Clinical trials: Systemic Inflammatory Markers
HIV Infections
The Anti-HIV Effects of Saquinavir Soft Gelatin Capsules Versus Indinavir in Patients Who Have Used Saquinavir Hard Gelatin Capsules for One Year
To determine, in HIV-infected patients, whether switching to a new soft gelatin capsule formulation of saquinavir or to indinavir following prolonged use of the original hard capsule formulation of saquinavir results in an acute…
- Trial name
- NCT00000848
- Testing
- Indinavir sulfate, Saquinavir
- Where
- 16 sites in United States
- Volunteers
- 144 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Neonatal Sepsis, Markers
Tissue Doppler Echocardiographic Assessment of Cardiac Function in Neonatal Sepsis
1. To assess myocardial function in neonates with sepsis using tissue doppler echocardiography. 2. To assess sepsis induced cardiac dysfunction. 3.
- Trial name
- NCT07572916
- Testing
- cardiac troponin, and blood culture
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis, Maternal Sepsis
mSEP: Testing of Physiological and Immune-metabolic Blood Markers for Maternal Sepsis
A prospective observational cohort study investigating physiological parameters vs biological markers of whole blood in septic and non-septic pregnant woman to predict systemic immune health
- Conditions
- Sepsis, Maternal Sepsis, Maternal Sepsis During Labor, SIRS
- Trial name
- NCT05023954
- Testing
- Blood test
- Where
- United Kingdom
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Cardiff University
Gastric Cancer
Prognostic Values of Inflammation-based Indices in Gastric Cancer
This study aims to evaluate the prognostic values of preoperative inflammation-based indices in patients undergoing potentially curative resection of gastric cancer.
- Trial name
- NCT05075421
- Testing
- Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 350 people
- Sponsor
- Gulhane Training and Research Hospital
Albumin Supplementation, Albumin Therapy
The Effect of Albumin Supplementation on the Inflammatory and Oxidative Stress Markers in Septic Patients
There is currently no uniform target for serum albumin levels in some pathological conditions, but recent studies have shown that serum albumin concentrations, disease severity, and mortality rates have been linked.
- Conditions
- Albumin Supplementation, Albumin Therapy, Sepsis
- Trial name
- NCT03950778
- Testing
- Human albumin
- Where
- 2 sites in Hungary
- Volunteers
- 40 people
- Sponsor
- University of Pecs
Sepsis, Surgery
Inflammatory Mediators of Acute Kidney Injury in Intensive Care
Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality.
- Conditions
- Sepsis, Surgery, Acute Kidney Injury
- Trial name
- PronMed (NCT03720860)
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Blood Stream Infection, Blood Stream Infections
Evaluation of Diagnostic Accuracy and Clinical Performance of the UllCORE Bloodstream Infection (BSI) Test
This study is designed to evaluate the clinical performance of the UllCORE Bloodstream Infection (BSI) Test, an investigational molecular diagnostic test intended to detect microorganisms and selected antimicrobial resistance…
- Conditions
- Blood Stream Infection, Blood Stream Infections, Sepsis, Fungemia
- Trial name
- B-RAPID (NCT07859852)
- Testing
- UllCORE BSI Test
- Where
- 20 sites in United States, France and 3 more
- Volunteers
- 1,500 people
- Sponsor
- Deepull Diagnostics S.L.
Sepsis
Clinical Protocol Validation to Identify Prognostic Markers for Critical Care Pediatric Patients
The purpose of this study is to monitor the respiratory, metabolic and nutritional status of critically ill pediatric patients undergoing mechanical ventilation and to correlate the clinical and physiopathological findings with…
- Trial name
- PCL07 (NCT00792883)
- Where
- Brazil
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Periodontal Disease, Periodontal Surgery
Serum Inflammatory Protein Concentration During Dental Treatment
The goal of this observational study is to study the molecular markers of stress in blood samples from people who are having periodontal surgery.
- Trial name
- NCT07468929
- Testing
- Blood samples for inflammatory markers, periodontal surgery, Periodontal maintenance
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University
AKI - Acute Kidney Injury
Renal Cell Arrest and Damage Biomarkers in Progression and Outcome of Septic AKI
The aim of the current study is to assess the predictive value of renal cell arrest biomarkers (urinary TIMP2 and IGFBP7), renal damage biomarkers (urinary KIM-1) and microscopic examination of urinary sediment in progression and…
- Trial name
- NCT06064487
- Testing
- renal cell arrest and damage biomarkers assessment
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Bipolar Disorder
Clinical Evaluation of the Antidepressant Effect of the Use of Probiotics in Bipolar Disorder
Bipolar Disorder (BD) is highly incapacitating and associated with premature mortality. Depressive symptoms and episodes are the most frequent cause of disability in subjects with BD and over half of patients do not respond…
- Trial name
- NCT05762887
- Testing
- Probiotic Group
- Where
- Brazil
- Volunteers
- 141 people
- Sponsor
- University of Sao Paulo
Schizophrenia, Physical Exercise
Physical Exercise on Simple Inflammatory Markers, Systemic Immune Inflammation Index, and Systemic Immune Response Index
Mental health is defined as a state of well-being in which a person can realize their talents, cope with the normal stresses of life, and support society by working efficiently and productively.
- Trial name
- NCT06574893
- Testing
- physical exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Septic Shock
Characterization of Hemostatic Disordres in Septic Shock: Searching for Biological Markers
Sepsis induces hemostatic disorders due to the exessive or inappropriate activation of inflammation, which could lead either to hypercoagulability or hypocoagulability.
- Trial name
- COASEPT (NCT02692053)
- Testing
- blood sampling
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Sepsis
Assessment of Red Cell Distribution Width's Prognostic Ability in Septic Intensive Care Unit Patients
Various biomarkers are used for predicting outcome from sepsis and septic shock, but single value doesn't give a clear-cut picture.
- Trial name
- NCT06847451
- Testing
- Prognostic biomarker as Red Cell Distribution Width
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Hypovolemic Shock, Cardiogenic Shock
Renal Resistive Index in Patients With Shock
This study consists of two substudies. The first substudy: 'Renal resistive index in critically ill patients with cardiogenic and septic shock' Design: cross-sectional observational Aim of this project is: 1.
- Conditions
- Hypovolemic Shock, Cardiogenic Shock, Septic Shock, Kidney Failure, Acute
- Trial name
- NCT02558166
- Where
- Netherlands
- Volunteers
- 92 people
- Sponsor
- Amsterdam UMC, location VUmc
Diabete Mellitus, Diabete Type 2
Inflammation and Diabetes: Evaluating Antioxidant Levels
The goal of this observational, cross-sectional study is to evaluate the relationships between dietary total antioxidant capacity, systemic inflammatory response markers, and nutritional parameters in adult patients with Type 2…
- Conditions
- Diabete Mellitus, Diabete Type 2, Inflamation, Systemic Inflammation
- Trial name
- IDEAL (NCT07734428)
- Testing
- No Interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Istanbul Bilgi University
Septic Shock, Severe Trauma
REAnimation Low Immune Status Markers
The fact that sepsis disrupts immune system homeostasis by inducing an initial cytokine storm, that participates to occurrence of organ failures and early death, followed by a compensatory anti-inflammatory response leading to…
- Conditions
- Septic Shock, Severe Trauma, Severe Burn, Major Surgery
- Trial name
- REALISM (NCT02638779)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Sepsis Syndrome, Septic Shock
Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis
Sepsis is a multifactorial syndrome characterized by a dynamic course and a clinical outcome dependent on several factors, and responsible for one in five deaths worldwide.
- Conditions
- Sepsis Syndrome, Septic Shock, Sepsis
- Trial name
- EPISEPSIS (NCT06446947)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Diabetes Mellitus, Type 2, Apical Periodontitis
Association of Apical Periodontitis With Systemic Level of Inflammatory Markers : A Longitudinal Intervention Study
While cross-sectional studies have reported a significant association between diabetes and Apical Periodontics, prospective studies are scarce.
- Trial name
- NCT05814965
- Testing
- endodontic treatment in the form of root canal treatment, endodontic treatment, assessment of inflammatory marker
- Where
- India
- Volunteers
- 280 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Lipid Disorder, Systemic Inflammatory Response
Evaluation of the Consumption of Lupins in Brine on Metabolic Markers in Healthy Individuals
The aim of the project was the evaluation of the effects of the consumption of different amounts of lupins in brine on lipid, glucose, inflammatory, oxidative stress, gut microbiota profile and (epi)genetic markers in healthy…
- Trial name
- SUPERLUPINO (NCT06595082)
- Testing
- 4-week lupins in brine consumption, 4-week lupins in brine consumption and dietary suggestion
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Teramo