Clinical trials: Systemic Inflammation (hsCRP)
Atherosclerotic Cardiovascular Disease, Heart Failure
Focus on Levels of Awareness and Perceptions Regarding hsCRP in Identifying Systemic Inflammation in ASCVD, CKD and Heart Failure Management
This is a survey-based study conducted among cardiologists and nephrologists treating people with Atherosclerotic Cardiovascular Disease (ASCVD), Heart Failure (HF) and Chronic Kidney Disease (CKD).
- Conditions
- Atherosclerotic Cardiovascular Disease, Heart Failure, Chronic Kidney Disease
- Trial name
- FLARE (NCT07160829)
- Testing
- No treatment given
- Where
- 4 sites in Australia, India and 2 more
- Volunteers
- 608 people
- Sponsor
- Novo Nordisk A/S
Inflammation, Periodontal Disease
Correlation Between Oral Health and Systemic Inflammation (COHESION)
COHESION is a randomized trial targeting reduction of systemic inflammation through an oral hygiene regimen incorporating a plaque-disclosing toothpaste and a control toothpaste.
- Conditions
- Inflammation, Periodontal Disease, Gingivitis
- Trial name
- COHESION (NCT03641989)
- Testing
- Plaque disclosing toothpaste, Non-plaque disclosing toothpaste
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Marshfield Clinic Research Foundation
Sepsis, SIRS
Performance Evaluation of the Nanomix eLab® CRP, PCT, and LAC Assays With the Nanomix eLab System
The performance of the eLab C-Reactive Protein, Procalcitonin, and Lactate Assays will be demonstrated during a method comparison study in which venous whole blood and plasma samples are used.
- Trial name
- NCT03876535
- Testing
- Nanomix eLab® System molecular diagnostic test (non-interventional)
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Nanomix
Sepsis, Osteoporotic Hip Fracture
Prediction of Mortality and Morbidity After Hip Fracture Using Monocyte Distribution Width (MDW)
Hip fracture is a common injury in older adults and is often associated with serious complications, longer hospital stays, and increased risk of death.
- Conditions
- Sepsis, Osteoporotic Hip Fracture, Hip Fracture
- Trial name
- MDW (NCT07350785)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Infection Systemic
Duration of Antibiotic Therapy in Critically Ill Patients: C-reactive Protein-guided Therapy Versus Best Practice
The judicious use of antibiotics is one of the main measures to limit the emergence of multidrug-resistant pathogen related to excessive antimicrobial use.
- Trial name
- NCT02987790
- Testing
- C-reactive protein
- Where
- Brazil
- Volunteers
- 135 people
- Sponsor
- Federal University of Minas Gerais
Crp
CRP/Albumin Ratio as a Predictive Inflammatory Marker for Postoperative SIRS and/or Sepsis
The goal of this observational study is to determine the value of CRP/Albumin Ratio as an inflammatory marker for predicting the development of postoperative Systemic Inflammatory Response Syndrome and/or Sepsis in…
- Trial name
- NCT06050759
- Testing
- CRP and Albumin level in blood sample
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
A Study to Understand the Real-world Awareness and Perceptions of Systemic inFLAMmation and rolE of hsCRP as a Biomarker in Patients With AtheroSclerotic CardioVascular Disease and Chronic Kidney Disease Among Nephrologists
The purpose of this survey is to collect information for scientific research and to better understand the role of systemic inflammation in identification, treatment and management of patients with Atherosclerotic Cardiovascular…
- Conditions
- Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD), Systemic Inflammation
- Trial name
- NCT06322641
- Testing
- No treatment given
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Novo Nordisk A/S
Neonatal Sepsis
Salivary C- Reactive Protein, Mean Platelet Volume and Neutrophil Lymphocyte Ratio as Diagnostic Markers for Neonatal Sepsis
To evaluate reliability of salivary C-reactive protein ,mean platelet volume , neutrophil -lymphocyte ratio , and platelet lymphocyte ratio in diagnosis of neonatal sepsis
- Trial name
- NCT04800445
- Testing
- Salivary CRP
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Systemic Inflammation (hsCRP)
Levels of Inflammation in Middle East People With Cardiovascular Disease With/Without Kidney Disease
This study will collect medical and background information from participants with diseases that affect the heart and blood vessels (cardiovascular disease) with/without kidney disease.
- Trial name
- INFLAMEAST (NCT06655493)
- Testing
- No treatment given
- Where
- 20 sites in Saudi Arabia, United Arab Emirates
- Volunteers
- 756 people
- Sponsor
- Novo Nordisk A/S
Septic Shock, Nonchemotherapy Drug-induced Neutropenia
Russian Clinical Trial of Mesenchymal Cells in Patients With Septic Shock and Severe Neutropenia
Septic shock remains a significant clinical problem associated with high rates of mortality among neutropenic patient despite antimicrobial therapy and supportive care.
- Conditions
- Septic Shock, Nonchemotherapy Drug-induced Neutropenia, Neutropenia After Chemotherapy in Oncohematological Patients, Neutropenia in Patients With Aplastic Anemia
- Trial name
- NCT01849237
- Testing
- Mesenchymal stromal cells, Standard therapy of septic shock
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- National Research Center for Hematology, Russia
Sepsis, Infection
C-reactive Protein Information and Blood Cultures for Emergency Department Patients With Sepsis
Patients with sepsis (2 or more systemic inflammatory response syndrome criteria and suspected infection) assessed in the emergency department have blood cultures obtained to identify potential blood stream infections (BSI).
- Conditions
- Sepsis, Infection, Bacteremia
- Trial name
- NCT03714841
- Testing
- CRP
- Where
- 2 sites in Canada
- Volunteers
- 208 people
- Sponsor
- University of British Columbia
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
A Multinational Survey-based Study to Understand the Real-world Awareness and Perceptions of Systemic inFLAMmation and rolE of hsCRP as a Biomarker in Patients With AtheroSclerotic CardioVascular Disease and Chronic Kidney Disease Among Cardiologists
The purpose of this survey is to collect information for scientific research and to better understand the role of systemic inflammation in identification, treatment and management of patients with ASCVD and CKD.
- Trial name
- FLAME-ASCVD (NCT05755373)
- Testing
- No treatment given
- Where
- India
- Volunteers
- 602 people
- Sponsor
- Novo Nordisk A/S
Severe Sepsis, Septic Shock
Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections
In this study the investigators aim to test if C-reactive protein (CRP)or procalcitonin(PCT) - guided strategy allows to reduce the antibiotic use in patients wiht severe sepsis and septic shock.
- Trial name
- NCT00934011
- Testing
- C-reactive protein guided antibiotic therapy, Procalcitonin guided antibiotic therapy
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- Federal University of Minas Gerais
Stroke, Post-Stroke Cognitive Impairment
Immune-Inflammatory Biomarkers in Predicting Early Cognitive Impairment in Adults With Acute Basal Ganglionic Stroke
Post-stroke cognitive impairment (PSCI) is a common and disabling complication that affects memory, thinking, and daily functioning after a stroke.
- Conditions
- Stroke, Post-Stroke Cognitive Impairment, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT07837466
- Volunteers
- 100 people
- Sponsor
- Assiut University
Prior Acute Myocardial Infarction, Evidence of Systemic Inflammation (C Reactive Protein Plasma >2 mg/l)
Interleukin-1 Blockade With Canakinumab to Improve Exercise Capacity in Patients With Chronic Systolic Heart Failure and Elevated High Sensitivity C-reactive Protein (Hs-CRP)
The proposed study is a sub-study of the CANTOS trial (A randomized, double-blind, placebo-controlled, event driven trial of quarterly subcutaneous canakinumab in the prevention of recurrent cardiovascular events among stable…
- Conditions
- Prior Acute Myocardial Infarction, Evidence of Systemic Inflammation (C Reactive Protein Plasma >2 mg/l), Reduced Left Ventricle Ejection Fraction (<50%), Symptoms of Heart Failure (NYHA Class II-III)
- Trial name
- NCT01900600
- Testing
- Cardiopulmonary exercise test, Echocardiogram
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Virginia Commonwealth University
Sepsis
Time Course of Procalcitonin and C Reactive Protein in Septic Patients Under Treatment With Corticosteroids
A systemic treatment with corticosteroids has been advocated for various bacterial infectious diseases. Since the production of CRP is down-regulated by corticosteroids, a smaller increase or a more rapid decrease of this acute…
- Trial name
- NCT00141973
- Where
- Switzerland
- Sponsor
- Ospedale Regionale Bellinzona e Valli
Systemic Inflammation (hsCRP), Healthy Aging
Evaluation of AppleX™ Apple Extract on Anti-Inflammatory and Healthy Aging Effects
The goal of this clinical trial is to learn if AppleX™ Apple Extract can help lower systemic inflammation in adults aged 45-70 with signs of low-grade inflammation.
- Conditions
- Systemic Inflammation (hsCRP), Healthy Aging, Vitality, Healthy Adult Participants
- Trial name
- NCT07678346
- Testing
- Apple Extract
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Nutraland USA, Inc.
Heart Transplant, Periodontitis
Effect of Non-Surgical Periodontal Therapy on Inflammation in Heart Transplant Recipients
Heart transplant recipients frequently exhibit chronic low-grade systemic inflammation, which can contribute to allograft dysfunction and cardiovascular complications.
- Conditions
- Heart Transplant, Periodontitis, Gingivitis, Systemic Inflammation
- Trial name
- NCT07791927
- Testing
- Full-mouth periodontal debridement
- Volunteers
- 20 people
- Sponsor
- Baskent University
Systemic Infection
Efficacy and Safety of a Protocol Using C-reactive Protein to Guide Antibiotic Therapy
The growing resistance of microorganisms to antimicrobials is a major threat to public health nowadays. Reducing the consumption of antibiotics is one of the main strategies to control this issue.
- Trial name
- NCT05841875
- Testing
- C reactive protein algorithm
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Federal University of Minas Gerais
Diabetes Mellitus, Periodontal Disease
Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus
This study aimed to investigate the effects of diode laser (DL) in addition to non-surgical periodontal treatment on periodontal parameters, systemic inflammatory response, and serum hemoglobin A1c (HbA1c) level in patients with…
- Trial name
- NCT03444363
- Testing
- Laser group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University