Clinical trials: Systemic Infection
Septic Shock
Vasopressin for Septic Shock Pragmatic Trial
Life-threatening low blood pressure due to a serious infection is called "septic shock." Septic shock is treated with vasopressors, medications that raise blood pressure.
- Trial name
- VASSPR (NCT06217562)
- Testing
- Vasopressin, Recommendation to use a lower initiation threshold for vasopressin, Recommendation to use a higher initiation threshold for vasopressin
- Where
- 13 sites in United States
- Volunteers
- 3,959 people
- Sponsor
- Intermountain Health Care, Inc.
Escalation of Care, Cardiopulmonary Arrest
Early Warning System for Clinical Deterioration on General Hospital Wards
The goal is to develop a two-tiered monitoring system to improve the care of patients at risk for clinical deterioration on general hospital wards (GHWs) at Barnes-Jewish Hospital (BJH).
- Conditions
- Escalation of Care, Cardiopulmonary Arrest, Respiratory Arrest, Severe Sepsis
- Trial name
- NCT01280942
- Testing
- EWS Nursing Alerts, Wireless Remote Sensor
- Where
- United States
- Volunteers
- 20,031 people
- Sponsor
- Washington University School of Medicine
Sepsis, Infections
The Role of NLR in the Diagnosis and Prognosis of Sepsis
Neutrophil-lymphocyte ratio (NLR), as an inflammatory index, is cheap and easy to obtain, and could be widely used in hospitals at all levels.
- Trial name
- NCT05636202
- Testing
- No intervention
- Where
- China
- Volunteers
- 606 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Bacteremia
Predicting the Optimal Empirical Antibiotic Therapy for Bacteremia Using an Artificial Intelligence-based Model
Bacteremia, a common infection associated with high morbidity and mortality, requires prompt and appropriate antibiotic treatment.
- Trial name
- OPTIBact (NCT07894237)
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 8,765 people
- Sponsor
- Nantes University Hospital
Sepsis, Severe Sepsis
Microcirculatory Oxygen Uptake in Sepsis
Forearm vasoocclusive testing (VOT) will be performed with laser-doppler spectrophotometry system in septic patients on ICU. Microcirculatory oxygen uptake will be checked for prognostic value and for associations with tissue…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02430142
- Testing
- Vasoocclusive testing
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- Universitätsmedizin Mannheim
Severe Sepsis
Symphony IL-6 Cutoff Validation Study for Patients at Risk of Severe Sepsis
Symphony IL-6 is a device that quantitates human IL-6 by fluorescence enzyme immunoassay (FEIA) from whole-blood specimens. Use of Symphony IL- 6 removes the need for plasma separation before testing.
- Trial name
- NCT05048927
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Bluejay Diagnostics, Inc.
Covid19, Corona Virus Infection
Clinical Outcomes of High Dose Vitamin D Versus Standard Dose in COVID-19 Egyptian Patients
Vitamin D is a secosteroid hormone which may have beneficial role in reducing COVID-19 adverse outcomes by first regulating the renin angiotensin system (RAS).
- Conditions
- Covid19, Corona Virus Infection, Cytokine Storm, Vitamin D Deficiency
- Trial name
- NCT04738760
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Ain Shams University
Sepsis, Blood Pressure
Midodrine Hydrochloride in Early Sepsis
The investigators would like to determine if early administration of oral Midodrine in participants diagnosed with sepsis will impact blood pressures and decrease the need for and/or doses of intravenous pressor agents.
- Trial name
- NCT03129542
- Testing
- Midodrine Hydrochloride 10 milligrams
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Mayo Clinic
Severe Sepsis, Septic Shock
Scandinavian Starch for Severe Sepsis/Septic Shock Trial
By tradition hydroxyethyl starch (HES) is used to obtain fast circulatory stabilisation in critically ill. High molecular weight HES may, however, cause acute kidney failure in patients with severe sepsis.
- Trial name
- 6S (NCT00962156)
- Testing
- 6% Hydroxyethyl starch 130/0.4, Ringers acetate
- Where
- 26 sites in Denmark, Finland and 2 more
- Volunteers
- 804 people
- Sponsor
- Anders Perner
Sepsis, Septic Shock
IL-40 and IL-41 Levels in Sepsis, Septic Shock, and Healthy Individuals
This study aims to investigate the blood levels of two recently identified immune-related proteins, Interleukin-40 (IL-40) and Interleukin-41 (IL-41), in patients with sepsis and its more severe form, septic shock.
- Conditions
- Sepsis, Septic Shock, Inflammation, Biomarkers
- Trial name
- NCT06963541
- Testing
- No intervention; Observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Melahat Yalcin Solak
Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia
Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for Cancer
This clinical trial studies massage therapy given by caregiver in treating quality of life of young patients undergoing treatment for cancer.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia, Angioimmunoblastic T-cell Lymphoma, Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative
- Trial name
- NCT01053494
- Testing
- massage therapy, questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Burns, Sepsis
Rapid Detection of Staphylococcus Aureus in Burn Patients
The purpose of this study is to determine if rapid early detection of the bacteria causing sepsis in burn patients improves patient outcomes.
- Trial name
- PCR-Staph (NCT01140269)
- Testing
- PCR test
- Where
- 4 sites in United States
- Volunteers
- 218 people
- Sponsor
- American Burn Association
Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury(ALI)
A Study on the Treatment of Patients With Acute Lung Injury Caused by Sepsis Through Microbiota Transplantation
Sepsis is a systemic inflammatory response syndrome triggered by infection, and it is a common critical illness in clinical practice, often leading to multiple organ dysfunction.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury(ALI), Sepsis Related Acute Lung Injury/Acute Respiratory Distress Syndrome
- Trial name
- NCT07342205
- Testing
- Human-derived active intestinal bacterial liquid group
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Septic Shock
Continuos Terlipressin Infusion in Septic Shock
The purpose of this study is to evaluate the efficacy of terlipressin for treating septic shock.
- Trial name
- NCT01697410
- Testing
- Terlipressin, Norepinephrine
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
ARDS, Human, Sepsis, Severe
The Effect pf Goal-directed De-escalation in ARDS on Organ Function and Mortality
Objective: To compare two de-escalation strategies guided by either extravascular lung water or global end-diastolic volume-oriented algorithms in patients with sepsis and ARDS. Design: A prospective randomized study.
- Trial name
- NCT04508296
- Testing
- Goal directed de-escalation therapy
- Where
- Russia
- Volunteers
- 46 people
- Sponsor
- Northern State Medical University
Leukemia, Lymphoma
Interleukin-2 Following Bone Marrow Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Interleukin-2 may stimulate a person's white blood cells to kill cancer cells. PURPOSE: Phase I trial to study the effectiveness of interleukin-2 following bone marrow transplantation in treating patients who have…
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00003962
- Testing
- aldesleukin
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Shock, Septic
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study
The objective of this pilot study is to assess overall feasibility prior to embarking on a larger randomized pragmatic trial comparing the clinical effectiveness of fluid resuscitation with NS versus LR for pediatric patients…
- Trial name
- PRoMPT BOLUS (NCT03340805)
- Testing
- Lactated Ringer, Normal saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Philadelphia
Sepsis
Statins for the Early Treatment of Sepsis
We propose a Phase II, randomized, placebo-controlled clinical trial to test the hypothesis that treatment with once-daily statins has a beneficial effect on inflammatory cytokines and clinical outcomes in adults hospitalized…
- Trial name
- SETS (NCT00528580)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Chicago
Sepsis Syndrome, Sepsis
Sepsis: From Syndrome to Personalized Care
This is a prospective, observational study designed to examine the performance of biomarkers, molecular biological methods and other analysis in blood from patient with suspected sepsis in the Emergency department, as well as…
- Conditions
- Sepsis Syndrome, Sepsis, Sepsis, Severe, Septic Shock
- Trial name
- NCT04203979
- Where
- Norway
- Volunteers
- 1,950 people
- Sponsor
- Oslo University Hospital
Sepsis
Reducing 30-Day Sepsis Readmissions: Impact of a Post Discharge Education Program
This study will advance the knowledge in the field by determining the effectiveness of discharge education regarding prevention of a new infection which is the highest cause of readmission for sepsis patient.
- Trial name
- NCT05602896
- Testing
- Sepsis education
- Sponsor
- Washington University School of Medicine
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