonates
Optimizing PreTerm Infant Ampicillin Dosing
The goal of this clinical trial is to learn if preterm infants who are prescribed antibiotics shortly after birth can safely receive a shorter course of antibiotics (24 to 36 hours instead of 48 hours).
- Conditions
- Early Onset Sepsis, Preterm Neonates, NICU, Ampicillin
- Trial name
- OPTI-Amp (NCT07610486)
- Testing
- Ampicillin prescribed by provider per standard of care for evaluation of early onset sepsis
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.